prostate pathology part 1 francisco g. la rosa, md associate professor, department of pathology...

Prostate Prostate PathologyPathology

Part 1Part 1

Francisco G. La Rosa, MDFrancisco G. La Rosa, MDAssociate Professor, Department of PathologyAssociate Professor, Department of Pathology

University of Colorado Denver, Aurora, ColoradoUniversity of Colorado Denver, Aurora, Colorado

NORMAL ANATOMYNORMAL ANATOMY

SAGITAL SECTION OF THE PROSTATE GLANDSAGITAL SECTION OF THE PROSTATE GLAND

SeminalVesicle

Central Zone

Bladder

Peri-urethralzone

Anterior ZoneFibro-muscular

PeripheralZone

TransitionZone

Urethra

3D VIEW OF THE PROSTATE3D VIEW OF THE PROSTATE

3D VIEW OF THE PROSTATE3D VIEW OF THE PROSTATE

CROSS SECTION OF THE PROSTATECROSS SECTION OF THE PROSTATE

FIBROMUSCULAR STROMAanterior

PERI-URETHRALSTROMA

EJACULATORY DUCTS

TRANZITIONALZONE

Seminal Vesicle

Urethra

CENTRALZONE

Peripheral Zone

Fibro-muscular Stromaanterior

HISTOLOGYHISTOLOGY

Bad HistologyBad Histology

Peripheral ZonePeripheral Zone

Central ZoneCentral Zone

Central ZoneCentral Zone

Central ZoneCentral Zone

Central ZoneCentral Zone

Central ZoneCentral Zone

40X40X Seminal VesiclesSeminal Vesicles

20X Seminal VesiclesSeminal Vesicles

20X20X Seminal VesiclesSeminal Vesicles

ParaganglionParaganglion

NeuronsNeurons40X40X

Benign Benign Lesions Lesions

InflammationInflammation

Acute InflammationAcute Inflammation

Acute InflammationAcute Inflammation

Acute InflammationAcute Inflammation

Acute InflammationAcute Inflammation

GranulomaGranuloma

20X20X Corpora AmylaceaCorpora Amylacea

20X20X Corpora AmylaceaCorpora AmylaceaCalcifiedCalcified

200X200X CristalloidCristalloid

200X200X Stromal NodulesStromal Nodules

H Y P E R P L A S I AH Y P E R P L A S I A

PRIMARY NODULAR PRIMARY NODULAR HYPERPLASIAHYPERPLASIA

Cell Type

Mesenchymal

Fibroblast

Smooth Muscle

Basal Cells

Secretory Cells

Special PatternsUsual Patterns

Predominantlystromal

Predominantlyglandular

Mixed

Small CellHyperplasia

LeiomatousHyperplasia

Basal CellHyperplasia

CrybiformHyperplasia

BENIGN NODULAR HYPERPLASIA

BENIGN NODULAR HYPERPLASIABENIGN NODULAR HYPERPLASIA

BENIGN NODULAR HYPERPLASIABENIGN NODULAR HYPERPLASIA

BPH & InflammationBPH & Inflammation

BPH & InflammationBPH & Inflammation

BASAL CELL HYPERPLASIABASAL CELL HYPERPLASIA

BASAL CELL HYPERPLASIABASAL CELL HYPERPLASIA200X

200X BASAL CELL HYPERPLASIABASAL CELL HYPERPLASIA

BASAL CELL HYPERPLASIA - HMWCKBASAL CELL HYPERPLASIA - HMWCK

ATROPHYATROPHY

20X20X SIMPLE SIMPLE ATROPHYATROPHY

200X

ATROPHYATROPHY

40X ATROPHYATROPHY

10X10X CYSTIC ATROPHYCYSTIC ATROPHY

PINPIN

Prostatic Intraepithelial NeoplasiaProstatic Intraepithelial Neoplasia

Secretorycells

Lumen

Basal Cells

BasalMembrane

Normal

Dysplasia Carcinoma

Mild Moderate Severe In situ Microinvasive

Low Grade High Grade

Prostatic Intra-epithelial Neoplasia

Prostatic Intraepithelial NeoplasiaProstatic Intraepithelial Neoplasia

Prostatic Intra-epithelial NeoplasiaProstatic Intra-epithelial Neoplasia

Prostatic Intra-epithelial NeoplasiaProstatic Intra-epithelial Neoplasia

Prostatic Intra-epithelial NeoplasiaProstatic Intra-epithelial Neoplasia

It continues in Part 2