module 2 - mps cells location and functions.ppt
TRANSCRIPT
![Page 1: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/1.jpg)
MONONUCLEAR MONONUCLEAR PHAGOCYTE PHAGOCYTE
SYSTEMSYSTEM(MPS)(MPS)
Distribution and Functional Significance
of MPS cells
![Page 2: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/2.jpg)
Mononuclear Phagocyte Mononuclear Phagocyte System (MPS) cells:System (MPS) cells:
MonocyteMonocyte MacrophageMacrophage Kupffer cellKupffer cell Microglia cellMicroglia cell Langerhans cellLangerhans cell Dendritic cellDendritic cell OsteoclastOsteoclast Multinuclear giant cellMultinuclear giant cell
![Page 3: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/3.jpg)
MONOCYTEMONOCYTE Largest leukocyte, 12 Largest leukocyte, 12
micrometers, or moremicrometers, or more Round/oval, to Round/oval, to
indented/horshoe-shapedindented/horshoe-shaped 3-8% of blood leukocytes3-8% of blood leukocytes LIR, additions are made to the LIR, additions are made to the
resident population of resident population of phagocyte CT by emigration of phagocyte CT by emigration of more monocytes from blood more monocytes from blood and transformation to and transformation to macrophagesmacrophages
![Page 4: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/4.jpg)
MONOCYTEMONOCYTE CIR, macrophages may be CIR, macrophages may be
closely packed and appear closely packed and appear like epitheloid cellslike epitheloid cells
On too large foreign objects On too large foreign objects too resistant to intracellular too resistant to intracellular digestion, monocytes digestion, monocytes coalesce to form huge coalesce to form huge multinucleated massesmultinucleated masses
Foreign body giant cellsForeign body giant cells
![Page 5: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/5.jpg)
![Page 6: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/6.jpg)
![Page 7: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/7.jpg)
![Page 8: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/8.jpg)
MACROPHAGEMACROPHAGE Production of cytokines,
chemotactic factors, & other molecules participating in inflammation & defense
CT, lymphoid organs, lungs, bone marrow
antigen processing & presentation
![Page 9: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/9.jpg)
If particles penetrate skin, macrophages enter lymph, & flow into lypmh nodes located along the course of the flow
Particles are then trapped into the network of sinuses lined by tissue macrophages
![Page 10: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/10.jpg)
![Page 11: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/11.jpg)
with Conidia
![Page 12: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/12.jpg)
KUPFFER CELLKUPFFER CELL Production of cytokines,
chemotactic factors, & other molecules participating in inflammation & defense
Found in LIVER sinusoids
antigen processing & presentation
![Page 13: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/13.jpg)
KUPFFER CELLKUPFFER CELL form an effective particulate filtration system that almost no bacteria from the GIT succeed in entering the general systemic circulation through portal bloodPhagocytosis: 1/100 of a second
![Page 14: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/14.jpg)
![Page 15: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/15.jpg)
MICROGLIA CELLMICROGLIA CELL CNS macrophages/brain
macrophages Production of cytokines,
chemotactic factors, & other molecules participating in inflammation & defense
Found in nerve tissue of CNS antigen processing &
presentation
![Page 16: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/16.jpg)
![Page 17: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/17.jpg)
LANGERHANS CELLLANGERHANS CELL Found in SKIN
(subcutaneous tissue) antigen processing &
presentation In local inflammations w/
subcutaneous tissue, local macrophages divide in situ, then form macrophages before the attack and destroy process
![Page 18: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/18.jpg)
![Page 19: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/19.jpg)
DENDRITIC CELLDENDRITIC CELL Found in LYMPH NODES antigen processing &
presentation antigen-presenting cells
(macrophages, B lymphocytes, and dendritic cells) are able to activate resting helper T-cells when the matching antigen is presented
![Page 20: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/20.jpg)
macrophages and B cells can only activate memory T cells, BUT dendritic cells can activate both memory and naive T cells
Are the most potent of all the antigen-presenting cells
DENDRITIC CELLDENDRITIC CELL
![Page 21: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/21.jpg)
![Page 22: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/22.jpg)
with Conidia
![Page 23: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/23.jpg)
OSTEOCLASTOSTEOCLAST Digestion of BONE Found in BONE (fusion of several
macrophages)
![Page 24: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/24.jpg)
![Page 25: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/25.jpg)
Macrophage of Bone Macrophage of Bone Marrow and SpleenMarrow and Spleen
Last line of defense of the macrophage system
Phagocytosis of unwanted debris in blood including old and abnormal RBC
![Page 26: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/26.jpg)
MULTINUCLEAR GIANT MULTINUCLEAR GIANT CELLCELL
Segregation and digestion of Segregation and digestion of foreign bodies foreign bodies
found in found in CONNECTIVE TISSUE CONNECTIVE TISSUE (fusion of several macrophages)(fusion of several macrophages)
Foreign body giant cellsForeign body giant cells monocytes coalesce to form monocytes coalesce to form
huge multinucleated masseshuge multinucleated masses
![Page 27: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/27.jpg)
SKIN APPENDAGESSKIN APPENDAGESGeneral Functions &
Descriptions
![Page 28: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/28.jpg)
HairHair Sebaceous glandSebaceous gland Sweat glandSweat gland NailNail
SKIN APPENDAGESSKIN APPENDAGES
![Page 29: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/29.jpg)
HAIRHAIR
![Page 30: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/30.jpg)
![Page 31: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/31.jpg)
SEBACEOUS GLANDSEBACEOUS GLAND
![Page 32: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/32.jpg)
![Page 33: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/33.jpg)
SWEAT GLANDSWEAT GLAND
![Page 34: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/34.jpg)
NAILNAIL
![Page 35: Module 2 - MPS Cells Location and Functions.ppt](https://reader034.vdocuments.us/reader034/viewer/2022042908/577cc9b01a28aba711a45495/html5/thumbnails/35.jpg)