research publications in-adme research a. avdeef
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in-ADME Research Copyright © 2011
Selected PublicationsA. Avdeef
in-ADME Research
www.in-ADME.com
in-ADME Research Copyright © 2011
in-ADME Research Copyright © 2011
in-ADME Research Copyright © 2011
in-ADME Research Copyright © 2011
in-ADME Research Copyright © 2011
J. Pharm. Sci. 2007, 96, 2893-2909
pIONRocheWyethNovartisPfizer
PAMPA “white paper”
in-ADME Research Copyright © 2011
Blood-Brain Barrier
pIONAmgen AstraZeneca
Eur. J. Pharm. Sci. 2009, 38, 421-137Pharm. Res. 2011, 28, 337-363Pharm. Res. 2011, 28, 517-530
in-ADME Research Copyright © 2011
Caco-2 pH ProfileDrug Disc. Today, 2003, 8, 997Eur. J. Pharm. Sci., 2004, 21,429Eur. J. Pharm. Sci., 2005, 24, 333
pIONKing’s College LondonValencia UnivUppsala Univ
Caco-2 & PAMPA
in-ADME Research Copyright © 2011
pIONAstraZeneca
Pharm. Res. 2010, 27, 480-486J. Med. Chem. 2010, 53, 3566-3584Eur. J. Pharm. Sci. 2011, 43, 109-124
Paracellular
in-ADME Research Copyright © 2011
Pharm. Res. 2006,23,2525Pharm.Res.2007,24, 530Eur. J. Pharm. Sci. 2008, 33, 29
Absorption Classification Maps
pIONHoffman-La Roche
in-ADME Research Copyright © 2011
Pharm. Res. 2008, 25, 2613Pharm. Res. 2009, 26, 2093Chem. Biodiv. 2009,11, 1796
Miniaturized Dissolution
(lowering API requirement by 10,000)
pIONpIONpION
Micro-Volume Dissolution
in-ADME Research Copyright © 2011
PAMPA-skin
pIONSemmelweis Univ
in-ADME Research Copyright © 2011
pKa at 37oC
pION
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