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Supporting Information

Synthesis and photophysical studies on naphthalimide derived fluorophores as markers in drug delivery

Nidhi Singh, Ritika Srivastava, Anuradha Singh and Ramendra K. Singh*Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad – 211002, India*Corresponding author (Tel.: +91.532.2461005; E mail address: rksinghsrk@gmail.com

Fluorescent studies on synthesized fluorophores compounds 2-6:

2 3 4

5 6

6-(6-Acetylamino-1, 3-dioxo-1H, 3H-benzo [de]isoquinolin-2-yl)-hexanoic acid (2)

6-(6-Ethoxycarbonylamino-1,3-dioxo-1H,3H-benzo[de] isoquinolin-2-yl)-hexanoic acid (3)

6-(6-tert-Butoxycarbonylamino-1,3-dioxo-1H,3H-benzo[de] isoquinolin-2-yl)-hexanoic acid (4)

6-(6-Methanesulphonylamino-1, 3-dioxo-1H, 3H-benzo [de]isoquinolin-2-yl)-hexanoic acid (5)

6-[1, 3-Dioxo-6-(toluene-4-sulfonylamino)-1H, 3H-benzo [de]isoquinolin-2-yl]-hexanoic acid (6)

Solvatochromic studies on compound 2-6

Fig.1. Solvatochromism of compound 2 (absorption and emission spectra)

Fig.2. Solvatochromism of compound 3 (absorption and emission spectra)

Fig.3. Solvatochromism of compound 4 (absorption and emission spectra)

Fig.4.

Solvatochromism of compound 5 (absorption and emission spectra)

Fig.5. Solvatochromism of compound 6 (absorption and emission spectra)

Time-resolved fluorescent measurement studies on compound 2-6

Fig.6.

Fluorescence Lifetime of compound 2 Fig.7.

Fluorescence Lifetime of compound 3

Fig.8. Fluorescence Lifetime of compound 4 Fig.9. Fluorescence Lifetime of compound 5

Fig.10. Fluorescence Lifetime of compound 6