integrated drug discovery and development services at piramal pharma solutions
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8/19/2019 Integrated Drug Discovery and Development Services at Piramal Pharma Solutions
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PIRAMAL DISCOVERY SOLUTIONS
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Delivering Globally Integr ated Solutions across the drug lif ecycle
Our r oots We are an integral part of Piramal Enterprises Ltd.,
a leading business group in India with multiple
business interests. As a Group, we are committed to
achieving excellence and leader ship by pr acticing
leading pharmaceutical company in India and a
dominant player on a global level.
With the changing dynamics of the pharmaceutical
We are the Contract Development & Manuf acturing
arm of Piramal Pharma Solutions, a part of Pir amal
Enterprises Ltd. Our capability as an integr ated
solutions provider enables us to serve Innovator
and Generic companies worldwide.
Our customers can avail a comprehensive r ange
of services across all phases of the drug lif ecycle
which includes Drug Discovery & Development,
Canada Toronto
Manufacturing and Packaging of Clinical Trial
Supplies, Delivering Commercial Volumes of APIs
as well as Finished Dosage products. To provide
flexibility and scalability of operations, we have
invested in a network of contract development and
manufacturing facilities located in North America,
Europe and Asia.
India Ahmedabad | Ennore Pithampur | Digwal | Mumbai
our core values of knowledge, action and car e.
We adhere to innovative, value-driven pr actices
in our diverse business initiatives, ranging fr om
healthcare and glass manufacturing to r eal-estate.
Our beginning in the Healthcare business goes
back to the year 1988 when we acquired Nicholas
Laboratories. Since then we have grown into a
industry worldwide, innovation and cost have
emerged as key challenges for pharmaceutical
companies worldwide. We enable our customers to
address these challenges by offering cost effective
and reliable delivery solutions across the pr oduct
lif ecycle.
U.S.A
United KingdomGrangemouth | Morpeth
Cambridge
Boston | Kentucky China Shanghai (Sourcing Office)
http://www.piramal.com/pharmasolutions/http://www.piramal.com/pharmasolutions/http://www.piramal.com/pharmasolutions/http://www.piramal.com/pharmasolutions/
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The advantage we carry
Our customers enjoy the benefits of
our global network of assets spread
across Europe, North America and
Asia. Our network enables us to
deliver benefits by str ategically
placing projects to take advantage
of low costs, local supply chains and
spec i f i c c u s t omer / mark e t r equir ements.
Piramal Enterprises Ltd.,
currently valued at mor e
than 1 billion USD, is
amongst the largest business
conglomerates in India. We
embrace a rich legacy of over
20 years in the business ofhealthcar e.
Our R&D team is led by scientists
with experience of working with
pharma companies across the
globe and hold expertise acr oss
various chemistries and r ange offormulation types.
Global Network
Integr ated Solutions
Financial Stability
ConsistentTr ack
Record
People &Science
Hallmarkof Quality & Saf ety
With capabilities across drug
discovery, development, scale-
up and manufacturing of APIs as
well as Formulations, we are well
positioned to address customer s’
needs across the entire drug
lifecycle. Our specialization in
Antibody Drug Conjugation,
Clinical Trial Supplies, Packaging
and Biocatalysis enables us to
provide differentiated services to
our customer s.
We are a pioneer in the Contract
Development and Manuf acturing
Services market and have an
experience of over two decades.
We have advanced manuf acturing
facilities approved by leading
regulatory agencies including
the US-FDA and MHRA. We are a
trusted supplier to more than 100
pharma companies across the
US, Europe and Japan including
all major Big Pharma and lar ge
Generic companies.
We believe that the best can
be delivered if only there is
an internal focus on quality.
Stringent quality and safety
norms are followed acr oss
our facilities worldwide.
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PIRAMAL DISCOVERY
SOLUTIONS We, Piramal Discovery Solutions (formerly known as O2h) are an integral part of Pir amal
Pharma Solutions and deliver early stage drug discovery services to Pharma companies,
Biotech companies and Academic institutions.
Our 10,000 m² (100,000+ ft²) greenfield campus is located in a Special Economic Zone
(SEZ), which is a government sponsored industrial park with specialized infr astructur e
to encourage export and industrialization. Our campus benefits from on-site customs
clearance, central waste and power management and secure buildings with access
control points.
Our modern and advanced facility hosts 28 lab units (12 fume-hood r econfigur able
modules), a write-up area and research campus that accommodates over300 scientists.
Our specialized areas ar e
- Medicinal and Synthetic Chemistry
- In vitro Biology
http://www.piramal.com/pharmasolutions/service-offerings/innovator/drug-discovery/http://www.piramal.com/pharmasolutions/service-offerings/innovator/drug-discovery/http://www.piramal.com/pharmasolutions/service-offerings/innovator/drug-discovery/http://www.piramal.com/pharmasolutions/service-offerings/innovator/drug-discovery/http://www.piramal.com/pharmasolutions/service-offerings/innovator/drug-discovery/
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MEDICINAL ANDSYNTHETIC CHEMISTRY We are a reputed service provider of discovery chemistry. W e have partnered with
a r ange of well known pharmaceutical and biotechnology companies from Europe,
USA and Japan. Our specialized team at PDS has a wide array of experience in
preparing small molecule NCEs with the requisite high quality specifications.
Our medicinal chemistry expertise includes hit expansion, hit to lead optimisation,
lead generation and lead optimisation. All of these can beaccessed as stand-alone
offerings or as a part of an integrated drug discovery pr oject.
Our demonstrated expertise lies in thefollowing chemistries
• Complex / multi-stage synthesis
• Heter ocyclic
• Chiral
• Carbohydr ate
• Peptide
• Aliphatic
• Nucleoside
• Natural pr oduct
Our techniques include
• Microwave chemistry
• High pressure chemistry
• Cryogenic chemistry
• Parallel synthesis
http://www.piramal.com/pharmasolutions/service-offerings/innovator/drug-discovery/synthetic-chemistry/http://www.piramal.com/pharmasolutions/service-offerings/innovator/drug-discovery/synthetic-chemistry/
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Our specificities include
• Cambridge (UK) project office providing logistical, communications and objective pr oject
management support
• We have perfected clear templates which enable the systematic day-to-day reporting and
measurement of scientific progress in the most effective manner
•
Performance and productivity metrics are represented in a graphical form and shared internally as well as with the client
• Communications with clients range from direct communication to secure space on our intranet
site for depositing documents and data arising during the pr ojects
• Our dedicated team of personnel includes purchasing officers, store/stock managers as well as
in-house customs liaising officer for efficient sourcing of starting materials
• Our IP (Intellectual Property) security model is designed to protect the I P of the clients during
the project lifecycle and beyond
• Our scientists at are supported by a 360º support system which aims at maximising their time
to focus on their pr ojects
• We value integrity in communication and action; social responsibility with respect to
waste management and making a contribution to the community
Our capabilities include
• Synthesis of small molecules on mg to kg scale (non-GMP) with the requiredhigh quality
specifications, using diverse synthetic methodologies
• Modular custom-built lab units accommodating 12 FTE chemists each
• Lab units can be tailored to customer requirement, with key-card access and IP / IP security
• Supported with latest equipment - NMR, LC-MS / MS, microwave, combiflashes and access
to literature (journals, patents etc.)
• Typical projects undertaken by us include: design and synthesis of discrete or series of
compounds, as well as synthesis of focused libraries for SAR / SPR optimization
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I. In vitro assays
• ADME: solubility, permeability, CYP inhibition / induction, plasma stability (across diff er ent
species), microsomal / S9 stability (across different species), plasma protein binding
• Tar get-based: enzymatic / kinase assays, binding assays, GPCR assays
• Cell-based: ELISA, proliferation, apoptosis, phosphorylation status, insulin sensitizer assays,
cytokine production assays using hPBMCs, signal transduction assays
IN VITRO BIOLOGY Our biology f acilities have been developed
to pr ovide f as
ter decision-making
points for our chemistry clients. Since 2008, we have doubled both our
capacity as well as capability to include a r ange of In vitro services to evaluate
activity and/ or potential liability of compounds. Currently, we are executing
biology studies for several of our clients whose medicinal chemistry work is
also being carried out by us; thus reducing the iterative cycle time of drug
discovery and helping clients progress their compounds faster through the
discovery stage. The biology work is available on a stand-alone basis as well
as part of an integrated drug discovery pr oject.
Our capabilities
• Purpose-built labs include industry standard formats of fluorescence, luminescence and
absorbance to help develop and optimize biochemical and / or cellular assays in a r ange of
therapeutic ar eas • In-depth expertise in pathophysiologically r elevant experimental models for multiple
therapeutic indications
• Customization of assays based on client’s r equir ement(s)
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We consider the ultimate metric to measure Each of the varied modules of the drugthe success of an IDD project is the capacity discovery process is available as a unique
to create intellectual property and value to point of entry individually as a subset of
our customers. Our goal of IDD is to afford services or as the traditional drug discovery
our clients access to specialized skills without pathway from hit identification through to
incurring their own fixed costs and operating lead generation and beyond. Our expertise
in a dynamic, flexible manner that suits the includes medicinal chemistry: hit expansion,
competitive commercial environment of drug hit to lead, lead generation/ optimization,discovery. computational chemistry, in vitro enzymatic
Successful IDD projects rely on efficientand cell-based screening, DMPK.
integration of various disciplines
- Medicinal chemistry
- In vitro & in vivo discoverybiology / pharmacology
- ADMET
- Computer-Aided Drug Discovery
- Operational excellence and expertise
INTEGRATEDDRUG DISCOVERY Our highly skilled team of scientists deliver services in Integr ated
Drug Discovery (IDD) projects incorporating medicinal chemistry (lead
generation, hit-to-lead and lead optimisation), and in vitro and in vivo
pharmacology. We offer expertise in multiple therapeutic indications.
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Our Cor e Values
Our Intellectual Property Policy
The cornerstone of our philosophy on
intellectual property rights (IPR) is built
on upholding the IP generated by the
company and all its associates. In order to
achieve this objective, wehave set up
various systems which ensure that we:
• Respect the IPR of all its clients, partners and competitor s
• Do not infringe any process or product knowingly and / or unknowingly
• Protect and enforce the IPR of the Company, our clients and partner s
• Introduce measures to r educe IPR infringement related risks
• Promote a culture of IPR compliance within the or ganization
• Conduct periodic IntellectualProperty Audits for effective IPR
management andmonitoring
Respectfor IP
We value the relationships we have
built with our customers. We believe
that ‘Customer Centricity’ is the driver
behind all our actions. Our perf ormance
is measured on the value delivered to
our customers. We partner with our
customers in developing and delivering
solutions.
Customer
Centricity Client Quality
All our manufacturing sites have been approved
by leading global regulatory agencies. All major
sites have been approved by the US-FDA without
any 483s
Our aspiration is to be the best in class in global
standards. Our process has evolved through the
stages of:
• Create robust quality base
• Strengthen and implement system
• Quality culture across the or ganization
• Execute best in class standar ds
Envir onment
We function as an envir onmental-friendly organization and our practices have enabled us to
• Pursue continuous improvement: Periodic audits and gap analysis are conducted
by Corporate EHS and cross functional teams
• Implementing EHS best practices through:ISO: 14001 and OHSAS: 18001
• Aim towards the goal of Sustainable Development by targeting the triple bottom
line growth in the fields of Economics, Environment and Society
• Ensuring continuity of the business processes through Business Continuity Plans
• Execute Process safety by implementing safety systems at all sites
• Enhance awareness, knowledge and skills of employees towards a safe, clean,
greener and healthier work place
Win Awards and Recognition
• Safety Award from National Safety Council of India, 2004 and 2005
• Runners-up at the ‘NE Business Awards Corporate Responsibility
& Envir onment’, 2009
• CII-National Award for Energy Efficient Operations, 2009
• Winner of State’s ‘EnvironmentAwar d’, 2010
• Golden Peacock Award for Occupational Health & Safety, 2012
• Frostand Sullivan’s Green Manufacturing Excellence award, 2012
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P P S / P D S / D E C 2
0 1 5
Piramal Enterprises Limited
247 Business Park, A - Wing, 6th floor,
LBS Marg, Vikhroli (W), Mumbai – 400 083. India. Phone: +91 22 3095 6666 Fax: +91 22 3095 6665
Email: str ategicmarketing.cell@pir amal.com
www.piramal.com/pharmasolutions/
mailto:strategicmarketing.cell@piramal.commailto:strategicmarketing.cell@piramal.commailto:strategicmarketing.cell@piramal.commailto:strategicmarketing.cell@piramal.commailto:strategicmarketing.cell@piramal.commailto:strategicmarketing.cell@piramal.commailto:strategicmarketing.cell@piramal.commailto:strategicmarketing.cell@piramal.comhttp://www.piramalpharmasolutions.com/http://www.piramalpharmasolutions.com/http://www.piramalpharmasolutions.com/http://www.piramalpharmasolutions.com/mailto:strategicmarketing.cell@piramal.com
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