brain health
Post on 14-Jul-2015
306 Views
Preview:
TRANSCRIPT
Naturopathic Treatments
For The Brain
By Dr. Michele Burklund, ND
Dr. Michele Burklund, ND
What is Naturopathic Medicine?
Naturopathic doctors are primary care
doctors that emphasize prevention,
treatment, and optimal health through
the use of therapeutic methods and
substances to encourage an individuals
inherent self-healing process combining
ancient wisdom and evidence-based
medicine
Dr. Michele Burklund, ND
So What Does That Actually Mean?
Premedical studies undergraduate degree
4-5 years of medical school studying
Pharmacology, Biochemistry, Anatomy, Pathology,
Histology, Immunology, Neurology, Physiology, Bio-
statistics, Lab Diagnosis, Radiology, Pediatrics, Geriatrics,
Psychiatry,...
310 credits, 1500 clinical hours, 150 precept hours
2 Rigorous Board Examinations
Dr. Michele Burklund, ND
…And also
Medical Herbalism
Physical Medicine
Pharmacognosy
Hydrotherapy
Therapeutic Nutrition
Nutraceuticals
**It’s very important to understand allopathic medicine and the benefits and interactions with natural substances.
Dr. Michele Burklund, ND
ND’s look at all areas of your life Stress
Relationships
Energy Level
Diagnosis (current and previous)
Lab work
Diet
Sleep
Medications
Supplements
Dr. Michele Burklund, ND
My Passion For Brain Health
My father was diagnosed with a glioblastoma back in 2003 and this is what
fueled my passion to become a naturopathic doctor and specialize in brain
health
He is in the audience right now! We both came to this amazing
conference together over 12 years ago and really love the research
and the compassion here at UCLA!
Dr. Michele Burklund, ND
My Background
EDUCATION
Seattle University: Finance and Premed (BA, MBA)
Bastyr University: Doctor of Naturopathic Medicine (NMD)
ADDITIONAL SPECIALTY CLINICAL TRAINING• University of Washington Hospital, Neuro-oncology preceptorship
• Bastyr University preceptorship Naturoapthic Neurology clinic
• Medical Detoxification
• Neuroplasticity Research and Stroke Rehabilitation
• ADHD and Mental Illness
• Botanical Medicine and Stem Cell Phytotherapy
• Northwest Naturopathic Neuroscience Award in 2013 for Ashwagandha Research
Presentation
Dr. Michele Burklund, ND
Natural Treatments Doesn’t Mean
Safe!
It’s very important to meet with a doctor before starting
any supplement, diet, herb, or new plan to rule out any
contraindications
Dr. Michele Burklund, ND
Timing Is Important
Each Phase of Treatment Has Different Approaches
Recovery From Surgery
During Chemotherapy
After Chemotherapy
During Radiation
After Radiation
Long Term Brain Support
Dr. Michele Burklund, ND
Not All Vitamins & Supplements Are
Created Equal!
Make sure the product is standardized and of clinical
grade
See if the company had any outside testing performed
free of bias
Look at the parts used (flower, bark, root) and make sure it’s what you are looking for.
Use organically sourced herbs
3rd party Tested
Dr. Michele Burklund, ND
ND’s Approach Cancer Treatment
with MD’s
ND’s work with MD’s to enhance treatment and reduce
side effects
There is NOT enough evidence, research, or treatments
for naturopathic medicine to be effective on their own
for brain cancer
Dr. Michele Burklund, ND
How Can Naturopathic Treatments
Help?
Dr. Michele Burklund, ND
Topics
Foods
Plants that Improve Cognition
Overall Brain Support
Holistic Treatments
Brain Exercises
Current Research
Dr. Michele Burklund, ND
Food As Medicine
Fruits with a low glycemic index and high in antioxidants
like blueberries, plums, raspberries.
Focus on greens like kale, spinach
Add spices like sage, tumeric, cinnamon.
Get protein
Dark Chocolate
Add Coconut Oil into your foods
Dr. Michele Burklund, ND
2/3rd of your brain is made up of fat!
2/3rd of your brain is composed of fat.. But not just any fat
70% of the myelin if fat (the protective sheath that covers
communicating neurons)
In the myelin the most common oeic acid which can be
found in olive oil, almonds, pecans, macadamias, and
avocados
Dr. Michele Burklund, ND
Hydrate
Dehydration can negatively impact short-term memory,
and concentration!
Bring a water bottle with you and eliminate soda
If your urine is darker than a glass of lemonade you
probably need to drink more water.
Drink a glass of water for every cup of coffee
Infuse the water with mint, rosemary, ginger
Try coconut water
Dr. Michele Burklund, ND
Prebiotics & Probiotics
Prebiotics
Leeks, Onion, Asparagus, Kale, Broccoli
Probiotics
Kefir, yogurt, fermented foods, miso soup
Dr. Michele Burklund, ND
Add Some Spice
Cinnamon: Helps control blood sugar, overall support
Tumeric: Decreases Inflammation, Anti-tumor
Cayenne: Blood Flow
Ginger: Reduces Nausea
Sage: Prevents Break Down of Ach
Rosemary: Prevents Break Down of Ach
Dr. Michele Burklund, ND
Smoothies
If the idea of preparing food sounds exhausting then just
blend it!
Dr. Michele Burklund, ND
What To Blend
Spirulina: blue green algae and packed with vitamins &
minerals, most bio-available protein
Greens: add spinach, kale, avocado
Fruits (low in sugar) like blueberries
Unsweeted almond milk or coconut milk
Nuts like cashews and almonds
Dr. Michele Burklund, ND
Reducing Sugar Intake
Increase fiber which prolongs the absorption and
reduces blood sugar spikes
Try to use natural sweeteners like vanilla bean, nutmeg,
and cinnamon
Start with protein
Pack nuts as snacks to reduce cravings during the day
like walnuts
Dr. Michele Burklund, ND
Plants That Improve Cognition
Bacopa
Ashwagandha
Gotu Kola
Rosemary
Huperzine A
Melissa Officinalis
Dr. Michele Burklund, ND
Bacopa
Dr. Michele Burklund, ND
Ashwagandha
Dr. Michele Burklund, ND
Gotu Kola
Dr. Michele Burklund, ND
Huperzine A
Dr. Michele Burklund, ND
Rosemary
Dr. Michele Burklund, ND
Lemon Balm
Dr. Michele Burklund, ND
Managing Symptoms
Nausea: Add a hint of fresh ginger to your water, chamomile tea
Aromatherapy with peppermint
Ginger infused ice cubes
Studies have shown that some seizure medications can deplete vitamins over a long period
Consider a multi-vitamin if yours in one
Folate
Biotin
Vitamins D, K, and B6
Dr. Michele Burklund, ND
Ginger Infused Ice For Nausea
Dr. Michele Burklund, ND
1. infuse fresh ginger in hot water.
2. Strain, then freeze the concoction in
ice cube trays.
3. Add them to water or chew on
them
Natural Treatment Research
Boswellia for cerebral inflammation (Janssen G et al 2000)
Green Tea: increased radiation sensitivity (Holick et at 2010)
Quercetin with temozolomide (Braganhol E et al 2006)
Dr. Michele Burklund, ND
Boswellia
From the resin of the tree Boswellia serrata
Capsule form, Standardized extract from clinical grade
company.
Dr. Michele Burklund, ND
Green Tea
Choose brewed over bottled (1 cup of brewed
contained the same amount of polyphenols as 20
bottles)
Journal of Toxicology 2013 found that tea coming from Sri
Lanka had the lowest levels of heavy metals
Opt for organic to limit pesticides
Dr. Michele Burklund, ND
Quercetin
It’s a group of plant pigments called flavonoids which
are antioxidants found in fruits and vegetables
Capers
Onions
Blueberries & Cranberries
Dr. Michele Burklund, ND
What Supplements Should I Take?
No “one size fits all”
Important not to conflict with therapy like N-acetyl cysteine or
alpha lipoic acid
Quality matters
See a trained doctor for proper dosages and appropriate
treatments
More does not equal better
Dr. Michele Burklund, ND
How Can Supplements Help?
Support neurotransmitter pathways
Balance gut flora
Improve deficiencies
Provide additional support
Support detoxification pathways
Enhance therapies
Improve quality of life
Decrease inflammation
Dr. Michele Burklund, ND
Looking At The Whole Body
Dr. Michele Burklund, ND
Sleep
Dr. Michele Burklund, ND
How To Improve It
Stay away from bright light 1 hour before bed (TV, laptop)
Calming teas like passionflower, chamomile, valarian
Aromatherapy
Meditation
Breathing exercises
Visualization
Progressive Muscle Relaxation
Dr. Michele Burklund, ND
Support
Brain Tumor Support Groups
Creating a calendar for friends and family to help
Local organizations
Asking for help
Dr. Michele Burklund, ND
Exercising Your Brain
Reading
Computer Based: Cognifit and Luminosity
Crossword Puzzles
Learning a new language
Dr. Michele Burklund, ND
Meditation
Over 19,000 studies on meditation!
A recent study (University of Massachusetts) showed that 27 minutes of meditation over a 6-week period showed an increase in gray matter in the hippocampus
Many Forms
Guided audio meditations
Classes
Deep breathing exercises
Visualization
Focus on a mantra
Dr. Michele Burklund, ND
Exercise To Enhance Brain Function
Dr. Michele Burklund, ND
Melatonin & Glioblastomas
20mg of melatonin with radiation showed increase
survival rates (1996)
A 2013 study thinks that it’s action could be related to
suppressing cell migration (inhibition of HIF-1a)
Dr. Michele Burklund, ND
Interesting Research
Dr. Michele Burklund, ND
The Gut Brain Axis
Dr. Michele Burklund, ND
Curcumin
Studies involved human GBM cell lines with curcumin and other studies
Involving temozolomide showed promise. More research needs to be done
Acts as a natural COX-2 inhibitor
Dr. Michele Burklund, ND
Sodium Dicholoroacetate (DCA)
More studies and research need to be done for brain
cancer patients
Phase 1 study performed on tolerance but not treatment
effects
Works on the mitochondria of cells and changes the way
tumor cells utilize glucose
Dr. Michele Burklund, ND
Remember to always consult your doctor before
starting a new treatment
Dr. Michele Burklund, ND
How To Find Naturopathic Doctor
For ND’s Trained At Accredited Medical
Schoolshttp://www.naturopathic.org/
Board Certified In Naturopathic Oncology
http://www.oncanp.org/find_fabno.html
Dr. Michele Burklund, ND
Questions?
Dr. Michele Burklund, ND
Keep in Contact
Email: mburklund@nestspasb.com
Phone: 805-770-2607
Clinic: 523 Chapala Street # 2 Santa Barbara
CA
Website: nestspasb.com
Dr. Michele Burklund, ND
Bibilography
Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic
factor. J Psychiatr Res. 2014 Oct 12;60C:56-64. PubMed PMID: 25455510.
Zheng X, Zhang X, Kang A, Ran C, Wang G, Hao H. Thinking outside the brain for cognitive improvement: Is
peripheral immunomodulation on the way?. Neuropharmacology. 2014 Jun 28;PubMed PMID: 24978103.
Santarnecchi E, D'Arista S, Egiziano E, Gardi C, Petrosino R, Vatti G, Reda M, Rossi A. Interaction between
Neuroanatomical and Psychological Changes after Mindfulness-Based Training. PLoS One. 2014;9(10):e108359.
PubMed PMID: 25330321; PubMed Central PMCID: PMC4203679.
Posner MI, Tang YY, Lynch G. Mechanisms of white matter change induced by meditation training. Front Psychol.
2014;5:1220. PubMed PMID: 25386155; PubMed Central PMCID: PMC4209813.
Gareau MG. Microbiota-gut-brain axis and cognitive function. Adv Exp Med Biol. 2014;817:357-71. PubMed PMID:
24997042.
Downey LA, Kean J, Nemeh F, Lau A, Poll A, Gregory R, Murray M, Rourke J, Patak B, Pase MP, Zangara A, Lomas J, Scholey A, Stough C. An acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a
special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performance. Phytother Res. 2013
Sep;27(9):1407-13. PubMed PMID: 23281132.
Dr. Michele Burklund, ND
Bibilography-2
Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res. 2013
Aug;16(4):313-26. PubMed PMID: 23772955; PubMed Central PMCID: PMC3746283.
Martín V, Sanchez-Sanchez AM, Herrera F, Gomez-Manzano C, Fueyo J, Alvarez-Vega MA, Antolín I, Rodriguez C. Melatonin-
induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour
stem cells. Br J Cancer. 2013 May 28;108(10):2005-12. PubMed PMID: 23632480; PubMed Central PMCID: PMC3670480.
Amen DG, Wu JC, Taylor D, Willeumier K. Reversing brain damage in former NFL players: implications for traumatic brain injury
and substance abuse rehabilitation. J Psychoactive Drugs. 2011 Jan-Mar;43(1):1-5. PubMed PMID: 21615001.
Knaepen K, Goekint M, Heyman EM, Meeusen R. Neuroplasticity - exercise-induced response of peripheral brain-derived
neurotrophic factor: a systematic review of experimental studies in human subjects. Sports Med. 2010 Sep 1;40(9):765-801.
PubMed PMID: 20726622.
Joseph JA, Shukitt-Hale B, Willis LM. Grape juice, berries, and walnuts affect brain aging and behavior. J Nutr. 2009
Sep;139(9):1813S-7S. PubMed PMID: 19640963.
Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ. Examining the nootropic effects of a
special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial.
Phytother Res. 2008 Dec;22(12):1629-34. PubMed PMID: 18683852.
Dr. Michele Burklund, ND
Bibilography-3
Wattanathorn J, Mator L, Muchimapura S, Tongun T, Pasuriwong O, Piyawatkul N, Yimtae K, Sripanidkulchai B, Singkhoraard J. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. J Ethnopharmacol. 2008 Mar 5;116(2):325-32. PubMed PMID: 18191355.
Zangara A. The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. Pharmacol Biochem Behav. 2003 Jun;75(3):675-86. PubMed PMID: 12895686.
Kennedy DO, Scholey AB, Tildesley NT, Perry EK, Wesnes KA. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav. 2002 Jul;72(4):953-64. PubMed PMID: 12062586.
Lissoni P, Meregalli S, Nosetto L, Barni S, Tancini G, Fossati V, Maestroni G. Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone. Oncology. 1996 Jan-Feb;53(1):43-6. PubMed PMID: 8570130.
Kudo H, Mio T, Kokunai T, Tamaki N, Sumino K, Matsumoto S. Quantitative analysis of glutathione in human brain tumors. J Neurosurg. 1990 Apr;72(4):610-5. PubMed PMID: 1690792.
Said HM, Redha R, Nylander W. Biotin transport in the human intestine: inhibition by anticonvulsant drugs. Am J Clin Nutr. 1989 Jan;49(1):127-31. PubMed PMID: 2911998.
Tohda,*C.,*Kuboyama,*T.,*and*Komatsu,*K.*Dendrite*extension*by*methanol*extract*of*Ashwagandha* (roots*of*Withania*somnifera)*in*SKQNQSH*cells.*Neuroreport*6Q26Q2000;11(9):1981Q1985.
Kuboyama,*T.,*Tohda,*C.,*Zhao,*J.,*Nakamura,*N.,*Hattori,*M.,*and*Komatsu,*K.*AxonQ*or*dendriteQpredominant*outgrowth*induced*by*constituents*from*Ashwagandha.*Neuroreport*10Q7Q 2002;13(14):1715Q1720
Dr. Michele Burklund, ND
Bibilography-4
Weinstein RS, Bryce GF, Sappington LJ, King DW, Gallagher BB. Decreased serum ionized calcium and normal vitamin D metabolite levels with anticonvulsant drug treatment. J Clin Endocrinol Metab. 1984 Jun;58(6):1003-9. PubMed PMID: 6725504.
Hahn TJ, Hendin BA, Scharp CR, Haddad JG Jr. Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults. N Engl J Med. 1972 Nov 2;287(18):900-4. PubMed PMID: 4561667.
Reynolds EH. Mental effects of anticonvulsants, and folic acid metabolism. Brain. 1968 Jun;91(2):197-214. PubMed PMID: 5721926.
Goodman, G.E. Journal of the National Cancer Institute, Dec. 1, 2004; vol 96: pp 1743-1750. Duffield-Lillico, A.J. and Begg, C.B. Journal of the National Cancer Institute, Dec. 1, 2004; vol 96: pp 1729-1731. News release, JNCI.
Newmaster S.G., Grguric M., Shanmughanandhan D., Ramalingam S. & Ragupathy S. (2013). DNA barcoding detects contamination and substitution in North American herbal products, BMC Medicine, 11 (1) 222.
Bercik P, Park AJ, Sinclair D, et al. . The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motility 2011; 23: 1132–1139
J Altern Complement Med. 2008 Jul;14(6):707-13. doi: 10.1089/acm.2008.0018.
http://news.harvard.edu/gazette/story/2011/01/eight-weeks-to-a-better-brain/
http://www.princeton.edu/~achaney/tmve/wiki100k/docs/Grey_matter.html
Dr. Michele Burklund, ND
top related