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SPP1710: “Dynamics of Thiol-based Redox Switches in Cellular Physiology”GBM Study Group “Redox Biology”
Sunday, 21.09.2014
15.00-18.30: Young investigator meeting SPP 1710: “Team building”, meet at the “Brückenaffe, Alte Brücke”
19:00: Get-togetherKulturbrauerei Heidelberg
Monday, 22.09.2014
09:00 Katja Becker and Hannes HerrmannWelcome
Session 1: Defined thiol switchesDiscussion leader: Tobias Dick
09:10 Neil Bulleid, GlasgowRedox regulation and disulfide formation in the endoplasmic reticulum
09:50 Leopold Flohé, MagdeburgHalf a century with glutathione peroxidases
10:10 Luise Krauth-Siegel, HeidelbergGPx-type enzymes protect trypanosomes from subcellular membrane damages
10:30 Marcus Conrad, MunichThe Cys/GSH/GPx4 axis in control of cell death and degenerative disease
10.50 Ivan Bogeski, Homburg/SaarThe interplay between ORAI channels and NADPH oxidase 2
11:10 Coffee break
Discussion leader: Andreas Meyer
11:40 Roland Lill, MarburgRedox events in the biogenesis of iron-sulfur proteins
12:00 Wilhelm Voth, GöttingenGET3 functions as ATP-independent chaperone under oxidative stress conditions
12.15 Rudi Glockshuber, ZürichReduction of ScoI and CoxB by the periplasmic thioredoxin TlpA
12:30 Poster session I.
Session 2: Discovery of new thiol switchesDiscussion leader: Karl-Josef Dietz
14:20 Nicolas Rouhier, Nancy Plant glutaredoxins: iron or redox players?15:00 Helmut Sies, Düsseldorf
Metabolic H2O2 generation: role in redox signaling and oxidative stress
15:20 Gaetano Calabrese, KaiserslauternRedox regulation in the mitochondrial intermembrane space
15:35 Martin Gruhlke, AachenUnravelling the physiological effects of the redox-toxin allicin from garlic
15.50 Peng Wang, BerlinThiol-based redox control of tetrapyrrole biosynthesis in higher plants
16.05 Eva-Maria Hanschmann, GreifswaldNrx interaction partners in cellular (de)differentiation
16:30 Bus to Castle tour19:00 Dinner Haus Buhl
Tuesday, 23.09.2014
Discussion leader: Sabine Zachgo
09:00 Jean-François Collet, Brussels
The dangerous life of periplasmic proteins, electrons to the rescue
09:40 Lars Leichert, BochumFunctional metagenomics of the thioredoxin superfamily
10.00 Isabel Aller, BonnCharacterization of the ER-oxidoreductases ERO1 and ERO2 from Arabidopsis thaliana
10:15 Nora Gutsche, OsnabrückInteractions of ROXYs with TGA transcription factors during the evolution of land plants
10:30 Andrea Viehauser, BielefeldCysteinyl residues in redox-related functions of cyclophilin Cyp20-3
10:45 Coffee break
11:15 Discussion: Redox in the future: What are tomorrow’s questions?
12:00 Poster session II.
Session 3: Engineered thiol switchesDiscussion leader: Blanche Schwappach
13.30 Martin Kerschensteiner, MunichIn vivo analysis of mitochondrial redox signals in nervous system pathology
13:50 Frank Böhmer, JenaOxidation of protein tyrosine phosphatases in acute myeloid leukemia cells
14:05 Marina Rubini, KonstanzAcceleration of protein folding by a single amino acid replacement in thioredoxin
14.20 Franziska Mohring, GiessenDetermination of the glutathione redox potential in subcellular compartments of Plasmodium falciparum
14:35 Bruce Morgan, HeidelbergInvestigating cellular H2O2 homeostasis with ultra-sensitive genetically-encoded probes
14.50 Closing remarks
15:00 End of the symposium