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Implementing a multilayer framework for pathway data integration, analysis and

visualization Zaynab Hammoud, Frank Kramer

Department of Medical Statistics

University Medical Center Göttingen, Germany

zaynab.hammoud@med.uni-goettingen.de

Pathway Resources

• Huge Amount of molecular pathways

• Lack of communication between data resources

Zaynab HAMMOUD 2

GWAS Catalog

Multilayered Graphs

Zaynab HAMMOUD 3

Edge-coloured Node-coloured

Color = Relationship Color = Type

Multilayered Graphs

What are the types of multilayered graphs?

Zaynab HAMMOUD 4

Multiplex

v2 v1

v3 v4 proj(G)

G1

v2 v1

v3 v4

G2

v2 v1

v3 v4

Multilevel

G(1)

G(2)

G(3)

Hypernetworks

H1

H2

H3

v3

v4

v5

v4

v3 v1

v2

v5

v4

H1

H2

H3

v5 v4

v1

v2

v3 G1

v1

v2 v3

G2

v4 v5

v7

v9 v8

v6

G3

G1

G2

G3

v1

v2

v5

v7

v9 v8

v6

v3

v4

Interconnected/interacting

Multipath Project

• How to map pathway knowledge to multilayer model?

• How is it implemented?

• What comes next?

Zaynab HAMMOUD 5

(n-1)th

Layer

nth

Layer

(n+1)th

Layer

Node 8 Node 8

Node 5 Node 7

Node 6 Node 4

Node 2

Node 1 Node 3

Generic Model

Gene 1

Gene 2

Gene 3

Metabolite 2 Metabolite 1

Protein 3

Protein 1

Protein 2

Complex 1/2

DNA Layer

Protein Layer

Metabolite Layer

Specific Model

Remove

Remove

Remove

Add

Add

Add

Standard Operations