module 2 - mps cells location and functions.ppt
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MONONUCLEAR MONONUCLEAR PHAGOCYTE PHAGOCYTE
SYSTEMSYSTEM(MPS)(MPS)
Distribution and Functional Significance
of MPS cells
Mononuclear Phagocyte Mononuclear Phagocyte System (MPS) cells:System (MPS) cells:
MonocyteMonocyte MacrophageMacrophage Kupffer cellKupffer cell Microglia cellMicroglia cell Langerhans cellLangerhans cell Dendritic cellDendritic cell OsteoclastOsteoclast Multinuclear giant cellMultinuclear giant cell
MONOCYTEMONOCYTE Largest leukocyte, 12 Largest leukocyte, 12
micrometers, or moremicrometers, or more Round/oval, to Round/oval, to
indented/horshoe-shapedindented/horshoe-shaped 3-8% of blood leukocytes3-8% of blood leukocytes LIR, additions are made to the LIR, additions are made to the
resident population of resident population of phagocyte CT by emigration of phagocyte CT by emigration of more monocytes from blood more monocytes from blood and transformation to and transformation to macrophagesmacrophages
MONOCYTEMONOCYTE CIR, macrophages may be CIR, macrophages may be
closely packed and appear closely packed and appear like epitheloid cellslike epitheloid cells
On too large foreign objects On too large foreign objects too resistant to intracellular too resistant to intracellular digestion, monocytes digestion, monocytes coalesce to form huge coalesce to form huge multinucleated massesmultinucleated masses
Foreign body giant cellsForeign body giant cells
MACROPHAGEMACROPHAGE Production of cytokines,
chemotactic factors, & other molecules participating in inflammation & defense
CT, lymphoid organs, lungs, bone marrow
antigen processing & presentation
If particles penetrate skin, macrophages enter lymph, & flow into lypmh nodes located along the course of the flow
Particles are then trapped into the network of sinuses lined by tissue macrophages
with Conidia
KUPFFER CELLKUPFFER CELL Production of cytokines,
chemotactic factors, & other molecules participating in inflammation & defense
Found in LIVER sinusoids
antigen processing & presentation
KUPFFER CELLKUPFFER CELL form an effective particulate filtration system that almost no bacteria from the GIT succeed in entering the general systemic circulation through portal bloodPhagocytosis: 1/100 of a second
MICROGLIA CELLMICROGLIA CELL CNS macrophages/brain
macrophages Production of cytokines,
chemotactic factors, & other molecules participating in inflammation & defense
Found in nerve tissue of CNS antigen processing &
presentation
LANGERHANS CELLLANGERHANS CELL Found in SKIN
(subcutaneous tissue) antigen processing &
presentation In local inflammations w/
subcutaneous tissue, local macrophages divide in situ, then form macrophages before the attack and destroy process
DENDRITIC CELLDENDRITIC CELL Found in LYMPH NODES antigen processing &
presentation antigen-presenting cells
(macrophages, B lymphocytes, and dendritic cells) are able to activate resting helper T-cells when the matching antigen is presented
macrophages and B cells can only activate memory T cells, BUT dendritic cells can activate both memory and naive T cells
Are the most potent of all the antigen-presenting cells
DENDRITIC CELLDENDRITIC CELL
with Conidia
OSTEOCLASTOSTEOCLAST Digestion of BONE Found in BONE (fusion of several
macrophages)
Macrophage of Bone Macrophage of Bone Marrow and SpleenMarrow and Spleen
Last line of defense of the macrophage system
Phagocytosis of unwanted debris in blood including old and abnormal RBC
MULTINUCLEAR GIANT MULTINUCLEAR GIANT CELLCELL
Segregation and digestion of Segregation and digestion of foreign bodies foreign bodies
found in found in CONNECTIVE TISSUE CONNECTIVE TISSUE (fusion of several macrophages)(fusion of several macrophages)
Foreign body giant cellsForeign body giant cells monocytes coalesce to form monocytes coalesce to form
huge multinucleated masseshuge multinucleated masses
SKIN APPENDAGESSKIN APPENDAGESGeneral Functions &
Descriptions
HairHair Sebaceous glandSebaceous gland Sweat glandSweat gland NailNail
SKIN APPENDAGESSKIN APPENDAGES
HAIRHAIR
SEBACEOUS GLANDSEBACEOUS GLAND
SWEAT GLANDSWEAT GLAND
NAILNAIL
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