increasing dimensionality using variable-energy ionisation

Select-eV:

Increasing dimensionality in GC×GC–TOF MS

Laura McGregor

lmcgregor@markes.com

BOGS 2014, 10th July; Liverpool

Outline

• Introduction to the BenchTOF

• Select-eV ion-source technology

– What, why and how?

• Case studies:

– GC×GC–TOF MS of a vacuum oil distillate

– Monitoring bio-accumulative substances

What is the BenchTOF?

• A reflectron time-of-flight mass spectrometer

• Platform-neutral

• Innovative design

Mass spectrometry at Markes

BenchTOF technology

Innovative design

High

accelerating

voltage

Differentially pumped source

and analyser chambers

Direct extraction optimises

sensitivity

Multi-stage reflectron

optimises resolution

Ion source technology

Historically…

Variable-energy electron ionisation

70 eV mass spectrum of p-cymene 14 eV mass spectrum of p-cymene

Water Framework Directive (WFD)

• Lower detection limits

• New monitoring methods and analytical

techniques are now necessary

• Focus is on “priority” substances, but what

about those of emerging concern?

GC×GC–TOF MS with Select-eV

River water extract

BPX5

BP

X50

Emerging contaminants

O

O

O

O

O

P

OO

O

CH3

CH3

70 eV

10 eV

14 eV

12 eV

Match factor = 879

Polycyclic Musks

Galaxolide (HHCB)

Implant extract

PCBs

Chloro-pesticides

Amgard TCMP (flame retardant)

Octocrylene (UV filter)

Tetrabromobenzene

Pharmaceuticals

Oxychlordane

PCB 44

Trans-nonachlor

Summary

• Hassle-free soft ionisation

• Improved sensitivity and selectivity

• Reduced matrix impact

• Lower detection limits

The full presentation can be

downloaded from the

Markes website http://www.markes.com/Resources/Scientific-

publications/Conference-presentations.aspx

Contact Markes

www.markes.com

enquiries@markes.com