high resolution mass spectrometer for target...
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MAT 95 XP
High Resolution Mass Spectrometerfor
Target Compound Analysis
High Resolution Mass Spectrometerfor
Target Compound Analysis
MAT 95 XP
3
Finnigan MAT 95 XPHRGC – HRMS
Finnigan MAT 95 XPHRGC – HRMS
The most powerful mass spectrometer for alldioxin and P.O.P. laboratories
Highly flexible GC-MS system
Fully automated regardless of injector type
Multicolumn operation
4
Mass SpectrometerMass Spectrometer
AutotuningAutotuning assures optimizedinstrument performance with mini-mal user interaction at any resolu-tion setting – fast, automated andreproducible.
Mass CalibrationThe MAT 95 XP requires only ONEcalibration table. The uniqueThermo Finnigan patented fieldprobe control enables this feature.
Advantages of this technique andthe single calibration are:
Simply forgetmass calibration
on theMAT 95 XP !
Long-term stability
Ease of use
Independent of allscan parameters
Applicable to allionization modes
Easy switchingbetween differentsample types
MAT 95 XP: Source control
IonSource
Magnet
EntranceSlit
Resolution AdjustmentResolution Adjustment
8000
12000
4000
0
Res
olut
ion
1 5 Number of acquisition10
Mass resolution is adjustablemanually or automatically byvarying only the entrance and exitslit. The resolution adjustmentfrom R=1,000 to R=10,000 showsexcellent transmission.
The resolution is calculated andstored for documentation in theanalysis LOG file within each MIDtime window.
This unique feature makes youranalysis perfectly reliable. It iseasy to meet the quality controlrequirements of different analyticalmethods.
316.7 317.0 317.3
316.9824
R = 10,000R = 10,000
10 %10 %
100 %100 %
R = 1,000R = 1,000
316.7 317.0 317.3
316.7 317.3
MAT 95 XP: Resolution adjustment
MAT 95 XP: Resolution stability over 48 hoursExit Slit
Detector
ESA
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EPA Methods 1613 and 8290for dioxins and furansEPA Methods 1613 and 8290for dioxins and furans
combination with a secondaryelectron multiplier.
Reporting of mass traces and quan-tification following EPA Methods1613 and 8290 is standard andfully automated.
The MAT 95 XP offers the ultimatedynamic range for highly specifictarget compound analysis coveringmore than 5 orders of magnitude.This important capability is basedon the Thermo Finnigan patented± 20 kV conversion dynode in
From instrument setupto quantification and reporting:
Complete solutions followingEPA Methods 1613 and 8290 areprovided with the MAT 95 XP !
0
20
40
60
80
100tetra penta hexa hepta octa
Segment 1 Segment 2 Segment 3 Segment 4 Segment 5
Inte
nsity
(%
)
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Dioxins/Furans: Quantification
Dioxins/Furans: QC Analysis
EPA Method 1668for PCB analysis
EPA Method 1668for PCB analysis
Dioxin and PCB analyses arefrequently requested for the samesample. Therefore, it is mandatoryto change GC methods andmultiple ion detection (MID) setupswithin the same analysis sequence.
With the MAT 95 XP, methods canbe changed, even in an unattend-ed overnight sequence. Highestflexibility is achieved with turnkeysolutions for quantification of alldioxins and PCBs.
Measurement quality is closelyrelated to reproducibility. Perform-ing the same PCB measurement25 times in fully automated mode,a standard deviation of less than6 % is achieved routinely.
0
20
40
60
80
100
deca
hepta
hexa
pentatetra
Segment 1 Segment 2 Segment 3 Segment 4 Segment 5
Inte
nsity
(%
)
Number of measurement1 5 15100
50000
100000
150000
200000
250000
Total ion current intensity
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PCBs: Reproducibility of measurements
PCBs: High resolution GC-MS ranging from Cl4 to Cl10
Similar to dioxins and furans, BFRsenter the same ecological chainand are found in biological sampleslike water, milk or air.
The brominated diphenylethers(PBrDPE), one important class of
BFRs, are of high interest becauseof their similarity to PCBs.
Due to the fragmentation of thePBrDPE (loss of 2 Br), some ionswould require resolution power of45,000 for complete separation.
To obtain unambiguous resultsat lower resolution (R=10,000) itis advantageous to measure eithertwo ratio masses or a high massmolecular ion.
Inte
nsity
(%
)
Mass [amu]721.30 721.35 721.40 721.45 721.50
20
40
60
80
100
0
Nona-BrDPE[M-2Br]
C12HOBr7
Hepta-BrDPE
[M]C12H3OBr7
RP = 10,000RP = 45,000
BrDPE: Quantification
BrDPE: Isotope pattern calculation
BFRAnalysis of Brominated Flame RetardantsBFRAnalysis of Brominated Flame Retardants
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Analysis of Toxaphenesby negative chemical ionization
Analysis of Toxaphenesby negative chemical ionization
Toxaphenes were applied world-wide as pesticides until banned inthe early ‘90s. Because of theirslow degradation it is a necessity toanalyze these toxic compounds inour food chain, especially in fish.
Low level detection can only beaccomplished by negative chemicalionization (NCI) at low ion sourcetemperatures.
The MAT 95 XP excels at NCI: itcan reproducibly detect and quan-tify at low femtogram levels. Theresponse curve shows linearity forBGVV 2 toxaphene standard over4 orders of magnitude.
Toxaphenes: Linearity
Toxaphenes: MID setup example
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Corr = 0.9994
0
200000
400000
600000
Area
0 10000 20000 30000 Amount [fg]40000
17.30 17.70
50 fgm/z 412.8150
16000
8000
0 1000500
10
The MAT 95 XP high resolutionsector field instrument is integra-ted into XcaliburTM, the uniqueWindows® NT-based softwareused worldwide on most ThermoFinnigan products.
The Sequence Setup allows auto-mated, unattended batch acquisi-tion of samples. Different sampletypes can be alternated in onesequence.
Special evaluation programsdesigned for high resolution massspectrometric applications areavailable by mouse click from theXcaliburTM main page.
Sequence SetupSequence Setup
100
50
00 10 20 30
100
50
00 10 20 30
100
50
00 10 20 30
1 2 3 ➔4 5 6
7 8 9
* 0 #
➔
➔
➔
OO
OO
OO
OOOO
CC
CH4CH4
CH4CH4
H3CH3C
InstrumentSetup
ProcessingSetup
LibraryBrowser
QuanBrowser
QualBrowser
SequenceSetup
XcaliburTM: Sequence Setup and status control
Dioxin Software PackageDioxin Software Package
The Target Compound Quanti-fication program was developedspecially for isotope dilution quan-tification. User interaction allowsfor the highest level of flexibilty.
A starting package containinga wide variety of quan files, in
accordance with methods such asEPA1613 or EN1948, is provided.
Together with the Response andReporter program the new TargetCompound Quantification packageis designed for both, beginnersand advanced users, meeting the
needs of any analytical laboratory.
For email reporting, sample resultscan be saved by mouse click eitheras HTML documents (TargetCompound Quantification) or asWord documents (Reporter). 11
Target Compound Response Program: CS1 - CS5 calibration
Target Compound Quantification: Setup
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System ConfigurationSystem Configuration
MAT 95 XP Standard Version
Full acceleration potential for all ionization modes
Resolution > 60,000
Mass range > 3,500 Da at maximum acceleration potential
Scan cycle time 0.2 s/decade
Multiple ion detection with 33 time segments per analysis and31 masses per time segment
Continuously variable entrance and exit slits with piezo effect actuators
Gas chromatograph
Differential pumping system with 3 turbomolecular pumps
Options: AutosamplerFast column exchange unitCIS 4 cold injection system
Dioxin Package A
MAT 95 XP dioxin version, including one gas chromatograph,one autosampler and one DB5MS fused silica column.
Options: Fast column exchange unitCIS 4 cold injection system
Dioxin Package B
MAT 95 XP dioxin version, including two gas chromatographs, twoautosamplers, one DB5MS and one Rtx2330 fused silica column.
Options: Fast column exchange unitCIS 4 cold injection system
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Installation RequirementsInstallation Requirements
SuppliesPower230 V +6% / -10%, 50 or 60 Hz.Three phase AC, 25 A each
GasesHelium with > 99.998% purity
Cooling water1 l/min, optionally closed loopsystem
EnvironmentTemperatureShould not vary more than ± 2ºC.Tolerable range between 15ºC and26ºC (59ºF/79ºF); best at 21ºC (70ºF).
Air conditioning loadApproximately 4.5 kW
2000 mm
1700 mm
1925
mm
400 mm
400
mm
WaterCooler
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InformationInformation
Web page
Simply visit our Web page for additional information aboutall instruments, new software releases, poster compilations,training schedules, service, support, etc.
www.ThermoFinniganMAT.de
Training
Although Thermo Finnigan’s instruments are easy to use,their full potential can best be achieved after complete famil-iarization. Training courses are conducted by experiencedpersonnel. The MAT 95 XP operating manual should allow aneasy start with the different measuring modes.
Support
Local users’ meetings in different countries provide the latestinformation about developments and applications.
Engineers and application chemists are available for supportand discussions whether they are attending a users’ meeting, aconference or a trade show. For any support, you have directaccess by telephone, telefax or internet.
Dioxin Special
For a quick start with your new high resolution massspectrometer we offer three to five days of on-site training.Furthermore, Thermo Finnigan can arrange training for samplecollection, clean-up of samples and laboratory organization.
Thermo Finnigan MAT GmbH, Barkhausenstr. 2, 28197 Bremen/Germany • Phone +49-421- 5493-0 • Fax +49-421- 5493-396
Worldwide represented byAustralia, Thermo Finnigan Australia Pty. Ltd, Unit 14, 38-46 South St., P.O. Box 239, Rydalmere, NSW 2116 • Phone +61-2-98989000 • Fax +61-2-98989800Belgium, Thermo Finnigan BVBA, Groenenborgerlaan 84, 2610 Antwerp-Wilrijk • Phone +32-3-8250670 • Fax +32-3-8250692France, Thermo Finnigan France SA, Hightec Sud, 12 av. des Tropiques, ZA de Courtaboeuf - BP 141, 91944 Les ULIS Cedex • Phone +33-1-69188810 • Fax +33-1-69299382Germany, Thermo Finnigan GmbH, Boschring 12, 63329 Egelsbach • Phone +49-6103-408-0 • Fax +49-6103-408-222Italy, Thermo Finnigan APG Italy, Strada Rivoltana, 20090 Rodano (MI) • Phone +39-02-95059-1 • Fax +39-02-95320-370Japan, ThermoQuest K.K., Nishi-Shinjuku Toyokuni Bldg., 2-5-8 Hatsudai, Shibuya-ku, Tokyo, 151-0061 • Phone +81-3-3372-3001 • Fax +81-3-3372-7051The Netherlands, Thermo Finnigan BV, Druivenstraat 33, 4816 KB Breda • Phone +31-76-5878722 • Fax +31-76-5714171People’s Republic of China, Thermo Finnigan Beijing Rep. Office, Room 912, Ping-an Mansion, No. 23, Finance Street, Beijing 100032;Phone +86-10-66210-839, -846 • Fax +86-10-66210-851Spain, Thermo Finnigan S.A., Avenida de Valdelaparra 27, Edificio Alcor, planta 2, 28108 Alcobendas (Madrid) • Phone +34-91-6574930 • Fax +34-91-6574937Sweden, Thermo Finnigan AB, Pyramidbacken 3, 141 75 Kungens Kurva • Phone +46-8-55646800 • Fax +46-8-55646808United Kingdom, Thermo Finnigan UK, Paradise, Hemel Hempstead, Herts HP2 4TG • Phone +44-1442-233555 • Fax +44-1442-233667U.S.A., Thermo Finnigan LLC, 355 River Oaks Parkway, San Jose, CA 95134 • Phone +1-408-965-6800 • Fax +1-408-965-6010
In countries not contained in the above list Thermo Finnigan is represented by renowned instrument distributors.
Information and specifications herein are subject to revision without prior notice.Availability of components and options subject to verification by local representative.
Copyright 2001© by Thermo Finnigan MAT GmbH, a Thermo Electron business. All rights reserved. Printed in Germany. 07/01 Part No. 1990731
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