neuronal properties of the dopaminergic neuron, h-cell dopamine ple, ddc, vmat, dat neuropeptide...

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Neuronal properties of the Dopaminergic neuron, H-cell

Dopamine ple, Ddc, VMAT, DAT

Neuropeptide receptor: NPFR1 Serotonin receptor: 5-HT1A Glutamate Receptor: Glu-RI

H-cell

tup regulates dopamine biosynthetic and transport genes

pdm2nub

tup

SoxN

D

BH1

HGTX

esg

sim

Pros

Ddc

zfh1

wor

ple

NPFR1

DAT

Glu-RI

5-HT1A

VMAT

Elav

CG31757

SNF4A

tup expression begins late s11

Proteins involved in catacholamine synthesis

Tyrosine L-DOPA Dopamine

TH (ple)

VMAT

Ddc

Catsup

GTP

BH4

GTPCH (Pu)

DAT

Catsup

Ddc is down regulated in tup mutants

Ddc Ab staining

Ddc

Ddc

Ddc/GFP

Ddc/GFP

Ddc enhancer analysis

Grainyhead binds element IDrifter binds Cf1

tup represses NPFR1 expression in abdominal segments

Mapping Antp midline expression

Antp is expressed in mVUMs in T1

Gene regulatory networks in the H-cell

pdm2nub

tup

SoxN

ac/sc

D

BH1

HGTX

esg

sim

Pros

Ddc

zfh1

wor

ple

NPFR1

DAT

Glu-RI

5-HT1A

VMAT

Elav

CG31757

SNF4A

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