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SPP1710: “Dynamics of Thiol-based Redox Switches in Cellular Physiology”GBM Study Group “Redox Biology”

Sunday, 21.09.2014

15.00-18.30: Young investigator meeting SPP 1710: “Team building”, meet at the “Brückenaffe, Alte Brücke”

19:00: Get-togetherKulturbrauerei Heidelberg

Monday, 22.09.2014

09:00 Katja Becker and Hannes HerrmannWelcome

Session 1: Defined thiol switchesDiscussion leader: Tobias Dick

09:10 Neil Bulleid, GlasgowRedox regulation and disulfide formation in the endoplasmic reticulum

09:50 Leopold Flohé, MagdeburgHalf a century with glutathione peroxidases

10:10 Luise Krauth-Siegel, HeidelbergGPx-type enzymes protect trypanosomes from subcellular membrane damages

10:30 Marcus Conrad, MunichThe Cys/GSH/GPx4 axis in control of cell death and degenerative disease

10.50 Ivan Bogeski, Homburg/SaarThe interplay between ORAI channels and NADPH oxidase 2

11:10 Coffee break

Discussion leader: Andreas Meyer

11:40 Roland Lill, MarburgRedox events in the biogenesis of iron-sulfur proteins

12:00 Wilhelm Voth, GöttingenGET3 functions as ATP-independent chaperone under oxidative stress conditions

12.15 Rudi Glockshuber, ZürichReduction of ScoI and CoxB by the periplasmic thioredoxin TlpA

12:30 Poster session I.

Session 2: Discovery of new thiol switchesDiscussion leader: Karl-Josef Dietz

14:20 Nicolas Rouhier, Nancy Plant glutaredoxins: iron or redox players?15:00 Helmut Sies, Düsseldorf

Metabolic H2O2 generation: role in redox signaling and oxidative stress

15:20 Gaetano Calabrese, KaiserslauternRedox regulation in the mitochondrial intermembrane space

15:35 Martin Gruhlke, AachenUnravelling the physiological effects of the redox-toxin allicin from garlic

15.50 Peng Wang, BerlinThiol-based redox control of tetrapyrrole biosynthesis in higher plants

16.05 Eva-Maria Hanschmann, GreifswaldNrx interaction partners in cellular (de)differentiation

16:30 Bus to Castle tour19:00 Dinner Haus Buhl

Tuesday, 23.09.2014

Discussion leader: Sabine Zachgo

09:00 Jean-François Collet, Brussels

The dangerous life of periplasmic proteins, electrons to the rescue

09:40 Lars Leichert, BochumFunctional metagenomics of the thioredoxin superfamily

10.00 Isabel Aller, BonnCharacterization of the ER-oxidoreductases ERO1 and ERO2 from Arabidopsis thaliana

10:15 Nora Gutsche, OsnabrückInteractions of ROXYs with TGA transcription factors during the evolution of land plants

10:30 Andrea Viehauser, BielefeldCysteinyl residues in redox-related functions of cyclophilin Cyp20-3

10:45 Coffee break

11:15 Discussion: Redox in the future: What are tomorrow’s questions?

12:00 Poster session II.

Session 3: Engineered thiol switchesDiscussion leader: Blanche Schwappach

13.30 Martin Kerschensteiner, MunichIn vivo analysis of mitochondrial redox signals in nervous system pathology

13:50 Frank Böhmer, JenaOxidation of protein tyrosine phosphatases in acute myeloid leukemia cells

14:05 Marina Rubini, KonstanzAcceleration of protein folding by a single amino acid replacement in thioredoxin

14.20 Franziska Mohring, GiessenDetermination of the glutathione redox potential in subcellular compartments of Plasmodium falciparum

14:35 Bruce Morgan, HeidelbergInvestigating cellular H2O2 homeostasis with ultra-sensitive genetically-encoded probes

14.50 Closing remarks

15:00 End of the symposium