m rcc 009 b arterial hypertension - quinze vingts

Assessment of retinal arteriolar walls in hypertension using the rtx1

E. Koch, D. Rosenbaum, X. Girerd and M. Paques Clinical Investigation Center 503, INSERM,

Quinze-Vingts National Eye Hospital, Paris, FranceICAN E3M Institute, Cardiovascular Prevention Unit,

Pitié-Salpêtrière University Hospital, Paris, France

rtx1 adaptive optics retinal cameraCase reportArterial hypertension

Imagine Eyes rtx1 case report -- hypertension

Imaging retinal arterioles with the rtx1

Color fundus camera (zoom in)

Imagine Eyes rtx1

Resolution 3-4 µm

Resolution 15-20 µm

Comparison with a conventional color fundus camera

Color fundus camera

Resolution 15-20 µm

The microscopic structure of arterioles has become visible

Healthy 36 y.o. male subject

Imagine Eyes rtx1 case report -- hypertension

Arteriolar microscopic structure

wall

lumen

Imagine Eyes rtx1 case report -- hypertension

Wall-to-lumen ratio in hypertension• Aged matched healthy subject and patient with

untreated arterial hypertension• Assessment at 4 deg away from the papillary disc

WLR = 0.21 WLR = 0.37

Healthy Hypertension

Imagine Eyes rtx1 case report -- dry AMD

Conclusion

• Adaptive optics retinal imaging the first non-invasive technique that enables examining the microscopic structure of arterioles, including vessel walls

• Measurements with the rtx1 revealed elevated wall-to-lumen ratio (WLR) in patients with untreated arterial hypertension

• See also: E. Koch, D. Rosenbaum, A. Brolly, J.-A. Sahel, P. Chaumet-Riffaud, X. Girerd, F. Rossant, and M. Paques, “Morphometric analysis of small arteries in the human retina using adaptive optics imaging,” Journal of Hypertension, vol. 32, no. 4, pp. 890–898, Apr. 2014.