patho1 lab 2nd exam
TRANSCRIPT
8/9/2019 Patho1 Lab 2nd Exam
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ReviewReview PathoPatho--LabLab
Exam 2Exam 2
8/9/2019 Patho1 Lab 2nd Exam
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DISEASES WITH A GENETIC DISEASES WITH A GENETIC
BACKGROUNDBACKGROUND
8/9/2019 Patho1 Lab 2nd Exam
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NEUROFIBROMA
- proliferation of all elements of
peripheral nerve
- elongated and serpentine
schwann cells in a mixoid stroma
- fibroblast and collagenFibroblast pink back
ground
Fat cells
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TESTICULAR ATROPHY
- seminiferous tubules transformed into a
hyaline scar
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XANTHOMA
-accumulation of foamy histiocytes, giant cells & Cholesterol needles
-Multinucleated cells
-Hypercholesterolemia (familial autosomal dominant)
8/9/2019 Patho1 Lab 2nd Exam
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RETINOBLASTOMA- proliferation of small, dark-blue, round
cells with scant (few) cytoplasm and
hyperchromatic nuclei.
- some cells are organized around a
central lumen forming rosettes
- there is a large amount of mitosis andareas of necrosis
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RETINOBLASTOMA
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Glycogenosis
- Large cell cytoplam PAS+
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DISEASES WITH AN IMMUNOLOGIC DISEASES WITH AN IMMUNOLOGIC
BACKGROUNDBACKGROUND
8/9/2019 Patho1 Lab 2nd Exam
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SIALOADENITIS
- inflammatory infiltration of lymphocytes
around salivary ducts
salivary ducts are hyalinized and destroyed
-associated with Sjogern syndrome-Dry mouth(xerotomia) and dry eyes
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SYSTEMIC LUPUS
ERYTHEMATOUS
- liquefactive
degeneration of theepidermal basal layer
- edema at the dermal
junction
- dermal perivascular
mononuclear cell
infiltration
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SYSTEMIC LUPUS
ERYTHEMATOUS
- liquefactive
degeneration of the
epidermal basal layer
- edema at the
dermal junction
8/9/2019 Patho1 Lab 2nd Exam
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SclerodermaScleroderma
SCLERODERMA
- loss of the rete
pegs and dermal
appendages
- perivascular inflammatory
infiltrate
- swelling and
degeneration of
the collagen
fibers which arethick and large
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AMYLOIDOSIS
- accumulation of amyloid material
- pink amorphous material within the
glomeruli and tubules
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BENIGN MESENCHYMAL TUMORSBENIGN MESENCHYMAL TUMORS
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HAMARTOMA
- accumulation of amyloid material
- pink amorphous material within the
glomeruli and tubules
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CHORISTOMA
-NORMALCELL
-abnormal place
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LIPOMA
- proliferation of mature adipocytes
surrounded by a fibroconnective capsule
8/9/2019 Patho1 Lab 2nd Exam
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LEIOMYOMA
- proliferation of mature smooth muscle
cells with cigar like nuclei
- cells are organized in different directions
giving the appearance of stormy pattern
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RHABDOMYOMA
- proliferation of large round or
polyhedral cells with centrally or
peripherally located nuclei,
eosinophilic cytoplasm withglycogen vacuoles - there is
also spider cells
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spider cells
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HIBERNOMA
- proliferation of large polyhedral
cells with small fatty vacuoles in
the cytoplasm
- centrally located nuclei with
prominent nucleoli; some cells
resemble adipocytes
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HIBERNOMA
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OSTECHONDROMA
proliferation of mature
hyaline cartilage, mixed
with proliferated bone
spicules-
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OSTEOMA
- proliferation of mature bone with
H AVERSI AN system
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GIANT CELL TUMOR OF TENDINOUS
SHEATH
- proliferation of spindle-shaped stromal
cells, mixed with histiocytes and giant
multinucleated cells
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GIANT CELL TUMOR OF BONE
- proliferation of spindle shaped stromal
cells, giant multinucleated cells betweenbone SPICULES
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FIBROMA
- proliferation of spindle-shaped fibroblast
closely packed within collagen fibers
- there is a stormy pattern
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Mesenchimoma
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BENIGN EPITHELI AL TUMORSBENIGN EPITHELI AL TUMORS
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INTRADERMAL CYST
- the wall of the cyst is lined by
squamous stratified epithelium
- the lumen is filled by a pink
laminar material like keratin
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INTRADERMAL CYST
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CYSTADENOMA
fibroconnective tissue wall line by columnar
epithelium
-Mass with cavity lined by secretory cells
and proliferation of ducts
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FIBROADENOMA
- proliferation of ductal
spaces lined by epithelium
and fibrous stroma
surrounded by a
fibroconnective capsule
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INTRADERMAL NEVUS
- Proliferation of melanocytes, small cells with round dark nuclei and
scant cytoplasm, which grows in a diffuse manner at the level of the
dermis
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WART
perinuclear clear
vacuoles in the
cytoplasm
epidermal hyperplasia (AC ANTHOSIS)
increased keratin layer (HYPERKERATOSIS)
undulant pro jection
of the epidermis into
the dermis
(PAPILLOMATOSIS)
hyperplasia of the
granulosa cell layer (HYPERGRANULOSIS)
8/9/2019 Patho1 Lab 2nd Exam
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MENINGIOMA
Proliferation of cells forming whorled clusters of cells, some of them with laminated
central calcification or Psamoma¶s bodies (Psamomatous pattern)
-proliferation of cells which growth as a scyncytium without visible cells membrane
Calcification
center
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MENINGIOMA
- proliferation of whrled cluster of
cells without visible cell membrane
- laminated calcifications or
Psamoma¶s bodies (calcification of
centers)
8/9/2019 Patho1 Lab 2nd Exam
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POLYPS
- proliferation of glandsand abundant capillaries
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KERATOACANTHOMA
- keratin-filled crater surrounded by
epithelial cells which extends:
1. Upward in a lip-like formation2. Downward into the dermis as irregular
tongues
- the epithelium is composed of enlarged
cells with a glassy cytoplasm that form
islands of keratin
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CILINDROMA
- islands of basaloid cells with
deposition of a basement
membrane material
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CILINDROMA
- islands of basaloid cells
with deposition of a
basement membranematerial
8/9/2019 Patho1 Lab 2nd Exam
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AMELOBLASTOMA
- nest or cords of
stratified squamous or
columnar epithelium
embedded in a loose
fibrous stroma
- some areas showpapillary projections