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Where Science Means Business An Introduction to Yissum
November 2007
Tami Kfir, VP Licensing Healthcare
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The Hebrew University Of Jerusalem
Over 1/3 of all academic scientific research In Israel
43% of Israel’s biotechnology research
>1/3 of PhD students in Israel
4 Campuses
5 Affiliated Hospitals
24,000 Students
1,200 Researchers (Staff Members)
1,600 Post-Graduate Students in Biotechnology
320 Researchers in Applied Sciences
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The Hebrew University of JerusalemMount Scopus Campus, Jerusalem
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The Hebrew University of Jerusalem
Edmond J. Safra Campus, Jerusalem
Agriculture & Environmental Sciences Campus, Rehovot
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The Hebrew University of JerusalemEin Kerem Campus, Jerusalem
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Israel’s Top University
U of Texas for Institute of Higher Education, Shanghai Jiaotong University Israel 12th worldwide in academic
research Hebrew University no. 1 in Israel 60th worldwide Only Israeli university in top 100
Times Higher Education 2006 HU 63rd worldwide in biomedicine HU 52nd worldwide in science 29th worldwide ex-US, UK
Newsweek Hebrew University 82nd worldwide Only Israeli university in top 100
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A Nobel Heritage
2002 Nobel Prize in Economics Daniel Kahneman, Princeton
2004 Nobel Prize in Physics David J. Gross, UC Santa Barbara
2004 Nobel Prize in Chemistry Avram Hershko, Technion Aaron Ciechanover, Technion
2005 Nobel Prize in Economics Robert J. Aumann, Hebrew University
2006 Nobel Prize in Chemistry Roger Kornberg, Stanford
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Top 20 Most Frequently Cited PapersStem Cells 1998-2004
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Biotech
Nano-science
Materials
ComputerSciences
Medicine
EnvironmentHomelandSecurity
Agriculture
A Broad Range of Technologies
ComputerEngineering
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Yissum’s Mission
To promote the transfer of Hebrew University technology for the benefit of society, while maximizing returns to support research, education and scientific excellence
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Current Snapshot
$1 Billion annual sales of Hebrew University- based products
5,000 patents 1,400 inventions 400 licenses 60 spin-offs
Raised $150 mil in past year from leading VCs
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A Record of Achievement
2006 revenues $40mil, up from $34mil in 2005 $29mil royalties $11mil sponsored research & services
HU research budget $100mil
Ranked in top 15 worldwide (AUTM) Leading US university royalties
MIT $35-40mil / year Research budget: $1 Billion
Stanford $50-60 / year Research budget: $900 Million
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Board of Directors Business leaders
Yissum Business-oriented organization
Founded 1964
The Hebrew University Non-profit organization
Where Science Means Business
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Board of Directors
Giora Yaron, PhD – ChairmanUri Banin, PhDReuven BeharHervé Bercovier, PhDS. Morry Blumenfeld, PhDMartin GerstelElhanan HacohenAlex Keynan, PhDAmos Mar-HaimHadar Ron, MDMoshe Vigdor
Chairman, Mercury; founder, P-Cube, ExanetHebrew University, Director Nanoscience CentreManaging Partner, FBC&Co.; chairman, NetafimHebrew University, VP R&DVC, ex-CEO GE Medical, IsraelEx-CEO Alza; chairman, CompugenHebrew University, VP & Director GeneralHebrew University, Prof. EmeritusDirector, JDA; Ex-CEO Clal IndustriesManaging Director, Israel Healthcare VenturesDirector General, Jewish Agency
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Product-based
Business-oriented
Mission/project focused
Confidentiality essential
Timeframes & milestones
Economic role
Knowledge-based
Curiosity-driven
Broad scope
Publications
No time limits
Educational role
Industry vs. Academia
The Challenge
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Intellectual Property
2006 Snapshot 100 new inventions 72 new patent applications 58 new patents granted
Intellectual Property at HU Yissum owns all IP
developed at HU Researchers receive
40-60% of revenues
Computer Science & Engeneering
13%
Applied Physics2%
Business Models1%
Agriculture6%
Materials13%
Life Science and Biotechnology
61%
Food and Nutrition2%
Environment2%
2006 New Inventions
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Global Reach
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Yissum’s Spin-offs
Rav-Galai
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Long Shelf Life & CherryTomatoes
The world’s most popularcocktail hybrids for greenhouse production
Prof. Nachum KedarProf. Haim Rabinowich Department of Field Crops,Vegetables and Genetics:Faculty of Agriculture, FoodAnd Environmental Sciences The Hebrew UniversityRehovot Campus 2006 sales $70 million
Success Stories - Tomatoes
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DOXIL®Doxorubicin HCI liposome injection Alza’s Lead Product for Oncology Prof. Yechezkel Barenholz Department of BiochemistryFaculty of Medicine The Hebrew UniversityOf Jerusalem 2006 sales $375 million
Success Stories - Doxil
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For Treatment of Alzheimer’sDisease and Dementia Prof. MartaWeinstock-Rosin Department of PharmacologyFaculty of Medicine The Hebrew UniversityOf Jerusalem 2006 sales $525 million
Success Stories - Exelon
Healthcare - Source of Innovations
• Faculty of Medicine
• School of Pharmacy
• School of Dental Medicine
• Faculty of Science
• Faculty of Agriculture
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Healthcare Technologies Scope
NCEs New Uses Drug Delivery Medical devices Diagnostics Research tools
Markets
• CNS • Dermatology • Oncology • Infectious Diseases • Cardiovascular • Respiratory diseases • Metabolic• Dianostic (biomarkers; Imaging,
Bioinformatics)• Devices mainly Therapeutics
World Wide Leaders in Drug Delivery
Main Expertise:
• Liposomes
• Sustained release
• Transdermal
• Nasal
• Colonic Delivery
• Biodegradable - Polymer encapsulates
• microparticulate and nanoparticulate targetable drug delivery systems
World Wide Leaders in Drug Delivery
Yechezkel Barenholz Simon Benita Daniel Cohen Abraham Domb Michael Friedman Nissim Garti Chaim Gilon Gershon Golomb Avraham Hochberg Amnon Hoffman Philip Lazarovici Shlomo Magdassi Abraham Rubinstein Elka Touitou Itamar Wilner
Bio Park
• First in Israel• Service & support from near by university and
hospitals• 10,000m2 of research laboratories
Commercial Efforts
Friendly WebSite Use of web – tools such as Pharma –
Licensing MiniPlans Israeli Opportunities: Incubators; BioLine;
Teva Active marketing worldwide including Bio-
Conferences Networking
The TTM can help you manage your entire technology transfer or licensing office. It can help increase the effectiveness of your office without increasing size. Some of the benefits using the TTM include:
The TTM can help you manage your entire technology transfer or licensing office. It can help increase the effectiveness of your office without increasing size. Some of the benefits using the TTM include:
Increase the quality of your invention disclosure Improve the financial management of your technology portfolio including connection to an external financial system (SAP) Maximize license revenues through effective contract management Improve contact with researchers in your organization allowing them external access to the system. Expand marketing reach of your organization for your technologies by allowing easy export of the technologies to external databases including the website Make powerful reports on the data for effective business management and follow up Integrated with Office environment Built with the most up to date technology
TTM (Technology Transfer Management)
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Thank you for your attention
Tami.kfir@yissum.co.il
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