how science will stop ageing - biotech innovation, health care, future pharma keynote speaker

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Future of gene tests, genetic counseling, gene therapy, pharmacogenomics, future of the pharmaceutical industry, genetic prophecy and predictions, predicting risk of illness and disease by analyzing genetic code. What is genetic engineering? Mutant animals and viruses, designer life. Future of pharma, drug research and drug development, patents and intellectual property rights. Genes linked to personality, mental illness, criminal behavior, violence and murder. Genes that influence long life, longevity, life expectancy and life insurance or medical or health insurance cover. Public Health Policy - institutes a and foundations for genome research. Gene therapy linked to choice of drug therapy. Analysing tumor genes in cancer chemotherapy to reduce side effects. Gene therapy in Parkinsons disease, diabetes and autoimmunde diseases such as rheumatoid arthritis. Impact of genetic screening on health care planning, hospital admissions, discharge, diagnosis and treatment. Calculating risk of sudden illness or risk of sudden death from family history and gene matching -- human genome project. Sharing gene profiles matched to patient records, patents on human genes and ownership of genetic information by customers, consumers and patients. Marketing of confidential gene test results and other clinical data. Transgenic animals, using animal organs for transplant, stem cells to grow new organs, organogenesis. How scientists and medical research is combining genes from two different animals or organs to make hybrids. Workshop for GSK by conference keynote speaker Patrick Dixon. Risks of genetic engineering -- lethal mutations in offspring, genetic disorders and congenital malformations. Assessing health insurance premiums, pensions, annuity rates, medical or hospital health insurance cover, based on genetic profiling. Legal and compliance issues in gene testing, regulations by government and recommendations by ethical committees. Genes as defence evidence against conviction of violent crime in law court. Doctors, nurses, clinicians, community workers, researchers -- need to work together to find socially acceptable treatments. Access to health care. Diagnostics using genetic data. Disease propensity models. Affordability of gene therapy. Genetic enhancements, performance boosting using injections of genes in athletics and Olympics or to increase human endurance, increase muscle bulk in weight training and body building as alternative to anabolic steroids. Increasing track speed , race times, break records. Drug abuse and drug doping in sport -- regulations and committees.

TRANSCRIPT

Dr Patrick Dixon Chairman Global Change Ltdhttp://www.globalchange.com

Take Hold of the FutureOpportunities for pharma to meet needs of older people

1 billion children à cities

1 billion children alive today

300 million à cities in China by 2020Real Estate over-supplyCommodity pressures

� IMF - adjusted for Purchasing Power Parity

6

>40% WDP Asia by 2015

1 billion over 60s in 10 years

• most are women

Europe Dying

4 couples needed to produce just

one great-grandchild

65% health spend on those over 65

The future is about

EMOTION

Search: know more than your

doctor

Future in developed markets is about performance not wellness

People Want to Look Better• 51% growth in botox treatment• 31% growth laser hair removal• 31% growth in cosmetic surgery enquiries

Brain Faster – and better?

may be

BrandTrustedNatural

Obesity Epidemic

�1 in 3 newborn babies in New York will develop diabetes

�Obesity costs US $100bn a year

Interesting Neutraceuticals

�Resveratol�Broccoli (sulforaphane)

�Flavonoids�Beta-carotene�Anthocyanins

�Alpha-linoleic acid�Glucosamine�Chondroitin�Ginseng�Garlic oil

Global Sales Nutraceutical Ingredients $24 Billion by 2015China will surpass the U.S. and Western Europe as the largest global producer and consumer by 2020. (Freedonia Group)

�Click to edit Master text styles

31

$100 for 1.7-ounces

Alzheimers: Souvenaid

�Souvenaid clinical trial�Multi-nutrient drink �MIT collaboration

Worn out Mitochondria – Energy Boost

R-alpha-lipoic acidAcetyl-L-carnitine

Computer-aidedClinical Decisions:

Safer - Less lawsuits

•Ottawa Hospital, Ontario, Canada - 3,000 iPads.

•Mayo Clinic - 10,000 iPhones and 2,000 iPads

Virtual Medicine

90% in US want to view test

results before their doctor

Mayo Clinic

2 million visitsevery month

Read Human Genome in an Hour • Fluidics• Biochemistry• Semiconductors• Genetics• Mathematics• Immunology• Robotics

Home Tele-Monitoring

Home Tele-Monitoring Ecosystem

• Diabetes, congestive heart failure, obstructive pulmonary

• 2.2 million at home

• > $22bn by 2015

• Mobile telephony

• swallow smart pill

• relays info about gut

• sensor-enabled tablets

• check if medication taken

Smart Tablet Startups

EU 8bn in UK alone

Independent Living

MobilityComfortSupportSafety

Faster healing

Can we stop ageing ?

Treatment which restores and maintains the youthful elasticity of

hardened arteries – and helps

Monkeys on diet live longer• After 20 years - 80% alive v 50% on normal calories• Less cancer, diabetes, heart disease, strokes, brain decay

54

Slow or no ageing is a reality

• Rockfish, Turtles, some Whales

• No signs of getting old

IrrationalRationing

Rationing all government budgets Health competes with ....Specialties competeDiseases / Patient groupsTreatment methods

Individuals also rationhealth v food v heat vholidays v clothes

Competition

Summary - Pharma and Ageing�Many new opportunities�See through older eyes�Connect with emotion�Timing is everything�Events + decisions

�Performance - wellness

�Diagnostics �Home monitoring�Neutraceuticals�Save treatment costs�Improve mobility�Prolong independence

Ageing remedies with real evidence will be tomorrow’s blockbusters

Dr Patrick Dixon Chairman Global Change Ltdhttp://www.globalchange.com

Take Hold of the FutureOpportunities for pharma to meet needs of older people

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