disciplina: slc0673 Ácidos...

Disciplina: SLC0673

Ácidos nucleicos

Prof. Dr. Andrei Leitão

Deoxyribonucleotides

2

Ribonucleotides

3

Nomenclature

4

DNA & RNA

5

Alcaline hydrolisis

6

Absorption spectra

7

Absorption spectra

8

Bacteriophage experiment

9

Chromosome & DNA

10

DNA replication & forms

11

Forms of DNA

Parent

strand

Parent

strand

Daughter

strands

DNA sequences

12

Palindrome

Mirror repeat

T T A G C A C G T G C T A A

A A T C G T G C A C G A T T

T T A G C A C C A C G A T T

A A T C G T G G T G C T A A

DNA folding

13

DNA triplex

14

DNA triplex

15

DNA quadruplex

16

Secondary structures of RNAs

17

Bulge

Single

strands

Internal

loop

Hairpin

Hairpin double helix

RNA folding

18

RNA 3D structures

19

tRNA of yeast

PDB: 1TRA

Ribozyme from

plant viruses

PDB: 1MME

mRNA from

protozoan

PDB: 1GRZ

DNA annealing

20

Heat denaturation of DNA

Partially denaturated DNA

Denaturation Annealing

Partially

denaturated

Separation

of strands Association of

strands by pairing

DNA hybridization

21

Sample 1 Sample 2 Mix &

cool

Duplex of

Sample 1

Duplex of

Sample 2

Hybrid

Duplex

DNA - epigenetics

22

Control of neuronal function

Control of the neuronal communication

Chem. Eng. News 2015, may, 4

Nat. Neurosci. 2015, DOI: 10.1038/nn.4008

Nonenzymatic reactions of nucleotides

23

UV damage

24

DNA sequencing

25

26

Ch

em

ica

l s

yn

the

sis

of

DN

A

Nucleoside phosphates

27

Nucleoside phosphates

28

Nucleoside phosphates

29