homogeneous ester hydrogenation api and controlled ... · to find out more visit...
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API and Controlled Substance Product GuideHomogeneous Ester Hydrogenation
To find out more visit JMFineChemicals.comor email FineChemicals@matthey.com
Ru-SNS (C1-750) available nowAchieving high activity is the key to success
• Saferreactions
•Milderconditions(lowertemperatureand/orpressure)
•Increasedchemoselectivityandfunctionalgrouptolerance(e.g.tohalogens)
•Simplerwork-upprocedures
•Reducedwaste(comparedtohydrides)
Advantages:An optimised homogeneous catalytic system can offer:
HN
EtS
SEt
Ru
PPh3
Cl
Cl
Ester Hydrogenation: Gusev TechnologyHomogeneousesterreductionisanemergingtechnologyforachallengingyetdesirabletransformationandiswidelyusedinthemanufactureofpharmaceuticals,detergents,cosmetics,flavoursandfragrances.
R 1 O
O
R 2R 1 OH HO
R 2+
R1=alkyl,alkenyl,aryl,heteroarylR2=methyl,ethyl,otheralkyl
Substrate ScopeWide substrate scope demonstrated by Gusev and JM (Ru-SNS)
N
O
O
Gusev et al Angew Chem Int Ed. 2013,52,2538-2542
85%conv.S/C20,000/1EtONa,THF,40°C,16h,50barH2
95%conv.S/C4,000/1tBuOK,THF,40°C,6h,50barH2
95%conv.S/C40,000/1EtONa,neat,40°C,14h,50barH2
99%conv.S/C1,000/1KOEt,Me-THF,65°C,4h,30barH2
O
O
O
O
O
O
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