accelerating clinical and translational research translational sciences: purdue resources charles...
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ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Translational Sciences:Purdue Resources
Charles BuckDirector of OperationsBindley Bioscience [email protected]
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Support for Success
Interdisciplinary team approach
Entrepreneurial driven culture
Administrative, business and scientific support
Seed grants for promising research
State-of-the-art research facilities and equipment
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Discovery ParkIntegrated core centers:•Nanotechnology•Bioscience•Entrepreneurship•Learning•Regenstrief Center for Healthcare engineering
•Oncological sciences•ACCESS – computation•Sustainability (GSI)
Burton D. Morgan Center for Entrepreneurship
Birck Nanotechnology
Center
Gerald D. and Edna E. Mann Hall
Bindley Bioscience Center
Discovery Learning Research Center
Project research centers and subcenters
InfrastructureAdministrative
Business team – SPS & business officeProject coordinationWeb site integrationSpecial events
TechnicalResearch Cores – partnership with
academic unitsEquipment and facilities
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Mass Spec profiling informatics
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Proteomics enabling longitudinal studies
Evaluate patient samples at baseline and 15 months
“Consistency of the platform enabled profiling of discrete human plasma samples comprising the largest human proteomic profile dataset to date. All of these data are available publicly for independent analysis and provide a resource for plasma protein biomarker discovery and verification.”
healthy 15 mo cancer patients baseline cancer patients
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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• Combined SPECT and x-ray CT Enables SPECT and CT image registration
• Multi-pinhole collimators High resolution imaging (350 um voxels) High sensitivity imaging (kBeq source)
• Data binning relative to biological rhythms Reduces blur
• List mode acquisition and statistical 3-D image reconstruction algorithm. Improves image quality
MiLabs U-SPECT-II/CT
Micro SPECT / CT Imaging
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Culex-L at work
Norepinephrine concentrations during automated (Culex-L) and manual (jugular stick) blood sampling
Purdue Translational PharmacologySuperior approach
for in vivo pharmacokinetics
and pharmacodynamics
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Animal models & preclinical studies
Terrier bladder cancer model
• Full service histology laboratory. Two board certified veterinary pathologists available for collaboration.
• The vet Clinical Trials Group provides the expertise & facilities for animal clinical trials (veterinary) & translational preclinical investigation (human)
• The Clinical Discovery Lab provides for: analysis and testing of orthopedic
/biomedical devices experimental surgery
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Body composition, diet, disease
Body plethysmography
Indirect calorimetry
Ingestive behavior
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Camp Calcium• Gain valuable information about bone health in adolescents to help
other children build strong bones in the future. • Ethnic group participation• Campers are educated about nutrition and bone health.
Faculty: Dr. Connie Weaver
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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BME/Nano Capabilities
• Electrical, mechanical, optical, acoustical devices and instruments
• Nano, micro, macro design and fabrication• Both diagnostic and therapeutic (e.g.,
bionano) device/protocol development• Diverse application areas (neurological,
cardiovascular, orthopedic, cancer)• Links to Indiana medical device companies• Extensive benchtop device testing
capabilities• Preclinical study planning expertise
Nano Fab in Birck
MRI research/patient center
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Tethered Nanocube-Carbon Nanotube Biosensor
Enhanced SEM image of the Au/Pd nanocube augmented single walled carbon nanotube (CNT) network glucose sensors.
Drs. D. Marshall Porterfield and Tim Fisher
25 mM
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Comparison with other available technologies
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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SpeechVive™ • Unobtrusive portable device
designed to improve speech and communication in patients with PD
• Uses the Lombard Effect, preserved in patients with PD, to elicit louder and clearer speech spontaneously
• Designed and built by CTSI biomedical/bionanotechnology team
Faculty: Dr. Jessica Huber
OTC licensed to AMIPurdue as a development partner• Design and engineer productization of prototype• Support to positioning device for FDA submission
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Alfred E. Mann Institute Purdue
- created by a $100 million endowment from the non-profit Alfred E. Mann Foundation for Biomedical Engineering (AEMFBE)
The Institute provides comprehensive –
• Intellectual Property Analysis and Development
• Market Analysis • Regulatory Pathway Planning • Reimbursement Strategies • Clinical Application Assessment • Product Development Process • Business Modeling • Licensing Strategies • Project Selection • Product Launch Strategies • Quality System Implementation • Technical Feasibility Study • Industrial Design • Product Requirement Specification • Clinical Studies • Manufacturing Process Validation • Competitive Analysis • Exit Strategies
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Office of Technology Commercialization
Nurture Innovation:
Trask Innovation Fund•98 innovations •Nanoscale investment: ave. $48,000 •TIF investments yielded 89 separate commercial licenses •TIF supported innovations are licensed at a 45% increase relative to technologies supported by federal funding alone
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Office of Technology Commercialization
Nurture Innovation:
Emerging Innovation Fund
•Established 2008, seeded by PRF makes a relative microscale investment in select Purdue-related new ventures.
•Leverage EIF investment to obtain macroscale funding from non-dilutive sources (SBIR, STTR) or institutional investor
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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University – business collaboration
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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CY2009: Deal Flow
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
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Thank you for your attention!