scientists like to actually see the things they research. but this isn't always possible

Scientists like to actually see the things they research .But this isn't always possible.

Source: Clipart ETC

Source: Wikipedia

Most of what we see is larger than the wavelength of visible light.

Scientists occasionally want to study things that are smaller thanthe wavelength of visible light.

Wavelength of ultraviolet light: 400 nanometersOne nanometer = one millionth of a millimeter

That was the case with the ribosome that Nobel Prize laureate Prof. Ada Yonath wanted to explore.

The diameter of a ribosome is about 20 nanometers, which is approximately 20 times smaller than the ultraviolet wavelength.

Wavelength of ultraviolet light: 400 nanometersOne nanometer = one millionth of a millimeter

To "see" the internal structure of bodies the size of a ribosome, scientists often expose them to x-rays.

This reveals the location of single atoms.

The wavelength of x-rays is about 20 times smaller than the diameter of ribosomes.

Source: NASA

The ribosome is a key component of living cells.

Source: Wikipedia

Living cells have a single nucleus and thousands of ribosomes.

Source: Wikipedia

Ribosomes translate the genetic information within the cell's nucleus into a process for producing proteins.

Source Wikipedia

Proteins are huge molecules, structured like folding chains and composed of a sequence of amino acids.

Source: Wikipedia

Proteins are one of the most important compounds that make up living organisms. They are found in every living cell.

Ribosomes themselves are composed, in part, of proteins

Source: Clipart ETC

Prof. Ada Yonath and other researchers wanted to know which proteins are contained in the ribosome and how they are organized spatially.

To find out, they needed to rely on x-rays.

Source: Prof' Ada Yonaths' Lab

The method for determining the structure of biological molecules using radiation is called x-ray crystallography.

Prof. Ada Yonath uses x-ray crystallography to study ribosomes.

Source NASA

To prepare a living substance for x-ray crystallography research, the substance itself needs to be crystallized.

Source: NASA

Different crystals diffract the x-rays directed at them in different ways.

The particular composition and spatial structure of each crystal create a unique picture.

This picture resembles a collection of dots.

Source: Wikipedia

All the pictures created during x-raying are entered into powerful computers, which feed them into a complex decoding process resulting in three-dimensional images.

The computer-assisted decoding relies on mathematical formulas and hypothetical structural models, based on data gathered through other methods.

Source: Wikipdia

As the x-raying proceeds, it is crucial to maintain the stability of the substance being examined. In many cases, the substance becomes hotter and the crystal is destroyed. The substance changes form, preventing the researcher from determining its structure.

Source: yomi955

Prof. Ada Yonath was the first to deal successfully with two complex problems: crystallizing the ribosome and preparing the crystal for x-ray without changing its form during the examination process.

Source: L'OREAL-UNESCO Awards For Women in Science

The living substance that Prof. Yonath used to examine ribosome structure was bacteria drawn from hot springs, which are resistant to high temperatures.

Prof. Yonath cooled samples of the substance to a temperature of -185º C, preventing its decomposition under experimental conditions.

Source: David Lisbona

This accomplishment earned her the 2009 Nobel Prize for Chemistry.

She shared the prize with Thomas Steitz of Yale University in the U.S. and Venkatraman Ramakrishnan of Cambridge University in Britain.

The three scientists were awarded the prize for their contribution to the study of ribosome structure and functioning.

Most antibiotic medicines attach themselves to bacterial ribosomes, preventing them from acting.

By understanding how antibiotics affect ribosomes, scientists can conduct research leading to the development of more effective drugs.

Source: The lab of Prof' Ada Yonath

Writing: Hanan CohenEditing: Nurit SnirGraphic design: Vadik Bakman