disciplina: slc0673 Ácidos...
TRANSCRIPT
Disciplina: SLC0673
Ácidos nucleicos
Prof. Dr. Andrei Leitão
Deoxyribonucleotides
2
Ribonucleotides
3
Nomenclature
4
DNA & RNA
5
Alcaline hydrolisis
6
Absorption spectra
7
Absorption spectra
8
Bacteriophage experiment
9
Chromosome & DNA
10
DNA replication & forms
11
Forms of DNA
Parent
strand
Parent
strand
Daughter
strands
DNA sequences
12
Palindrome
Mirror repeat
T T A G C A C G T G C T A A
A A T C G T G C A C G A T T
T T A G C A C C A C G A T T
A A T C G T G G T G C T A A
DNA folding
13
DNA triplex
14
DNA triplex
15
DNA quadruplex
16
Secondary structures of RNAs
17
Bulge
Single
strands
Internal
loop
Hairpin
Hairpin double helix
RNA folding
18
RNA 3D structures
19
tRNA of yeast
PDB: 1TRA
Ribozyme from
plant viruses
PDB: 1MME
mRNA from
protozoan
PDB: 1GRZ
DNA annealing
20
Heat denaturation of DNA
Partially denaturated DNA
Denaturation Annealing
Partially
denaturated
Separation
of strands Association of
strands by pairing
DNA hybridization
21
Sample 1 Sample 2 Mix &
cool
Duplex of
Sample 1
Duplex of
Sample 2
Hybrid
Duplex
DNA - epigenetics
22
Control of neuronal function
Control of the neuronal communication
Chem. Eng. News 2015, may, 4
Nat. Neurosci. 2015, DOI: 10.1038/nn.4008
Nonenzymatic reactions of nucleotides
23
UV damage
24
DNA sequencing
25
26
Ch
em
ica
l s
yn
the
sis
of
DN
A
Nucleoside phosphates
27
Nucleoside phosphates
28
Nucleoside phosphates
29