dissertaion

THE CREATION OF ANTIBACTERIAL FIBRES

JOSEFIN ILLERGÅRD

10x

vs

Ag+

TWO REASONS

0,00 0,50 1,00 1,50

Göteborg

Lysekil

Uddevalla

TRICLOSAN (µg/L)

ANTIBACTERIAL

SURFACES

CONTACT-ACTIVE

VS

LEACHING

LEACHING

COMMON

UNWANTED

THE BACTERIA

HYDROPHOBICITY EFFECT 50 nm

Figure Tiller et al 2001

INFLUENCE OF CHARGE

Figure from Murata et al 2007

CHARGE

+ WELL-DESCRIBED

- ORGANIC SOLVENTS

- HARSH CONDITIONS

POLYELECTROLYTE MULTILAYERS

+ WATER BASED

+ SIMPLE

- ?

POLYVINYLAMINE

Model surface

0

5

10

15

20

25

0 10 20 30 40 50 60 70

Sauerb

rey m

ass (

mg/m

2)

100 mM

10 mM

1 mM

QCM-D

FLAT & DENSE

HYDROPHOBIC TAILS

ELECTROSTATICS

0%

10%

20%

30%

40%

50%

1 3 5 7# LAYERS

PVAm

PVAm-C8

GROWTH REDUCTION

PVAm, PVAm-C8

-40%

Fibres

CHARGE UP

pH OPTIMIZATION

FIBRE OXIDATION

POLYMER CONTENT (mg/m2)

0 20 40

oxidized fibres

fibres

modelsurface

1 BACTERIA REMOVAL

> 99.9 %

Some remains

2 BACTERIAL GROWTH

# LAYERS ON FIBRES

0,00

0,02

0,04

0,06

0,08

0,10

1 LAYER 3 LAYERS 5 LAYERS Ref

Absorb

ance u

nits

EFFECT OF FIBRE-OXIDATION

0,00

0,04

0,08

0,12

0,16

FIBRES OXIDIZED Ref

Absorb

ance u

nits 24 h

48 h

3 ELECTRON MICROSCOPY

0,0

0,5

1,0

1,5

2,0

FIBRES OXIDIZED Ref

µm

BACTERIAL LENGTH

Ref OXIDIZED

CONTACT-ACTIVE

ANTIBACTERIAL

FIBRES

PULP PROCESSES

ex. CTMP

ACKNOWLEDGEMENTS

VINNOVA, SCA AND BASF

SUPERVISORS MONICA & LARS

COLLEUGES

FAMILY

JOSEFIN ILLERGÅRD josefika@kth.se