about aromatase inhibitors anastrozole, letrozole & exemestane at research liquids

Aromatase Inhibitors

About

AromataseInhibitors

Aromatase inhibitors (AIs) are a class of drugs used

in the treatment of breast cancer and ovarian

cancer in postmenopausal women. They may also be

used off-label to treat or prevent gynaecomastia in

men.

Aromatase is the enzyme that synthesizes estrogen.

As breast and ovarian cancers require estrogen to

grow, AIs are taken to either block the production of

estrogen or block the action of estrogen on receptors.

Types OfAromataseInhibitors

There are 2 types of aromatase inhibitors (AIs)

approved to treat breast cancer:

Irreversible steroidal inhibitors

Such as exemestane (Aromasin), forms a permanent

and deactivating bond with the aromatase enzyme.

Non-steroidal inhibitors

Such as anastrozole (Arimidex) and letrozole (Femara),

inhibit the synthesis of estrogen via reversible

competition for the aromatase enzyme.

Exemestane

Product

Exemestane

Details:

Exemestane is a steroidal irreversible CYP19

(aromatase) inhibitor. Exemestane is structurally

related to natural androstenedione and acts as a false

CYP19 enzyme substrate. This effect is also known as

"suicide inhibition". Exemestane has been found to

inhibit human placental CYP19. Buy Exemestane of

high quality only at Research Liquids.

Description:

Liquid Exemestane is an irreversible steroidal

aromatase inhibitor (IC50 = 20 nM). Destabilizes

aromatase and lowers estrogen levels.

Targets: Aromatase

Exemestane

Anastrozole

Product

Details:

Anastrozole belongs to a class of compounds known as

aromatase inhibitors. An enzyme known as aromatase is

responsible for producing estrogen by converting androgens

into estrogen. Aromatase inhibitors like Anastrozole prevent

aromatase from fulfilling that role by binding to it and

rendering it inactive. Aromatase inhibitors fall into two

categories: reversible (such as letrozole and Anastrozole )

and irreversible; irreversible aromatase

inhibitors permanently bind to the circulating aromatase

complex. Buy Anastrozole of high quality only at Research

Liquids.

Exemestane

Description:

Liquid Anastrozole is a third-generation nonsteroidal

selective aromatase inhibitor.

Targets: Aromatase

Exemestane

Letrozole

Product

Details:

Letrozole is a potent, reversible non-steroidal

aromatase inhibitor (IC50 = 11.5 nM). Displays

antitumor effects in several animal models. Suppresses

the endogenous aromatase-induced proliferation of

MCF-7 cells. Buy Letrozole of high quality only at

Research Liquids.

Letrozole

Description:

Liquid Letrozole is a third generation nonsteroidal

CYP19 aromatase inhibitor.

Targets: CYP19

Letrozole