patho1 lab 2nd exam

8/9/2019 Patho1 Lab 2nd Exam

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ReviewReview PathoPatho--LabLab

Exam 2Exam 2

DISEASES WITH A GENETIC DISEASES WITH A GENETIC

BACKGROUNDBACKGROUND

NEUROFIBROMA

- proliferation of all elements of

peripheral nerve

- elongated and serpentine

schwann cells in a mixoid stroma

- fibroblast and collagenFibroblast pink back

ground

Fat cells

TESTICULAR ATROPHY

- seminiferous tubules transformed into a

hyaline scar

XANTHOMA

-accumulation of foamy histiocytes, giant cells & Cholesterol needles

-Multinucleated cells

-Hypercholesterolemia (familial autosomal dominant)

RETINOBLASTOMA- proliferation of small, dark-blue, round

cells with scant (few) cytoplasm and

hyperchromatic nuclei.

- some cells are organized around a

central lumen forming rosettes

- there is a large amount of mitosis andareas of necrosis

RETINOBLASTOMA

Glycogenosis

- Large cell cytoplam PAS+

DISEASES WITH AN IMMUNOLOGIC DISEASES WITH AN IMMUNOLOGIC

BACKGROUNDBACKGROUND

SIALOADENITIS

- inflammatory infiltration of lymphocytes

around salivary ducts

salivary ducts are hyalinized and destroyed

-associated with Sjogern syndrome-Dry mouth(xerotomia) and dry eyes

SYSTEMIC LUPUS

ERYTHEMATOUS

- liquefactive

degeneration of theepidermal basal layer

- edema at the dermal

junction

- dermal perivascular

mononuclear cell

infiltration

SYSTEMIC LUPUS

ERYTHEMATOUS

- liquefactive

degeneration of the

epidermal basal layer

- edema at the

dermal junction

SclerodermaScleroderma

SCLERODERMA

- loss of the rete

pegs and dermal

appendages

- perivascular inflammatory

infiltrate

- swelling and

degeneration of

the collagen

fibers which arethick and large

AMYLOIDOSIS

- accumulation of amyloid material

- pink amorphous material within the

glomeruli and tubules

BENIGN MESENCHYMAL TUMORSBENIGN MESENCHYMAL TUMORS

HAMARTOMA

- accumulation of amyloid material

- pink amorphous material within the

glomeruli and tubules

CHORISTOMA

-NORMALCELL

-abnormal place

LIPOMA

- proliferation of mature adipocytes

surrounded by a fibroconnective capsule

LEIOMYOMA

- proliferation of mature smooth muscle

cells with cigar like nuclei

- cells are organized in different directions

giving the appearance of stormy pattern

RHABDOMYOMA

- proliferation of large round or

polyhedral cells with centrally or

peripherally located nuclei,

eosinophilic cytoplasm withglycogen vacuoles - there is

also spider cells

spider cells

HIBERNOMA

- proliferation of large polyhedral

cells with small fatty vacuoles in

the cytoplasm

- centrally located nuclei with

prominent nucleoli; some cells

resemble adipocytes

HIBERNOMA

OSTECHONDROMA

proliferation of mature

hyaline cartilage, mixed

with proliferated bone

spicules-

OSTEOMA

- proliferation of mature bone with

H AVERSI AN system

GIANT CELL TUMOR OF TENDINOUS

SHEATH

- proliferation of spindle-shaped stromal

cells, mixed with histiocytes and giant

multinucleated cells

GIANT CELL TUMOR OF BONE

- proliferation of spindle shaped stromal

cells, giant multinucleated cells betweenbone SPICULES

FIBROMA

- proliferation of spindle-shaped fibroblast

closely packed within collagen fibers

- there is a stormy pattern

Mesenchimoma

BENIGN EPITHELI AL TUMORSBENIGN EPITHELI AL TUMORS

INTRADERMAL CYST

- the wall of the cyst is lined by

squamous stratified epithelium

- the lumen is filled by a pink

laminar material like keratin

INTRADERMAL CYST

CYSTADENOMA

fibroconnective tissue wall line by columnar

epithelium

-Mass with cavity lined by secretory cells

and proliferation of ducts

FIBROADENOMA

- proliferation of ductal

spaces lined by epithelium

and fibrous stroma

surrounded by a

fibroconnective capsule

INTRADERMAL NEVUS

- Proliferation of melanocytes, small cells with round dark nuclei and

scant cytoplasm, which grows in a diffuse manner at the level of the

dermis

perinuclear clear

vacuoles in the

cytoplasm

epidermal hyperplasia (AC ANTHOSIS)

increased keratin layer (HYPERKERATOSIS)

undulant pro jection

of the epidermis into

the dermis

(PAPILLOMATOSIS)

hyperplasia of the

granulosa cell layer (HYPERGRANULOSIS)

MENINGIOMA

Proliferation of cells forming whorled clusters of cells, some of them with laminated

central calcification or Psamoma¶s bodies (Psamomatous pattern)

-proliferation of cells which growth as a scyncytium without visible cells membrane

Calcification

center

MENINGIOMA

- proliferation of whrled cluster of

cells without visible cell membrane

- laminated calcifications or

Psamoma¶s bodies (calcification of

centers)

POLYPS

- proliferation of glandsand abundant capillaries

KERATOACANTHOMA

- keratin-filled crater surrounded by

epithelial cells which extends:

1. Upward in a lip-like formation2. Downward into the dermis as irregular

tongues

- the epithelium is composed of enlarged

cells with a glassy cytoplasm that form

islands of keratin

CILINDROMA

- islands of basaloid cells with

deposition of a basement

membrane material

CILINDROMA

- islands of basaloid cells

with deposition of a

basement membranematerial

AMELOBLASTOMA

- nest or cords of

stratified squamous or

columnar epithelium

embedded in a loose

fibrous stroma

- some areas showpapillary projections

patho1 lab 2nd exam

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