AIDS in IndiaA Regional Symposium-Workshop

onResearch, Trials and Treatment

July 31st to August 6th 2004

Program Book

VenueJawaharlal Nehru Centre for

Advanced Scientific Research (JNCASR), Bangalore

National Institute for Mental Healthand Neurosciences (NIMHANS), Bangalore

AIDS in India – A RegionalSymposium-Workshop

Research, Trials and Treatment

July 31st to August 6th 2004

Venue

Jawaharlal Nehru Centre forAdvanced Scientific Research (JNCASR), Bangalore

National Institute for Mental Healthand Neurosciences (NIMHANS), Bangalore

7/31/04, Saturday

Registration and Laboratory workshop

VenueJawaharlal Nehru Centre for

Advanced Scientific Research (JNCASR)

8:30 AM Registration

9:00AM Welcome

9:30AM Tea

10:00AM Laboratory Session 1Drug susceptibility in HIV(Instructor: Pheroze Joshi)

12:00 Noon Laboratory Session 2Elispot assay(Instructor: Amara Rama Rao)

1:00 PM Lunch

2:00PM Laboratory Session 1bDrug susceptibility (…continued)

2:30PM Laboratory Session 2bElispot assay (…continued)

3.30PM Tea

5:00PM Laboratory Session 3Detection of M. tuberculosis(Instructor: Vanaja Kumar)

6.30PM Dinner

7:15PM Laboratory Session 4Use of Reporter cell lines for HIV(Instructor: Udaykumar Ranga)

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8/1/04, Sunday

Registration and Laboratory workshop

A.M. Venue:National Institute of Mental Health and

Neurosciences

8:30AM-1:00PM Laboratory Session 5Viral Load and CD4measurements(Instructor: V. Ravi)

P.M. Venue:JNCASR

2:00PM Laboratory Session 2cElispot assay(…continued)

3:00PM Laboratory Session 6Use of retroviral vectorsfor gene therapy(Instructor: Ganjam Kalpana)

4.00 PM Tea

5:30PM Laboratory Session 2d/Elispotassay (…continued)

7:00PM Dinner

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8/02/04, Monday

Inauguration, Plenary and SymposiumSessions I and II

Venue:Jawaharlal Nehru Centre for Advanced Scientific

Research (JNCASR)

Inauguration

8:30AM Welcoming RemarksUdaykumar RangaAssistant Professor, JawaharlalNehru Centre for AdvancedScientific Research, Jakkur,Bangalore

8:35AM Introductory RemarksVinayaka R. PrasadProgram Director, AIDSInternational Training and ResearchProgram, Albert Einstein College ofMedicine, Bronx, NY, USA

8:40AM Inaugural AddressDr. C. N. R. RaoProfessor, Jawaharlal Nehru Centrefor Advanced Scientific Research,Bangalore

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9:10AM Plenary LectureMark A. WainbergMcGill University AIDS Centre,Montreal, Canada“The Critical Need for HIV/AIDSPrevention Research inDeveloping Countries”

Symposium Session IHIV/AIDS

Co-Chairs: Dr. Ruth MacklinDr. M. S. Shaila

09:40AM Session OverviewM. S. ShailaDepartment of Microbiology andCell Biology, Indian Institute ofScience, Bangalore

9:50AM Ruth MacklinAlbert Einstein College of Medicine,Bronx, New York, USA“Ethical Challenges in HIV/AIDSPrevention Research”

10:10AM Tasnim AzimICDDR, B, Center for Health andPopulation Research, Bangladesh“HIV epidemic in Bangladesh:Can it be averted?”

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10:30AM Ganjam V. KalpanaAlbert Einstein College ofMedicine, Bronx, New York, USA“Role of a host factor in HIV-1replication”

10:50AM Coffee Break

11:05AM Shahid JameelInternational Center for GeneticEngineering and Biotechnology,New Delhi”Role of HIV-1 Nef protein inviral pathogenesis”

11:25AM Sundarasamy MahalingamCentre for DNA Fingerprinting andDiagnostics, Hyderabad“Lentiviral accessory proteins:Lead roles for the supportingcast”

11:45PM Debashis MitraNational Centre for Cell Science,Pune“Mitochondrial dysfunction inHIV induced T cell apoptosis”

12:05PM Gopalan SridharanChristian Medical College, Vellore“Certain aspects of theimmunological profile of SouthIndian HIV infected individuals”

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12:25PM Robin MukhopadhyayaCancer Research Institute, Mumbai“A first-generation lentiviralvector system for gene delivery,derived from an Indian HIV-2isolate: In vitro studies”

12:45PM Ernest DruckerAlbert Einstein College ofMedicine, Bronx, New York“The Role of Unsterile MedicalProcedures in the Origin of theAIDS Epidemic”

1:05PM – 1:45PM Lunch break

Symposium Session IIPrevention, Vaccines and AntiretroviralStrategies

Co-Chairs: Suniti SolomonGen. Raghunath

1:45PM Session OverviewSuniti SolomonYRG Care, Chennai

1:55PM Plenary Lecture IKenneth MayerProgram Director, AITRP, BrownUniversity, Rhode Island“The Biology of HIVTransmission and Prevention:What we know and what weneed to know”

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2:25PM Plenary Lecture IIMarty MarkowitzAaron Diamond AIDS ResearchCenter, New York, NY, USA“Treating Primary HIV Infection:Lessons Learned and FutureGoals”

2:55PM Vinayaka PrasadAlbert Einstein College of Medicine,Bronx, NY, USA“Can RNA-based drugs ever riseto the challenge of HIV/AIDS?RNA Interference vs. RNAAptamers against HIV”

3:15PM Vijay MehraInternational AIDS VaccineInitiative, New York, NY, USA“IAVI efforts in acceleratingAIDS vaccine development”

3:35PM Coffee Break

3:50PM Ramesh ParanjpeNational AIDS Research Institute,Pune“Cytolytic T Lymphocyteresponse in Subtype C infectedIndian patients”

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4:10PM Shekhar ChakrabortyNational Institute of Cholera andEnteric Diseases, Calcutta“Characterization of HIV strainscirculating in Eastern andNortheastern India: Developmentof a Candidate Vaccine”

4:30PM Ramarao AmaraEmory University, Atlanta, GA“DNA/MVA Vaccines for HIV/AIDS”

4:50PM N. K. MehraAll India Institute of MedicalSciences, New Delhi“Immunomodulatory genes andHIV Infection”

5:10PM Laurie BaumannAlbert Einstein College of Medicine,Bronx, NY“Behavioral Approaches to HIVPrevention in Adolescents”

6:00PM Departure to Banquet Site

7:00PM Arrive at Cottage Industries ExpoCultural Program and Banquet

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8/03/04, Tuesday

Symposium sessions III and IV

Venue:National Institute of Mental Health and

Neurosciences (NIMHANS)

8:30AM Welcome remarksDr. D. NagarajaDirector, National Institute ofMental Health andNeurosciences, Bangalore

Symposium Session III

Opportunistic Infections of AIDS

Co-Chairs: Jaya S. TyagiWilliam Jacobs, Jr.

8:45AM Session OverviewDr. Jaya S. Tyagi,All India Institute of MedicalSciences, New Delhi

8:50AM Plenary LectureWilliam Jacobs, Jr.Howard Hughes Medical ResearchInstitute, Albert Einstein College ofMedicine, Bronx, NY, USA“The Primary Mechanism ofAttenuation of BCG: Can we dobetter?”

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9:20AM S. VijayaIndian Institute of Science,Bangalore“Can the human immuneresponse guide the design ofbetter TB vaccines?”

9:40AM Jaya S. TyagiAll India Institute of MedicalSciences, New Delhi“Two-component signaltransduction systems of M.tuberculosis”

10:00AM Anil TyagiUniversity of Delhi, South Campus,New Delhi“Mycobacterium tuberculosis -Gene regulation, Pathogenesisand TB vaccine”

10:20AM Coffee Break

10:50AM Manikuntala KunduBose Institute, Calcutta, India“Mycobacterium avium-inducedsignaling in host macrophages”

11:10AM Soumya SwaminathanTuberculosis Research Centre,Chennai“Overview of tuberculosis in theHIV Era”

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11:30AM Vanaja KumarTuberculosis Research Centre,Chennai“New mycobacteriophageconstructs to improve thesensitivity of luciferase reporterphage assay for TB diagnosis inAIDS patients”

11:50AM Uma BanerjeeAll India Institute of MedicalSciences, New Delhi“Opportunistic Infections in HIVdisease in India: How preparedare we?”

12:10-1:10PM Lunch Break

Symposium Session IV

NeuroAIDS

Co-Chairs: Dr. Jeymohan JosephDr. P. Sathishchandra

1:10PM Session OverviewJeymohan JosephNational Institute of Mental Health,National Institutes of Health, USA

1:15PM Plenary LectureIgor GrantUniversity of California, San Diego“Neurocognitive Assessment inHIV”

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1:45PM Richard PriceUniversity of California, SanFrancisco, CA“AACTG5199: A Protocol for anInternational Study of the Impactof Antiretroviral therapy onNeurological Function inResource Restricted Settings”

2:05PM Bruce BrewSt. Vincents Hospital, Sydney,Australia“The Asia Pacific NeuroAIDSConsortium: Strengths andweaknesses”

2:25PM Mahendra KumarUniversity of Miami School ofMedicine, Miami, FL USA“Neurocognition in HIV infectionin South India: Preliminary Data”

2:45PM Coffee Break

3:15PM P. SatishchandraNational Institute of Mental Healthand Neurosciences, Bangalore“Opportunistic infections in thenervous system secondary toretroviral infections”

3:35PM S. K. ShankarNational Institute of Mental Healthand Neurosciences, Bangalore“Spectrum of pathological lesionsin HIV/AIDS in India”

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3:55PM Uday Kumar RangaJawaharlal Nehru Centre forAdvanced Scientific Research,Bangalore, India“Does the low incidence of HIV-associated dementia in Indiacorrelate to the Tat protein ofHIV-1?”

4:15PM Avindra NathJohns Hopkins University,Baltimore, MD, USA“Neuropathogenesis of HIVdementia”

4:35PM Robert PaulBrown University, Providence, RI,USA“Neuroimaging markers of HIV-related cognitive symptoms inthe context of ART”

5:00-630 PM Madelon Halula, Mary Kirker,Priti Mehrotra & Paula StricklandNational Institute of Allergy andInfectious Diseases, NIH, USAGrant-Writing Workshop:Session I

7:30PM Dinner

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8/04/04, Wednesday

Roundtable Group Discussions

Venue:Jawaharlal Nehru Centre for Advanced Scientific

Research (JNCASR)

8:30AM - 9:30AM Ethics in Clinical Trials andScientific Research -1R. Macklin, AlbertEinstein College ofMedicine, Bronx, NY,USAA. Jesani, CEHAT, New Delhi

9:45AM - 10:00AM Tea Break

10:00AM – 11:00AM Antiretroviral TreatmentModalities - 1M. Markowitz, AaronDiamond AIDS ResearchCenter, NY, USAK. Satish, WokhartHospital, Bangalore

11:15AM – 12:15PM Fundamentals ofEpidemiology andStatistics -1Paul Marantz, AlbertEinstein College ofMedicine, Bronx, NY, USA

12:30PM – 1:30PM Lunch

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1:30PM – 2:30PM Biology of HIV/AIDSPreventionKenneth Mayer, BrownUniversity, Rhode Island

2:45PM – 3:15PM Coffee Break

3:15PM – 4:15PM Behavioral Methods ofAIDS Prevention- ILarie Bauman, AlbertEinstein College ofMedicine, Bronx, NY, USASunil Mehra, MAMTA, NewDelhi

4:30PM – 5:30PM HIV and Infectious Risks ofBlood Transfusion-IRobert Reiss, New YorkBlood Center, New York, USALatha Jagannathan,Bangalore Medical ServicesTrust, BangaloreVasanthapuram Ravi,NIMHANS, BangaloreNilkantrai Vaishnav,Bhavnagar Blood Bank,Bhavnagar, Gujarath

5:30PM Laboratory Session 7Heteroduplex mobility shiftassaysUdaykumar Ranga, JNCASR,Bangalore

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6:30PM Dinner

7:30PM-9:30PM Laboratory Session 7Heteroduplex mobilityshift assaysUdaykumar Ranga, JNCASR,Bangalore

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8/05/04,Thursday

Roundtable Group Discussions

Venue:Jawaharlal Nehru Centre for

Advanced Scientific Research (JNCASR)

8:30AM – 9:30AM Ethics in Clinical Trials andScientific Research - 2R. Macklin, Albert EinsteinCollege of Medicine, Bronx,NY, USAA. Jesani, CEHAT, New Delhi

9:45AM - 10:00AM Tea Break

10:00AM – 11:00AM Antiretroviral TreatmentModalities - 2M. Markowitz, AaronDiamond AIDS ResearchCenter, NY, USAK. Satish, Wokhart Hospital,Bangalore

11:15AM – 12:15PM Fundamentals ofEpidemiology andStatistics - 2Paul Marantz, AlbertEinstein College of Medicine,Bronx, NY, USA

12:30PM – 1:30PM Lunch

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1:30PM – 2:30PM Behavioral Methods ofAIDS Prevention- 2Larie Bauman, AlbertEinstein College of Medicine,Bronx, NY, USASunil Mehra, MAMTA, NewDelhi

2:45PM – 3:15PM Tea Break

3:15PM – 4:15PM HIV and Infectious Risks ofBlood Transfusion - 2Robert Reiss, New YorkBlood Center, New York, USALatha Jagannathan,Bangalore Medical ServicesTrust, BangaloreVasanthapuram Ravi,NIMHANS, BangaloreNilkantrai Vaishnav,Bhavnagar Blood Bank,Bhavnagar, Gujarath

4:30PM – 5:30PM Grant - WritingWorkshop - 2Madelon Halula, MaryKirker, Priti Mehrotra &Paula Strickland, NationalInstitute of Allergy andInfectious Diseases, NIH, USA

6:30PM Dinner

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7:30PM Laboratory Session 7bHeteroduplex mobilityshift assaysUdaykumar Ranga,JNCASR, Bangalore

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8/06/04, Friday

Laboratory Workshop

Venue:Jawaharlal Nehru Centre for

Advanced Scientific Research (JNCASR)

8:30AM Laboratory Session 1b/DrugSusceptibility (continued)

10:45AM Tea Break

11:00AM Laboratory Session 4/Use ofReporter cell lines for HIV(continued)

1:00PM Lunch

2:00PM Laboratory Session 4/Use ofReporter cell lines for HIV(continued)

4:00PM Closing CeremonyValedictory AddressDr. M. R. S. RaoPresident, Jawaharlal Nehru Centrefor Advanced Scientific Research,Bangalore

4:30PM Vote of ThanksDr. Ganjam V. KalpanaAlbert Einstein College of Medicine,Bronx, NY USA

4:45PM High Tea

6:.00PM Upon prior request, packeddinners will be available.

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8/07/04, Saturday

One-day sight seeing excursion(to Mysore and Brindavan Gardens).

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