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Implementing a multilayer framework for pathway data integration, analysis and
visualization Zaynab Hammoud, Frank Kramer
Department of Medical Statistics
University Medical Center Göttingen, Germany
Pathway Resources
• Huge Amount of molecular pathways
• Lack of communication between data resources
Zaynab HAMMOUD 2
GWAS Catalog
Multilayered Graphs
Zaynab HAMMOUD 3
Edge-coloured Node-coloured
Color = Relationship Color = Type
Multilayered Graphs
What are the types of multilayered graphs?
Zaynab HAMMOUD 4
Multiplex
v2 v1
v3 v4 proj(G)
G1
v2 v1
v3 v4
G2
v2 v1
v3 v4
Multilevel
G(1)
G(2)
G(3)
Hypernetworks
H1
H2
H3
v3
v4
v5
v4
v3 v1
v2
v5
v4
H1
H2
H3
v5 v4
v1
v2
v3 G1
v1
v2 v3
G2
v4 v5
v7
v9 v8
v6
G3
G1
G2
G3
v1
v2
v5
v7
v9 v8
v6
v3
v4
Interconnected/interacting
Multipath Project
• How to map pathway knowledge to multilayer model?
• How is it implemented?
• What comes next?
Zaynab HAMMOUD 5
(n-1)th
Layer
nth
Layer
(n+1)th
Layer
Node 8 Node 8
Node 5 Node 7
Node 6 Node 4
Node 2
Node 1 Node 3
Generic Model
Gene 1
Gene 2
Gene 3
Metabolite 2 Metabolite 1
Protein 3
Protein 1
Protein 2
Complex 1/2
DNA Layer
Protein Layer
Metabolite Layer
Specific Model
Remove
Remove
Remove
Add
Add
Add
Standard Operations