1

ABBA J. KASTIN, M.D. Professor and Endowed Chair, Pennington Biomedical Research Center

President, International Neuropeptide Society/Society for Biologically Active Peptides

H-index: 85; Citations: >33,500 EDUCATION

A.B. Harvard College, 1956

M.D. Harvard Medical School, 1960 TRAINING

7/60 - 7/62 Residency in Medicine, Vanderbilt University Hospital

7/62 - 9/64 Clinical Associate, Endocrinology Branch, National Cancer Institute, National Institutes of Health

9/64 - 1/65 Special NIH Postdoctoral Fellow with Dr. Andrew V. Schally

ACADEMIC APPOINTMENTS

7/61 - 7/62 Assistant, Department of Medicine, Vanderbilt University

9/64 - 1/65 Assistant, Department of Medicine, Tulane University

1/65 - 7/66 Instructor, Department of Medicine, Tulane University

7/66 - 7/71 Assistant Professor, Department of Medicine, Tulane University

7/71 - 7/74 Associate Professor, Department of Medicine, Tulane University

7/74 - 7/04 Professor, Department of Medicine, Tulane University

7/86 - 7/04 Professor, Neuroscience Training Program, Tulane University

7/86 – 9/06 Consulting Professor, Department of Psychology, University of New Orleans

2

8/04 - present Professor and Endowed Chair, Pennington Biomedical Research Center,

Louisiana State University Systems CURRENT FUNDING: “Leptin transport across the BBB: The role of ObR(+) astrocytes”. 5R01DK054880-12, 4/1/99 –

6/30/15, PI “Consequences of astrocyte leptin receptor upregulation on obesity”. 5R01 DK-92245-02.

7/26/11 – 4/30/15, PI “Neuroimmune modulation across the BBB: Regulation of IL15 trafficking by TNF”, NINDS

5R01 NS062291, 9/1/08 – 8/31/15, co-investigator HOSPITAL APPOINTMENTS Veterans Administration Hospital:

9/64 - 1/65 Medical Research Fellow

1/65 - 1/68 Clinical Investigator

7/66 - 1/68 Clinical Consultant in Endocrinology

1/68 - 7/04 Chief, Endocrinology Section Charity Hospital:

7/66 - 7/69 Assistant Visiting Physician

7/69 - 7/79 Visiting Physician

7/79 - 7/89 Senior Visiting Physician HONORARY DEGREES 1980 Doctorate (Honoris Causa), National University (Federico Villarreal) of Peru 1984 Doctorate of Science (Honoris Causa), University of New Orleans, LSU System

3

2008 Doctorate (Honoris Causa), Uppsala University, Sweden HONORARY SOCIETY MEMBERSHIPS 1966 La Societe de Dermo-Chimie 1970 Chilean Society of Endocrinology 1976 Philippine Society of Endocrinology and Metabolism 1980 Peruvian Ob/Gyn Society 1980 Peruvian Endocrine Society 1980 Polish Endocrine Society 1984 Hungarian Endocrine Society 2006 Brazilian Society of Toxinology (SBTx) 2008 Indian Society for Comparative Endocrinology AWARDS 1975 Federal Business Association "Eagle" Award and Key to the City of New Orleans 1975 Recipient (with Dr. A.V. Schally), Edward T. Tyler Fertility Award 1979 Copernicus Medal of the Medical Faculty of Krakow, Poland 1981 Distinguished Alumni Hall of Fame (First Annual Induction), Cleveland Heights High School 1982 William S. Middleton Award 2001 Strand Award 2007 Honorary Professor, The Peking University Health Science Center, China 2010 Honorary Professor, Lanzhou University, China

4

MISCELLANEOUS 1978 Most cited scientist list, Institute for Scientific Information, Current Contents, 7/10/78;

Science 202: 296, 1978-top 300; Current Contents 10/12/81-top 100; The Scientist 3/19/90-top 100

1980 - 2015 Founding Editor-in-Chief, Peptides, an international journal 1980s – present Nominator: Japan Prize, Kyoto Prize, International Prize for Biology 1993 - present President, International Neuropeptide Society/Society for Biologically Active Peptides 2006 Editor, 1st ed, Handbook of Biologically Active Peptides. Academic Press/Elsevier, 2nd ed

2013 2008 Co-Editor (with Weihong Pan), Henry Stewart Talks: The Blood-Brain Barrier, London Mention in popular press: Time, Washington Post, Boston Globe, Congressional Record, Fortune, New York Magazine, Harper’s Bazaar, Cosmopolitan, The Scientist, Medical World News (6x), Science News (7x) ADVISORY BOARDS 7/74 - 7/77 National Pituitary Agency 1/78 - 12/81 National Association for Retarded Citizens 2/79 - 12/80 Food and Drug Association 7/84 - 12/95 Pre-reviewer in Endocrinology, Residency Review Committee for Internal

Medicine, Accreditation Council for Graduate Medical Education 10/11/89 Congressional testimony, U.S. House of Representatives, representing American

Federation for Clinical Research. 1/98 – 12/00 Bar-Ilan University-Tel Hashomer Brain Research Center, Israel 1/98 - 12/03 Self-Assessment Committee, AMA Accreditation Program (AMA).

5

EDITORIAL BOARDS 1/76-1/80 Journal of Clinical Endocrinology and Metabolism. 1/76-4/95 Brain Research Bulletin 1/77-12/95 Neuroscience and Biobehavioral Reviews 7/85- 1/01 New Trends in Experimental and Clinical Psychiatry 3/88-3/90 Progress in NeuroEndocrinImmunology 1/89-1/95 Pharmacology, Biochemistry and Behavior 1/90-1/95 Molecular and Cellular Neurosciences 1/93-1/95 Physiology and Behavior 1/94-12/04 Endocrine Practice 7/95-6/00 Neuroimmunomodulation 7/96-12/00 Sulzberger & Graham Publishing, Ltd., Professional Books in

Pharmacology, Neuroscience and Biomedical Sciences 1/99-12/06 Harwood Academic Publishers, Book Series: Nutrition, Brain, and

Behavior 1/03-present Current Pharmaceutical Design (1/10-present, Section Editor: Endocrine and

Metabolic Agents) 1/04-1/07 Medicinal Chemistry Reviews – Online 1/05-present Medicinal Chemistry 8/07-12/09 Clinical Medicine: Endocrinology and Diabetes 1/10-present Clinical Medical Insights: Endocrinology and Diabetes TEACHING 1976-77 Distinguished Scientist Lecturer, Department of Anatomy, Tulane University

6

School of Medicine 1977-1996 Outstanding Teacher Awards, Tulane medical students’ Owl Club 1989-90 Welcome Visiting Professor (FASB), East Tennessee State University 1995 Guest of Honor, Research Day in Medicine, LSU Medical Center 1997 Visiting Senior Scientist, JSPS/NIH, Japan 2004 Jim Flood Memorial Lecture, St. Louis University 2007 Kalra Brain-Body Dialogue Lecture, University of Florida 2008 David Rabin Visiting Professor Lectures, Vanderbilt University SOCIETIES 1964 American Federation for Clinical Research 1965 The Endocrine Society 1965 American Association for Advancement of Science 1966 American Physiological Society 1967 Society for Experimental Biology and Medicine 1969 Society for Neuroscience 1970 International Society of Psychoneuroendocrinology 1972 International Society of Neuroendocrinology (Charter Member) 1978 International Pigment Cell Society (Charter Member) 1990 American Peptide Society (Charter Member) 1991 American Association of Clinical Endocrinology (Charter Member) 1992 International Behavioral Neuroscience Society (Council, 1992-1994; Fellow) 1993 The International Neuropeptide Society/Society for Biologically Active Peptides

7

(President, 1993-present) 1994 Council of Biology Editors (Editorial Policy Committee, 1998-2001) 1995 American College of Endocrinology (Fellow) CIVIC/COMMUNITY Green Wave Masters Swim Club (President, 1978 – 1984)

Civic Symphony Orchestra of New Orleans (President, 1990; Chairman, Nominating Committee, 1991 – 2005) Jewish Federation of Greater New Orleans (Board of Trustees, 1982 – 1988) Harvard Club of Louisiana (President, 1991-1995; Chairman, Advisory Committee, 1996 – 2010) Visual Arts Visiting Committee, Loyola University, New Orleans (2004 – 2011) Jewish Federation of Greater Baton Rouge (Board of Directors, 2012) Louisiana Philharmonic Orchestra (Advisory Board, 1997 – 2014) Opéra Louisiane (Board of Directors, 2007 – 2013) Baton Rouge Symphony Orchestra (Board of Directors, 2007 – 2013)

8

FULL PUBLICATIONS 1. Kastin, A.J. and G.T. Ross. Melanocyte stimulating hormone (MSH) and ACTH

activities of pituitary homografts in albino rats. Endocrinology 75: 187-191, 1964. 2. Kastin, A.J. and R.F. Gittes. Skin graft challenge to pituitary transplants in the rat.

Endocrinology 75: 457-460, 1964. 3. Kastin, A.J. and G.T. Ross. Modified in vivo assay for MSH. Experientia 20: 461-464,

1964. 4. Gittes, R.F., A.J. Kastin, D.B. Geoff and A.F. Ketcham. Deficiency of effective

histocompatibility antigens in pituitary and parathyroid tissue. Surgical Forum 15: 164-166, 1964.

5. Kastin, A.J., M.B. Lipsett, A.K. Ommaya and J.M. Moser. Asymptomatic hypernatremia:

physiological and clinical study. Am. J. Med. 38: 306-315, 1965. 6. Douglas, G.W., A.J. Kastin and R.W. Huntington. Carcinoma arising in a retroperitoneal

mullerian cyst, with widespread metastasis during pregnancy. Am. J. Ob. Gyn. 91: 210-216, 1965.

7. Paul, W.E., A.J. Kastin and W.D. Odell. The effect of ionizing radiation on melanocyte-

stimulating and steroidogenic activities of corticotropin. Biochem. Biophys. Acta 100: 263-269, 1965.

8. Kastin, A.J. and G.T. Ross. MSH and ACTH activities in pituitaries of frogs with

hypothalamic lesions. Endocrinology 77: 45-48, 1965. 9. Schally, A.V., C.Y. Bowers, A. Kuroshima, Y. Ishida, T.W. Redding and A.J. Kastin.

Hormonal activities of beef and pig hypothalamus. Excerp. Med. Int. Cong. Series no. 87, pp. 275-283, Proc. XXIII International Congress of Physiological Sciences, 1965.

10. Kastin, A.J., A.V. Schally, H. Yajima and K. Kubo. Melanocyte stimulating hormone

activity of synthetic MSH and ACTH peptides in vivo and in vitro. Nature 207: 978-979, 1965.

11. Kastin, A.J., A. Arimura and A.V. Schally. Topical absorption of polypeptide hormones

with dimethylsulfoxide. Arch. Dermatol. 93: 471-473, 1966. 12. Gittes, R.F. and A.J. Kastin. Effects of increasing numbers of pituitary transplants in

hypophysectomized rats. Endocrinology 78: 1023-1031, 1966. 13. Kastin, A.J. and A.V. Schally. In vivo assay for melanocyte lightening substances.

9

Experientia 22: 389, 1966. 14. Schally, A.V., A.J. Kastin, J.F. Barrett, W.H. Carter, C.Y. Bowers and W.F. White. On

vasodepressor activity in the hypothalamus. Biochem. Pharmacol. 15: 1805-1811, 1966. 15. Kastin, A.J. and A.V. Schally. MSH activity in pituitaries of rats treated with

hypothalamic extracts. Gen. Comp. Endocrinol. 7: 452-456, 1966. 16. Schally, A.V. and A.J. Kastin. Purification of a bovine hypothalamic factor which

elevates pituitary MSH levels in rats. Endocrinology 79: 768-772, 1966. 17. Kastin, A.J. and A.V. Schally. MSH activity in pituitary glands of rats treated with

tranquilizing drugs. Endocrinology 79: 1018-1020, 1966. 18. Kastin, A.J., G.T. Ross and A.V. Schally. Controle hypothalamique de la secretion de

MSH. Arch. Biochim. Cosmet. 9: 9, 1966. 19. Kastin, A.J. and A.V. Schally. Autoregulation of release of melanocyte stimulating

hormone from the rat pituitary. Nature 213: 1238-1240, 1967. 20. Kastin, A.J. and A.V. Schally. MSH activity in pituitaries of rats treated with

hypothalamic extracts from various animals. Gen. Comp. Endocrinol. 8: 344-347, 1967. 21. Kastin, A.J., T.W. Redding and A.V. Schally. MSH activity in rat pituitaries after

pinealectomy. Proc. Soc. Exp. Biol. Med. 124: 1275-1277, 1967. 22. Schally, A.V., A.J. Kastin, T.W. Redding, C.Y. Bowers, H. Yajima and K. Kubo.

Thyroid stimulating and pigmentary effects of synthetic peptides related to α-MSH and ACTH. Metabolism 16: 824-829, 1967.

23. Kastin, A.J., L. Barrett, S. Viosca, A. Arimura and A.V. Schally. MSH activity in rat

pituitaries after stress. Neuroendocrinology 2: 200-208, 1967. 24. Kastin, A.J., A.V. Schally, S. Viosca, L. Barrett and T.W. Redding. MSH activity in the

pituitaries of rats exposed to constant illumination. Neuroendocrinology 2: 257-262, 1967.

25. Schally, A.V., A.J. Kastin, W. Locke and C.Y. Bowers. Hypothalamic releasing and

inhibiting factors. In: Hormones in Blood. C.H. Gray and A.L. Bacharach, eds., Academic Press, New York, 1: 491-525, 1967.

26. Schally, A.V., W. Locke, A.J. Kastin and C.Y. Bowers. Some aspects of

neuroendocrinology. Yearbook of Endocrinology, pp. 5-29, 1967-68.

10

27. Schally, A.V., A. Arimura, C.Y. Bowers, S. Sawano, A.J. Kastin, T.W. Redding, T. Saito, W.F. White and A.I. Cohen. Physiological and biochemical studies on some highly purified hypothalamic releasing factors. In: Pharmacology of Hormonal Polypeptides and Proteins. R. Back, R. Paoletti and L. Martini, eds., Plenum Press, pp. 158-166, 1968.

28. Schally, A.V., A. Arimura, C.Y. Bowers, A.J. Kastin, S. Sawano and T.W. Redding.

Hypothalamic neurohumors regulating anterior pituitary function. Rec. Prog. Horm. Res. 24: 497-581, 1968.

29. Kastin, A.J., G. Gennser, A. Arimura, M.C. Miller and A.V. Schally. Melanocyte-

stimulating and corticotrophic activities in human foetal pituitary glands. Acta Endocrinologica 58: 6-10, 1968.

30. Kastin, A.J., M.C. Miller and A.V. Schally. MSH activity in the rat pituitary after

treatment with nembutal and morphine: A new bioassay for MSH-release inhibiting factor (MIF). Endocrinology 83: 137-140, 1968.

31. Kastin, A.J., S. Kullander, N.E. Borglin, K. Dyster-Aas, B. Dahlberg, D. Ingvar, C.E.T.

Krakau, M.C. Miller, C.Y. Bowers and A.V. Schally. Extrapigmentary effects of MSH in amenorrheic women. Lancet 1: 1007-1010, 1968.

32. Schally, A.V. and A.J. Kastin. The present concept of the nature of hypothalamic

hormones stimulating and inhibiting the release of pituitary hormones. Triangle 9: 19-25, 1969.

33. Kastin, A.J., A.V. Schally, S. Viosca and M.C. Miller. MSH activity in plasma and

pituitaries of rats after various treatments. Endocrinology 84: 20-27, 1969. 34. Sandman, C.A., A.J. Kastin and A.V. Schally. Melanocyte-stimulating hormone and

learned appetitive behavior. Experientia 25: 1001-1002, 1969. 35. Kastin, A.J., M.C. Miller and A.V. Schally. Modified in vitro assay for MSH. Experientia

25: 192-193, 1969. 36. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, C.Y. Bowers and A. Diaz-Infante.

Stimulation of LH release in men and women by hypothalamic LH-releasing hormone purified from porcine hypothalami. J. Clin. Endocrinol. Metab. 29: 1046-1050, 1969.

37. Kastin, A.J. Neuroendocrine research in the Veterans Administration, Special report.

January 29, 1969, part B. 38. Kastin, A.J., S. Viosca and A.V. Schally. Assay of mammalian MSH-release regulating

factor(s). In: Hypophysiotropic Hormones of the Hypothalamus. J. Meites, ed., Williams and Wilkins, Baltimore, pp. 171-183, 1970.

11

39. Dyster-Aas, K., A.J. Kastin, R.P. Vidacovich and A.V. Schally. Melanocyte-stimulating

activity in serum and the aqueous flare response in rabbits. J. Endocrinol. 46: 285-286, 1970.

40. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, C.Y. Bowers and F. Gomez-Perez.

Administration of LH-releasing hormone to selected subjects. Am. J. Ob. Gyn. 108: 177-182, 1970.

41. Gosbee, J.L., J. Kraicer, A.J. Kastin and A.V. Schally. A functional relationship between

the pars intermedia and ACTH secretion in the Rat. Endocrinology 86: 560-567, 1970. 42. Schally, A.V. and A.J. Kastin. The role of sex steroids and hypothalamic LH-releasing

hormone and FSH-releasing hormone in the regulation of gonadotropin secretion from the anterior pituitary gland. In: Advances in Steroid Biochemistry. M.H. Briggs, ed. Academic Press, New York, pp. 41-69, 1970.

43. Schally, A.V., A. Arimura, A.J. Kastin, J. Reeves, C.Y. Bowers, Y. Baba and W.F.

White. Hypothalamic LH-releasing hormone: Chemistry, physiology and effect in humans. In: Mammalian Reproduction. H. Gibian and E.J. Plotz, eds., Springer-Verlag, Berlin, pp. 45-83, 1970.

44. Schally, A.V., A. Arimura, C.Y. Bowers, I. Wakabayashi, A.J. Kastin, T.W. Redding,

J.C. Mittler, R.M.G. Nair, P. Pizzolato and A.J. Segal. Purification of hypothalamic releasing hormones of human origin. J. Clin. Endocrinol Metab. 31: 291-300, 1970.

45. Bowers, C.Y., A.V. Schally, D.S. Schalch, C. Gual, A.J. Kastin and K. Folkers. Activity

and specificity of synthetic thyrotropin-releasing hormone in man. Biochem. Biophys. Res. Comm. 39: 352-355, 1970.

46. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, M.C. Miller and F. Flores. Increased

release of LH after administration of LH-RH to men pretreated with clomiphene. J. Clin. Endocrinol. Metab. 31: 689-692, 1970.

47. Kastin, A.J., A.V. Schally, C. Gual and A.R. Midgley. Clinical studies with LH-releasing

hormone. Acta Endocrinol Panam. 1: 147-153, 1970. 48. Gual, C., F. Flores, A.J. Kastin, A.V. Schally and A.R. Midgley. Valoracion de la funcion

hipofisiaria en el humano mediante el empleo de hormonas liberadoras hipotalamicas (LH-RH). Reunion A.. Soc. Mex. Nutr. Endocrinol. 10: 331-340, 1970.

49. Sandman, C.A., A.J. Kastin and A.V. Schally. Behavioral inhibition as modified by

melanocyte-stimulating hormone (MSH) and light-dark condition. Physiol. Behav. 6: 45-48, 1971.

12

50. Schally, A.V., A. Arimura, A.J. Kastin, C.Y. Bowers, T.W. Redding, I. Wakabayashi, Y.

Baba, R.M.G. Nair, J.F. Barrett and J.J. Reeves. Recent advances in hypothalamic hormones regulating pituitary function. In: Recent Advances in Endocrinology. E. Mattar, G. Mattar and V.H.T. James, eds., Excerp. Med. Int. Congr. Series no. 238, pp. 293-310, 1971.

51. Kastin, A.J. and A.V. Schally. Control of MSH release in mammals. In: Recent Advances

in Endocrinology. E. Mattar, G. Mattar and V.H.T. James, eds., Excerp. Med. Int. Congr. Series no. 238, pp. 311-317, 1971.

52. Bowers, C.Y., A.V. Schally, A.J. Kastin, A. Arimura, D.S. Schalch, C. Gual, E.

Castineda and K. Folkers. Synthetic thyrotropin-releasing hormone. Activity in men and women, specificity of action, inhibition by triiodothyronine, and activity orally. J. Med. Chem. 14: 477-481, 1971.

53. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, A. Arimura, M.C. Miller and A.

Cabeza. Administration of LH-releasing hormone of human origin to man. J. Clin. Endocrinol. Metab. 32: 287-289, 1971.

54. Kastin, A.J., A. Arimura, A.V. Schally and M.C. Miller. Mass-action type, direct

feedback control of pituitary MSH release. Nature 231: 29-30, 1971. 55. Sandman, C.A., P.M. Denman, L.H. Miller, J.R. Knott, A.V. Schally and A.J. Kastin.

Electroencephalographic measures of melanocyte stimulating hormone activity. J. Comp. Physiol. Psychol. 76: 103-109, 1971.

56. Schally, A.V. and A.J. Kastin. Hypothalamic neuroendocrine mediators. Acta. Physiol.

Polonica 22 (Suppl. 3): 5-19, 1971. 57. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, M.C. Miller and A. Cabeza. Dose

response relationship of LH to LH-releasing hormone in man. J. Clin. Invest. 50: 1551-1553, 1971.

58. Kastin, A.J., A. Zarate, A.R. Midgley, E. Canales and A.V. Schally. Ovulation confirmed

by pregnancy after infusion of porcine LH-RH. J. Clin Endocrinol. Metab. 33: 980-982, 1971.

59. Nair, R.M.G., A.J. Kastin and A.V. Schally. Isolation and structure of hypothalamic

MSH release-inhibiting hormone. Biochem. Biophys. Res. Comm. 43: 1376-1425, 1971. 60. Kastin, A.J., A.V. Schally and S. Viosca. Inhibition of MSH release in frogs by direct

application of L-prolyl-L-leucylglycinamide to the pituitary. Proc. Soc. Exp. Biol. Med. 137: 1437-1439, 1971.

13

61. Kastin, A.J., L.H. Miller, D. Gonzalez-Barcena, W.D. Hawley, K. Dyster-Aas, A.V.

Schally, M.L. Velasco-Parra and M. Velasco. Psycho-physiologic correlates of MSH activity in man. Physiol. Behav. 7: 893-896, 1971.

62. Schally, A.V., A. Arimura, A.J. Kastin, H. Matsuo, Y. Baba, T.W. Redding, R.M.G.

Nair, L. Debeljuk and W.F. White. Gonadotropin-releasing hormone: one polypeptide regulates the secretion of LH and FSH. Science 173: 1036-1038, 1971.

63. Schally, A.V., A.J. Kastin and A. Arimura. Hypothalamic FSH and LH-regulating

hormone: structure, physiology, and clinical studies. Fertil. Steril. 22: 703-721, 1971. 64. Anderson, M.S., C.Y. Bowers, A.J. Kastin, D.S. Schalch, A.V. Schally, P.S. Snyder, R.D.

Utiger, J.F. Wilbur and A.J. Wise. Synthetic thyrotropin releasing hormone (TRH): a potent stimulator of thyrotropin secretion in man. N. Engl. J. Med. 285: 1279-1283, 1971.

65. Schally, A.V. and A.J. Kastin. Stimulation and inhibition of fertility through

hypothalamic agents. Drug Therapy 1: 29-32, 1971. 66. Plotnikoff, N.P., A.J. Kastin, M.S. Anderson and A.V. Schally. DOPA potentiation by a

hypothalamic factor, MSH release-inhibiting hormone (MIF). Life Sci. 10: 1279-1283, 1971.

67. Hollander, C.S., T. Mitsuma, A.J. Kastin, L. Shenkman, M. Blum and D.A. Anderson.

Hypertriiodothyroninaemia as a premonitory manifestation of thyrotoxicosis. Lancet 2: 731-733, 1971.

68. Kastin, A.J. and A.V. Schally. MSH release in mammals. In: Pigmentation: Its genesis

and biologic control. V. Riley, ed. Appleton-Century-Crofts, New York, pp. 215-223, 1972.

69. Kastin, A.J., A. Zarate, M.C. Miller, A. Hernandez-Ayup, K. Dyster-Aas, C. Gual and

A.V. Schally. Anovulatory uterine bleeding after administration of MSH to women with secondary amenorrhea. J. Reprod. Fertil. 28: 185-189, 1972.

70. Kastin, A.J., A.V. Schally, D. Gonzalez-Barcena, D.S. Schalch and L. Lee. Different

responses to two hypothalamic hormones in acromegalics. Arch. Int. Med. 130: 923-927, 1972.

71. Sandman, C.A., L.H. Miller, A.J. Kastin and A.V. Schally. A neuroendocrine influence

on attention and memory. J. Comp. Physiol. Psychol. 80: 54-58, 1972. 72. Arimura, A., A.J. Kastin and A.V. Schally. Recent progress in physiological and clinical

studies with LH- and FSH-releasing hormone. In: Gonadotropins. B. Saxena, C. Beling

14

and H. Gandy, eds. John Wiley and Sons, Inc., New York, pp. 32-48, 1972. 73. Kastin, A.J., A.V. Schally, D.S. Schalch, S.G. Korenman, M.C. Miller, C. Gual and E.

Perez-Pasten. Characterization of the hormonal responses to luteininzing hormone-releasing hormone (LH-RH) in prepubertal and adult subjects. Pediat. Res. 6: 481-486, 1972.

74. Denman, P.M., L.H. Miller, C.A. Sandman, A.V. Schally and A.J. Kastin.

Electrophysiological correlates of melanocyte-stimulating hormone activity in the frog. J. Comp. Physiol. Psychol. 80: 59-65, 1972.

75. Gual, C., A.J. Kastin and A.V. Schally. Clinical experience with hypothalamic releasing

hormones. Thyrotropin releasing hormone (TRH). Rec. Prog. Horm. Res. 28: 173-200, 1972.

76. Kastin, A.J., C. Gual and A.V. Schally. Clinical experience with hypothalamic releasing

hormones. Luteinizing hormone-releasing hormone and other hypophysiotropic hormones. Rec. Prog. Horm. Res. 28: 201-227, 1972.

77. Schally, A.V. and A.J. Kastin. Hypothalamic releasing and inhibiting hormones. Gen.

Comp. Endocrinol. Supplement 3: 76-85, 1972. 78. Schally, A.V., A. Arimura, A.J. Kastin, L. Debeljuk, H. Matsuo, Y. Baba, R.M.G. Nair

and T.W. Redding. The hypothalamic hormone regulating LH and FSH secretion. In: Biology of Reproduction: Basic and Clinical Studies. J.T. Velardo and B.A. Kasprow, eds., Oxford Univ. Press, pp. 61-68, 1972.

79. Kastin, A.J., A.V. Schally, C. Gual and A. Arimura. Release of LH and FSH after

administration of synthetic LH-releasing hormone. J. Clin. Endocrinol. Metab. 34: 753-756, 1972.

80. Schally, A.V., A.J. Kastin and A. Arimura. FSH-releasing hormone and LH-releasing

hormone. In: Vitamins and Hormones. R.S. Harris, P. Munson, E. Diczfalusy and J. Glover, eds., Academic Press, New York, vol. 30, pp. 83-164, 1972.

81. Kastin, A.J. and A.V. Schally. The hypothalamus influences the menstrual cycle. Ob.

Gyn. Suppl. to Medical World News, January, pp. 79-80, 1972. 82. Schally, A.V., A.J. Kastin and A. Arimura. The hypothalamus and reproduction. Am. J.

Ob. Gyn. 114: 423-442, 1972. 83. Kastin, A.J., A.V. Schally, C. Gual, S. Glick and A. Arimura. Clinical evaluation in men

of a substance with growth-hormone releasing activity in rats. J. Clin. Endocrinol. Metab. 35: 326-329, 1972.

15

84. Plotnikoff, N.P., A.J. Kastin, M.S. Anderson and A.V. Schally. Oxotremorine antagonism

by a hypothalamic hormone, melanocyte-stimulating hormone release-inhibiting factor, MIF. Proc. Soc. Exp. Biol. Med. 140: 811-814, 1972.

85. Kastin, A.J., S. Viosca, R.M.G. Nair, A.V. Schally and M.C. Miller. Interactions between

pineal, hypothalamus, and pituitary involving melatonin, MSH-release inhibiting factor, and MSH. Endocrinology 91: 1323-1328, 1972.

86. Zarate, A., E. Canales, A.V. Schally, L. Ayala-Valdes and A.J. Kastin. Successful

induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatory infertility. Fertil. Steril. 23: 672-674, 1972.

87. Schalch, D.S., D. Gonzalez-Barcena, A.J. Kastin, A.V. Schally and L.A. Lee.

Abnormalities in the release of TSH in response to thyrotropin-releasing hormone (TRH) in patients with disorders of the pituitary, hypothalamus, and basal ganglia. J. Clin. Endocrinol. Metab. 35: 609-615, 1972.

88. Nair, R.M.G., A.J. Kastin and A.V. Schally. Isolation and structure of another

hypothalamic peptide possessing MSH-release inhibiting activity. Biochem. Biophys. Res. Comm. 47: 1420-1425, 1972.

89. Schally, A.V., A. Arimura and A.J. Kastin. The LH and FSH-releasing hormone. Proc.

Symp. 4th International Congress of Endocrinology 273: 93-97, 1972. 90. Kastin, A.J., N.P. Plotnikoff, R.M.G. Nair, T.W. Redding and M.S. Anderson. MIF: Its

pituitary and extra-pituitary effects. In: Hypothalamic Hypophysiotropic Hormones: Clinical and Physiological Studies. Excerp. Med. Int. Congr. Series no. 263., Amsterdam, C. Gual and E. Rosemberg, eds., pp. 159-166, 1972.

91. Zarate, A., E.S. Canales, A.V. Schally, A.J. Kastin and J. Soria. Induction of ovulation

with synthetic luteinizing hormone-releasing hormone in suspected hypothalamic infertility. In: Hypothalamic Hypophysiotropic Hormones: Clinical and Physiological Studies. Excerp. Med. Int. Congr. Series no. 263., Amsterdam, C. Gual and E. Rosemberg, eds., pp. 251-253, 1972.

92. Gonzalez-Barcena, D., A.J. Kastin, A. Arimura, J.A. Bermudez, D. Lee, J. Ruelas and

A.V. Schally. Effects of synthetic LH-RH administered by different routes. In: Hypothalamic Hypophysiotropic Hormones: Clinical and Physiological Studies. Excerp. Med. Int. Congr. Series no. 263., Amsterdam, C. Gual and E. Rosemberg, eds., pp. 291-298, 1972.

93. Bergada, G., R.E. Mancini. O. Vilar, M.A. Rivarola, J.C. Calamera, C. Bianculli, A.V.

Schally and A.J. Kastin. Effect of chronic administration of synthetic LH-RH/FSH-RH

16

on prepubertal boys and in hypogonadotropic hypogonadism. In: Hypothalamic Hypophysiotropic Hormones: Clinical and Physiological Studies. Excerp. Med. Int. Congr. Series no. 263., Amsterdam, C. Gual and E. Rosemberg, eds., pp. 299-301, 1972.

94. Dunn, J.D., A.J. Kastin, A.J. Carrillo and A.V. Schally. Additional evidence for

dissociation of MSH and ACTH release. J. Endocrinol. 55: 463-464, 1972. 95. Kastin, A.J., R.H. Ehrensing, D.S. Schalch and M.S. Anderson. Improvement in mental

depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. Lancet 2: 740-742, 1972.

96. Dempsey, G.L., A.J. Kastin and A.V. Schally. The effects of MSH on a restricted passive

avoidance response. Horm. Behav. 3: 333-337, 1972. 97. Nockton, R., A.J. Kastin, S.T. Elder and A.V. Schally. Passive and active avoidance

responses at two levels of shock after administration of melanocyte-stimulating hormone. Horm. Behav. 3: 339-344, 1972.

98. Kastin, A.J. and A. Barbeau. Preliminary clinical studies with L-prolyl-L-leucyl-glycine

amide in Parkinson's disease. Can. Med. Assoc. J. 107: 1079-1081, 1972. 99. Schally, A.V., A. Arimura and A.J. Kastin. Hypothalamic hormones and fertility. Proc.

3rd European Congress of Sterility, Athens, Greece, pp. 843-848, 1972. 100. Velasco, M., A.J. Kastin and D. Gonzalez-Barcena. Effects of melanocyte-stimulating

hormone on the cortical somatic evoked responses in man. Neuropharmacology 11: 395-407, 1972.

101. Kastin, A.J. and A.V. Schally. Assay of MSH-releasing inhibiting factor (MIF). In:

Peptide Hormones. S.A. Berson and R.S. Yalow, eds., North Holland Pub. Co., Amsterdam, pp. 422-427, 1973.

102. Schally, A.V., A. Arimura and A.J. Kastin. Hypothalamic releasing and inhibiting

hormones. In: Biology Data Book. P.L. Altman and D.S. Dittmer, eds., Vol. 2, pp. 660-661, 1973.

103. Kastin, A.J., D. Gonzalez-Barcena, H. Friesen, L.S. Jacobs, D.S. Schalch, A. Arimura,

W.H. Daughaday and A.V. Schally. Unaltered plasma prolactin levels in men after administration of synthetic LH-releasing hormone. J. Clin. Endocrinol. Metab. 36: 375-377, 1973.

104. Redding, T.W., A.J. Kastin, R.M.G. Nair and A.V. Schally. The distribution, half-life,

and excretion of 14C and 3H-labeled L-prolyl-L-leucyl-glycinamide in the rat. Neuroendocrinology 11: 92-100, 1973.

17

105. Arimura, A., M. Saito, Y. Yaoi, T. Kumasaka, H. Kato, T. Koyama, N. Nishi, A.J. Kastin

and A.V. Schally. Comparison of the effects of subcutaneous and intravenous injection of synthetic LH-RH on serum LH and FSH levels in men. J. Clin. Endocrinol. Metab. 36: 385-388, 1973.

106. Kastin, A.J., L.H. Miller, R. Nockton, C.A. Sandman, A.V. Schally and L.O. Stratton.

Behavioral aspects of MSH. Prog. Brain Res. 39: 461-470, 1973. 107. Plotnikoff, N.P., A.J. Kastin, M.S. Anderson and A.V. Schally. Deserpidine antagonism

by a tripeptide, L-prolyl-L-leucylglycinamide. Neuroendocrinology 11: 67-71, 1973. 108. Schally, A.V., A. Arimura and A.J. Kastin. Hypothalamic regulating hormones. Science

179: 341-350, 1973. 109. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, M. Torres-Zamora, E. Perez-Pasten, A.

Kato and A.V. Schally. Responses to thyrotropin-releasing hormone in patients with renal failure and after infusion in normal men. J. Clin. Endocrinol. Metab. 36: 117-120, 1973.

110. Schally, A.V., A.J. Kastin, A. Arimura, D. Coy, E. Coy, L. Debeljuk and T.W. Redding.

Recent basic and clinical studies with luteinizing hormone-releasing hormone (LH-RH) and its analogues. J. Reprod. Fertil. Suppl. 20: 119-136, 1973.

111. Sandman, C.A., A.J. Kastin, A.V. Schally, J.W. Kendall and L.H. Miller. Neuroendocrine

responses to physical and psychological stress. J. Comp. Physiol. Psychol. 84: 386-390, 1973.

112. Zarate, A., A.J. Kastin, J. Soria, E.S. Canales and A.V. Schally. Effect of synthetic

luteinizing hormone-releasing hormone (LH-RH) in two brothers with hypogonadotropic hypogonadism and anosmia. J. Clin. Endocrinol. Metab. 36: 612-614, 1973.

113. Medeiros-Neto, G.A., S.P.A. Toledo, A.M. Pupo, M. Sucupira, F. Fraige-Filho, E.

Mattar, A.J. Kastin and A.V. Schally. Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormonal deficiencies. J. Clin. Endocrinol. Metab. 37: 972-976, 1973.

114. Aldinger, E.E., W.D. Hawley, A.V. Schally and A.J. Kastin. Cardiovascular actions of

melanocyte-stimulating hormone (MSH) in the dog. J. Endocrinol. 56: 613-614, 1973. 115. Kastin, A.J., G.D. Beach, W.D. Hawley, J.W. Kendall, M.S. Edwards and A.V. Schally.

Dissociation of MSH and ACTH release in man. J. Clin. Endocrinol. Metab. 36: 770-772, 1973.

116. Carillo, A.J., A.J. Kastin, J.D. Dunn and A.V. Schally. MSH activity in plasma and

18

pituitaries of rats with large hypothalamic lesions. Neuroendocrinology 12: 120-128, 1973.

117. Kastin, A.J., M.C. Miller, L. Ferrell and A.V. Schally. General activity in intact and

hypophysectomized rats after administration of melanocyte-stimulating hormone (MSH), melatonin, and Pro-Leu-Gly-NH2. Physiol. Behav. 10: 399-401, 1973.

118. Stratton, L.O. and A.J. Kastin. Melanocyte-stimulating hormone in learning and

extinction of two problems. Physiol. Behav. 10: 689-692, 1973. 119. Kastin, A.J., N.P. Plotnikoff, S. Viosca, M.S. Anderson and A.V. Schally. MSH-Release

inhibiting factors: recent studies. Yale J. Biol. Med. 46: 617-622, 1973. 120. Nair, R.M.G., T.W. Redding, A.J. Kastin and A.V. Schally. Site of inactivation of MSH

release-inhibiting hormone by human plasma. Biochem. Pharmacol. 22: 1915-1919, 1973.

121. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, J.A. Bermudez, D. Lee, A. Arimura, J.

Ruelas, I. Zepeda and A.V. Schally. Synthetic LH-releasing hormone (LH-RH) administered to normal men by different routes. J. Clin. Endocrinol. Metab. 37: 481-484, 1973.

122. Kastin, A.J., A. Barbeau, R.H. Ehrensing, N.P. Plotnikoff and A.V. Schally. Melanocyte-

stimulating hormone and the hypothalamic hormone which inhibits its release. In: Advances in Neurology. F.W. McDowell and A. Barbeau, eds., Raven Press, New York, Vol. 5, pp. 225-229, 1973.

123. Redding, T.W., A.J. Kastin, D. Gonzalez-Barcena, D.H. Coy, E.J. Coy, D.S. Schalch and

A.V. Schally. The half-life, metabolism, and excretion of tritiated luteinizing hormone-releasing hormone (LH-RH) in man. J. Clin. Endocrinol. Metab. 37: 626-631, 1973.

124. Schally, A.V., A. Arimura, A.J. Kastin, T. Uehara, J. Takahara, D.H. Coy and E.J. Coy.

Inhibition of the release of growth hormone In vitro by α-melanocyte-stimulating hormone. Biochem. Biophys. Res. Comm. 52: 1314-1319, 1973.

125. Sandman, C.A., W.D. Alexander and A.J. Kastin. Neuroendocrine influences on visual

discrimination and reversal learning in the albino and hooded rat. Physiol. Behav. 11: 613-617, 1973.

126. Stratton, L.O., A.J. Kastin and W.P. Coleman. Activity and dark-preference responses of

albino and hooded rats receiving MSH. Physiol. Behav. 11: 907-909, 1973. 127. Schally, A.V., A.J. Kastin, A. Arimura, D.H. Coy and J. Vilchez-Martinez. Potential role

of hypothalamic hormones in fertility control. In: Regulation of Human Fertility. K.S.

19

Moghissi and T.N. Evans, eds., Wayne State Univ. Press, pp. 115-131, 1973. 128. Zarate, A., J. Soria, E.S. Canales, A.J. Kastin and A.V. Schally. Pituitary FSH and LH

reserve in women with isolated gonadotropin deficiency. Ob. Gyn. 42: 507-510, 1973. 129. Hall, R., G.M. Besser, A.V. Schally, D.H. Coy, D. Evered, D.J. Goldie, A.J. Kastin, A.S.

McNeilly, C.H. Mortimer, C. Phenekos, W.M.G. Tunbridge and D. Weightman. Action of growth hormone-release inhibitory hormone in healthy men and acromegalics. Lancet 2: 581-584, 1973.

130. Woolf, P.D., D. Gonzalez-Barcena, D.S. Schalch, L.A. Lee, J.P. Arzac, A.V. Schally and

A.J. Kastin. Lack of effect of steroids on thyrotropin-releasing hormone (TRH) mediated thyrotropin (TSH) release. Neuroendocrinology 13: 56-62, 1973-74.

131. Zarate, A., J. Soria, E.S. Canales, A.J. Kastin, A.V. Schally and R. Guzman Toledano.

Pituitary response to synthetic luteinizing hormone-releasing hormone in Prader-Willi syndrome, prepubertal and pubertal children. Neuroendocrinology 13: 321-326, 1973-74.

132. Kastin, A.J., S. Viosca and A.V. Schally. Regulation of melanocyte- stimulating hormone

release. In: Handbook of Physiology. E. Knobil and W.H. Sawyer, eds., Vol. 4, pp. 551-562, 1974.

133. Kastin, A.J., A.V. Schally, A. Zarate, A. Arimura, D. Gonzalez-Barcena, G. Medeiros-

Neto and D.S. Schalch. Analysis of clinical studies with natural and synthetic LH-RH in man. Israel J. Med. Sci. 10: 1305-1310, 1974. Also In: Heterogeneity of Polypeptide Hormones. D. Rabinowitz and J. Roth, eds., Academic Press, New York, p. 123, 1974.

134. Kastin, A.J., A.V. Schally, A. Barbeau and R.H. Ehrensing. Endocrine and extra-

endocrine studies of hypothalamic hormones in man. In: Recent Studies of Hypothalamic Function. K. Lederis and K.E. Cooper, eds., Karger, Basel, pp. 196-206, 1974.

135. Brown, G.M., I.V. Uhlir, J. Seggie, A.V. Schally and A.J. Kastin. Effect of septal lesions

on plasma levels of MSH, corticosterone, GH, and prolactin before and after exposure to novel environment: role of MSH in the septal syndrome. Endocrinology 94: 583-587, 1974.

136. Schally, A.V., A. Arimura, A.J. Kastin, D.H. Coy, E.J. Coy, J. Vilchez-Martinez, R.

Geiger, W. Konig and H. Wissman. Physiological, veterinary, and clinical effects of hypothalamic releasing hormones (RH), especially LH-RH. Pure Appl. Chem. 37: 315-328, 1974.

137. Kastin, A.J., W.D. Hawley, M.C. Miller, A.V. Schally and C. Lancaster. Plasma MSH

and cortisol levels in 567 patients with special reference to brain trauma. Endocrinol. Exper. 8: 97-105, 1974.

20

138. Zarate, A., E.S. Canales, J. Soria, L.S. Jacobs, W.H. Daughaday, A.J. Kastin and A.V.

Schally. Gonadotropin and prolactin secretion in human pseudocyesis: effect of synthetic luteinizing hormone-releasing hormone (LH-RH) and thyrotropin releasing hormone (TRH). Ann. Endocrinol. 35: 445-450, 1974.

139. Zarate, A., E.S. Canales, J. Soria, A.J. Kastin, A.V. Schally and A. Gonzalez. Further

observations on the therapy of anovulatory sterility with synthetic luteinizing hormone-releasing hormone. Fertil. Steril. 25: 3-10, 1974.

140. Zanartu, J., A. Dabancens, A.J. Kastin and A.V. Schally. Effect of synthetic

hypothalamic gonadotropin releasing hormone in anovulatory sterility. Fertil. Steril. 25: 160-169, 1974.

141. Plotnikoff, N.P., F.N. Minard and A.J. Kastin. DOPA potentiation in ablated animals and

brain levels of biogenic amines in intact animals after prolyl-leucylglycinamide. Neuroendocrinology 14: 271-279, 1974.

142. Ehrensing, R.H. and A.J. Kastin. Melanocyte-stimulating hormone-release inhibiting

hormone as an anti-depressant: a pilot study. Arch. Gen. Psychiat. 30: 63-65, 1974. 143. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch and A.V. Schally. Differential effect of

various doses of mestranol on the release of LH and FSH in response to LH-releasing hormone. Fertil. Steril. 25: 439-442, 1974.

144. Kastin, A.J., A.V. Schally, D. Gonzalez-Barcena, D.H. Coy and D.S. Schalch. Clinical

comparison of natural LH-RH, synthetic LH-RH and two analogues of LH-RH. J. Clin. Endocrinol. Metab. 38: 801-804, 1974.

145. Kastin, A.J., G.L. Dempsey, B. LeBlanc, K. Dyster-Aas and A.V. Schally. Extinction of

an appetitive operant response after administration of MSH. Horm. Behav. 5: 135-139, 1974.

146. Stratton, L.O. and A.J. Kastin. Avoidance learning at two levels of motivation in rats

receiving MSH. Horm. Behav. 5: 149-155, 1974. 147. Arimura, A., A.J. Kastin, A.V. Schally, M. Saito, T. Kumasaka, T. Yaoi, N. Nishi and K.

Ohkura. Immunoreactive LH-releasing hormone in plasma: midcycle elevation in women. J. Clin. Endocrinol. Metab. 38: 510-513, 1974.

148. Arimura, A., A.J. Kastin, D. Gonzalez-Barcena, G. Siller, R.E. Weaver and A.V. Schally.

Disappearance of LH-releasing hormone in man as determined by radioimmunoassay. Clin. Endocrinol. 3: 421-425, 1974.

21

149. Schally, A.V., A.J. Kastin and A. Arimura. The role of the hypothalamus in reproduction. Ciba Review, pp. 1-2, 1974.

150. Ehrensing, R.H., A.J. Kastin, D.S. Schalch, H. Friesen, R. Vargas and A.V. Schally.

Affective state and thyrotropin and prolactin responses after repeated injections of thyrotropin-releasing hormone in depressed patients. Am. J. Psychiat. 131: 714-718, 1974.

151. Besser, G.M., C.H. Mortimer, D. Carr, A.V. Schally, D.H. Coy, D. Evered, A.J. Kastin,

W.M.G. Tunbridge, M.O. Thorner and R. Hall. Growth hormone release inhibiting hormone in acromegaly. Brit. Med. J. 1: 352-355, 1974.

152. Gonzalez-Barcena, D., A.J. Kastin, D.H. Coy, S. Glick, D.S. Schalch, L.A. Lee, J.P.

Arzac and A.V. Schally. Unaltered plasma GH levels in acromegalics and normal men and women after administration of (pyro)Glu-Ser-Gly-NH2, a proposed GH-releasing hormone. J. Clin. Endocrinol. Metab. 38: 1134-1136, 1974.

153. Kastin, A.J., C. Nissen, T.W. Redding, R.M.G. Nair and A.V. Schally. Delayed

disappearance of 14C-labeled-Pro-Leu-Gly-NH2 from the blood of hypophysectomized rats. Neuroendocrinology 16: 36-42, 1974.

154. Mortimer, C.H., D. Carr, T. Lind, S.R. Bloom, C.N. Mallinson, A.V. Schally, W.M.G.

Tunbridge, L. Yeomans, D.H. Coy, A.J. Kastin, G.M. Besser and R. Hall. Effects of growth hormone release inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients. Lancet 1: 697-701, 1974.

155. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, M.C. Miller, L. Lee, R. Rivas-Llamas

and A.V. Schally. Response to LH-RH in women before and after treatment with prednisone. Int. J. Fertil. 19: 107-110, 1974.

156. Plotnikoff, N.P. and A.J. Kastin. Oxotremorine antagonism by prolyl-leucyl-glycine

amide administered by different routes and with several anticholinergics. Pharmacol. Biochem. Behav. 2: 417-419, 1974.

157. Sandman, C.A., W. Beckwith, M.M. Gittis and A.J. Kastin. Melanocyte-stimulating

hormone (MSH) and overtraining effects on extradimensional shift (EDS) learning. Physiol. Behav. 13: 163-166, 1974.

158. Redding, T.W., A.J. Kastin, D. Gonzalez-Barcena, D.H. Coy, Y. Hirotsu, J. Ruelas and

A.V. Schally. The disappearance, excretion, and metabolism of tritiated prolyl-leucyl-glycinamide in man. Neuroendocrinology 16: 119-126, 1974.

159. Kastin, A.J., A. Arimura, D. Gonzalez-Barcena, D.H. Coy, M.C. Miller, N. Nishi, L. Lee,

22

H. Duron-Huerta, D.S. Schalch and A.V. Schally. Increased potency of four analogues of LH-releasing hormone in man. Int. J. Fertil. 19: 202-206, 1974.

160. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, M.C. Miller, R. Henriquez-Espinoza

and A.V. Schally. Response to LH-RH in men infused with theophylline. Int. J. Fertil. 19: 207-209, 1974.

161. Stone, S.C., F. Jaramillo, A.J. Kastin, A. Arimura, J.R. Vargas, A.V. Schally and R.P.

Dickey. Effect of LH-RH on antibody formation, sperm count and plasma levels of gonadotropins and testosterone in normal men. Int. J. Fertil. 19: 192-196, 1974.

162. Plotnikoff, N.P. and A.J. Kastin. Pharmacological studies with a tripeptide, prolyl-leucyl-

glycinamide. Arch. Int. Pharm. Therap. 211: 211-224, 1974. 163. Kastin, A.J., A.C. Paulsen, J. Zanartu and S.S.C. Yen. Hypothalamic control of

reproduction. Contemp. Ob./Gyn. 3: 143-170, 1974. 164. Plotnikoff, N.P., A.J. Kastin and A.V. Schally. Growth hormone release inhibiting

hormone: neuropharmacological studies. Pharmacol. Biochem. Behav. 2: 693-696, 1974. 165. Miller, L.H., A.J. Kastin, C.A. Sandman, M. Fink and W.J. Van Veen. Polypeptide

influence on attention, memory, and anxiety in man. Pharmacol. Biochem. Behav. 2: 663-668, 1974.

166. Alford, F.O., S.R. Bloom, J.D.N. Nabarro, R. Hall, G.M. Besser, D.H. Coy, A.J. Kastin

and A.V. Schally. Glucagon control of fasting glucose in man. Lancet 2: 974-976, 1974. 167. Besser, G.M., C.H. Mortimer, A.S. McNeilly, M.O. Thorner, G.A. Batistoni, S.R. Bloom,

K.W. Kastrup, K.F. Hanssen, R. Hall, D.H. Coy, A.J. Kastin and A.V. Schally. Long term infusion of growth hormone releasing inhibiting hormone in acromegaly: effects on pituitary and pancreatic hormones. Brit. Med. J. 4: 622-627, 1974.

168. Bloom, S.R., C.H. Mortimer, M.O. Thorner, G.M. Besser, R. Hall, A. Gomez-Pan, V.M.

Roy, R.C.G. Russell, D.H. Coy, A.J. Kastin and A.V. Schally. Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone. Lancet 2: 1106-1109, 1974.

169. Bermudez, J.A., A.J. Kastin, D.S. Schalch, D. Lee-Benitez, E. Perez-Pasten, D.

Gonzalez-Barcena and A.V. Schally. Hormone response to synthetic LH-releasing hormone (LH-RH) in prepubertal, pubertal, and adult human males. Endocr. Res. Comm. 1: 477-493, 1974.

170. Zarate, A., E.S. Canales, J. Soria, A.J. Kastin, A.V. Schally and A. Gonzales. Induction

of ovulation with synthetic luteinizing hormone-releasing hormone. In: Recent Progress

23

in Reproductive Endocrinology. P.G. Crosignani and V.H.T. James, eds., Academic Press, London, pp. 811-826, 1974.

171. Zarate, A., E.S. Canales, A.V. Schally and A.J. Kastin. Clinical applications of synthetic

releasing hormones: Utilization for diagnostic purposes. In: Biological and Clinical Aspects of Reproduction. VIII World cong. Fertil. Steril., Buenos Aires, Nov. 3-9, Excerp. Med. Int. Cong. Ser. No. 394, pp. 332-334, 1974.

172. Schally, A.V., A. Arimura, A.J. Kastin, D.H. Coy, E.J. Coy, L. Debeljuk, J. Vilchez-

Martinez, T.W. Redding, T. Uehara, J. Takahara and W.H. Carter. Recent advances in the chemistry and physiology of hypothalamic hormones, especially the LH-releasing hormone. In: Some Aspects of Hypothalamic Regulation of Endocrine Functions. P. Franchimont, ed., F.K. Schattauer Verlag, Stuttgart, pp. 5-14, 1975.

173. Kastin, A.J., A. Arimura and A.V. Schally. Contributions of clinical studies with natural

LH-RH to subsequent studies with the synthetic hormone. In: Some Aspects of Hypothalamic Regulation of Endocrine Functions. P. Franchimont, ed., F.K. Schattauer Verlag, Stuttgart, pp. 99-103, 1975.

174. Kastin, A.J., N.P. Plotnikoff, C.A. Sandman, M.A. Spirtes, R.M. Kostrzewa, S.M. Paul,

L.O. Stratton, L.H. Miller, F. Labrie, A.V. Schally and H. Goldman. The effects of MSH and MIF on the brain. In: Anatomical Neuroendocrinology. W.E. Stumpf and L.D. Grant, eds. Karger, Basel, pp. 290-297, 1975.

175. Dupont, A., A.J. Kastin, F. Labrie, G. Pelletier, R. Puviani and A.V. Schally. Distribution

of radioactivity in the organs of the rat and mouse after injection of 125I-α-melanocyte stimulating hormone. J. Endocrinol. 64:237-241, 1975.

176. Dupont, A., F. Labrie, G. Pelletier, R. Puviani, D.H. Coy, A.V. Schally and A.J. Kastin.

Distribution of radioactivity in the organs of the rat and mouse after injection of L-[3H]prolyl-leucylglycinamide. J. Endocrinol. 64: 243-248, 1975.

177. Kastin, A.J., C.A. Sandman, L.O. Stratton, A.V. Schally and L.H. Miller. Behavioral and

electrographic changes in rat and man after MSH. Prog. Brain Res. 42: 143-150, 1975. 178. Kastin, A.J., N.P. Plotnikoff, R. Hall and A.V. Schally. Hypothalamic hormones and the

central nervous system. In: Hypothalamic Hormones, M. Motta, P.G. Crosignani and L. Martini, eds., Academic Press, New York, pp. 261-268, 1975.

179. Soria, J., A. Zarate, E.S. Canales, A. Ayala, A.V. Schally, D.H. Coy, E.J. Coy and A.J.

Kastin. Increased and prolonged LH-RH/FSH-RH activity of synthetic [D-Ala-6, des-Gly-NH2]-LH-RH-ethylamide in normal women. Am. J. Ob. Gyn. 123: 145-146, 1975.

180. Gonzalez-Barcena, D., A.J. Kastin, D.H. Coy, D.S. Schalch, M.L. Vasconcelos, A.

24

Gonzalez-Sanchez and A.V. Schally. Respuesta a la administracion aguda de la hormona hipotalamic inhibidora de la hormona de crecimiento y de un analogo en acromegalia. Arch Invest. Med. 6: 505-512, 1975.

181. Goldman, H., C.A. Sandman, A.J. Kastin and S. Murphy. MSH affects regional perfusion

of the brain. Pharmacol. Biochem. Behav. 3: 661-664, 1975. 182. Spirtes, M.A., R.M. Kostrezewa and A.J. Kastin. MSH and MIF-1 effects on serotonin

levels and synthesis in various rat brain areas. Pharmacol. Biochem. Behav. 3: 1011-1015, 1975.

183. Stratton, L.O. and A.J. Kastin. Increased acquisition of a complex appetitive task after

MSH and MIF. Pharmacol. Biochem. Behav. 3: 901-904, 1975. 184. Sandman, C.A., J.M. George, J.D. Nolan, H. Van Riezen and A.J. Kastin. Enhancement

of attention in man with ACTH/MSH 4-10. Physiol. Behav. 15: 427-431, 1975. 185. Kastin, A.J., T.W. Redding, R. Hall, G.M. Besser and A.V. Schally. Lipid mobilizing

hormones of the hypothalamus and pituitary. Pharmacol. Biochem. Behav. 3, Suppl. 1: 121-126, 1975.

186. Zarate, A., E.S. Canales, H. Villalobos, J. Soria, L.S. Jacobs, A.J. Kastin and A.V.

Schally. Pituitary hormonal reserve in patients presenting hyperprolactinemia, intrasellar masses, and amenorrhea without galactorrhea. J. Clin. Endocrinol. Metab. 40: 1034-1037, 1975.

187. Plotnikoff, N.P. and A.J. Kastin. GH-RIF, LH-RH, TRH, MIF-I, substance P, and

angiotensin - central nervous system studies. In: Peptides: Chemistry, Structure and Biology. R. Walter and J. Meienhofer, eds., Ann Arbor Sci. Pub., pp 645-649, 1975.

188. Pelletier, G., F. Labrie, A.J. Kastin, D.H. Coy and A.V. Schally. Radioautographic

localization of radioactivity in rat brain after intraventricular or intracarotid injection of [3H]L-prolyl-leucylglycinamide. Pharmacol. Biochem. Behav. 3: 675-679, 1975.

189. Pelletier, G., F. Labrie, A.J. Kastin and A.V. Schally. Radioautographic localization of

radioactivity in rat brain after intracarotid injection of 125I-α-melanocyte-stimulating hormone. Pharmacol. Biochem. Behav. 3: 671-674, 1975.

190. Plotnikoff, N.P. and A.J. Kastin. Neuropharmacology of hypothalamic releasing factors.

Biochem. Pharmacol. 25: 363-365, 1976. 191. Besser, G.M., A.M. Paxton, S.A.N. Johnson, E.J. Moody, C.H. Mortimer, R. Hall, A.

Gomez-Pan, A.V. Schally, A.J. Kastin and D.H. Coy. Impairment of platelet function by growth hormone release inhibiting hormone. Lancet 1: 1166, 1975.

25

192. Gomez-Pan, A., W.M.G. Tunbridge, A. Duns, R. Hall, G.M. Besser, D.H. Coy, A.V.

Schally and A.J. Kastin. Hypothalamic hormone interaction in acromegaly. Clin. Endocrin. 4: 455-460, 1975.

193. Kostrzewa, R.M., A.J. Kastin and M.A. Spirtes. α-MSH and MIF-I effects on

catecholamine levels and synthesis in various rat brain areas. Pharmacol. Biochem. Behav. 3: 1017-1023, 1975.

194. Carr, D., A. Gomez-Pan, D.R. Weightman, V.C.M. Roy, R. Hall, G.M. Besser, M.O.

Thorner, A.S. McNeilly, A.V. Schally, A.J. Kastin and D.H. Coy. Growth hormone-release inhibiting hormone: actions on thyrotropin and prolactin secretion after thyrotropin releasing hormone. Brit. Med. J. 3: 67-69, 1975.

195. Schalch, D.S., D. Gonzalez-Barcena, A.J. Kastin, L. Landa, L.A. Lee, M.T. Zamora and

A.V. Schally. Plasma gonadotropins after administration of LH-releasing hormone in patients with renal or hepatic failure. J. Clin. Endocrinol. Metab. 41: 921-925, 1975.

196. Spirtes, M.A., N.P. Plotnikoff and A.J. Kastin. Effects of hypothalamic peptides on the

brain. In: CNS and Behavioural Pharmacology. A. Airaksinen, ed., pp. 121-129, 1975. 197. Schally, A.V., A.J. Kastin and A. Arimura. The hypothalamus and reproduction. Am. J.

Ob. Gyn. 122: 857-862, 1975. 198. Gonzalez-Barcena, D., A.J. Kastin, M.C. Miller, D.S. Schalch, D.H. Coy, A.V. Schally

and A. Escalante-Herrera. Stimulation of LH release after oral administration of an analogue of LH-releasing hormone (LH-RH). Lancet 2: 1126-1128, 1975.

199. Plotnikoff, N.P., W.F. White, A.J. Kastin and A.V. Schally. Gonadotropin releasing

hormone (GnRH): neuropharmacological studies. Life Sci. 17: 1685-1692, 1975. 200. Gomez-Pan, A., J.D. Reed, M. Albinus, B. Shaw, R. Hall, G.M. Besser, D.H. Coy, A.J.

Kastin and A.V. Schally. Direct inhibition of gastric acid and pepsin secretion by growth-hormone release-inhibiting hormone in cats. Lancet 1: 888-890, 1975.

201. Kastin, A.J., C.A. Sandman and A.V. Schally. Effects of MSH on the brain. In: Unique

Properties of Melanocytes, V. Riley, ed., S. Karger, Basel, Vol. 3, pp. 228-236, 1976. 202. Medeiros-Comaru, A.M., J. Rodrigues, L.C. Povoa, S. Franco, T. Dimetz, D.H. Coy, A.J.

Kastin and A.V. Schally. Clinical studies with long acting superactive analogs of LH-RH in women with secondary amenorrhea. Int. J. Fertil. 21: 239-245, 1976.

203. Kastin, A.J., A.V. Schally, D. Gonzalez-Barcena, A. Zarate, M. Besser and R. Hall.

Clinical studies with hypothalamic peptides. In: Basic Applications and Clinical Uses of

26

Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopez del Campo, eds., Excerp. Med. Int. Cong. Ser. no. 374: 235-243, 1976.

204. Gonzalez-Barcena, D., A.J. Kastin, A. Escalente-Herrera, A. Gonzalez-Martinez, D.H.

Coy and A.V. Schally. Long acting analogues of LH-RH. In: Basic Applications and Clinical Uses of Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopez del Campo, eds., Excerp. Med. Int. Cong. Ser. No. 374: 300-306, 1976.

205. Gomez-Pan, A., R. Hall, G.M. Besser, C.H. Mortimer, A.V. Schally, A.J. Kastin and

D.H. Coy. Thyrotropin-releasing hormone: clinical studies. In: Basic Applications and Clinical Uses of Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopez del Campo, eds., Excerp. Med. Int. Cong. Series no. 374: 313-318, 1976.

206. Besser, G.M., R. Hall, C.H. Mortimer, A. Gomez-Pan, A.V. Schally, A.J. Kastin and

D.H. Coy. Growth hormone release inhibiting hormone: actions on the pituitary. In: Basic Applications and Clinical Uses of Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopes del Campo, eds., Excerp. Med. Int. Cong. Series no. 374: 343-346, 1976.

207. Hall, R., A. Gomez-Pan, G.M. Besser, C.H. Mortimer, A.V. Schally, A.J. Kastin and

D.H. Coy. The extra-pituitary actions of growth hormone-release inhibiting hormone. In: Basic Application and Clinical Uses of Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopes del Campo, eds. Excerp. Med. Int. Cong. Series no. 374: 347-350, 1976.

208. Kastin, A.J., N.P. Plotnikoff, A.V. Schally and C.A. Sandman. Endocrine and CNS

effects of hypothalamic peptides and MSH. In: Reviews of Neuroscience. S. Ehrenpreis and I.J. Kopin, eds., Raven Press, New York, pp. 111-148, 1976.

209. Kastin, A.J., C. Nissen, K. Nikolics, K. Medzihradszky, D.H. Coy, I. Teplan and A.V.

Schally. Distribution of [3H]α-MSH in rat brain. Brain Res. Bull. 1: 19-26, 1976. 210. Barbeau, A., M. Roy and A.J. Kastin. Double-blind evaluation of oral L-prolyl- L-leucyl-

glycine amide in Parkinson's disease. Can. Med. Assoc. J. 114: 120-122, 1976. 211. Barbeau, A. and A.J. Kastin. Polypeptide therapy in Parkinson's disease - A new

approach. In: Advances in Parkinsonism, W. Birkmayer and O. Hornykiewicz, eds., Editiones Roche, Basel, pp. 483-487, 1976.

212. Stratton, L.O. and A.J. Kastin. Melanocyte-stimulating hormone and MSH/ACTH 4-10

reduce tonic immobility in the lizard. Physiol. Behav. 16: 771-774, 1976. 213. Schally, A.V., A.J. Kastin and D.H. Coy. LH-releasing hormone and its analogues: recent

basic and clinical investigations. Int. J. Fertil. 21: 1-30, 1976.

27

214. Cox, B., A.J. Kastin and H. Schnieden. A comparison between a melanocyte-stimulating

hormone inhibitory factor (MIF-I) and substances known to activate central dopamine receptors. Eur. J. Pharm. 36:141-147, 1976.

215. Stone, S.C., R.P. Dickey, A.J. Kastin and A.V. Schally. LH-RH and steroid levels in

normal ovulatory women. Ob. Gyn. 48: 146-149, 1976. 216. Schally, A.V., D.H. Coy and A.J. Kastin. Physiological and clinical effects of LH

releasing hormone (LH-RH) and its analogs. In: Recent Advances in Human Reproduction. A. Campos da Paz, V.A. Drill, M. Hayashi, W. Rodrigues and A.V. Schally, eds. Excerp. Med. Int. Cong. Series no. 107: 73-78, 1976.

217. Zarate, A., A. Ayala, A.V. Schally, A.J. Kastin, E.S. Canales, D.H. Coy and E.J. Coy.

The use of long-acting LH-RH analogs in the treatment of female infertility. In: Recent Advances in Human Reproduction. A. Campos da Paz, V.D. Drill, M. Hayashi, W. Rodrigues and A.V. Schally, eds., Excerp. Med. Int. Cong. Ser. No. 370: 106-109, 1976.

218. Forsbach, G., A. Ayala, A. Zarate, E.S. Canales, J. Soria, A.V. Schally, A.J. Kastin, D.H.

Coy and E.J. Coy. Long-acting luteinizing hormone-releasing hormone (LH-RH) analogs in the treatment of female infertility. Arch. Invest. Med. 7: 43-48, 1976.

219. Plotnikoff, N.P. and A.J. Kastin. Neuropharmacological tests with α-melanocyte

stimulating hormone. Life Sci. 18: 1217-1222, 1976. 220. Schally, A.V., D.H. Coy, A. Arimura, T.W. Redding, C.A. Meyers, J. Vilchez, E.

Pedroza, A. Gordin, J. Molnar, A.J. Kastin, F. Labrie, R. Hall, A. Gomez-Pan and G.M. Besser. Structure-activity relationship of hypophysiotropic hormones. Proc. 5th Int. Cong. Endocrin., Excerp. Med. Int. Cong Ser. Vol. 1: 163-167, 1976.

221. Kastin, A.J., C.A. Sandman, L.H. Miller and A.V. Schally. Some questions related to

MSH. Mayo Clin. Proc. 51: 632-636, 1976. 222. Kadowitz, P.J., B.M. Chapnick and A.J. Kastin. Comparison of α-MSH and several

vasoactive substances on vascular resistance in the feline mesenteric vascular bed. Pharmacol. Biochem. Behav. 5: 219-221, 1976.

223. Beckwith, B.E., C.A. Sandman and A.J. Kastin. Influence of 3 short chain peptides (α-

MSH, MSH/ACTH 4-10, MIF-I) on dimensional attention. Pharmacol. Biochem. Behav. 5, Suppl. 1: 11-16, 1976.

224. Miller, L.H., L.C. Harris, H. van Riezen and A.J. Kastin. Neuroheptapeptide influence on

attention and memory in man. Pharmacol. Biochem. Behav. 5, Suppl. 1: 17-21, 1976.

28

225. Sandman, C.A., J. George, B.B. Walker, J.D. Nolan and A.J. Kastin. Neuropeptide MSH/ACTH 4-10 enhances attention in the mentally retarded. Pharmacol. Biochem. Behav. 5, Suppl. 1: 23-28, 1976.

226. Panksepp, J., P. Reilly, P. Bishop, R.B. Meeker, T.R. Vilberg and A.J. Kastin. Effects of

α-MSH on motivation, vigilance and brain respiration. Pharmacol. Biochem. Behav. 5, Suppl. 1: 59-64, 1976.

227. Stratton, L.O., C.A. Gibson, K.G. Kolar and A.J. Kastin. Neonatal treatment with TRH

affects development, learning, and emotionality in the rat. Pharmacol. Biochem. Behav. 5, Suppl. 1: 65-67, 1976.

228. Ehrensing, R.H. and A.J. Kastin. Clinical investigations for emotional effects of

neuropeptide hormones. Pharmacol. Biochem. Behav. 5, Suppl. 1: 89-93, 1976. 229. Christensen, C.W., C.T. Harston, A.J. Kastin, R.M. Kostrzewa and M.A. Spirtes.

Investigations on α-MSH and MIF-I effects on cyclic AMP levels in rat brain. Pharmacol. Biochem. Behav. 5, Suppl. 1: 117-120, 1976.

230. Spirtes, M.A., N.P. Plotnikoff, R.M. Kostrzewa, C.T. Harston, A.J. Kastin and C.W.

Christensen. Possible association of increased rat behavioral effects and increased striatal dopamine and norepinephrine levels during the DOPA-potentiation test. Pharmacol. Biochem. Behav. 5, Suppl. 1: 121-124, 1976.

231. Kostrzewa, R.M., M.A. Spirtes, J.W. Klara, C.W. Christensen, A.J. Kastin and T.H. Joh.

Effects of L-prolyl-L-leucyl-glycine amide (MIF-I) on dopaminergic neurons. Pharmacol. Biochem. Behav. 5, Suppl. 1: 125-127, 1976.

232. Greenberg, R., C.E. Whalley, F. Jourdikian, I.S. Mendelson, K. Nikolics, D.H. Coy, A.V.

Schally and A.J. Kastin. Peptides readily penetrate the blood-brain barrier: uptake of peptides by synaptosomes is passive. Pharmacol. Biochem. Behav. 5, Suppl. 1: 151-158, 1976.

233. Barbeau, A., M. Gonce and A.J. Kastin. Neurologically active peptides. Pharmacol.

Biochem. Behav. 5, Suppl. 1: 159-163, 1976. 234. Goldman, H., E.B. Skelley, C.A. Sandman, A.J. Kastin and S. Murphy. Hormones and

regional brain blood flow. Pharmacol. Biochem. Behav. 5, Suppl. 1: 165-169, 1976. 235. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, D.H. Coy and A.V. Schally. Prolonged

elevation of luteinizing hormone (LH) after intranasal administration of an analogue of LH releasing hormone. Fertil. Steril. 27: 1246-1249, 1976.

236. Gomez-Pan, A., M.H. Snow, D.A. Piercy, V. Robson, R. Wilkinson, R. Hall, D.C.

29

Evered, G.M. Besser, A.V. Schally, A.J. Kastin and D.H. Coy. Actions of growth hormone-release inhibiting hormone (somatostatin) on the renin aldosterone system. J. Clin. Endocrinol. Metab. 43: 240-243, 1976.

237. Kastin, A.J., B. Kuzemchak, R.G. Thompkins, A.V. Schally and M.C. Miller. Melanin in

the rat brain. Brain Res. Bull. 1: 567-572, 1976. 238. Kastin, A.J., C. Nissen, A.V. Schally and D.H. Coy. Blood-brain barrier, half-time

disappearance, and brain distribution for labeled enkephalin and a potent analog. Brain Res. Bull. 1: 583-589, 1976.

239. Marks, N., F. Stern and A.J. Kastin. Biodegradation of α-MSH and derived peptides by

rat brain extracts, and by rat and human serum. Brain Res. Bull 1: 591-593, 1976. 240. Plotnikoff, N.P., A.J. Kastin, D.H. Coy, C.W. Christensen, A.V. Schally and M.A.

Spirtes. Neuropharmacological actions of enkephalin after systemic administration. Life Sci. 19: 1283-1288, 1976.

241. Coy, D.H., A.J. Kastin, A.V. Schally, O. Morin, N.G. Caron, F. Labrie, J.M. Walker, R.

Fertel, G.G. Berntson and C.A. Sandman. Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalin. Biochem. Biophys. Res. Commun. 73: 632-638, 1976.

242. Dunn, J.D., A.J. Kastin and A.J. Carrillo. Circadian variation in plasma melanocyte

stimulating hormone activity in the rat. Int. J. Chronobiol. 4: 163-169, 1976. 243. Kastin, A.J., E.L. Scollan, M.G. King, A.V. Schally and D.H. Coy. Enkephalin and a

potent analog facilitate maze performance after intraperitoneal administration in rats. Pharmacol. Biochem. Behav. 5: 691-695, 1976.

244. Schally, A.V. and A.J. Kastin. Hormones of the hypothalamus. La Recherche 7: 36-45,

1976. 245. Zarate, A., E.S. Canales, J. Soria, G. Forsbach, A.J. Kastin and A.V. Schally. Therapeutic

use of gonadoliberin (FSH/LH-RH) in women. Fertil. Steril. 27: 1233-1239, 1976. Also In: Modern Trends in Infertility and Conception Control. E.E. Wallach and R.D. Kempers, eds., Williams and Williams Co., Baltimore, p. 203, 1979.

246. Sandman, C.A. and A.J. Kastin. Pituitary peptide influences on attention and memory. In:

Neurobiology of Sleep and Memory. R.R. Drucker-Colin and J.L. McGaugh, eds., Academic Press, New York, pp. 347-360, 1977.

247. Kastin, A.J., L.H. Miller, C.A. Sandman, A.V. Schally and N.P. Plotnikoff. CNS and

pituitary effects of hypothalamic peptides and MSH. In: Essays in Neurochemistry and

30

Neuropharmacology. M.B.H. Youdim, W. Lovenberg, O.F. Sharman, J.R. Lagnado, eds., J. Wiley and Sons, New York, pp. 139-176, 1977.

248. Ehrensing, R.H. and A.J. Kastin. TRH: Clinical investigations for nonendocrine actions

in man. In: Clinical Neuroendocrinology. L. Martini and G.M. Besser, eds., Academic Press, New York, pp. 133-142, 1977.

249. Kastin, A.J., A. Barbeau, N.P. Plotnikoff, A.V. Schally and R.H. Ehrensing. MIF-I:

Actions in man. In: Clinical Neuroendocrinology. L. Martini and G.M. Besser, eds., Academic Press, New York, pp. 393-400, 1977.

250. Sandman, C.A., A.J. Kastin and L.H. Miller. Central nervous system actions of MSH and

related pituitary peptides. In: Clinical Neuroendocrinology. L. Martini and G.M. Besser, eds., Academic Press, New York, pp. 443-469, 1977.

251. Sandman, C.A. and A.J. Kastin. Neuropeptide influences on behavior: a possible

treatment for disorders of attention. In: Neuroregulation: Hypotheses about Psychiatric Disorders. J. Barchas, D.H. Hamburg and E. Usdin, eds., Oxford Univ. Press, New York, pp. 287-295, 1977.

252. Ehrensing, R.H., A.J. Kastin, P.F. Larson and G.A. Bishop. Melanocyte-stimulating

hormone release-inhibiting factor-I and tardive dyskinesia. Dis. Nerv. Sys. 38: 303-307, 1977.

253. Ashton, H., J.E. Millman, R. Telford, J.W. Thompson, T.F. Davies, R. Hall, S. Shuster,

A.J. Thody, D.H. Coy and A.J. Kastin. Psychopharmacological and endocrinological effects of melanocyte stimulating hormones in normal man. Psychopharmacology 55: 165-172, 1977.

254. Beckwith, B.E., C.A. Sandman, D. Hothersall and A.J. Kastin. Influence of neonatal

injections of α-MSH on learning, memory and attention in rats. Physiol. Behav. 18: 63-71, 1977.

255. Sandman, C.A., J. George, T.R. McCanne, J.D. Nolan, J. Kaswan and A.J. Kastin.

MSH/ACTH 4-10 influences behavioral and physiological measures of attention. J. Clin. Endocrinol. Metab. 44: 884-891, 1977.

256. Walker, M.J., G. Berntson, C.A. Sandman, D.H. Coy, A.V. Schally and A.J. Kastin. An

analogue of enkephalin having a prolonged opiate-like effect in vivo. Science 196: 85-87, 1977.

257. Schally, A.V., D.H. Coy, A. Arimura, T.W. Redding, A.J. Kastin, J. Vilchez-Martinez, E.

Pedroza, A. Gordin, J. Molnar, C.A. Meyers, F. Labrie, R. Hall, D. Reed, A. Gomez-Pan and G.M. Besser. Hypothalamic regulatory hormones and their synthetic analogs. In:

31

Proceedings of the Vth International Symposium on Medicinal Chemistry, Paris, July 19-22, 1976. J. Mathieu, ed., Elsevier Scientific Pub. Corp., Amsterdam, pp. 1-9, 1977.

258. Beckwith, B.W., R.K. O'Quin, M.S. Petro, A.J. Kastin and C.A. Sandman. The effects of

neonatal injections of α-MSH on the open field behavior of juvenile and adult rats. Physiol. Psychol. 5: 295-299, 1977.

259. Coy, D.H., P. Gill, A.J. Kastin, A. Dupont, L. Cusan, F. Labrie, D. Britton and R. Fertel.

Synthetic and biological studies on unmodified and modified fragments of human ß-lipotropin with opioid activities. In: Peptides, M. Goodman and J. Meienhoffer, eds., Wiley and Sons, New York, pp. 107-110, 1977.

260. Schally, A.V., A.J. Kastin and A. Arimura. Hypothalamic hormones: the link between

brain and body. Am. Sci. 65: 712-719, 1977. 261. Miller, L.H., A.J. Kastin and C.A. Sandman. Psychobiological actions of MSH in man.

In: Melanocyte Stimulating Hormone: Control, Chemistry and Effects. Frontiers of Hormone Research, Vol. 4. F.J.H. Tilders, D.F. Swaab and T.B. Greidanus, eds., Karger, Basel, pp. 153-161, 1977.

262. Geiger, R., J. Sandow and A.J. Kastin. Synthesis and properties of (11-serine) α-

melanotropin. Hoppe-Seyler's Z. Physiol. Chem. 358: 1475-1481, 1977. 263. Plotnikoff, P.J. and A.J. Kastin. Neuropharmacological review of hypothalamic releasing

factors. In: Neuropeptide Influences on the Brain and Behavior. L.H. Miller, C.A. Sandman and A.J. Kastin, eds., Raven Press, New York, pp. 81-107, 1977.

264. Sandman, C.A., L.H. Miller and A.J. Kastin. Introduction: Perspectives on the behavioral

effects of the neuropeptides. In: Neuropeptide Influences on the Brain and Behavior. L.H. Miller, C.A. Sandman and A.J. Kastin, eds., Raven Press, New York, pp. 1-9, 1977.

265. Miller, L.H., S.C. Fischer, G.A. Groves, M.E. Rudrauff and A.J. Kastin. MSH/ACTH 4-

10 influences on the CAR in human subjects: a negative finding. Pharmacol. Biochem. Behav. 7: 417-419, 1977.

266. Walker, J.M., C.A. Sandman, G.G. Berntson, R.F. McGivern, D.H. Coy and A.J. Kastin.

Endorphin analogs with potent and long-lasting analgesic effects. Pharmacol. Biochem. Behav. 7: 543-548, 1977.

267. Gonzalez-Barcena, D., A.J. Kastin, D.H. Coy, K. Nikolics and A.V. Schally. Suppression

of gonadotropin release in man by an inhibitory analogue of LH-releasing hormone. Lancet 2: 997-998, 1977.

268. Porter, J.R., A.J. Kastin, G. Pelle-Day and R.G. Tompkins. Regional in vitro uptake of a

32

synthetic [3H]-labeled-melanin into rat brain. Brain Res. Bull. 2: 401-404, 1977. 269. Grynbaum, A., A.J. Kastin, D.H. Coy and N. Marks. Breakdown of enkephalin and

endorphin analogs by brain extracts. Brain Res. Bull. 2: 479-484, 1977. 270. Marks, N., F. Stern, A.J. Kastin and D.H. Coy. Degradation of delta sleep inducing

peptide (DSIP) and its analogs by brain extracts. Brain Res. Bull. 2: 491-493, 1977. 271. Schally, A.V., D.H. Coy, A. Arimura, J. Vilchez, T.W. Redding and A.J. Kastin. Survey

of the structure synthesis and biological activity of hypothalamic releasing and inhibiting hormones. In: Hypothalamic Hormones - Chemistry, Physiology and Clinical Applications. D. Gupta and W. Voelter, eds., Verlag Chemie, pp. 1-12, 1978.

272. Ehrensing, R.H. and A.J. Kastin. Dose-related biphasic effect of prolyl-leucyl-

glycinamide (MIF-I) in depression. Am. J. Psychiat. 135: 562-566, 1978. 273. Kastin, A.J., C.A. Sandman, A.V. Schally and R.H. Ehrensing. Clinical effects of

hypothalamic-pituitary peptides upon the central nervous system. In: Clinical Neuropharmacology. H.L. Klawans, ed., Raven Press, New York. 3: 133-152, 1978.

274. Christensen, C.W., M.A. Spirtes, R.M. Kostrzewa and A.J. Kastin.

Neuropharmacological aspects of hypothalamic peptides and alpha-MSH. In: Current Studies of Hypothalamic Factors. Vol. 1 - Hormones. K. Lederis and W.L. Veale, eds., S. Karger, Basel, pp. 182-191, 1978.

275. Sandman, C.A. and A.J. Kastin. A behavioral strategy for the CNS actions of the

neuropeptides. In: Current Studies of Hypothalamic Factors. Vol. 2 - Metabolism and Behaviour. W.L. Veale and K. Lederis, eds., S. Karger, Basel, pp. 163-174, 1978.

276. Schally, A.V., D.H. Coy, A. Arimura, T.W. Redding, A.J. Kastin, C. Meyers, J. Seprodi,

R. Chang, W.-Y. Huang, K. Chihara, E. Pedroza, J. Vilchez and R. Millar. Hypothalamic peptide hormones and their analogues. In: Pharmacology of the Hypothalamus, B. Cox, I.D. Morris and A.H. Weston, eds., McMillan Press, London, pp. 161-206, 1978.

277. Spirtes, M.A., C.W. Christensen, C.T. Harston and A.J. Kastin. α-MSH and MIF-I effects

on cGMP levels in various rat brain regions. Brain Res. 144: 189-193, 1978. 278. Britton, D.R., R. Fertel, D.H. Coy and A.J. Kastin. The effect of enkephalin and

endorphin analogs on receptors in the mouse vas deferens. Biochem. Pharm. 27: 2275-2277, 1978.

279. Veith, J.L., C.A. Sandman, J.M. Walker, D.H. Coy and A.J. Kastin. Systemic

administration of endorphins selectively alters open field behavior of rats. Physiol. Behav. 20: 539-542, 1978.

33

280. Kastin, A.J., D.H. Coy, A.V. Schally and L.H. Miller. Peripheral administration of

hypothalamic peptides results in CNS changes. Pharmacol. Res. Commun. 10: 293-312, 1978.

281. Kastin, A.J., D.H. Coy, Y. Jacquet, A.V. Schally and N.P. Plotnikoff. CNS effects of

somatostatin. Metabolism 27 (Suppl. 1): 1247-1252, 1978. 282. Coy, D.H., A.J. Kastin, M.J. Walker, R.F. McGivern and C.A. Sandman. Increased

analgesic activities of a fluorinated and a dimeric analogue of [D-Ala-2]-methionine enkephalinamide. Biochem. Biophys. Res. Commun. 83: 977-983, 1978.

283. Kanade, A., A.E. Ruiz, K. Tornyos, I. Wakabayashi and A.J. Kastin. Panhypopituitarism

and anemia secondary to traumatic fracture of the sella turcica. J. Endocrin. Invest. 1: 263-268, 1978.

284. Olson, R.D., A.J. Kastin, G.F. Michell, G.A. Olson, D.H. Coy and D.M. Montalbano.

Effects of endorphin and enkephalin analogs on fear habituation in goldfish. Pharmacol. Biochem. Behav. 9: 111-114, 1978.

285. Kostrzewa, R.M., A.J. Kastin and S.K. Sobrian. Potentiation of apomorphine action in

rats by L-prolyl-L-leucyl-glycine amide. Pharmacol. Biochem. Behav. 9: 375-378, 1978. 286. Redding, T.W., A.J. Kastin, K. Nikolics, A.V. Schally and D.H. Coy. Disappearance and

excretion of labeled α-MSH in man. Pharmacol. Biochem. Behav. 9: 207-212, 1978. 287. Kastin, A.J., E.L. Scollan, R.H. Ehrensing, A.V. Schally and D.H. Coy. Enkephalin and

other peptides reduce passiveness. Pharmacol. Biochem. Behav. 9: 515-519, 1978. 288. Olson, R.D., A.J. Kastin, D. Montalbano-Smith, G.A. Olson, D.H. Coy and G.F. Michell.

Neuropeptides and the blood-brain barrier in goldfish. Pharmacol. Biochem. Behav. 9: 521-524, 1978.

289. Olson, G.A., R.D. Olson, A.J. Kastin, F.X. Castellanos, M.T. Kneale, D.H. Coy and R.H.

Wolf. Behavioral effects of D-Ala2-ß-endorphin in squirrel monkeys. Pharmacol. Biochem. Behav. 9: 687-692, 1978.

290. Kastin, A.J., D.H. Coy, A.V. Schally and C.A. Meyers. Activity of VIP, somatostatin and

other peptides in the mouse vas deferens assay. Pharmacol. Biochem. Behav. 9: 673-676, 1978.

291. Sandman, C.A. and A.J. Kastin. Interaction of α-MSH and MIF-I with D-amphetamine on

open-field behavior of rats. Pharmacol. Biochem. Behav. 9: 759-762, 1978.

34

292. Kastin, A.J. CNS actions of various hypothalamic-pituitary peptides in animals and man. Neurosci. Res. Prog. Bull. 16: 328-332, 1978.

293. Kastin, A.J., C.A. Sandman, N.P. Plotnikoff, D.H. Coy, R.D. Olson, A.V. Schally and

L.H. Miller. Central nervous system effects of MSH and hypothalamic peptides. In: Clinical Psychoneuroendocrinology in Reproduction. L. Carenza, P. Pancheri and L. Zichella, eds., Academic Press, New York, pp. 47-56, 1978.

294. Panksepp, J., T. Vilberg, N.J. Bean, D.H. Coy and A.J. Kastin. Reduction of distress

vocalization in chicks by opiate-like peptides. Brain Res. Bull 3: 663-667, 1978. 295. Marks, N., A.J. Kastin, F. Stern and D.H. Coy. Metabolism of potent enkephalin analogs

(FK 33-823, D-Ala2, pentafluorophenylalanine-4-enkephalinamide and a dimer of D-Ala2- enkephalin) and D-amino acid substituted derivatives of human ß-endorphin. Brain Res. Bull. 3: 687-690, 1978.

296. Kastin, A.J., C. Nissen, A.V. Schally and D.H. Coy. Radioimmunoassay of DSIP-like

material in rat brain. Brain Res. Bull 3: 691-695, 1978. 297. Coy, D.H., A.J. Kastin and N.P. Plotnikoff. Etudes biologiques faites avec les

encephalines, les endorphins et leurs analogues. Ann. Anesth. Franc. 19: 373-378, 1978. 298. Schally, A.V., A. Arimura, D.H. Coy, A.J. Kastin, C.A. Meyers, T.W. Redding, K.

Chihara, W.Y. Huang, R.C.C. Chang, E. Pedroza and J. Vilchez-Martinez. Hypothalamic hormones regulating pituitary (and other) functions: their physiology and biochemistry as well as recent studies with their synthetic analogues. In: Central Regulation of the Endocrine System. K. Fuxe, T. Hokfelt and R. Luft, eds., Plenum Press, New York, pp. 9-29, 1978.

299. Kastin, A.J., D.H. Coy, R.D. Olson, J. Panksepp, A.V. Schally and C.A. Sandman.

Behavioral effects of the brain opiates enkephalin and endorphin. In: Central Nervous System Effects of Hypothalamic Hormones and Other Peptides. R. Collu, A. Barbeau, J.R. Ducharme, J.-G. Rochefort, eds., Raven Press, New York, pp. 273-281, 1979.

300. Schally, A.V., A.M. Medeiros-Comaru and A.J. Kastin. Hormonas hipothalamicas y su

aplicacion en la pratica medica. Tribuna Medica 16: 2, 1979. 301. Kastin, A.J., R.D. Olson, A.V. Schally and D.H. Coy. CNS effects of peripherally

administered brain peptides. Life Sci. 25: 401-414, 1979. 302. Schally, A.V., D.H. Coy, C.A. Meyers and A.J. Kastin. Hypothalamic peptide hormones:

Basic and clinical studies. In: Hormonal Proteins and Peptides. C.H. Li, ed., Academic Press, New York, pp. 1-54, 1979.

35

303. Wass, J.A.H., G.M. Besser, A. Gomez-Pan, M.F. Scanlon, R. Hall, A.J. Kastin, D.H. Coy and A.V. Schally. Comparison of long-acting analogues of luteinizing hormone releasing hormone in man. Clin. Endocrinol. 10: 419-430, 1979.

304. Kostrzewa, R.M., J.C. Hardin, R.L. Snell, A.J. Kastin, D.H. Coy and F. Bymaster. MIF-I

and postsynaptic receptor sites for dopamine. Brain Res. Bull. 4: 657-662, 1979. 305. Olson, G.A., R.D. Olson, A.J. Kastin, M.T. Green, R. Roig-Smith, C.W. Hill and D.H.

Coy. Effects of an enkephalin analog on complex learning in the rhesus monkey. Pharmacol. Biochem. Behav. 11: 341-345, 1979.

306. King, M.G., A.J. Kastin, R.D. Olson and D.H. Coy. Systemic administration of Met-

enkephalin, [D-Ala2]-Met-enkephalin, ß-endorphin, and [D-Ala2]-ß-endorphin: effects on eating, drinking, and activity measures in rats. Pharmacol. Biochem. Behav. 11: 407-411, 1979.

307. Sandman, C.A., R.F. McGivern, C. Berka, M. Walker, D.H. Coy and A.J. Kastin.

Neonatal administration of ß-endorphin produces “chronic” insensitivity to thermal stimuli. Life Sci. 25: 1755-1760, 1979.

308. Kastin, A.J., B. Kuzemchak, A.V. Schally and M.W. Eggert. Rat brain melanin at

different ages and after various treatments. Brain Res. Bull. 4: 793-797, 1979. 309. Olson, R.D., A.J. Kastin, G.J. LaHoste, G.A. Olson and D.H. Coy. Possible non-narcotic

component to action of opiate peptides on tonic immobility. Pharmacol. Biochem. Behav. 11: 705-708, 1979.

310. Kastin, A.J., M.T. Jemison and D.H. Coy. Analgesia after peripheral administration of

enkephalin and endorphin analogues. Pharmacol. Biochem. Behav. 11: 713-716, 1979. 311. Kastin, A.J., C. Nissen, A.V. Schally and D.H. Coy. Additional evidence that small

amounts of a peptide can cross the blood-brain barrier. Pharmacol. Biochem. Behav. 11: 717-719, 1979.

312. Kastin, A.J., R.D. Olson, R.H. Ehrensing, M.C. Berzas, A.V. Schally and D.H. Coy.

MIF-I's differential actions as an opiate antagonist. Pharmacol. Biochem. Behav. 11: 721-723, 1979.

313. King, B.M., F.X. Castellanos, A.J. Kastin, M.C. Berzas, M.D. Mauk, G.A. Olson and

R.D. Olson. Naloxone-induced supression of food intake in normal and hypothalamic obese rats. Pharmacol. Biochem. Behav. 11: 729-732, 1979.

314. Nance, D.W., D.H. Coy and A.J. Kastin. Experiments with a proposed anorexigenic

tripeptide: pyro-Glu-His-Gly-OH. Pharmacol. Biochem. Behav. 11: 733-735, 1979.

36

315. Kostrzewa, R.M., Fukushima, H., C.T. Hartson, K.W. Perry, R.W. Fuller and A.J. Kastin.

Striatal dopamine turnover and MIF-I. Brain Res. Bull. 4: 799-802, 1979. 316. Huang, W.Y., R.C.C. Chang, A.J. Kastin, D.H. Coy and A.V. Schally. Isolation and

structure of pro-methionine-enkephalin, a new potential enkephalin precursor from porcine hypothalami. Proc. Natl. Acad. Sci. 76: 6177-6180, 1979.

317. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiates: through 1978.

Neurosci. Biobehav. Rev. 3: 285-299, 1979. 318. Schally, A.V., A.M. Comaru-Schally, J. Zadina and A.J. Kastin. LH-RH and its

stimulatory and inhibitory analogues: clinical studies. In: Psychoneuroendocrinology in Reproduction. L. Zichella and P. Pancheri, eds., Elsevier Press, Amsterdam, pp. 9-18, 1979.

319. Kastin, A.J., R.H. Ehrensing, D.H. Coy, A.V. Schally and R.M. Kostrzewa. Behavioral

effects of brain peptides, including LH-RH. In: Psychoneuroendocrinology in Reproduction. L. Zichella and P. Pancheri, eds., Elsevier Press, Amsterdam, pp. 69-80, 1979.

320. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. The opioid neuropeptides enkephalin

and endorphin and their hypothesized relation to pain. In: Pain: Meaning and Management. W.L. Smith, S.C. Gross and H. Merskey, eds., Spectrum Pub., New York, p. 21, 1980.

321. Schally, A.V., T.W. Redding, R.C.C. Chang, A. Arimura, W.Y. Huang, D.H. Coy, C.A.

Meyers, E. Pedroza, A.J. Kastin and C. Turkelson. Chemistry and physiology of hypothalamic hormones. In: Polypeptide Hormones. R.F. Beers, Jr. and E.G. Bassett, eds., Raven Press, New York, pp. 169-184, 1980.

322. Kastin, A.J., J.E. Zadina, D.H. Coy, A.V. Schally and C.A. Sandman. Hypothalamic

peptides affect behavior after systemic injection. In: Polypeptide Hormones. R.F. Beers, Jr. and E.G. Bassett, eds., Raven Press, New York, pp. 223-234, 1980.

323. Olson, R.D., A.J. Kastin, G.A. Olson and D.H. Coy. Behavioral effects after systemic

injection of opiate peptides. Psychoneuroendocrinology 5: 47-52, 1980. 324. Kastin, A.J., R.H. Ehrensing, R.D. Olson, A.V. Schally and D.H. Coy. Neurological

effects of MIF-I, MSH, and opiate peptides in clinical studies. Int. J. Neurol. 14: 205-209, 1980.

325. Kastin, A.J., A.V. Schally and R.M. Kostrzewa. Possible aminergic mediation of MSH

release and of the CNS effects of MSH and MIF-I. Fed. Proc. 39: 2931-2936, 1980.

37

326. Kastin, A.J., L.A. Wade, D.H. Coy, A.V. Schally and R.D. Olson. Peptides and the

blood-brain barrier. In: Brain and Pituitary Peptides. W. Wuttke, A. Weindl, K.H. Voigt and R.R. Dries, eds., Munich, Karger, pp. 71-78, 1980.

327. Kastin, A.J., G.A. Olson, C.A. Sandman, D.H. Coy, A.V. Schally and R.D. Olson. Brain

opiates affect behavior after systemic injection. In: Growth Hormone and Other Biologically Active Peptides. A. Pecile and E.E. Muller, eds., Excerpta Med., Amsterdam, pp. 201-206, 1980.

328. Miller, L.H., G.A. Groves, M.J. Bopp and A.J. Kastin. A neuroheptapeptide influence on

cognitive functioning in the elderly. Peptides 1: 55-57, 1980. 329. O'Steen, W.K. and A.J. Kastin. Relationship of melanocyte-stimulating hormone to

photoreceptor damage. Peptides 1: 19-22, 1980. 330. Yehuda, S., J. Zadina, A.J. Kastin and D.H. Coy. D-amphetamine-induced hypothermia

and hypermotility in rats: changes after systemic administration of ß-endorphin. Peptides 1: 179-185, 1980.

331. Mauk, M.D., G.A. Olson, A.J. Kastin and R.D. Olson. Behavioral effects of LH-RH.

Neurosci. Biobehav. Rev. 4: 1-8, 1980. 332. LaHoste, G.J., G.A. Olson, A.J. Kastin and R.D. Olson. Behavioral effects of melanocyte

stimulating hormone. Neurosci. Biobehav. Rev. 4: 9-16, 1980. 333. Yehuda, S., A.J. Kastin and D.H. Coy. Antagonistic actions of MIF-I on the hypothermia

and hypomotility induced by ß-endorphin or morphine. Int. J. Neurosci. 11: 317-320, 1980.

334. Ehrensing, R.H. and A.J. Kastin. Effects of MIF-I and TRH on the brain. In: Hormones

and the Brain. D. de Wied and P.A. van Keep, eds., MIP Press, Lancaster, pp. 155-165, 1980.

335. Kastin, A.J., G.A. Olson, A.V. Schally and D.H. Coy. DSIP-More than a sleep peptide?

Trends Neurosci. 3: 163-165, 1980. 336. Hanker, J.P., J. Knippenberg, A.J. Kastin, E.J. Wickings, A.V. Schally, D.H. Coy and

H.P.G. Schneider. Gonadotropin release during repeated administration of D-Leu6 des Gly10- LH-RH-EA at different stages of the menstrual cycle and in functional amenorrhea. Int. J. Fertil. 25: 7-17, 1980.

337. Davis, K.L., A.J. Kastin, B.A. Beilstein and A.L. Vento. MSH and MIF-I in animal

models of tardive dyskinesia. Pharmacol. Biochem. Behav. 13: 37-40, 1980.

38

338. Coy, D.H. and A.J. Kastin. Tyrosine-modified analogs of methionine-enkephalin and

their effects on the mouse vas deferens. Peptides 1: 175-177, 1980. 339. Schally, A.V., R.C.C. Chang, W.-Y. Huang, D.H. Coy, A.J. Kastin and T.W. Redding.

Isolation, structure, biological characterization, and synthesis of ß-[Tyr9] melanotropin-(9-18) decapeptide from pig hypothalami. Proc. Natl. Acad. Sci.USA 77: 3947-3951, 1980.

340. Schally, A.V., A.M. Comaru-Schally and A.J. Kastin. Present status of the use of LH-RH

and its analogs in the diagnosis and therapy of infertility. In: The LH Releasing Hormone. C. Beling and A. Wentz, eds., Masson Pub. Co., New York, pp. 1-13, 1980.

341. Kastin, A.J. and A.V. Schally. Early clinical studies with LH-RH. In: The LH Releasing

Hormone. C. Beling and A. Wentz, eds., Masson Pub. Co., New York, pp.15-20, 1980. 342. Yehuda, S. and A.J. Kastin. Interaction of MIF-I or α-MSH with D-amphetamine or

chlorpromazine on thermoregulation and motor activity of rats maintained at different ambient temperatures. Peptides 1: 243-248, 1980.

343. Yehuda, S., A.J. Kastin and D.H. Coy. Thermoregulatory and locomotor effects of DSIP:

paradoxical interaction with D-amphetamine. Pharmacol. Biochem. Behav. 13: 895-900, 1980.

344. Yehuda, S. and A.J. Kastin. Peptides and thermoregulation. Neurosci. Biobehav. Rev. 4:

459-471, 1980. 345. Sandman, C.A., B.E. Beckwith and A.J. Kastin. Are learning and attention related to the

sequence of amino acids in ACTH/MSH peptides? Peptides 1: 277-280, 1980. 346. Kastin, A.J., R.M. Kostrzewa, A.V. Schally and D.H. Coy. Neonatal administration of

Met-enkephalin facilitates maze performance of adult rats. Pharmacol. Biochem. Behav. 13: 883-886, 1980.

347. Coy, D.H. and A.J. Kastin. Structure-CNS activity studies with the enkephalins.

Pharmacol. Ther. 10: 657-668, 1980. 348. Kastin, A.J., M.D. Mauk, A.V. Schally and D.H. Coy. Unusual dose-related effect of an

endorphin analog in a complex maze. Physiol. Behav. 25: 959-962, 1980. 349. Kastin, A.J., D.H. Coy, A.V. Schally and J.E. Zadina. Dissociation of effects of LH-RH

analogs on pituitary regulation and reproductive behavior. Pharmacol. Biochem. Behav. 13: 913-914, 1980.

39

350. Kastin, A.J., S.P. Lawrence and D.H. Coy. Radioimmunoassay of MIF-1/Tyr-MIF-1-like material in rat pineal. Pharmacol. Biochem. Behav. 13: 901-905, 1980.

351. Kastin, A.J., C. Nissen, J.E. Zadina, A.V. Schally and R.H. Ehrensing. Naloxone-like

actions of MIF-1 do not require the presence of the pituitary. Pharmacol. Biochem. Behav. 13: 907-912, 1980.

352. Kastin, A.J., A. Arimura, D. Gonzalez-Barcena, J. Fishback, A.V. Schally and D.H. Coy.

Dynamics of injected somatostatin in blood of patients with hepatic failure and acromegaly. Peptides 1: 257-259, 1980.

353. McGivern, R.F., J.M. Harris, N. Yessaian, A.J. Kastin, D.H. Coy, C.A. Sandman and E.P.

Noble. Antagonism of ethanol induced sleep-time by α-MSH, MSH/ACTH 4-10 and naloxone. Substance and Alcohol Actions/Misuse 1: 335-342, 1980.

354. LaHoste, G.J., R.D. Olson, G.A. Olson and A.J. Kastin. Effects of pavlovian conditioning

and MIF-1 on the development of morphine tolerance in rats. Pharmacol. Biochem. Behav. 13: 799-804, 1980.

355. Olson, R.D., A.J. Kastin, T.K. von Almen, D.H. Coy and G.A. Olson. Systemic injections

of gastro-intestinal peptides alter behavior in rats. Peptides 1: 383-385, 1980. 356. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiates: 1979. Peptides

1: 365-379, 1980. 357. Olson, R.D., A.J. Kastin, G.A. Olson, B.M. King, T.K. von Almen, M.C. Berzas, M.L.

Ibanez and D.H. Coy. MIF-1 suppresses deprivation-induced fluid consumption in rats. Peptides 1: 353-357, 1980.

358. Gonzalez-Barcena, D., H. Trevino Ortiz, F. Gordon, A.J. Kastin, D.H. Coy and A.V.

Schally. Influence of LH-RH agonists and antagonists on gonadotropin release in humans. Int. J. Fertil. 25: 185-189, 1980.

359. Canales, E.S., H. Montvelinsky, A. Zarate, A.J. Kastin, D.H. Coy and A.V. Schally.

Suppressive effect of an inhibitory LHRH analog on the gonadotropin release to LHRH in normal women. Int. J. Fertil. 25: 190-192, 1980.

360. Canales, E.S., H. Montvelinsky, MA. E. Fonseca, A. Zarate, A.J. Kastin, D.H. Coy and

A.V. Schally. The use of a potent stimulatory LHRH analog (D-Trp-6, LHRH) in the induction of ovulation. Int. J. Fertil. 25: 193-197, 1980.

361. Kastin, A.J., J.E. Zadina and A.V. Schally. Foundations of the clinical use of LHRH:

early studies with the porcine hypothalamic Hormone. Materia Medical Polona 12: 33, 1980.

40

362. Hudson, R., A. King, G. Singer, A. Tucker, D.H. Coy and A.J. Kastin. Schedule-induced

self-injection of enkephalin and heroin by the rat. In: Problems in Pain. C. Peck and M. Wallace, eds., Pergamon Press, pp. 73-77, 1980.

363. Meyers, C.A., A.J. Kastin, A.V. Schally and D.H. Coy. Use of the mouse vas deferens

assay to evaluate the action of somatostatin peptides on gastric acid secretion. Digestion 21: 21-24, 1981.

364. Kastin, A.J., R.D. Olson, E. Fritschka and D.H. Coy. Neuropeptides and the blood-brain

barrier. In: Cerebral Microcirculation and Metabolism. J. Cervos-Navarro and E. Fritschka, eds., Raven Press, New York, pp. 139-145, 1981.

365. Walker, J.M., G.G. Berntson, C.A. Sandman and A.J. Kastin. Induction of analgesia by

central administration of Org 2766, an analog of ACTH 4-9. Eur. J. Pharm. 69: 71-79, 1981.

366. Sandman, C.A. and A.J. Kastin. Intraventricular administration of MSH induces

hyperalgesia in rats. Peptides 2: 231-233, 1981. 367. Ehrensing, R.H., A.J. Kastin and A.V. Schally. Behavioral and hormonal effects of

prolonged high doses of LHRH in male impotency. Peptides 2, Suppl. 1: 115-121, 1981. 368. Kastin, A.J., W.A. Banks, N. Marks and R.D. Olson. Dissociative effects of CNS

peptides with some unusual applications of RIA. In: Physiological Peptides and New Trends in Radioimmunology. Ch. A. Bixollon, ed., Elsevier, Amsterdam, pp. 89-99, 1981.

369. Sandman, C.A., A.J. Kastin and A.V. Schally. Neuropeptide influences on the central

nervous system: A psychobiological perspective. In: Neuroendocrine Regulation and Altered Behaviour. P.D. Hrdina and R.L. Singhal, eds., Croom Helm Ltd., pp. 4-27, 1981.

370. Olson, R.D., A.J. Kastin, G.A. Olson and D.H. Coy. Behavioural modulation by systemic

administration of enkephalins and endorphins. In: Neuroendocrine Regulation and Altered Behaviour. P.D. Hrdina and R.L. Singhal, eds., Croom Helm Ltd., pp. 142-150, 1981.

371. Kastin, A.J., G.A. Olson, C.A. Sandman and R.E. Ehrensing. Possible role of peptides in

senile dementia. In: Strategies for the Development of an Effective Treatment for Senile Dementia. T. Crook and S. Gershon, eds., Mark Powley Associates, pp. 139, 1981.

372. Kastin, A.J., R.D. Olson, C.A. Sandman, A.V. Schally and D.H. Coy. Multiple

independent actions of neuropeptides on behavior. In: Endogenous Peptides and Learning

41

and Memory Processes. J.L. Martinez, R.A. Jensen, R.B. Messing, H. Rigter and J.L. McGaugh, eds., Academic Press, New York, pp. 563-577, 1981.

373. Sandman, C.A. and A.J. Kastin. The influence of fragments of the LPH chains on

learning, memory and attention in animals and man. Pharmacol. Ther. 13: 39-60, 1981. 374. Sankar, R., F.R. Domer and A.J. Kastin. Selective effects of α-MSH and MIF-1 on the

blood-brain barrier. Peptides 2: 345-347, 1981. 375. Miller, L.H., A.J. Kastin, M. Hayes, A. Sterste, J. Garcia and D.H. Coy. Inverse

relationship between onset and duration of EEG effects of six peripherally administered peptides. Pharmacol. Biochem. Behav. 15: 845-848, 1981.

376. Olson, R.D., R.C. Fernandez, A.J. Kastin, G.A. Olson, S.W. Delatte, T.K. von Almen,

D.G. Erickson, D.C. Hastings and D.H. Coy. Low doses of naloxone and MIF-1 peptides increase fluid consumption in rats. Pharmacol. Biochem. Behav. 15: 921-924, 1981.

377. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiates: 1980. Peptides

2: 349-369, 1981. 378. Kastin, A.J., L.C. Honour and D.H. Coy. Kyotorphins affect aversive pecking in chicks.

Physiol. Behav. 27: 1073-1076, 1981. 379. Kastin, A.J., C. Nissen and D.H. Coy. DSIP-like immunoreactivity in the developing rat

brain. Brain Res. Bull. 7: 687-690, 1981. 380. Kastin, A.J., P.F. Castellanos, W.A. Banks and D.H. Coy. Radioimmunoassay of DSIP-

like material in human blood: possible protein binding. Pharmacol. Biochem. Behav. 15: 969-974, 1981.

381. Kastin, A.J., C. Nissen and D.H. Coy. Permeability of the blood-brain barrier to DSIP

peptides. Pharmacol. Biochem. Behav. 15: 955-959, 1981. 382. Kastin, A.J., S.P. Lawrence and D.H. Coy. Radioimmunoassayable N-Tyr-MIF-1-like

activity in rat brain is increased by pinealectomy. Brain Res. Bull. 7: 697-702, 1981. 383. Kastin, A.J., L.C. Honour and D.H. Coy. Effects of MIF-1 and three related peptides on

reserpine-induced hypothermia in mice. Pharmacol. Biochem. Behav. 15: 983-985, 1981. 384. Moldow, R.L., A.J. Kastin, C.S. Hollander, D.H. Coy and C.A. Sandman. Brain ß-

endorphin-like immunoreactivity in adult rats given ß-endorphin neonatally. Brain Res. Bull. 7: 683-686, 1981.

385. Luciano, M.G., J.E. Zadina, A.J. Kastin and D.H. Coy. Mu and delta opiate receptors in

42

rat brain are affected by GTP but not by MIF-1. Brain Res. Bull. 7: 677-682, 1981. 386. Zadina, J.E., A.J. Kastin, L.A. Fabre and D.H. Coy. Facilitation of sexual receptivity in

the rat by an ovulation-inhibiting analog of LHRH. Pharmacol. Biochem. Behav. 15: 961-964, 1981.

387. Sander, G.E., T.D. Giles, A.J. Kastin, A.C. Quiroz, A. Kaneish and D.H. Coy.

Cardiopulmonary pharmacology of enkephalins in the conscious dog. Peptides 2: 403-407, 1981.

388. Davis, B.M., G.M. Brown, M. Miller, H.G. Friesen, A.J. Kastin and D.L. Davis. Effects

of cholinergic stimulation on pituitary hormone release. Psychoneuroendocrinology 7: 347-354, 1982.

389. Kastin, A.J., R.D. Olson, C.A. Sandman, D.H. Coy, J.E. Zadina and R.H. Ehrensing.

CNS actions of peripherally administered peptides: some unresolved issues. In: Changing Concepts of the Nervous System. A.R. Morrison and P.L. Strick, eds., Academic Press, New York, pp. 757-768, 1982.

390. Olson, R.D., A.J. Kastin, G.A. Olson and D.H. Coy. Central nervous system effects after

systemic injection of opiate peptides. In: Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications. N.S. Shah and A.G. Donald, eds., Plenum Press, pp. 6l-74, l982.

391. Olson, G.A., A.J. Kastin, D.H. Coy and R.D. Olson. Systemic injections of enkephalins

and endorphins alter behavior. In: Analgesia by Peridural and Spinal Opiates. A.L. Cools and G.M.M. Nijhuis, eds., pp. 63-73, 1982.

392. Kastin, A.J., D.H. Coy, A.V. Schally and R.D. Olson. Dissociative actions of peptides on

the brain. In: Functional Regulation at the Cellular and Molecular Levels. R.A. Corradino, ed., Elsevier, pp. 91-103, 1982.

393. Sander, G., T. Giles, A. Kastin, A. Kaneish and D. Coy. Leucine-enkephalin: reversal of

intrinsic cardiovascular stimulation by pentobarbital. Eur. J. Pharmacal. 78: 467, 1982. 394. Ehrensing, R.H. and A.J. Kastin. MIF-1 and regulation of the hypothalamic-pituitary-

adrenocortical system in depression. In: Biological Markers in Psychiatry and Neurology. E. Usdin and I. Handin, eds., Pergamon Press, New York, pp. 299-305, 1982.

395. Clarkson, D.B., B.M. King, R.C. Hemmer, G.A. Olson, A.J. Kastin and R.D. Olson.

Naloxone decreases consumption of liquid and solid sucrose in vagotomized rats. Physiol. Behav. 29: 927-930, 1982.

396. Ehrensing, R.H., G.F. Michell and A.J. Kastin. Similar antagonism of morphine analgesia

43

by MIF-1 and naloxone in Carassius auratus. Pharmacol. Biochem. Behav. 17: 757-761, 1982.

397. Banks, W.A., A.J. Kastin and D.H. Coy. Delta sleep-inducing peptide crosses the blood-

brain-barrier in dogs: some correlations with protein binding. Pharmacol. Biochem. Behav. 17: 1009-1014, 1982.

398. Kastin, A.J., C. Nissen and R.D. Olson. Failure of MIF-1 or naloxone to reverse

ischemic- induced neurologic deficits in gerbils. Pharmacol. Biochem. Behav. 17: 1083-1085, 1982.

399. Kastin, A.J., W.A. Banks, P.F. Castellanos, C. Nissen and D.H. Coy. Differential

penetration of DSIP peptides into rat brain. Pharmacol. Biochem. Behav. l7: 1187-l191, l982.

400. Zadina, J.E., A.J. Kastin, E.F. Krieg and D.H. Coy. Characterization of binding sites for

N-Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) in rat brain. Pharmacol. Biochem. Behav. l7: 1193-1198, l982.

401. Kastin, A.J. and L.A. Fabre. Limitations to effect of α-MSH on permeability of blood-

brain barrier to IV 99mTc-pertechnetate. Pharmacol. Biochem. Behav. l7:1199-1201, l982. 402. Kastin, A.J., L.C. Honour, J. Sueiras-Diaz and D.H. Coy. Opposite effects of CRF and

ACTH on reserpine-induced hypothermia. Pharmacol. Biochem. Behav. l7: l203-l206, l982.

403. Hemmer, R.C., G.A. Olson, A.J. Kastin, J.H. McLean and R.D. Olson. Effects of

naloxone and its quaternary form on fluid consumption in rats. Pharmacol. Biochem. Behav. l7: l287-l290, l982.

404. Sander, G.E., A.J. Kastin and T.D. Giles. MIF-1 does not act like naloxone in

antagonizing the cardiovascular activity of leucine-enkephalin in the conscious dog. Pharmacol. Biochem. Behav. 17: l301-l303, l982.

405. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiates: l981. Peptides

3: l039-l072, l982. 406. Kastin, A.J., A.V. Schally, G.A. Olson and D.H. Coy. Early questions involving

hypothalamic peptides. In: The Anterior Pituitary Gland. A.S. Bhatnagar, ed., Raven Press, pp. 55-59, l983.

407. Kastin, A.J., W.A. Banks, J.E. Zadina and M. Graf. Brain peptides: the dangers of

constricted nomenclatures. Life Sci. 32: 295-30l, l983.

44

408. Kastin, A.J. and C.A. Sandman. Possible role of peptides in mental retardation. In: Curative Aspects of Mental Retardation: Biomedical and Behavioral Advances. F.J. Menolascino, R. Neman, J.A. Stark, eds. Paul H. Brookes Publishing Co., Inc. pp. l47-l64, l983.

409. Banks, W.A., A.J. Kastin and D.H. Coy. Delta sleep-inducing peptide (DSIP)-like

material is absorbed by the gastrointestinal tract of the neonatal rat. Life Sci 33: l587-l597, l983.

410. Kastin, A.J., H. Vaudry, J.E. Zadina and R.D. Olson. MIF-l, Tyr-MIF-l, and MSH:

control of MSH release and extra-pigmentary effects. Amer. Zool. 25: 55l-558, l983. 411. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: l982. Peptides 4: 563-576,

l983. 412. Tonon, M.C., P. Leroux, P. Saulot, H. Vaudry, D.H. Coy and A.J. Kastin. Effect of Tyr-

Pro-Leu-Gly-NH2 on melanotropin-stimulating hormone release in the frog and rat. Gen. Comp. Endocrinol. 52: l7-22, l983.

4l3. Banks, W.A. and A.J. Kastin. Aluminium increases permeability of the blood-brain

barrier to labelled DSIP and ß-endorphin: possible implications for senile and dialysis demenita. Lancet pp. l227-l229, l983.

4l4. Banks, W.A. and A.J. Kastin. CSF-plasma relationships for DSIP and some other

neuropeptides. Pharmacol. Biochem. Behav. l9: l037-l040, l983. 4l5. Hayashi, T., A.J. Kastin, D.H. Coy and R.D. Olson. Tyr-MIF-l affects passive avoidance

behavior but not motor activity in rats. Brain Res. Bull. ll: 659-662, l983. 4l6. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiate systems may

modulate learning and memory. In: Psychoneuroendocrine Dysfunction. N.S. Shah and A.G. Donald, eds., Plenum Press, pp. 279-292, 1984.

4l7. Kastin, A.J., R.D. Olson, G.A. Olson and D.H. Coy. Effects of hypothalamic peptides on

behavior. In: The Hypothalamus. J.R. Givens, ed. Year Book Medical Publisher, Inc., pp. 29l-301, 1984.

4l8. Feldman, S.C. and A.J. Kastin. Localization of neurons containing immunoreactive delta

sleep-inducing peptide in the rat brain: an immunocytochemical study. Neuroscience 11: 303-3l8, 1984.

4l9. Marks, N., M.J. Berg, A.J. Kastin and D.H. Coy. Evidence for conversion of N-Tyr-MIF-

l into MIF-l by a specific brain aminopeptidase. Neurochem. Int. 6: 347-353, 1984.

45

420. Graf, M.V. and A.J. Kastin. Delta-sleep-inducing peptide (DSIP): a review. Neurosci. Biobehav. Rev. 8: 83-93, 1984.

421. Kastin, A.J., J.E. Zadina, W.A. Banks and M.V. Graf. Misleading concepts in the field of

brain peptides. Peptides 5 (Suppl. 1): 249-253, 1984. 422. Banks, W.A., A.J. Kastin, E.G. Biglieri and A.E. Ruiz. Primary adrenal hyperplasia: a

new subset of primary hyperaldosteronism. J. Clin. Endocrinol. Metab. 58: 783-785, 1984.

423. Banks, W.A., A.J. Kastin and D.H. Coy. Evidence that [125I]N-Tyr-delta sleep-inducing

peptide crosses the blood-brain barrier by a non-competitive mechanism. Brain Res. 30l: 20l-207, 1984.

424. Graf, M.V., C.A. Hunter and A.J. Kastin. Presence of delta-sleep-inducing peptide-like

material in human milk. J. Clin. Endocrinol. Metab. 59: l27-l32, 1984. 425. Graf, M.V., A.J. Kastin., D.H. Coy and J.E. Zadina. DSIP reduces amphetamine-induced

hyperthermia in mice. Physiol. Behav. 33: 29l-295 1984. 426. Vilberg, T.R., J. Panksepp, A.J. Kastin and D.H. Coy. The pharmacology of endorphin

modulation of chick distress vocalization. Peptides 5:823-827, 1984. 427. Kastin, A.J., G.A. Olson, J.E. Zadina and R.D. Olson. Disparate effects of peripherally

administrated endorphins and enkephalins in laboratory animals. In: Central and Peripheral Endorphins. E.E. Muller and A.R. Genazzani, eds., Raven Press, New York, pp. 99-l08, 1984.

428. Graf, M.V. and A.J. Kastin. DSIP-like material exists in peripheral organs of rats in large

dissociable forms. Proc. Soc. Exp. Biol. Med. l77: l97-204, 1984. 429. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: l983. Peptides 5: 975-992,

1984. 430. Fischman, A.J., A.J. Kastin and M.V. Graf. HPLC shadowing: artifacts in peptide

characterization monitored by RIA. Peptides 5: l007-l0l0, 1984. 431. Graf, M.V., A.J. Kastin and A.J. Fischman. DSIP occurs in free forms in mammalian

plasma, human CSF, and urine. Pharmacol. Biochem. Behav. 21: 76l-766, 1984. 432. Kastin, A.J., J. Dickson and A.J. Fischman. DSIP-like material in brain parts of rats

running a complex maze. Physiol. Behav. 33: 427-431, 1984. 433. Fischman, A.J., A.J. Kastin and M.V. Graf. Circadian variation of DSIP-like material in

46

rat plasma. Life Sci. 35: 2079-2084, 1984. 434. Kastin, A.J., D.A. Abel, R.H. Ehrensing, D.H. Coy and M.V. Graf. Tyr-MIF-l and MIF-l

are active in the water wheel test for antidepressant drugs. Pharmacol. Biochem. Behav., 21: 767-771, 1984.

435. Hayashi, T., A.F. Fischman, A.J. Kastin and D.H. Coy. Some analogs of Tyr-MIF-l affect

passive avoidance behavior but not motor activity in rats. Pharmacol. Biochem. Behav. 21: 809-812, 1984.

436. Kastin, A.J., E. Stephens, R.H. Ehrensing and A.J. Fischman. Tyr-MIF-l acts as an opiate

antagonist in the tail-flick test. Pharmacol. Biochem. Behav. 21: 937-941, 1984. 437. Banks, W.A. and A.J. Kastin. A brain-to-blood carrier-mediated transport system for

small, N-tyrosinated peptides. Pharmacol. Biochem. Behav. 21: 943-946, 1984. 438. Kastin, A.J., P.F. Castellanos, A.J. Fischman, J.K. Proffitt and M.V. Graf. Evidence for

peptide aggregation. Pharmacol. Biochem. Behav. 21: 969-973, 1984. 439. Ehrensing, R.H., A.J. Kastin and G.F. Michell. Antagonism of morphine analgesia by

prolyl-leucyl-glycinamide (MIF-l) in humans. Pharmacol. Biochem. Behav. 21: 975-978, 1984.

440. Zadina, J.E. and A.J. Kastin. A rapid filtration method for receptor binding:

characterization with mu and delta opiate receptors. Pharmacol. Biochem. Behav. 21: 947-95l, 1984.

441. Feldman, S.C. and A.J. Kastin. The distribution of neurons containing delta sleep-

inducing peptide in the hippocampal formation. Brain Res. Bull. l3: 833-837, 1984. 442. Graf, M.V., A.J. Kastin and G.A. Schoenenberger. Delta-sleep inducing peptide and two

of its analogs reduce nocturnal increase of N-acetyltransferase activity in rat pineal gland. J. Neurochem. 44: 629-632, 1985.

443. Banks, W.A. and A.J. Kastin. Aluminum alters the permeability of the blood-barrier to

some non-peptides. Neuropharmacology. 24: 407-412, 1985. 444. Graf, M.V., A.J. Kastin and A.J. Fischman. Interaction of arginine vasopressin and

corticotropin releasing factor demonstrated with an improved bioassay. Proc. Soc. Exp. Biol. Med. l79: 303-308, 1985.

445. Kastin, A.J., J.E. Zadina, C.A. Sandman and R.D. Olson. Perinatal injections of opiate

and other peptides exert long-term effects. In: Endorphins, Neuroregulators and Behaviour in Human Reproduction. P. Pancheri, L. Zichella and P. Falaschi, eds.,

47

Excerpta Med. (Amsterdam) Cur. Clin. Prac. Ser. 26: 16-22, 1985. 446. Banks, W.A. and A.J. Kastin. The aluminum-induced increase in blood-brain barrier

permeability to delta-sleep inducing peptide occurs throughout the brain and is independent of phosphorus and acetylcholinesterase levels. Psychopharmacology 86: 84-89, 1985.

447. Graf, M.V., A.J. Kastin, D.H. Coy, A.J. Fischman. Delta-sleep-inducing peptide reduces

CRF-induced corticosterone release. Neuroendocrinology 4l: 353-356, 1985. 448. Banks, W.A. and A.J. Kastin. Peptides and the blood-brain barrier: lipophilicity as a

predictor of permeability. Brain Res. Bull. l5: 287-292, 1985. 449. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1984. Peptides 6: 769-79l,

1985. 450. Banks, W.A., A.J. Kastin and J.K. Selznick. Modulation of immunoactive levels of DSIP

and blood-brain barrier permeability by lighting and diurnal rhythm. J. Neurosci. Res. l4: 347-355, 1985.

451. Banks, W.A., A.J. Kastin and E.A. Michals. Transport of thyroxine across the blood-

brain barrier is directed primarily from brain to blood in the mouse. Life Sci. 37: 2407-2414, 1985.

452. Zadina, J.E. and A.J. Kastin. Interactions between the antiopiate Tyr-MIF-l and the mu

opiate morphiceptin at their respective binding sites in brain. Peptides 6: 965-970, 1985. 453. Kastin, A.J., E. Stephens, J.E. Zadina, D.H. Coy and A.J. Fischman. Tyr-MIF-l,

identified in brain tissue, and its analogs are active in two models of antinociception. Pharmacol. Biochem. Behav. 23: l045-l049, 1985.

454. Olson, G.A., S.W. Delatte, A.J. Kastin, J.H. McLean, D.F. Phillpott and R.D. Olson.

Naloxone and fluid consumption in rats: Dose-response relationships for l5 days. Pharmacol. Biochem. Behav. 23: l065-l068, 1985.

455. Banks, W.A. and A.J. Kastin. Aging and the blood-brain barrier: changes in the carrier-

mediated transport of peptides in rats. Neurosci. Lett. 6l: l7l-l75, 1985. 456. Zadina, J.E., A.J. Kastin, D.H. Coy and B.A. Adinoff. Developmental, behavioral, and

opiate receptor changes after prenatal or postnatal β-endorphin, CRF, or Tyr-MIF-l. Psychoneuroendocrinology l0: 367-383, 1985.

457. Banks, W.A. and A.J. Kastin. Permeability of the blood-brain barrier to neuropeptides:

the case for penetration. Psychoneuroendocrinology l0: 385-399, 1985.

48

458. Graf, M.V., A.J. Kastin and A.J. Fischman. The natural occurrence and some extra-sleep

effects of DSIP. In: Endogenous Sleep Substances and Sleep Regulation. S. Inoue and A.A. Borbely, eds., Japan Scientific Societies Press, Tokyo: VNU Science Press BV Utrecht, The Netherlands, pp. 155-l65, 1985.

459. Galina, Z.H. and A.J. Kastin. MIF-l antagonizes warm-, but not cold-water stress-induced

analgesia: dissociation from immobility. Peptides 6: 1109-1112, 1985. 460. Olson, G.A., M.F. Pignatiello, A.J. Kastin, B.F. Geiger and R.D. Olson. Lesions in

ventromedial hypothalamus or amygdala do not affect naloxone's suppression of water consumption. Physiol. Behav. 36: 967-970, 1986.

461. Coy, D.H. and A.J. Kastin. Structure-CNS activity studies with the enkephalins. In:

Neuropeptides and Behavior. D. de Wied, W.H. Gispen and Tj.B. van Wimersma Greidanus, eds., Pergamon Press, Oxford, pp. 385-396, 1986.

462. Miller, L.H., B.A. Turnbull, A.J. Kastin and D.H. Coy. Sleep-wave activity of a delta

sleep-inducing peptide analog correlates with its penetrance of the blood-brain barrier. Sleep 9: 80-84, 1986.

463. Kastin, A.J., T.D. Giles and J.C. Dickson. Immunoreactive plasma concentrations of an

endogenous antiopiate are higher in spontaneously hypertensive rats than in Wistar-Kyoto rats. Hypertension 8: l98-202, 1986.

464. Kastin, A.J., R.H. Ehrensing, C. Hara and D.H. Coy. Parallel behavioral and EEG studies

of the CNS effects of MSH in animals and humans. In: Central Actions of ACTH and Related Peptides. D. de Wied and W. Ferrarri, eds., Liviana Press, Padova, pp. l47-l52, 1986.

465. Graf, M.V., A.J. Kastin and G.A. Schoenenberger. Delta sleep-inducing peptide in

spontaneously hypertensive rats. Pharmacol. Biochem. Behav. 24: l797-l799, 1986. 466. Hara, C. and A.J. Kastin. Acute administration of MIF-l or Tyr-MIF-l inhibits

haloperidol- induced catalepsy in rats. Pharmacol. Biochem. Behav. 24: l785-l787, 1986. 467. Banks, W.A. and A.J. Kastin. Aging, peptides, and the blood-brain barrier: implications

and speculations. In: Treatment Development Strategies for Alzheimer's Disease. T. Crook, R. Bartus, S. Ferris and S. Gershon, eds., pp. 245-265, 1986.

468. Zadina, J.E., W.A. Banks and A.J. Kastin. Central nervous system effects of peptides,

l980-1985: a cross-listing of peptides and their central actions from the first six years of the journal Peptides. Peptides 7: 497-537, 1986.

49

469. Zadina, J.E. and A.J. Kastin. Neonatal peptides affect developing rats: β-endorphin alters nociception and opiate receptors, corticotropin-releasing factor alters corticosterone. Devel. Brain Res. 29: 2l-30, 1986.

470. Banks, W.A., A.J. Kastin, D.H. Coy and E. Angulo. Entry of DSIP peptides into dog

CSF: Role of physicochemical and pharmacokinetic parameters. Brain Res. Bull. 17: 155-158, 1986.

471. Hara, C. and A.J. Kastin. Biphasic effects of MIF-1 and Tyr-MIF-1 on apomorphine-

induced sterotypy in rats. Pharmacol. Biochem. Behav. 25: 757-761, 1986. 472. Banks, W.A., A.J. Kastin, A.J. Fischman, D.H. Coy and S.L. Strauss. Carrier-mediated

transport of enkephalins and N-Tyr-MIF-1 across blood-brain barrier. Am. J. Physiol. 251: E477-E482, 1986.

473. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1985. Peptides 7: 907-

933, 1986. 474. Galina, Z.H. and A.J. Kastin. Minireview: Existence of antiopiate systems as illustrated

by MIF-1/Tyr-MIF-1. Life Sci. 39: 2153-2159, 1986. 475. Pretorius H.T., A.J. Kastin and W.A. Banks. Binding of Tyr-MIF-1 to isolated brain

capillaries. Brain Res. Bull. 17: 829-831, 1986. 476. Zadina, J.E. and A. J. Kastin. Interactions of Tyr-MIF-1 at opiate receptor sites.

Pharmacol. Biochem. Behav. 25: 1303-1305, 1986. 477. Graf, M.V. and A. J. Kastin. Delta sleep-inducing peptide (DSIP): an update. Peptides 7:

1165-1187, 1986. 478. Banks, W.A. and A. J. Kastin. Modulation of the carrier-mediated transport of the Tyr-

MIF-1 across the blood-brain barrier by essential amino acids. J. Pharmacol Exp. Ther. 239: 668-672, 1986.

479. Zadina, J.E. and A.J. Kastin. Multi-independent actions of peptides in the brain: LHRH,

MIF-1 and CRF. Amer. Zool. 26: 951-964, 1986. 480. Kastin, A.J., R.D. Olson, J.E. Zadina and W.A. Banks. Relationship of clinical to basic

research with peptides as illustrated by MSH. In: Neural and Endocrine Peptides and Receptors. T.W. Moody, ed., Plenum Press, New York, pp. 645-652, 1986.

481. Moldow, R.L., A.J. Kastin, M. Graf and A. J. Fischman. Stress mediated changes in

hypothalamic corticotropin releasing factor-like immunoreactivity. Life Sci. 40: 413-418, 1987.

50

482. Sandman, C.A. and A.J. Kastin. Behavioral actions of ACTH and related peptides. In:

Hormonal Proteins and Peptides. C.H. Li, ed., Academic Press, Inc., Orlando, pp. 147-171, 1987.

483. Kastin, A.J., Z.H. Galina, A. Horvath and R.D. Olson. Some principles in the peptide

field. J. Allergy Clin. Immunol. 79: 6-11, 1987. 484. Kastin, A.J. and J.C. Dickson. Hypophysectomy increases Tyr-MIF-1-like

immunoreactivity in rat plasma. Neuroendocrinology 45: 177-181, 1987. 485. Galina, Z.H. and A.J. Kastin. Tyr-MIF-1 attenuates antinociceptive responses induced by

three models of stress-analgesia. Br. J. Pharmacol. 90: 669-674, 1987. 486. Zadina, J.E., A.J. Kastin, P.K. Manasco, M.F. Pignatiello and K.L. Nastiuk. Long-term

hyperalgesia by neonatal ß-endorphin and morphiceptin is blocked by neonatal Tyr-MIF-1. Brain Res. 409: 10-18, 1987.

487. Kastin, A.J., R.H. Ehrensing, W.A. Banks and J.E. Zadina. Possible therapeutic

implications of the effects of some peptides in the brain. Prog. Brain Res. 72: 223-234, 1987.

488. Kastin, A.J., J.E. Zadina, R.H. Ehrensing and D. Schwartzenburg. MIF-1 and Tyr-MIF-1

can act differently from amitriptyline in an animal modelof depression. New Trends Exp. Clin. Psychiat. 3: 49-58, 1987.

489. Banks, W.A. and A.J. Kastin. Saturable transport of peptides across the blood-brain

barrier. Life Sci. 41: 1319-1338, 1987. 490. Kastin, A.J. and R.D. Olson. Melanocyte-stimulating hormone (MSH). In: Encyclopedia

of Neuroscience. G. Adelman, ed., Birkhauser Inc., Boston, pp. 622-623, 1987. 491. Kastin, A.J. and R.H. Ehrensing. Neuropeptides, MIF-1/Tyr-MIF-1. In: Encyclopedia of

Neuroscience. G. Adelman, ed., Birkhauser Inc., Boston, pp. 838-839, 1987. 492. Kastin, A.J. and J.E. Zadina. Peptides, multiple independent actions. In: Encyclopedia of

Neuroscience. G. Adelman, ed., Birkhauser Inc., Boston, pp. 936-937, 1987. 493. Kastin, A.J. and W.A. Banks. Peptides and the blood-brain barrier. In: Encyclopedia of

Neuroscience. G. Adelman, ed., Birkhauser, Inc., Boston, pp. 937-938, 1987. 494. Kastin, A.J. and M.V. Graf. Delta sleep-inducing peptide (DSIP). In: Encyclopedia of

Neuroscience. G. Adelman, ed., Birkhauser, Inc., Boston, pp. 1106-1107, 1987.

51

495. Miller, L.G. and A.J. Kastin. MIF-1 and Tyr-MIF-1 augment GABA-stimulated benzodiazepine receptor binding. Peptides 8: 751-755, 1987.

496. Banks, W.A., A.J. Kastin and E.A. Michals. Tyr-MIF-1 and met-enkephalin share a

saturable blood-brain barrier transport system. Peptides 8: 899-903, 1987. 497. Miller, L.G., A.J. Kastin and D.J. Greenblatt. Tyr-MIF-1 augments benzodiazepine

receptor binding in vivo. Pharmacol. Biochem. Behav. 28: 521-524, 1987. 498. Banks, W.A., A.J. Kastin, A. Horvath and E.A. Michals. Carrier-mediated transport of

vasopressin across the blood-brain barrier of the mouse. J. Neurosci. Res. 18: 326-332, 1987.

499. Barrera, C.M., A.J. Kastin and W.A. Banks. D-[Ala1]-peptide T-amide is transported from

blood to brain by a saturable system. Brain Res. Bull. 19: 629-633, 1987. 500. Miller, L.G., A.J. Kastin and R.B. Roy. Effects of Tyr-MIF-1 and MIF-1 at the GABAA

receptor chloride channel site. Brain Res. Bull. 19: 743-745, 1987. 501. Strimas, J.H., D.S. Chi and A.J. Kastin. Brain peptide reverses effect of morphine on

human lymphocytes. Peptides 8: 1165-1167, 1987. 502. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1986. Peptides 8: 1135-

1164, 1987. 503. Galina, Z.H. and A.J. Kastin. Differential activity of the endogenous antiopiate Tyr-MIF-

1 after various intensities of stress. Neurosci. Lett. 84: 312-316, 1988. 504. Banks, W.A., A.J. Kastin and B.J. Nager. Analgesia and the blood-brain barrier transport

system for Tyr-MIF-1/enkephalins: evidence for a dissociation. Neuropharmacology 27: 175-179, 1988.

505. Banks, W.A., A.J. Kastin and M.B. Fasold. Differential effect of aluminum on the blood-

brain barrier transport of peptides, technetium, and albumin. J. Pharmacol. Exp. Ther. 244: 579-585, 1988.

506. Banks, W.A. and A.J. Kastin. Peptides and the senescent blood-brain barrier. Neurobiol.

Aging 9: 48-49, 1988. 507. Fischman, A.J., A.J. Kastin, M.V. Graf and R.L. Moldow. Constant light and dark affect

the circadian rhythm of the hypothalamic-pituitary-adrenal axis. Neuroendocrinology 47: 309-316, 1988.

508. Banks, W.A. and A.J. Kastin. Twenty-one hormones fail to inhibit the brain to blood

52

transport system for Tyr-MIF-1 and the enkephalins in mice. J. Pharm. Pharmacol. 40: 289-291, 1988.

509. Iyer, K.S., G.A. Marks, A.J. Kastin and S.M. McCann. Evidence for a role of delta sleep-

inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat. Proc. Nat. Acad. Sci. USA 85: 3653-3656, 1988.

510. Banks, W.A. and A.J. Kastin. Interactions between the blood-brain barrier and

endogenous peptides: Emerging clinical implications. Am. J. Med. Sci. 31: 459-465, 1988.

511. Kastin, A.J., J.E. Zadina, G.A. Olson and W.A. Banks. Considerations regarding some

peptides involved in biorhythms, reproduction, stress, and pineal function. In: Biorhythms and Stress in the Physiopathology of Reproduction. P. Pancheri and L. Zichella, eds., Hemisphere Publishing Corporation, New York, pp. 11-19, 1988.

512. Zadina, J.E. and A.J. Kastin. Developmental and long-term effects of perinatal stress and

peptides released during stress. In: Biorhythms and Stress in the Physiopathology of Reproduction. P. Pancheri and L. Zichella, eds., Hemisphere Publishing Corporation, New York, pp. 485-491, 1988.

513. Pulvirenti, L. and A.J. Kastin. Blockade of brain dopamine receptors antagonizes the

anti- immobility effect of MIF-1 and Tyr-MIF-1 in rats. Eur. J. Pharmacol. 151: 289-292, 1988.

514. Graf, M., A.J. Fischman, A.J. Kastin and R.L. Moldow. Circadian variation in response

to CRF-41 and AVP. Am. J. Physiol. 255: E265-E271, 1988. 515. Banks, W.A., A.J. Kastin, C.M. Barrera and D.A. Durham. Movement of peptides

between the blood and the central nervous system: a brief perspective. European Conference Biotechnology; Scientific, Technical and Challenges: Verona, Italy, pp. 135-140, 1988.

516. Banks, W.A. and A.J. Kastin. Peptides and the blood brain barrier: penetration and

modulating influences. In: Peptide and Amino Acid Transport Mechanisms in the Central Nervous System. L. Rakic, D.J. Begley, H. Davson and B.V. Zlokovic, eds., Stockton/MacMillan Press, New York, pp. 21-32, 1988.

517. Pulvirenti, L. and A.J. Kastin. Naloxone, but not Tyr-MIF-1, reduces volitional ethanol

drinking in rats: correlation with degree of spontaneous preference. Pharmacol. Biochem. Behav. 31: 129-134, 1988.

518. Miller, L.G., A.J. Kastin, R.B. Roy, A. Gaver, A.J. Fischman and A. Horvath. Structural

specificity of MIF-1 and Tyr-MIF-1 in augmenting GABA-stimulated benzodiazepine

53

receptor binding. Res. Commun. Chem. Pathol. Pharmacol. 62: 365-368, 1988. 519. Banks, W.A., T.L. Trentman, A.J. Kastin and Z.H. Galina. The general anesthesia

induced by various drugs differentially affects analgesia and its variability. Pharmacol. Biochem. Behav. 31: 397-403, 1988.

520. Banks. W.A., A.J. Kastin, M.B. Fasold, C.M. Barrera and G. Augereau. Studies of the

slow bidirectional transport of iron and transferrin across the blood-brain barrier. Brain Res. Bull. 21: 881-885, 1988.

521. Pulvirenti, L. and A.J. Kastin. MIF-1 reduces stress-induced eating in rats. New Trends

Exp. Clin. Psychiat. 4: 229-233, 1988. 522. Banks, W.A., A.J. Kastin, T.L. Trentman, H.S. Haynes, B.G. Johnson and Z.H. Galina.

Mediation of serotonin-induced analgesia by the 5HT2 receptor in the pentobarbital anesthetized mouse model. Brain Res. Bull. 21: 887-891, 1988.

523. Horvath, A. and A.J. Kastin. Isolation of tyrosine-melanocyte-stimulating hormone

release-inhibiting factor 1 from bovine brain tissue. J. Biol. Chem. 264: 2175-2179, 1989. 524. Beckwith, B.E. and A.J. Kastin. Central actions of melanocyte- stimulating hormone

(MSH). In: Peptide Hormones: Effects and Mechanisms of Action. A.N. Vilar and P.M. Conn, eds., CRC Press, 1: 195-218, 1989.

525. Zadina, J.E., A.J. Kastin, L.J. Ge, H. Gulden and K.J. Bungart. Chronic, but not acute,

administration of morphine alters antiopiate (Tyr-MIF-1) binding sites in rat brain. Life Sci. 44: 555-561, 1989.

526. Banks, W.A. and A.J. Kastin. Inhibition of the brain to blood transport system for

enkephalins and Tyr-MIF-1 in mice addicted or genetically predisposed to drinking ethanol. Alcohol. 6: 53-57, 1989.

527. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1987. Peptides 10: 205-

236, 1989. 528. Kostrzewa, R.M., T.G. White, J.E. Zadina and A.J. Kastin. MIF-1 attenuates

apomorphine stereotypies in adult rats after neonatal 6-hydroxydopamine. Eur. J. Pharmacol. 163: 33-42, 1989.

529. Pignatiello, M.F., G.A. Olson, A.J. Kastin, R.H. Ehrensing, J.H. McLean and R.D. Olson.

MIF-1 is active in a chronic stress animal model of depression. Pharmacol. Biochem. Behav. 32: 737-742, 1989.

530. Banks, W.A. and A.J. Kastin. Effect of neurotransmitters on the system that transports

54

Tyr-MIF-1 and the enkephalins across the blood-brain barrier: a dominant role for serotonin. Psychopharmacology. 98: 380-385, 1989.

531. Kastin, A.J., L.G. Miller and D.S. Schwartzenburg. MIF-1 and Tyr-MIF-1 fail to alter

benzodiazepine-induced hypothermia. Pharmacol. Biochem. Behav. 33: 261-263, 1989. 532. Banks, W.A. and A.J. Kastin. Aluminum-induced neurotoxicity: alterations in membrane

function at the blood-brain barrier. Neurosci. Biobehav. Rev. 13: 47-53, 1989. 533. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1988. Peptides 10: 1253-

1280, 1989. 534. Banks, W.A., A.J. Kastin and D.A. Durham. Bidirectional transport of interleukin-1 alpha

across the blood-brain barrier. Brain Res. Bull. 23: 433-437, 1989. 535. Barrera, C.M., W.A. Banks and A.J. Kastin. Passage of Tyr-MIF-1 from blood to brain.

Brain Res. Bull. 23: 439-442, 1989. 536. Kastin, A.J., D. Schwartzenburg, L. Tsui, L.G. Miller, G.A. Olson and R.D. Olson.

Differential effects of Tyr-MIF-1 and naloxone in two animal models involving benzodiazepine. Brain Res. Bull. 23: 443-446, 1989.

537. Chi, D.S., J.H. Strimas and A.J. Kastin. In vitro studies of Tyr-MIF-1 with human

lymphocytes. Brain Res. Bull. 23: 549-552, 1989. 538. Banks, W.A. and A.J. Kastin. Quantifying carrier-mediated transport of peptide from the

brain to the blood. Methods Enzymol. P. M. Conn, ed., Academic Press, San Diego, 168: 652-660, 1989.

539. Miller, L.G., A.J. Kastin and R.B. Roy. MIF-1 and Tyr-MIF-1 augment muscimol-

stimulated chloride uptake in cerebral cortex. Brain Res. Bull. 23: 413-415, 1989. 540. Zadina, J.E., A.J. Kastin and L.-J. Ge. Tyr-MIF-1 binding in brain is not altered by

ligands selective for the GABAA/benzodiazepine receptor. Neurosci. Lett. 110: 143-147, 1990.

541. Kastin, A.J., W.A. Banks and J.E. Zadina. Hormones and messenger peptides in normal

brain function. In: Principles and Practice of Endocrinology and Metabolism. K.L. Becker, ed., J.B. Lippincott Co., Philadelphia, pp. 1474-1479, 1990.

542. Kastin, A.J., W.A. Banks and J.E. Zadina. A decade of changing perceptions about

neuropeptides. Ann. NY Acad. Sci. 579: 1-7, 1990. 543. Banks, W.A. and A.J. Kastin.Editorial Review: Peptide transport systems for opiates

55

across the blood-brain barrier. Am. J. Physiol. 259: E1-E10, 1990. 544. Sandman, C.A. and A.J. Kastin. Neuropeptide modulation of development and behavior:

implications for psychopathology. In: Application of Basic Neuroscience to Child Psychiatry. S.I. Deutsch, A. Weizman and R.Weizman, ed., Plenum Press, New York, pp. 101-124, 1990.

545. Zadina, J.E., S.L. Chang, L.-J. Ge, A.J. Kastin and R.E. Harlan. Downregulation of mu

opiate receptors by morphine and presence of Tyr-MIF-1 binding sites in SH-SY5Y human neuroblastoma cells. In: New Leads in Opioid Research. J.M. van Ree, A.H. Mulder, V.M. Weigant and T.B. van Wimersma Greidanus eds., Excerpta Medica, Amsterdam, pp.151-153, 1990.

546. Banks, W.A. and A.J. Kastin. Uptake of peptides containing Tyr-Pro by human and

mouse erythrocytes. Biochem. Pharmacol. 40: 607-614, 1990. 547. Zadina, J.E., A.J. Kastin, L.-J. Ge and V. Brantl. Hemorphins, cytochrophins, and human

ß-casomorphins bind to antiopiate (Tyr-MIF-1) as well as opiate binding sites in rat brain. Life Sci. 47: PL25-PL30, 1990.

548. Banks, W.A. and A.J. Kastin. Exchange of peptides between the circulation and the

nervous system: role of the blood-brain barrier. In: Circulating Regulatory Factors and Neuroendocrine Function. J.C. Porter and D. Jezova, eds., Plenum Press, New York, pp. 59-69, 1990.

549. Banks, W.A., A.V. Schally, C.M. Barrera, M.B. Fasold, D.A. Durham, V.J. Csernus, K.

Groot and A.J. Kastin. Permeability of the murine blood-brain barrier to some octapeptide analogs of somatostatin. Proc. Natl. Acad. Sci. USA. 87: 6762-6766, 1990.

550. Horvath, A. and A.J. Kastin. Evidence for presence of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-

NH2) in human brain cortex. Int. J. Pept. Protein Res. 36: 281-284, 1990. 551. Banks, W.A., A.J. Kastin, E.A. Michals and C.M. Barrera. Stereospecific transport of

Tyr-MIF-1 across the blood-brain barrier by peptide transport system-1. Brain Res. Bull. 25: 589-592, 1990.

552. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1989. Peptides 11: 1277-

1304, 1990. 553. Zadina, J.E., A.J. Kastin, L.-J. Ge and V. Brantl. Casomorphin-related peptides bind to

non-opiate (Tyr-MIF-1) sites as well as opiate receptors in brain. In: ß-Casomorphins and Related Peptides. F. Nyberg and V.Brantl, eds., Uppsala, Sweden, pp 61-63, 1990.

554. Miller, L.G. and A.J. Kastin. MIF-1 and Tyr-MIF-1 do not alter GABA binding on the

56

GABAA receptor. Brain Res. Bull. 25: 917-918, 1990. 555. Krowicki, Z.K. and A.J. Kastin. Effects of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on GH,

LH, prolactin, FSH, and TSH secretion in rats with and without morphine. Neuropeptides 18: 41-47, 1991.

556. Britton, J.R. and A.J. Kastin. Biologically active polypeptides in milk. Am. J. Med. Sci.

301: 124-132, 1991. 557. Banks, W.A. and A.J. Kastin. Leucine modulates peptide transport system-1 across the

blood-brain barrier at a stereospecific site within the central nervous system. J. Pharm. Pharmacol. 43: 252-254, 1991.

558. Banks, W.A. and A.J. Kastin. Regulation of the passage of peptides across the blood-

brain barrier. In: Peptides, Peptoids and Proteins. P.D. Garzone, W.A. Colburn and M. Mokotoff, eds., pp. 148-153, 1991.

559. Durham, D.A., W.A. Banks and A.J. Kastin. Carrier-mediated transport of labeled

oxytocin from brain to blood. Neuroendocrinology 53: 447-452, 1991. 560. Banks, W.A. and A.J. Kastin. Blood to brain transport of interleukin links the immune

and central nervous systems. Life Sci. 48: PL117-PL121, 1991. 561. Barrera, C.M., A.J. Kastin, M.B. Fasold and W.A. Banks. Bidirectional saturable

transport of LHRH across the blood-brain barrier. Am. J. Physiol. 261: E312-E318, 1991. 562. Kastin, A.J., J. Seligson, J.H. Strimas and D.S. Chi. Failure of Met-enkephalin to enhance

natural killer cell activity. Immunobiology 183: 55-68, 1991. 563. Banks, W.A., Kastin, A.J. and C.M. Barrera. Delivering peptides to the central nervous

system: dilemnas and strategies. Pharm. Res. 8: 1345-1350, 1991. 564. Kastin, A.J., M.A. Pearson and W.A. Banks. EEG evidence that morphine and an

enkephalin analog cross the blood-brain barrier. Pharmacol. Biochem. Behav. 40: 771-774, 1991.

565. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1990. Peptides 12: 1407-

1432, 1991. 566. Banks, W.A., A.J. Kastin, C.M. Barrera and L.M. Maness. Lack of saturable transport

across the blood-brain barrier in either direction for ß-amyloid (Alzheimer's disease protein). Brain Res. Bull. 27: 819-823, 1991.

567. Barrera, C.M., W.A. Banks, M.B. Fasold and A.J. Kastin. Effects of various reproductive

57

hormones on the penetration of LHRH across the blood-brain barrier. Pharmacol. Biochem. Behav. 41: 255-257, 1991.

568. Banks, W.A., L. Ortiz, S.R. Plotkin and A.J. Kastin. Human interleukin (IL) 1α, murine

IL-1α and murine IL-1ß are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 259: 988-996, 1991.

569. Banks, W.A. and A.J. Kastin. The interleukins-1α, -1ß, and -2 do not acutely disrupt the

murine blood-brain barrier. Int. J. Immunopharmacol. 14: 629-636, 1992. 570. Zhang, X.-Y, J.E. Zadina, M. Ehrlich and A.J. Kastin. Tyr-MIF-1, but not MIF-1 or

morphine, decreases cyclic AMP-dependent protein kinase activity extracted from HeLa cells. Mol. Cell. Neurosci. 3: 348-353, 1992.

571. Banks, W.A. and A.J. Kastin. Human interleukin-1α crosses the blood-testis barriers of

the mouse. J. Androl. 13: 254-259, 1992. 572. Banks, W.A. and A.J. Kastin. Bidirectional passage of peptides across the blood-brain

barrier. Prog. Brain Res. 91: 139-148, 1992. 573. Zadina, J.E., A.J. Kastin, D. Kersh and A. Wyatt. Tyr-MIF-1 and hemorphin can act as

opiate agonists as well as antagonist in the guinea pig ileum. Life Sci. 51: 869-885, 1992. 574. Banks, W.A. and A.J. Kastin. Exchange of peptides between the central nervous system

and the blood. Chimicaoggi 10: 38-40, 1992. 575. Erchegyi, J., A.J. Kastin, J.E. Zadina, Qiu, X.-D. Isolation of a heptapeptide Val-Val-Tyr-

Pro-Trp-Thr-Gln (valorphin) with some opiate activity. Int. J. Pept. Protein Res. 39: 477-484, 1992.

576. Erchegyi, J., A.J. Kastin and J. Zadina. Isolation of a novel tetrapeptide with opiate and

antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1). Peptides 13: 623-632, 1992.

577. Petersheim, M., R.L. Moldow, H.N. Halladay, A.J. Kastin and A.J. Fischman.

Conformational studies of N-Tyr-MIF-1 in aqueous solution by 1H nuclear magnetic resonance spectroscopy. Int. J. Pept. Protein Res. 40: 41-48, 1992.

578. Kostrzewa, R.M., R. Brus, D.H. Coy, H. Criswell. P.S. Coogan and A.J. Kastin. D-

Ala2,F5 Phe4-dynorphin amide, an opiate with analgesic and toxic properties. Pol. J. Pharmacol. Pharm. 44: 109-120, 1992.

579. Zlokovic, B.V., W.A. Banks, H. Elkadi, J. Erchegyi, J.B. Mackic, J.G. McComb and A.J.

Kastin. Transport, uptake and metabolism of blood-borne vasopressin by the blood-brain

58

barrier. Brain Res. 590: 213-218, 1992. 580. Banks, W.A., A.J. Kastin and J.B. Jaspan. Orally administered cyclo(His-Pro) reduces

ethanol-induced narcosis in mice. Pharmacol. Biochem. Behav. 43: 939-941, 1992. 581. Banks, W.A., A.J. Kastin, S. Radulovic, F.K. Conley, D.L. Johnson and A.V. Schally.

Selective uptake of the somatostatin analog RC-160 across the blood-brain tumor barrier of mice with KHT sarcomas. Anti-Cancer Drugs 3: 513-518, 1992.

582. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1991. Peptides 13: 1247-

1287, 1992. 583. Kastin, A.J., L. Fabre, M.M. Brown and R.D. Olson. Age- and sex-related changes in

Tyr-MIF-1-like immunoreactivity in rat plasma. Neuroendocrinology 56: 902-906, 1992. 584. Erchegyi, J., J.E. Zadina, X.-D. Qiu, D.C. Kersh, L.-J. Ge, M.M. Brown and A.J. Kastin.

Structure-activity relationship of analogs of the endogenous brain peptides Tyr-MIF-1 and Tyr-W-MIF-1. Pept. Res. 6: 31-38, 1993.

585. Zadina, J.E., S.L. Chang, L.-J. Ge and A.J. Kastin. Mu opiate receptor down-regulation

by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp. Ther. 265: 254-265, 1993.

586. Hackler, L., A.J. Kastin, J. Erchegyi and J.E. Zadina. Isolation of Tyr-W-MIF-1 from

bovine hypothalami. Neuropeptides 24: 159-164, 1993. 587. Kostrzewa, R.M. and A.J. Kastin. Tyr-MIF-1 attenuates development of tolerance to

spiperone-induced catalepsy in rats. Brain Res. Bull. 31: 707-712, 1993. 588. Malin, D.R., J.E. Zadina, J.R. Lake, R.B. Rogillio, T.M. Benson, L.S. Corriere, B.P.

Handunge and A.J. Kastin. Tyr-MIF-1 precipitates abstinence syndrome in morphine-dependent rats. Brain Res. 610: 169-171, 1993.

589. Kastin, A.J., L. Fabre, W.A. Banks and J.E. Zadina. Uptake, content, regulation of

plasma concentrations, and binding of Tyr-MIF-1 by the adrenals. Neuroendocrinology. 57: 541-549, 1993.

590. Banks, W.A., A.J. Kastin, V. Akerstrom and J.B. Jaspan. Radioactively iodinated

cyclo(His-Pro) crosses the blood-brain barrier and reverses ethanol-induced narcosis. Am. J. Physiol. 26: E723-E729, 1993.

591. Zadina, J.E., A.J. Kastin, V. Kenigs, C. Bruno and L. Hackler. Prolonged analgesia after

intracerebroventricular Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Neurosci. Lett. 155: 220-222, 1993.

59

592. Banks, W.A. and A.J. Kastin. The potential for alcohol to affect the passage of peptide

and protein hormones across the blood-brain barrier: a hypothesis for a disturbance in brain-body communication. NIAAA Research Monograph 23: 401-411, 1993.

593. Banks, W.A., A.J. Kastin and C.A. Ehrensing. Endogenous peptide Tyr-Pro-Trp-Gly-

NH2 (Tyr-W-MIF-1) is transported from the brain to the blood by peptide transport system-1. J. Neurosci. Res. 35: 690-695, 1993.

594. Banks, W.A., A.J. Kastin, G.A. Olson and R.D. Olson. Permeability of the blood-brain

barrier and blood-testis barrier to LH, FSH, and albumin in younger and older mice. Neuroendocrinol. Lett. 15: 177-181, 1993.

595. Banks, W.A., A.J. Kastin, G. Komaki and A. Arimura. Pituitary adenylate cyclase

activating polypeptide (PACAP) can cross the vascular component of the blood-testis barrier in the mouse. J. Andrology 14: 170-173, 1993.

596. Banks, W.A. and A.J. Kastin. Peptide binding in blood and passage across the blood-

brain barrier. In: Proceedings of the International Symposium on Blood Binding and Drug Transfer. J.P. Tillement, H. Eckert, E. Albengres, J. Barre, P. Baumann, F. Belpaire and M. Lemaire, eds., Editions Fort et Clair, Paris pp. 223-241, 1993.

597. Gutierrez, E.G., W.A. Banks and A.J. Kastin. Murine tumor necrosis factor alpha is

transported from blood to brain in the mouse. J. Neuroimmunol. 47: 169-176, 1993. 598. Banks, W.A. and A.J. Kastin. Measurement of transport of cytokines across the blood-

brain barrier. In: Neurobiology of Cytokines, Part A., P.M.Conn and E.B. De Souza, eds., Academic Press, San Diego, 16: 67-77, 1993.

599. Harrison, L.M., J.E. Zadina, W.A. Banks and A.J. Kastin. Effects of neonatal treatment

with Tyr-MIF-1, morphiceptin, and morphine on development, tail flick, and blood-brain barrier transport. Dev. Brain Res. 75: 207-212, 1993.

600. Banks, W.A., A.J. Kastin and E.G. Gutierrez. Interleukin-1α in blood has direct access to

cortical brain cells. Neurosci. Lett. 163: 41-44, 1993. 601. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1992. Peptides 14: 1339-

1378, 1993. 602. Banks, W.A., A.J. Kastin, G. Komaki and A. Arimura. Passage of pituitary adenylate

cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-

38 across the blood-brain barrier. J. Pharmacol. Exp. Ther. 267: 690-696, 1993. 603. Banks, W.A. and A.J. Kastin. Physiological consequences of the passage of peptides

60

across the blood brain barrier. Rev. Neurosci. 4: 365-372, 1993. 604. Banks, W.A. and A.J. Kastin. Opposite direction of transport across the blood-brain

barrier for Tyr-MIF-1 and MIF-1: comparison with morphine. Peptides 15: 23-29, 1994. 605. Kastin, A.J., K. Hahn, J. Erchegyi, J.E. Zadina, L. Hackler, M. Palmgren and W.A.

Banks. Differential metabolism of Tyr-MIF-1 and MIF-1 in rat and human plasma. Biochem. Pharmacol. 47: 699-709, 1994.

606. Waguespack, P.J., W.A. Banks and A.J. Kastin. Interleukin-2 does not cross the blood-

brain barrier by a saturable transport system. Brain Res. Bull. 34: 103-109, 1994. 607. Maness, L.M., A.J. Kastin, J.T. Weber, W.A. Banks, B.S. Beckman and J.E. Zadina. The

neurotrophins and their receptors: structure, function, and neuropathology. Neurosci. Biobehav. Rev. 18: 143-159, 1994.

608. Hackler, L., A.J. Kastin and J.E. Zadina. Isolation of a novel peptide with a unique

binding profile from human brain cortex: Tyr-K-MIF-1 (Tyr-Pro-Lys-Gly-NH2). Peptides 15: 945-950, 1994.

609. Kastin, A.J., W.A. Banks, K. Hahn and J.E. Zadina. Extreme stability of Tyr-MIF-1 in

CSF. Neurosci. Lett. 174: 26-28, 1994. 610. Banks, W.A. and A.J. Kastin. Effects of aluminum on blood-brain barrier structure and

function. Life Chemistry Reports 11: 141-149, 1994. 611. Banks, W.A., A.J. Kastin, H.M. Sam, V.T. Cao, B. King, L.M. Maness and A.V. Schally.

Saturable efflux of the peptides RC-160 and Tyr-MIF-1 by different parts of the blood-brain barrier. Brain Res. Bull. 35: 179-182, 1994.

612. Ahmed, B., A.J. Kastin, W.A. Banks and J.E. Zadina. CNS effects of peptides: a cross-

listing of peptides and their central actions published in the journal Peptides, 1986-1993. Peptides 15: 1105-1155, 1994.

613. Zadina, J.E., L.M. Harrison, L.-J. Ge, A.J. Kastin and S.L. Chang. Differential regulation

of mu and delta opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp. Ther. 270: 1086-1096, 1994.

614. Banks, W.A., A.J. Kastin and C.A. Ehrensing. Blood-borne interleukin-1α is transported

across the endothelial blood-spinal cord barrier of mice. J. Physiol. 479.2: 257-264, 1994. 615. Ehrensing, R.H., A.J. Kastin, G.F. Wurzlow, G.F. Michell and A.H. Mebane.

Improvement in major depression after low subcutaneous doses of MIF-1. J. Affect.

61

Disord. 31: 227-233, 1994. 616. Harrison, L.M., A.J. Kastin, J.T. Weber, W.A. Banks, D.L. Hurley and J.E. Zadina. The

opiate system in invertebrates. Peptides 15: 1309-1329, 1994. 617. Banks, W.A., A.J. Kastin and E.G. Gutierrez. Penetration of interleukin-6 across the

murine blood-brain barrier. Neurosci. Lett. 179: 53-56, 1994. 618. Maness, L.M., W.A. Banks, M.B. Podlisny, D.J. Selkoe and A.J. Kastin. Passage of

human amyloid ß-protein 1-40 across the murine blood-brain barrier. Life Sci. 55: 1643-1650, 1994.

619. Kastin, A.J., W.A. Banks, R.D. Olson and J.E. Zadina. Novel concepts from novel

peptides. Ann. NY Acad. Sci. 739: 1-10, 1994. 620. Jaspan, J.B., W.A. Banks and A.J. Kastin. Study of passage of peptides across the blood-

brain barrier: biological effects of cyclo(His-Pro) after intravenous and oral administration. Ann. NY Acad. Sci. 739: 101-107, 1994.

621. Banks, W.A. and A.J. Kastin. Brain-to-blood transport of peptides and the alcohol

withdrawal syndrome. Ann. NY Acad. Sci. 739: 108-118, 1994. 622. Gergen, K.A., S.L. Chang, Y.F. Niu, A.J. Kastin and J.E. Zadina. Expression of the FOS

proto-oncogene protein in brain after icv administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Peptides 15: 1505-1511, 1994.

623. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1993. Peptides 15: 1531-

1556, 1994. 624. Kastin, A.J., K. Hahn, W.A. Banks and J.E. Zadina. Delayed degradation of Tyr-MIF-1

in neonatal rat plasma. Peptides 15: 1561-1563, 1994. 625. Zadina, J.E., A.J. Kastin, L. Hackler and S.L. Chang. Cyclic analogues of Tyr-W-MIF-1

with prolonged analgesic activity and potency comparable to DAMGO and morphine. Peptides 15: 1567-1569, 1994.

626. Zadina, J.E., A.J. Kastin, L.-J. Ge and L. Hackler. Mu, delta, and kappa opiate receptor

binding of Tyr-MIF-1 and of Tyr-W-MIF-1, its active fragments, and two potent analogs. Life Sci. 55: PL461-PL466, 1994.

627. Gutierrez, E.G., W.A. Banks and A.J. Kastin. Blood-borne interleukin-1 receptor

antagonist crosses the blood-brain barrier. J. Neuroimmunol. 55: 153-160, 1994. 628. Hackler, L., M.E. Carey and A.J. Kastin. Enhanced isolation of Tyr-MIF-1 from fresh

62

human brain cortex. Brain Res. Bull. 36: 109-111, 1995. 629. Kastin, A.J., L. Fabre, W.A. Banks, L. Hackler and J.E. Zadina. Increase in plasma Tyr-

MIF-1-like immunoreactivity after hypophysectomy is robust and reversible by corticosterone. Neuropeptides 28: 65-71, 1995.

630. Banks, W.A. and A.J. Kastin. Blood-brain permeability: pharmacological implications

with special emphasis on peptides. In: Pharmacokinetics. P. G. Welling and F. L. Tse, eds., Marcel Dekker, Inc., New York, 67: 119-138, 1995.

631. Kastin, A.J., K. Hahn, J.E. Zadina, W.A. Banks and L. Hackler. Melanocyte- stimulating

hormone release-inhibiting factor-1 (MIF-1) can be formed from Tyr-MIF-1 in brain mitochondria but not in brain homogenate. J. Neurochem. 64: 1855-1859, 1995.

632. Banks, W.A. and A.J. Kastin. Regional variation in transport of pancreatic polypeptide

across the blood-brain barrier. Pharmacol. Biochem. Behav. 51: 139-147, 1995. 633. Bollinger, J.E., J.T. Mague, W.A. Banks, A.J. Kastin and D.M. Roundhill. Lipophilic

hexadentate aluminum complexes of new phenolate-derivatized cyclohexanetriamine ligands and their effect on the peptide transport system (PTS-1). Inorg.Chem. 34: 2143-2152, 1995.

634. Zadina, J.E., A.J. Kastin, L.M. Harrison, L.-J. Ge and S.L. Chang. Opiate receptor

changes after chronic exposure to agonists and antagonists. Ann. NY Acad. Sci. 757: 353-361, 1995.

635. Kastin, A.J., W.A. Banks, B. Ahmed and J.E. Zadina. Influence of hormones and

messenger peptides on normal brain function. In: Principles and Practice of Endocrinology & Metabolism. K.L. Becker, ed., J.B. Lippincott, Philadelphia, pp. 1682-1691, 1995.

636. Banks, W.A. and A.J. Kastin. Permeability of the blood-brain barrier to melanocortins.

Peptides 16: 1157-1161, 1995. 637. Banks, W.A., D.J. Wustrow, W.L. Cody, M.D. Davis and A.J. Kastin. Permeability of the

blood-brain barrier to the neurotensin8-13 analog NT1. Brain Res. 695: 59-63, 1995. 638. Banks, W.A., S.R. Plotkin and A.J. Kastin. Permeability of the blood-brain barrier to

soluble cytokine receptors. Neuroimmunomodulation 2: 161-165, 1995. 639. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1994. Peptides 16: 1517-

1555, 1995. 640. Banks, W.A., A.J. Kastin, L.M. Maness, W, Huang and J.B. Jaspan. Permeability of the

63

blood-brain barrier to amylin. Life Sci. 57: 1993-2001, 1995. 641. Maness, L.M., W.A. Banks, J.E. Zadina and A.J. Kastin. Selective transport of blood-

borne interleukin-1α into the posterior division of the septum of the mouse brain. Brain Res. 700: 83-88, 1995.

642. Banks, W.A., A.J. Kastin and P. Zatta. The blood-brain barrier in aluminum toxicity and

Alzheimer's disease. In: Non-neuronal Cells in Alzheimer's Disease. P. Zatta and M. Nicolini, eds., World Scientific Publishing Co. Pte. Ltd., Singapore, pp. 1-12, 1995.

643. Banks, W.A., A.J. Kastin and R.D. Broadwell. Passage of cytokines across the blood-

brain barrier. Neuroimmunomodulation 2: 241-248, 1995. 644. Banks, W.A. and A.J. Kastin. Peptide transport system-1. In: New Concepts of a Blood-

Brain Barrier. J. Greenwood, D. Begley, M.B. Segal and S. Lightman (Eds.) Plenum Press, p. 111-117, 1995.

645. Maness, L.M., W.A. Banks, J.E. Zadina and A.J. Kastin. Periventricular penetration and

disappearance of ICV Tyr-MIF-1, DAMGO, tyrosine, and albumin. Peptides 17: 247-250, 1996.

646. Banks, W.A. and A.J. Kastin. Reversible association of the cytokines MIP-1α and MIP-

1β with the endothelia of the blood-brain barrier. Neurosci. Lett. 205: 202-206, 1996. 647. Banks, W.A., A.J. Kastin, W. Huang, J.B. Jaspan and L.M. Maness. Leptin enters the

brain by a saturable system independent of insulin. Peptides 17: 305-311, 1996. 648. Gergen, K., J.E. Zadina, A.J. Kastin and D. Paul. Intrathecal Tyr-W-MIF-1 produces

potent, naloxone-reversible analgesia modulated by α2-adrenoceptors. Eur. J. Pharmacol. 298: 235-239, 1996.

649. Martins, J.M., A.J. Kastin and W.A. Banks. Unidirectional specific and modulated brain

to blood transport of corticotropin-releasing hormone. Neuroendocrinology 63: 338-348, 1996.

650. Kastin, A.J., J.E. Zadina, R.D. Olson and W.A. Banks. The history of neuropeptide

research: version 5.a. In: Neuropeptides: Basic and Clinical Advances. J.N. Crawley and S. McLean, eds., Ann. NY Acad. Sci., New York. 780: 1-18, 1996.

651. Bollinger, J.E., W.A. Banks, A.J. Kastin and D.M. Roundhill. Iron-59 complexes of

lipophilic hexadentate phenolate-derivatized cyclohexanetriamine ligands. Inorganic Chimica Acta 242: 201-204, 1996.

652. Plotkin, S.R., W.A. Banks and A.J. Kastin. Comparison of saturable transport and

64

extracellular pathways in the passage of interleukin-1α across the blood-brain barrier. J. Neuroimmunol. 67: 41-47, 1996.

653. Zadina, J.E., D. Paul, K.A. Gergen, L.-J. Ge, L. Hackler and A.J. Kastin. Binding of Tyr-

W-MIF-1 (Tyr-Pro-Trp-Gly-NH2) and related peptides to μ1 and μ2 opiate receptors. Neurosci. Lett. 215: 65-69, 1996.

654. Cashion, M.F., W.A. Banks and A.J. Kastin. Sequestration of centrally administered

insulin by the brain: effects of starvation, aluminum, and TNF-α. Horm Behav. 30: 280-286, 1996.

655. Pan, W.H., W.A. Banks, M.K. Kennedy, E.G. Gutierrez and A.J. Kastin. Differential

permeability of the BBB in acute EAE: enhanced transport of TNF-α. Am. J. Physiol. 34: E636-E642, 1996.

656. Banks, W.A. and A.J. Kastin. Passage of peptides across the blood-brain barrier:

pathophysiological perspectives. Life Sci. 59: 1923-1943, 1996. 657. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1995. Peptides 17: 1421-

1466, 1996. 658. Bollinger, J.E., W.A. Banks, A.J. Kastin, M.J. Welch and D.M. Roundhill.

Biodistribution of the lipophilic complexes 59Fe(RsalH2)3tach (R=H, NO2 and OMe) and 68Ga(NO2salH2)3tach. Nucl. Med. Biol. 23: 645-652, 1996.

659. Banks, W.A., L.M. Maness, M.F. Banks and A.J. Kastin. Aluminum-sensitive

degradation of amyloid β-protein1-40 by murine and human intracellular enzymes. Neurotoxicol. Teratol. 18: 671-677, 1996.

660. Banks, W.A., A.J. Kastin, L.M. Harrison and J.E. Zadina. Perinatal treatment of rats with

opiates affects the development of the blood-brain barrier transport system PTS-1. Neurotoxicol. Teratol. 18: 711-715, 1996.

661. Banks, W.A., M.B. Fasold and A.J. Kastin. Measurement of efflux rates from brain to

blood. In: Methods in Molecular Biology, Neuropeptide Protocols. G.B. Irvine and C.H. Williams, eds., Humana Press Inc., Totowa, NJ, Vol. 73, pp. 353-360, 1997.

662. Banks, W.A., A.J. Kastin and S.I. Rapoport. Permeability of the blood-brain barrier to

circulating free fatty acids. In: Handbook of Essential Fatty Acid Biology: Biochemistry, Physiology and Behavioral Neurobiology. S. Yehuda, D.I. Mostofsky, eds., Humana Press, Totowa, NJ, pp. 3-14, 1997.

663. Shayo, M., R.N. McLay, A.J. Kastin, and W.A. Banks. The putative blood-brain barrier

transporter for the β-amyloid binding protein apolipoprotein J is saturated at

65

physiological concentrations. Life Sci. 60: PL115-PL118, 1997. 664. Zadina, J.E., L. Hackler, L.-J. Ge and A.J. Kastin. A potent and selective endogenous

agonist for the μ-opiate receptor. Nature 386: 499-502, 1997. 665. Martins, J.M., W.A. Banks and A.J. Kastin. Acute modulation of the active carrier-

mediated brain-to-blood transport of corticotropin-releasing hormone. Am. J. Physiol. 272: E312-E319, 1997.

666. Plotkin, S.R., W.A. Banks, P.J. Waguespack and A.J. Kastin. Ethanol alters the

concentration of Met-enkephalin in brain by affecting peptide transport system-1 independent of preproenkephalin mRNA. J. Neurosci. Res. 48: 273-280, 1997.

667. Banks, W.A and A.J. Kastin. The role of blood-brain barrier transporter PTS-1 in

regulating concentrations of methionine enkephalin in blood and brain. Alcohol 14: 237-245, 1997.

668. Maness, L.M., W.A. Banks and A.J. Kastin. Investigation of blood-brain barrier

penetration and central nervous system distribution of peptides and proteins by in vivo autoradiography. STP Pharma Sciences 7: 12-16, 1997.

669. Pan, W., W.A. Banks and A.J. Kastin. Permeability of the blood-brain and blood-spinal

cord barriers to interferons. J. Neuroimmunol. 76: 105-111, 1997. 670. Kastin, A.J., R.D. Olson, J.M. Martins, G.A. Olson, J.E. Zadina and W.A. Banks.

Chronic fatigue syndrome: possible integration of hormonal and immunological observations. In: Chronic Fatigue Syndrome. S. Yehuda and D.I. Mostofsky, eds., Plenum Press, New York, p. 161-192, 1997.

671. Champion, H.C., J.E. Zadina, A.J. Kastin, L. Hackler, L.-J. Ge and P.J. Kadowitz . The

endogenous mu-opioid receptor agonists endomorphins 1 and 2 have novel hypotensive activity in the rabbit. Biochem. Biophys. Res. Commun. 235: 567-570, 1997.

672. Pan, W., W.A. Banks and A.J. Kastin. Blood-brain permeability to ebiratide and TNF in

acute spinal cord injury. Exp. Neurol. 146: 367-373, 1997. 673. Banks, W.A., A.J. Kastin and V. Akerstrom. HIV-1 protein GP120 crosses the blood-

brain barrier: role of adsorptive endocytosis. Life Sci. 61: PL119-PL125, 1997. 674. Banks,W.A., A.J. Kastin, L.M. Maness, M.F.Banks, M. Shayo and R.N.McLay.

Interactions of β-amyloids with the blood-brain barrier. In: Cerebrovascular Pathology in Alzheimer’s Disease. J.C. de la Torre and V. Hachinski, eds., Ann NY Acad. Sci., New York, 826: 191-199, 1997.

66

675. Banks, W.A. and A.J. Kastin. Relative contributions of peripheral and central sources to levels of IL-1α in the cerebral cortex of mice: assessment with species-specific enzyme immunoassays. J. Neuroimmunol. 79: 22-28, 1997.

676. Pan,W., J.E. Zadina, R.E. Harlan, J.T. Weber, W.A. Banks and A.J. Kastin. Tumor

necrosis factor-α: a neuromodulator in the CNS. Neurosci. Biobehav. Rev. 21: 603-613, 1997.

677. McLay, R.N., S.M. Freeman, R.E. Harlan, C.F. Ide, A.J. Kastin and J.E. Zadina. Aging in

the hippocampus: interrelated actions of neurotrophins and glucocorticoids. Neurosci. Biobehav. Rev. 21: 615-629, 1997.

678. Banks, W.A., J.B. Jaspan and A.J. Kastin. Selective, physiological transport of insulin

across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays. Peptides 18: 1257-1262, 1997.

679. Champion, H.C., J.E. Zadina, A.J. Kastin, L. Hackler, L.-J. Ge and P.J. Kadowitz.

Endomorphin 1 and 2, endogenous ligands for the μ-opioid receptor, decrease cardiac output, and total peripheral resistance in the rat. Peptides 18: 1393-1397, 1997.

680. Banks, W.A., J.B. Jaspan, W. Huang and A.J. Kastin. Transport of insulin across the

blood-brain barrier: saturability at euglycemic doses of insulin. Peptides 18: 1423-1429, 1997.

681. McLay, R.N., W.A. Banks and A.J. Kastin. Granulocyte macrophage-colony stimulating

factor crosses the blood-testis barrier in mice. Biol. Reprod. 57: 822-826, 1997. 682. McLay, R.N., M. Kimura, W.A. Banks and A.J. Kastin. Granulocyte macrophage-

colony-stimulating factor crosses the blood-brain and blood-spinal cord barriers. Brain 120: 2083-2091, 1997.

683. Banks, W.A., J.B. Jaspan and A.J. Kastin. Effect of diabetes mellitus on the permeability

of the blood-brain barrier to insulin. Peptides 18: 1577-1584, 1997. 684. Hackler, L., J.E. Zadina, L.-J. Ge and A.J. Kastin. Isolation of relatively large amounts of

endomorphin-1 and endomorphin-2 from human brain cortex. Peptides 18: 1635-1639, 1997.

685. Martin-Schild, S., J.E. Zadina, A.A. Gerall, S. Vigh and A.J. Kastin. Localization of

endomorphin-2-like immunoreactivity in the rat medulla and spinal cord. Peptides 18: 1641-1649, 1997.

686. Olson,G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1996. Peptides 18: 1651-

1688, 1997.

67

687. Martins, J.M., W.A. Banks and A.J. Kastin. Transport of CRH from mouse brain directly

affects peripheral production of β-endorphin by the spleen. Am. J. Physiol. 273:E1083-E1089, 1997.

688. Champion, H..C., J.E. Zadina, A.J. Kastin and P.J. Kadowitz. The endogenous μ-opioid

agonists, endomorphin 1 and 2, have vasodilator activity in the hindquarters vascular bed of the rat. Life Sci. 61: PL409-PL416, 1997

689. Plotkin, S.R., W.A. Banks and A.J. Kastin. Enkephalin, PPE mRNA, and PTS-1 in

alcohol withdrawal seizure-prone and -resistant mice. Alcohol 15: 25-31, 1998. 690. Kastin, A.J., K. Hahn, W.A. Banks and J.E. Zadina. Regional differences in the

metabolism of Tyr-MIF-1 and Tyr-W-MIF-1 by rat brain mitochondria. Biochem. Pharmacol. 55: 33-36, 1998.

691. Higashida, H., N. Hoshi, R. Knijnik, J.E. Zadina and A.J. Kastin. Endomorphins inhibit

high-threshold Ca2+channel currents in rodent NG108-15 cells overexpressing μ-opioid receptors. J. Physiol. 507: 71-75, 1998.

692. Harrison, L.M., A.J. Kastin and J.E. Zadina. Differential effects of endomorphin-1,

endomorphin-2, and Tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 19: 749-753. 1998.

693. Harrison, L.M., A.J. Kastin and J.E. Zadina. Tyr-W-MIF-1 attenuates down-regulation of

opiate receptors in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp.Ther. 284: 611-617, 1998.

694 Banks, W.A., V. Akerstrom and A.J. Kastin. Adsorptive endocytosis mediates the

passage of HIV-1 across the blood-brain barrier: evidence for a post-internalization coreceptor. J. Cell Sci. 111: 533-540, 1998.

695. Pan, W., W.A. Banks and A.J. Kastin. Permeability of blood-brain barrier to

neurotrophins. Brain Res. 788: 87-94, 1998. 696. Banks, W.A. and A.J. Kastin. Differential permeability of the blood-brain barrier to two

pancreatic peptides: insulin and amylin. Peptides 19: 883-889, 1998. 697. Champion, H.C., J.E. Zadina, A.J. Kastin and P.J. Kadowitz. Endomorphin 1 and 2 have

vasodepressor activity in the anesthetized mouse. Peptides 19: 925-929, 1998. 698. Banks, W.A., A.J. Kastin and A. Arimura. Effect of spinal cord injury on the

permeability of the blood-brain and blood-spinal cord barriers to the neurotropin PACAP. Exp. Neurol. 151: 116-123, 1998.

68

699. Banks, W.A., A.J. Kastin and C.A Ehrensing. Diurnal uptake of circulating interleukin-

1α by brain, spinal cord, testis and muscle. Neuroimmunomodulation 5: 36-41, 1998. 700. Maness, L.M., A.J. Kastin and W.A. Banks. Relative contributions of a CVO and the

microvascular bed to delivery of blood-borne IL-1α to the brain. Am J. Physiol. 275: E207-E212, 1998.

701. Czapla, M.A., H.C. Champion, J.E. Zadina, A.J. Kastin, L. Hackler, L.-J. Ge and P.J.

Kadowitz. Endomorphin 1 and 2, endogenous μ-opioid agonists, decrease systemic arterial pressure in the rat. Life Sci. 62: PL175-PL179, 1998.

702. Champion, H.C., T.J. Bivalacqua, D.G. Lambert, S.M. McWilliams, J.E. Zadina, A.J.

Kastin and P.J Kadowitz. Endomorphin 1 and 2, the endogenous μ-opioid agonists, produce biphasic changes in systemic arterial pressure in the cat. Life Sci. 63: PL131-PL136, 1998.

703. Champion, H.C., T.J. Bivalacqua, D.E. Friedman, J.E. Zadina, A.J. Kastin and P.J.

Kadowitz. Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat. Peptides 19: 1595-1602, 1998.

704. Harrison, L.M., A.J. Kastin and J.E. Zadina. Opiate tolerance and dependence: receptors,

G-proteins, and antiopiates. Peptides 19: 1603-1630, 1998. 705. Maness, L.M., A.J. Kastin, C.L. Farrell and W.A. Banks. Fate of leptin after

intracerebroventricular injection into the mouse brain. Endocrinology 139: 4556-4562, 1998.

706. Martin-Schild, S., A.A. Gerall, A.J. Kastin and J.E. Zadina. Endomorphin-2 is an

endogenous opioid in primary sensory afferent fibers. Peptides 19: 1783-1789, 1998. 707. Olson, G.A., R.D. Olson, A.L. Vaccarino and A.J. Kastin. Endogenous opiates: 1997.

Peptides 19: 1791-1843, 1998. 708. Pan, W., W.A. Banks, M.B. Fasold, J. Bluth and A.J. Kastin. Transport of brain-derived

neurotrophic factor across the blood-brain barrier. Neuropharmacology 37: 1553-1561, 1998.

709. Martin-Schild, S., A.A. Gerall, A.J. Kastin and J.E. Zadina. Differential distribution of

endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent. J. Comp. Neurol. 405: 450-471, 1999.

710. Kastin, A.J and V. Akerstrom. Nonsaturable entry of neuropeptide Y into brain. Am. J.

69

Physiol. 276: E479-E482, 1999. 711. Pan, W. and A.J. Kastin. Penetration of neurotrophins and cytokines across the blood-

brain/blood-spinal cord barrier. Adv. Drug Delivery Rev. 36: 291-298, 1999. 712. Kastin, A.J. and V. Akerstrom. Orexin A but not orexin B rapidly enters brain from blood

by simple diffusion. J. Pharmacol. Exp. Ther. 289: 219-223, 1999. 713. Banks, W.A., A.J. Kastin, J.M. Brennan and K.L. Vallance. Adsorptive endocytosis of

HIV-1 gp120 by blood-brain barrier is enhanced by lipopolysaccharide. Exp. Neurol. 156: 165-171, 1999.

714. Cashion, M.F., W.A. Banks, K.L. Bost and A.J. Kastin. Transmission routes of HIV-1

gp120 from brain to lymphoid tissues. Brain Res. 822: 26-33, 1999. 715. Pan, W., A.J. Kastin, L.M. Maness and J.M. Brennan. Saturable entry of ciliary

neurotrophic factor into brain. Neurosci. Lett. 263: 69-71, 1999. 716. Pan, W., A.J. Kastin, R.L. Bell and R.D. Olson. Upregulation of tumor necrosis factor α

transport across the blood-brain barrier after acute compressive spinal cord injury. J. Neuroscience 19: 3649-3655, 1999.

717. Kastin, A.J., C.A. Sandman, G.A. Olson and R.D. Olson. Melanocyte-stimulating

hormone (MSH) and its analogs. In: Encyclopedia of Neuroscience, 2nd Ed., G.A. Adelman and G.H. Smith, eds. Elsevier Science, Amsterdam, pp. 1125-1126, 1999.

718. Kastin, A.J., W.A. Banks and W. Pan. Peptides and cytokines cross the blood-brain

barrier. In: Encyclopedia of Neuroscience, 2nd Ed., G.A. Adelman and G.H. Smith, eds. Elsevier Science, Amsterdam, pp. 1607-1608, 1999.

719. Kastin, A.J., R.H. Ehrensing and J.E. Zadina. The Tyr-MIF-1 family of peptides. In:

Encyclopedia of Neuroscience, 2nd Ed., G.A. Adelman and G.H. Smith, eds. Elsevier Science, Amsterdam, pp. 2082-2083, 1999.

720. McLay, R.N., S.M. Freeman, R.E. Harlan, A.J. Kastin and J.E. Zadina. Tests used to

assess the cognitive abilities of aged rats: their relation to each other and to hippocampal morphology and neurotrophin expression. Gerontology 45: 143-155, 1999.

721. Sakurada, S., J.E. Zadina, A.J. Kastin, S. Katsuyama, T. Fujimura, K. Murayama, M.

Yuki, H. Ueda and T. Sakurada. Differential involvement of μ-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception. Eur. J. Pharmacol. 372: 25-30, 1999.

722. Banks, W.A., R.N. McLay, A.J. Kastin, U. Sarmiento and S. Scully. Passage of leptin

across the blood-testis barrier. Am. J. Physiol. 276: E1099-E1104, 1999.

70

723. Banks, W.A., A.J. Kastin and W. Pan. Uptake and degradation of blood-borne insulin by

the olfactory bulb. Peptides 20: 373-378, 1999. 724. Nores, W.L., R.D. Olson, G.A. Olson, A.L. Vaccarino, R.L. Bell, J.E. Zadina and A.J.

Kastin. Tyr-W-MIF-1-induced conditioned place preference. Peptides 20: 479-484, 1999. 725. Bell, R.L., A.L. Vaccarino, R.D. Olson, G.A. Olson, W.L. Nores, J.G. Cambre, J.E.

Zadina and A.J. Kastin. Tolerance and morphine-induced cross-tolerance are shown to Tyr-W-MIF-1 analgesia. Peptides 20: 971-978, 1999.

726. Pan, W. and A.J. Kastin. Entry of EGF into brain is rapid and saturable. Peptides 20:

1091-1098, 1999. 727. Pan, W., A.J. Kastin, W.A. Banks and J.E. Zadina. Effects of peptides: a cross-listing of

peptides and their central actions published in the journal Peptides from 1994 through 1998. Peptides 20: 1127-1138, 1999.

728. Maresh, G.A., A.J. Kastin, T.T. Brown, J.E. Zadina and W.A. Banks. Peptide transport

system-1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either. Brain Res. 839: 336-340, 1999.

729. Kastin, A.J. and V. Ackerstrom. Entry of CART into brain is rapid but not inhibited by

excess CART or leptin. Am. J. Physiol. 277: E901-E904, 1999. 730. Pan, W., K. Vallance and A.J. Kastin. TGFα and the blood-brain barrier: accumulation in

cerebral vasculature. Exp. Neurol. 160: 454-459, 1999. 731. Kastin, A.J., W. Pan, L.M. Maness and W.A. Banks. Peptides crossing the blood-brain

barrier: some unusual observations. Brain Res. 848: 96-100, 1999. 732. Kastin, A.J. Multiple direct actions of peptides on the CNS. Brain Res. Bull. 50: 361-362,

1999. 733. Zadina, J.E., S. Martin-Schild, A.A. Gerall, A.J. Kastin, L. Hackler, L.-J. Ge and X.

Zhang. Endomorphins: novel endogenous μ-opiate receptor agonist in regions of high μ-opiate receptor density. Ann. NY Acad. Sci. 897: 136-144, 1999.

734. Champion, H.C., T.J. Bivalacqua, J.E. Zadina, A.J Kastin and P.J. Kadowitz. Vasodilator

responses to the endomorphin peptides, but not nociceptin/OFQ, are mediated by nitric oxide release. Ann. NY Acad. Sci. 897: 165-172, 1999.

735. Kelly, J.P., G. Nicolau, A. Redmond, B.E. Leonard, J. Noble, L. Sverdlov, R. Molinar,

A.J. Kastin, R.H. Ehrensing and J.P. Feigher. The effect of treatment with a new

71

antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. J. Affect. Disord. 55: 231-236, 1999.

736. Kastin, A.J., W. Pan, L.M. Maness, R.J. Koletsky and P. Ernsberger. Decreased transport

of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides 20: 1449-1453, 1999.

737. Vaccarino, A.L., G.A. Olson, R.D. Olson and A.J. Kastin. Endogenous opiates: 1998.

Peptides 20: 1527-1574, 1999. 738. Kastin, A.J., V. Akerstrom, L. Hackler and J.E. Zadina. Phe13,Tyr19-Melanin-

concentrating hormone and the blood-brain barrier: role of protein binding. J. Neurochem. 74: 385-391, 2000.

739. Pan W., A.J. Kastin and J.M. Brennan. Saturable entry of leukemia inhibitory factor from

blood to the central nervous system. J. Neuroimmunol. 106: 172-180, 2000. 740. Kastin, A.J. and V. Akerstrom. Fasting, but not adrenalectomy, reduces transport of

leptin into the brain. Peptides 21: 679-682, 2000. 741. Kastin, A.J. and V. Akerstrom. Mahogany (1377-1428) enters brain by a saturable

transport system. J. Pharmacol. Exp. Ther. 294: 633-634, 2000. 742. Maness, L.M., W.A. Banks and A.J. Kastin. Persistence of blood-to-brain transport of

leptin in obese leptin-deficient and leptin receptor-deficient mice. Brain Res. 873: 165-167, 2000.

743. Soignier, R.D., A.L. Vaccarino, A.M. Brennan, A.J. Kastin and J.E. Zadina. Analgesic

effects of endomorphin-1 and endomorphin-2 in the formalin test in mice. Life Sci. 67: 907-912, 2000.

744. Somogyvari-Vigh, A., W. Pan, D. Reglodi, A.J Kastin and A. Arimura. Effect of middle

cerebral artery occlusion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat. Regul. Pept. 91: 89-95, 2000.

745. Pan, W. and A.J. Kastin. Interactions of IGF-1 with the blood-brain barrier in vivo and in

situ. Neuroendocrinology 72: 171-185, 2000. 746. Sakurada, S., T. Hayashi, M. Yuki, T. Fujimura, K. Murayama, A. Yonezawa, C.

Sakurada, M. Takeshita, J.E. Zadina, A.J. Kastin and T. Sakurada. Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone. Brain Res. 881: 1-8, 2000.

747. Kastin, A.J. and W. Pan. Dynamic regulation of leptin entry into brain by the blood-brain

72

barrier. Reg. Pep. 92: 37-43, 2000. 748. Kastin, A.J., V. Akerstrom and L. Hackler. Agouti-related protein (83-132) aggregates

and crosses the blood-brain barrier slowly. Metabolism 49: 1444-1448, 2000. 749. Feighner, J.P., R.H. Ehrensing, A.J. Kastin, B.E. Leonard, L. Sverdlov, G. Nicolau, A.

Patel, J. Hlavka, H. Abajian and J.F. Noble. A double-blind, placebo-controlled, efficacy, safety, and pharmacokinetic study of INN 00835, a novel antidepressant peptide, in the treatment of major depression. J. Affect. Disord. 61: 119-126, 2000.

750. Plotkin, S.R., W.A. Banks, L.M. Maness and A.J. Kastin. Differential transport of rat and

human interleukin-1α across the blood-brain barrier and blood-testis barrier in rats. Brain Res. 881: 57-61, 2000.

751. McLay, R.N., A.J. Kastin and J.E. Zadina. Passage of interleukin-1β across the blood-

brain barrier is reduced in aged mice: a possible mechanism for diminished fever in aging. Neuroimmunomodulation 8: 148-153, 2000.

752. Kastin, A.J., V.A. Akerstrom and W. Pan. Activation of urocortin transport into brain by

leptin. Peptides 21: 1811-1818, 2000. 753. Wilson, A.M., R.D. Soignier, J.E. Zadina, A.J. Kastin, W.L. Nores, R.D. Olson and G.A.

Olson. Dissociation of analgesic and rewarding effects of endomorphin-1 in rats. Peptides 21: 1871-1874, 2000.

754. Vaccarino, A.L. and A.J. Kastin. Endogenous opiates: 1999. Peptides 21: 1975-2034,

2000. 755. Kastin, A.J., V. Akerstrom, L. Hackler and W. Pan. Adrenomedullin and the blood-brain

barrier. Horm. Metab. Res. 33: 19-25, 2001. 756. Pan, W. and A.J. Kastin. Changing the chemokine gradient: CINC1 crosses the blood-

brain barrier. J. Neuroimmunol. 115: 64-70, 2001. 757. Kastin, A.J., W. Pan, J.E. Zadina and W.A. Banks. The endocrine brain. In: Principles

and Practice of Endocrinology and Metabolism, edited by K.L. Becker, Philadelphia: Lippincott Williams & Wilkins, 2001, pp. 1611-1615.

758. Kastin, A.J. and V. Akerstrom. Glucose and insulin increase the transport of leptin

through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice. Neuroendocrinology 73: 237-242, 2001.

759. Kastin, A.J. and V. Akerstrom. Pretreatment with glucose increases entry of urocortin

into mouse brain. Peptides 22: 829-834, 2001.

73

760. Pan, W. and A.J. Kastin. Diurnal variation of leptin entry from blood to brain involving

partial saturation of the transport system. Life Sci. 68: 2705-2714, 2001. 761. Plotkin, S.R., W.A. Banks, C.S. Cohn and A.J. Kastin. Withdrawal from alcohol in

withdrawal seizure-prone and -resistant mice: evidence for enkephalin resistance. Pharmacol. Biochem. Behav. 68: 379-387, 2001.

762. Maresh, G.A., L.M. Maness, J.E. Zadina and A.J. Kastin. In vitro demonstration of a

saturable transport system for leptin across the blood-brain barrier. Life Sci. 69: 67-73, 2001.

763. Pan, W., A.J. Kastin, L. Gera and J.M Stewart. Bradykinin antagonist decreases early

disruption of the blood-spinal cord barrier after spinal cord injury in mice. Neurosci. Lett. 307: 25-28, 2001.

764. Smith, R.R., S. Martin-Schild, A.J. Kastin and J.E. Zadina. Decreases in endomorphin-2-

like immunoreactivity concomitant with chronic pain after nerve injury. Neuroscience 105: 773-778, 2001.

765. Kastin, A.J., K. Hahn and J.E. Zadina. Regional differences in peptide degradation by rat

cerebral microvessels: A potential novel regulatory mechanism for communication between blood and brain. Life Sci. 69: 1305-1312, 2001.

766. Kastin, A.J., M.B. Fasold, R.R. Smith, K.A. Horner and J.E. Zadina. Saturable brain-to-

blood transport of endomorphins. Exp. Brain Res. 139: 70-75, 2001. 767. Pan, W. and A.J. Kastin. Increase in TNF transport after SCI is specific for time, region,

and type of lesion. Exp. Neurol. 170: 357-363, 2001. 768. Kastin, A.J., V. Akerstrom, and L.M. Maness. Chronic loss of ovarian function decreases

transport of leptin into mouse brain. Neurosci. Lett. 310: 69-71, 2001. 769. Sakurada, S., T. Hayashi, M. Yuhki, T. Orito, J.E. Zadina, A.J.Kastin, T. Fujimura, K.

Murayama, C. Sakurada, T. Sakurada, M. Narita, T. Suzuki, K. Tan-no, and L.F. Tseng. Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse. Eur. J. Pharmacol. 427: 203-210, 2001.

770. Feighner, J.P., R.H. Ehrensing, A.J. Kastin, A. Patel, L. Sverdlov, J. Hlavka, H.B.

Abajian, J.F. Noble and G. Nicolau. Double-blind, placebo-controlled study of INN 00835 (netamiftide) in the treatment of outpatients with major depression. Int. Clin. Psychopharmacol. 16: 1-8, 2001.

771. Gozes, I., D.E. Brenneman, P. Geppetti, A.J. Kastin, R.E. Mains, T.W. Moody, K.

74

Seroogy, A.D. Spier, and M. Zimmermann. Neuropeptides: brain messengers of many faces. Trends in Neurosci. 24: 687-690, 2001.

772. Banks, W.A., B.M. King, K.N. Rossiter, R.D. Olson, G.A. Olson, and A.J. Kastin.

Obesity-inducing lesions of the central nervous system alter leptin uptake by the blood-brain barrier. Life Sci. 69: 2765-2773, 2001.

773. Kastin, A.J., V. Akerstrom, and W. Pan. Validity of multiple-time regression analysis in

measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides 22: 2127-2136, 2001.

774. McLay, R.N., W. Pan, and A.J. Kastin. Effects of peptides on animal and human

behavior: a review of studies published in the first twenty years of the journal Peptides. Peptides 22: 2181-2255, 2001.

775. Vaccarino, A.L. and A.J. Kastin. Endogenous opiates: 2000. Peptides 22: 2257-2328,

2001. 776. Kastin, A.J., V. Akerstrom, and L. Hackler. Food deprivation decreases blood galanin-

like peptide and its rapid entry into the brain. Neuroendocrinology 74: 423-432, 2001. 777. Pan, W. and A.J. Kastin. Upregulation of the transport system for TNFα at the blood-

brain barrier. Arch. Physiol. Biochem. 109: 350-353, 2001. 778. Pan, W., G. Cornelissen, F. Halberg, and A.J. Kastin. Circadian rhythm of tumor necrosis

factor α uptake into mouse spinal cord (Selected Contribution). J. Appl. Physiol. 92: 1357-1362, 2002.

779. Kastin, A.J., M.B. Fasold, and J.E. Zadina. Endomorphins, Met-Enkephalin, Tyr-MIF-1,

and the P-glycoprotein efflux system. Drug Metab. Disp. 30: 231-234, 2002. 780. Pan, W. and A.J. Kastin. TNFα transport across the blood-brain barrier is abolished in

receptor knockout mice. Exp. Neurol. 174: 193-200, 2002. 781. Kastin, A.J., V. Akerstrom, and W. Pan. Interactions of glucagon-like peptide-1 (GLP-1)

with the blood-brain barrier. J. Molec. Neurosci. 18: 7-14, 2002. 782. Kastin, A.J. and V. Akerstrom. Differential interactions of urocortin/corticotropin-

releasing hormone peptides with the blood-brain barrier. Neuroendocrinology 75: 367-374, 2002.

783. Wang, Q.P., J.E. Zadina, J.-L.Guan, A.J. Kastin, H. Funahashi, and S. Shioda.

Endomorphin-2 immunoreactivity in the cervical dorsal horn of the rat spinal cord at the electron microscopic level. Neuroscience 113: 593-605, 2002.

75

784. Sakurada, S., T. Hayashi, M. Yuhki, T. Fujimura, K. Murayama, A. Yonezawa, C.

Sakurada, M. Takeshita, T. Sato, J.E. Zadina, A.J. Kastin, and T. Sakurada. Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone. Peptides 23: 895-901, 2002.

785. Pan, W., B. Solomon, L. M. Maness, and A.J. Kastin. Antibodies to β-amyloid decrease

the blood-to-brain transfer of β-amyloid peptide. Exp. Biol. Med. 227: 609-615, 2002. 786. Kastin, A.J., W. Pan, V. Akerstrom, L. Hackler, C. Wang, and C.M. Kotz. Novel peptide-

peptide cooperation may transform feeding behavior. Peptides 23: 2189-2196, 2002. 787. Pan, W., L. Zhang, J. Liao, B. Csernus, and A.J. Kastin. Selective increase in TNFα

permeation across the blood-spinal cord barrier after SCI. J. Neuroimmunol. 14: 111-117, 2003.

788. Pan, W., A.J. Kastin, T. Rigai, R. McLay, and C.G. Pick. Increased hippocampal uptake

of tumor necrosis factor α and behavioral changes in mice. Exp. Brain Res. 149: 195-199, 2003.

789. Kastin, A.J., and V. Akerstrom. Entry of exendin-4 into brain is rapid but may be limited

at high doses. Int. J. Obes. 27: 313-318, 2003. 790. Wang, Q.-P., J.E. Zadina, J.-L. Guan, A.J. Kastin, and S. Shioda. Electron microscopic

examination of the endomorphin 2-like immunoreactive neurons in the rat hypothalamus. Brain Res. 969: 126-134, 2003.

791. Kastin, A.J., V. Akerstrom, and W. Pan. Glial cell line-derived neurotrophic factor does

not enter normal mouse brain. Neurosci. Lett. 340: 239-241, 2003. 792. Kastin, A.J. and W. Pan. Feeding peptides interact in several ways with the blood-brain

barrier. Curr. Pharm. Des. 9: 789-794, 2003. 793. Pan, W. and A.J. Kastin. Interactions of cytokines with the blood-brain barrier:

Implications for feeding. Curr. Pharm. Des 9: 827-831, 2003 794. Kastin, A.J., V. Akerstrom, and W. Pan. Interleukin-10 as a CNS therapeutic: the

obstacle of the blood-brain/blood-spinal cord barrier. Mol. Brain Res. 114: 168-171, 2003.

795. Kastin, A.J., V. Akerstrom, L. Hackler, and W. Pan. Different mechanisms influencing

permation of PDGF-AA and PDGF-BB across the blood-brain barrier. J. Neurochem 87: 7-12, 2003.

76

796. Kastin, A.J., V. Akerstrom, and W. Pan. Circulating TGF-β does not cross the intact blood-brain barrier. J. Molec. Neurosci. 21: 43-48, 2003.

797. Kastin, A.J., and W. Pan. Peptide transport across the blood-brain barrier. In: Peptide

Transport and Delivery into the Central Nervous System, edited by Laszlo Prokai and Katalin Prokai-Tatrai, Basel, Switzerland: Birkhäuser Verlag, 2003, pp 79-100.

798. Pan, W., B. Csernus, and A.J. Kastin. Upregulation of p55 and p75 receptors mediating

TNF α transport across the injured blood-spinal cord barrier. J. Molec. Neurosci. 21: 173-184, 2003.

799. Kastin, A.J., and W. Pan. Brain influx of endogenous peptides affecting food intake. In:

Blood-Spinal Cord and Brain Barriers in Health and Disease, edited by Hari Shanker Sharma and Jan Westman, San Diego, California: Elsevier, 2004, pp 57-62.

800. Pan, W., and A.J. Kastin. Transport of cytokines and neurotrophins across the blood-

brain barrier and their regulation after spinal cord injury. In: Blood-Spinal Cord and Brain Barriers in Health and Disease, edited by Hari Shanker Sharma and Jan Westman, San Diego, California: Elsevier, 2004, pp 395-407.

801. Kastin, A.J., Victoria Akerstom, and Weihong Pan. Neuregulin 1-β1 enters brain and

spinal cord by receptor-mediated transport. J. Neurochem. 88: 965-970, 2004. 802. Pan, W., and A.J. Kastin. Polypeptide delivery across the blood-brain barrier. Current

Drug Targets - CNS & Neurological Disorders. 3: 131-136, 2004. 803. Somogyvari-Vigh, A., A.J. Kastin, J. Liao, J.E. Zadina, and W. Pan. Endomorphins exit

the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells. Exp. Brain. Res. 156: 224-230, 2004.

804. Kastin. A.J. Editorial: Twenty-five years of peptides. Peptides 25: 315-317, 2004. 805. Pejovic V, V.Soskic, W. Pan, A.J.Kastin. Brain proteome of mice lacking the receptors

for tumor necrosis factor α. Proteomics, 4: 1461 - 1464, 2004 806. Pan W, V. Akerstrom, J. Zhang, V. Pejovic, A.J. Kastin. Modulation of feeding-related

peptide/protein signals by the blood-brain barrier. J. Neurochem. 90: 455 - 461, 2004 807. Pan W, A.J. Kastin. Why study transport of peptides and proteins at the neurovascular

interface. Brain Res. Rev. 46: 32 - 43, 2004 808. Pan, W., A.J. Kastin, T.C. Zankel, P. van Kerhof, T. Terasaki, and G. Bu. Efficient

transfer of receptor-associated protein (RAP) across the blood-brain barrier. J. Cell Sci. 117: 5071-5078, 2004.

77

809. Yu, Y., A. Jawa, W. Pan, and A.J. Kastin. Effects of peptides, with emphasis on feeding,

pain, and behavior: A 5-year (1999-2003) review of publications in Peptides. Peptides 25: 2257-2289, 2004.

810. Kastin, A.J. and W. Pan. Targeting neurite growth inhibitors to induce CNS regeneration.

Curr. Pharm. Des. 11: 1247-1253, 2005. 811. Xiang, S., W. Pan, and A.J. Kastin. Strategies to create a regenerating environment for

the injured spinal cord. Curr. Pharm. Des. 11: 1267-1277, 2005. 812. Ding, Y., A.J. Kastin and W. Pan. Neural plasticity after spinal cord injury. Curr. Pharm.

Des. 11: 1441-1450, 2005. 813. Pan, W., Y. Yu, C.M. Cain, F. Nyberg, P.O. Couraud, and A.J. Kastin. Permeation of

growth hormone across the blood-brain barrier. Endocrinology 146: 4898-4904, 2005. 814. Pan, W., A.J. Kastin, Y. Yu, C.M. Cain, T. Fairburn, A.M. Stütz, C. Morrison, and G.

Argyropoulos. Selective tissue uptake of AgRP (82-131) and its modulation by fasting. Endocrinology 146: 5533-5539, 2005.

815. Pan, W., Y. Yu, F. Nyberg, and A.J. Kastin. Growth hormone, insulin, and insulin-like

growth factor-1: Do they interact at the blood-brain barrier? In: The Somatotropic Axis in Brain Function, edited by Fred Nyberg, San Diego, California: Elsevier, 2006, pp 75-79.

816. Pan, W., Y. Ding, Y. Yu, H. Ohtaki, T. Nakamachi, and A.J. Kastin. Stroke upregulates

TNFα transport across the blood-brain barrier. Exp. Neurol. 198: 222–233, 2006. 817. Pan, W., H. Tu, and A.J. Kastin. Differential BBB interactions of three ingestive

peptides: obestatin, ghrelin, and adiponectin. Peptides 27: 911-916, 2006. 818. Kastin, A.J. & W. Pan. Editorial: Intranasal leptin: blood-brain barrier bypass (BBBB)

for obesity? Endocrinology 147: 2086-2087, 2006. 819. Pan, W, X. Xiang, H. Tu, and A.J. Kastin. Cytokines interact with the blood-brain barrier.

Chapter 11, in: The Blood-brain Barriers: From Ontogeny to Artificial Interfaces. Volume I, Dermietzel R, Spray DC and Nedergaard M ed., Winheim, Germany: Wiley-VCH, 2006, pp 247-264.

820. Yu, Y., A.J. Kastin, and W. Pan. Reciprocal interactions of insulin and IGF-I in receptor-

mediated transport across the blood-brain barrier. Endocrinology 147: 2611-2615, 2006.

78

821. Pan W., C. Cain, Y. Yu, and A.J. Kastin. Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury. J. Neuroimmunol. 174: 119-125, 2006.

822. Pan, W, Y. Yu, R. Yemane, C. Cain, C. Yu, and A.J. Kastin. Permeation of hepatocyte

growth factor across the blood-brain barrier. Exp Neurol 201:99-104, 2006. 823. Yu, C., A.J. Kastin, Y. Ding, and W. Pan. Gamma glutamyl transpeptidase is a dynamic

indicator of endothelial response to stroke. Exp Neurol 203:116-122, 2007. 824. Tu, H., A.J. Kastin, and W. Pan. CRH-R1 and CRH-R2 are both trafficking and signaling receptors for urocortin. Mol Endocrinol 21:700-711, 2007. 825. Pan, W. and A.J. Kastin. Mahogany, blood-brain barrier, and fat mass surge in AVY mice. Int J Obes 31:1030-1032, 2007. 826. Tu, H., W. Pan, L. Feucht, and A.J. Kastin. Convergent trafficking pattern of leptin after

endocytosis mediated by ObRa – ObRd. J Cell Physiol. 212:215-222, 2007. 827. Pan W, A.J. Kastin, J. Daniel, C. Yu, L.M. Baryshnikova, and C.S. von Bartheld. TNF

trafficking in cerebral vascular endothelial cells. J Neuroimmunol 185:47-56, 2007. 828. Yu, C., A.J. Kastin, H. Tu, and W. Pan. Opposing effects of proteasomes and lysosomes

on LIFR: modulation by TNF. J Mol Neurosci 32:80-89, 2007. 829. Pan, W., M. Barron, H. Hsuchou, H. Tu, and A.J. Kastin. Increased leptin permeation across the blood-brain barrier after chronic alcohol ingestion. Neuropsychopharmacology 33:859-866, 2008. 830. Tu, H., A.J. Kastin, C. Bjørbæk, and W. Pan. Urocortin trafficking in cerebral microvessel endothelial cells. J Mol Neurosci. 31:171-182, 2007. 831. Pan, W. and A.J. Kastin. Adipokines and the blood-brain barrier. Peptides 28:1317-1330, 2007. 832. Yu, C., A.J. Kastin, and W. Pan. TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression. J Cell Physiol. 213: 161-166, 2007. 833. Pan, W. and. Kastin A.J. Peptide/polypeptide transport in the central nervous system. In: Handbook of Neurochemistry and Molecular Neurobiology: Neural Membranes and Transport. Lajtha, A. and Reith, E.A., eds, New York: Springer, 2007, pp 406-422. 834. Pan, W., H. Tu, C. Yu, H. Hsuchou, Y. Yang, and A.J. Kastin. Differential role of TNF receptors in cellular trafficking of intact TNF. Cell Physiol Biochem 20:559-568, 2007.

79

835. Yu, C., W. Pan, H. Tu, S. Waters, and A.J. Kastin. TNF activates p-glycoprotein in cerebral microvascular endothelial cells. Cell Physiol Biochem 20:853-858, 2007. 836. Pan, W., H. Hsuchou, and A.J. Kastin. Nesfatin-1 crosses the blood–brain barrier without saturation. Peptides 28:2223-2228, 2007. 837. Hsuchou, H., Pan, W., and A.J. Kastin. The fasting polypeptide FGF21 can enter brain from blood. Peptides 28:2382-2386, 2007. 838. Pan, W. and A.J. Kastin. From MIF-1 to endomorphin: the TYR-MIF-1 family of peptides. Peptides 28:2411-2434, 2007. 839. Pan, W. and A.J. Kastin. Tumor necrosis factor and stroke: role of the blood-brain barrier. Prog Neurobiol 83:363-374, 2007. 840. Pan W., H. Hsuchou, H. Tu, and A.J. Kastin. Developmental changes of leptin receptors in cerebral microvessels: unexpected relation to leptin transport. Endocrinology 149:877- 885, 2008. 841. Pan, W. and A.J. Kastin. In vivo techniques quantifying blood-brain barrier permeability to small proteins in mice. In: Neuropeptide Techniques. Gozes, I., ed, Totowa, NJ: Humana Press, 2007, pp 97-113. 842. Tu H., A.J. Kastin, H. Hsuchou, W. Pan. Soluble receptor inhibits leptin transport. J Cell Physiol 214:301-305, 2008. 843. Pan, W. and A.J. Kastin. Urocortin and the brain. Prog Neurobiol 84:148-56, 2008. 844. Pan W., H. Tu, H. Hsuchou, J. Daniel, A.J. Kastin. Unexpected amplification of leptin- induced Stat3 signaling by urocortin: implications for obesity. J Mol Neurosci 33:232- 238, 2007. 845. Wang, Q-P., J-L Guan, W. Pan, A.J. Kastin, S. Shioda. A diffusion barrier between the area postrema and nucleus tractus solitarius. Neurochem Res 33:2035-43, 2008. 846. Pan, W., H. Hsuchou, C. Yu, and A.J. Kastin. Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS. J Neurochem 106:313-319, 2008. 847. Pan, W., H. Hsuchou, Y. He, A. Sakharkar, C. Cain, C. Yu, and A.J. Kastin. Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice. Endocrinology 149:2798-806, 2008. 848. Kastin, A.J. and Pan W. Peptides and Hormesis. Crit Rev Toxicol 38:1-3, 2008.

80

849. Pan W., C. Yu, H. Hsuchou, Y. Zhang, and A.J. Kastin. Neuroinflammation facilitates LIF entry into brain: role of TNF. Am J Physiol Cell Physiol 294: C1436-42, 2008. 850. Kastin A.J. and W. Pan. Blood-brain barrier and feeding: regulatory roles of saturable transport systems for ingestive peptides. Curr Pharm Des 14:1615-19, 2008. 851. Pan, W., and A.J. Kastin. Cytokine transport across the injured blood-spinal cord barrier. Curr Pharm Des 14:1620-4, 2008. 852. Yu, C., G. Argyropoulos, Y. Zhang, A.J. Kastin, H. Hsuchou, and W. Pan.

Neuroinflammation activates Mdr1b efflux transport through NFκB: promoter analysis in BBB endothelia. Cell Physiol Biochem 22:745-56, 2008.

853. He Y, Kastin AJ, Hsuchou H, Pan W. The Cdk5/p35 kinases modulate leptin-induced

STAT3 signaling. Journal of Molecular Neuroscience, 39:49-58, 2009 854. Hsuchou H, He Y, Kastin AJ, Tu H, Markadakis EN, Rogers RC, Fossier PB, Pan W.

Obesity induces functional astrocytic leptin receptors in hypothalamus. Brain, 132:889-902, 2009

855. Kheterpal I, Kastin AJ, Mollah S, Yu C, Hsuchou H, Pan W. Mass spectrometric

quantification of MIF-1 in mouse brain by multiple reaction monitoring. Peptides, 30:1276-81, 2009.

856. Zhang Y, Wu X, Kastin AJ, Hsuchou H, Rosenblum CI, Pan W. Melanocortin potentiates

leptin-induced STAT3 signaling via MAPK pathway. Journal of Neurochemistry, 110:390-9, 2009

857. Pan W, Hsuchou H, Wu X, Kastin AJ. Cessation of blood-to-brain influx of interleukin-

15 during development of EAE. Journal of Cerebral Blood Flow and Metabolism, 29:1568-78, 2009

858. Hsuchou H, Pan W, Barnes MJ, Kastin AJ. Leptin receptor mRNA in rat brain astrocytes.

Peptides, 30:2275-80, 2009 859. Pan W, Yu C, Hsuchou H, Khan RS, Kastin AJ. Cerebral microvascular IL15 is a novel

mediator of TNF action. Journal of Neurochemistry, 111:819-27, 2009 860. Hsuchou H, Kastin AJ, Wu X, Tu H, Pan W. CRHR1 in cerebral microvessels changes

during development and influences urocortin transport across the BBB. Endocrinology, 151:1221-7, 2010

861. He Y, Wu X, Hsuchou H, Kastin AJ, Khan RS, Pistell PJ, Wang W-H, Li Z, Guo X, Pan

W. Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal

81

dependent memory. Journal of Neuroscience, 30:4725-34, 2010 862. He Y, Wu X, Khan RS, Kastin AJ, Cornelissen-Guillaume GG, Hsuchou H, Robert B,

Halberg F, Pan W. IL15 receptor deletion results in circadian changes of thermoregulation and metabolic activity. Journal of Molecular Neuroscience, 41:315-21, 2010

863. Khan RS, Yu C, Kastin AJ, Ehrensing R, Hsuchou H, Stone KP, Pan W. Brain activation

by peptide Pro-Leu-Gly-NH2 (MIF-1). International Journal of Peptides, 2010. pii: 537639 PMID: 20721355

864. Tu H, Hsuchou H, Kastin AJ, Wu X, Pan W. Unique leptin trafficking by a tailless

receptor. FASEB Journal, 24:2281-91, 2010 865. Pan W, Yu C, Huschou H, Kastin AJ. The role of cerebral vascular NFκB in LPS-

induced inflammation: differential regulation of efflux transporter and transporting cytokine receptors. Cellular Physiology and Biochemistry, 25: 623-30, 2010.

866. Wu X, Pan W, Stone KP, Zhang Y, Hsuchou H, Kastin AJ. Expression and signaling of

novel IL15Ralpha splicing variants in cerebral endothelial cells of the blood-brain barrier. Journal of Neurochemistry, 114:122-9, 2010

867. Wu X, He Y, Kastin AJ, Hsuchou H, Pan W. Cerebral interleukin-15 shows upregulation

and beneficial effects in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 223:65-72, 2010

868. Wu X, Kastin AJ, Hsuchou H, Pan W. The effects of IL2Rgamma knockout on

depression and contextual memory. Behavioral Brain Research, 213:319-22, 2010 869. Wu X, Kastin AJ, He Y, Hsuchou H, Rood JC, Pan W. Essential role of interleukin-15

receptor in normal anxiety behavior. Brain, Behavior, and Immunity, 24: 1340 – 6, 2010 870. Kastin AJ, Pan W. Concepts for biologically active peptides. Current Pharmaceutical

Design, 16: 3390 – 3400, 2010 871. Hsuchou H, Kastin AJ, Tu H, Abbott NJ, Couraud PO, Pan W. Role of astrocytic leptin

receptor subtypes on leptin permeation across hCMEC/D3 endothelial cells. Journal of Neurochemistry, 115: 1288 – 1298, 2010

872. Wu X, Hsuchou H, Kastin AJ, He Y, Khan RS, Stone KP, Cash MS, Pan W. Interleukin-

15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor. Psychoneuroendocrinology, 36: 266-78, 2011

873. Pan W, Wu X, Kastin AJ, Zhang Y, Hsuchou H, Halberg F, Chatu F, Khan RS, Robert B,

82

Cornelissen-Guillaume GG. Potential protective role of IL15Rα during inflammation. Journal of Molecular Neuroscience, 43: 412-23, 2011

874. Pan W, Hsuchou H, Xu C, Wu X, Bouret SG, Kastin AJ. Astrocytes modulate

distribution and neuronal signaling of leptin in the hypothalamus of obese Avy mice. Journal of Molecular Neuroscience, 43: 478-84, 2011

875. Stone KP, Kastin AJ, Hsuchou H, Yu C, Pan W. Rapid endocytosis of interleukin-15 by

cerebral endothelia. Journal of Neurochemistry, 116: 544-53, 2011 876. Pan W, Nyberg F, Kastin AJ. Interactions of growth hormone, insulin-like growth factor-

1, and ghrelin with the blood-brain barrier. The Open Endocrinology Journal, 2011 877. Pan W, Stone KP, Huschou H, Manda VK, Zhang Y, Kastin AJ. Cytokine signaling

modulates blood-brain barrier function. Current Pharmaceutical Design, 17: 3729-40, 2011

878. Stone KP, Kastin AJ, Pan W. NFκB is an unexpected major mediator of interleukin-15

signaling in cerebral endothelia. Cellular Physiology and Biochemistry, 28: 115-24, 2011 879. Hsuchou H, Kastin AJ, Tu H, Markadakis EN, Stone KP, Wang Y, Heymsfield SB, Chua

SC Jr, Obici S, Magrisso IJ, Pan W. Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB. Peptides 32: 1392-9, 2011

880. Pan W, Huschou H, Cornelissen-Guillaume GG, Jayaram B, Wang Y, Tu H, Halberg F,

Wu X, Chua SC Jr, Kastin AJ. Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity. J Appl Physiol, 112:1410-8, 2012

881. Hsuchou H, Kastin AJ, Pan W. Blood-borne metabolic factors in obesity exacerbate

injury-induced astrogliosis. J Mol Neurosci, 47: 267-277, 2012 882. Pan W, Hsuchou H, Jayaram B, Khan RS, Huang EYK, Wu X, Chen C, Kastin AJ.

Leptin action on non-neuronal cells in the CNS: potential clinical implications. Ann NY Acad Sci, 1264:64-71, 2012

883. Hsuchou H, Kastin AJ, Mishra PK, Pan W. C-reactive protein increases BBB

permeability: Implications for obesity and neuroinflammation. Cellular Physiology and Biochemistry, 30:1109-1119, 2012

884. Pan W, Wu X, He Y, Hsuchou H, Huang EYK, Mishra PK, Kastin AJ. Brain interleukin-

15 in neuroinflammation and behavior. Neurosci Biobehav Rev, 37: 184-192, 2013 885. Wu X, Hsuchou H, Kastin AJ, Mishra PK, Pan W. Upregulation of astrocytic leptin

receptor in mice with experimental autoimmune encephalomyelitis. J Mol Neurosci,

83

49:446-56, 2013 886. Jayaram B, Khan RS, Kastin AJ, Hsuchou H, Wu X, Pan W. Protective role of astrocytic

leptin signaling against excitotoxicity. J Mol Neurosci, 49: 523-30, 2013 887. Hsuchou H, Jayaram B, Kastin AJ, Wang Y, Ouyang S, Pan W. Endothelial cell leptin

receptor mutant mice have hyperleptinemia and reduced tissue uptake. J Cell Physiol, 228: 1610 – 6, 2013

888. Hsuchou H, Mishra PK, Kastin AJ, Wu X, Wang Y, Ouyang S, Pan W. Saturable leptin

transport across the BBB persists in EAE mice. J Mol Neurosci, 51: 364-70, 2013 889. Jayaram B, Pan W, Wang Y, Hsuchou H, Mace A, Cornelissen-Guillaume GG, Mishra

PK, Koza RA, Kastin AJ. Astrocytic leptin receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity. J Applied Physiol, 114:734-41, 2013

890. Ouyang S, Hsuchou H, Kastin AJ, Pan W. TNF stimulates nuclear export and secretion of

IL-15 by acting on CRM1 and ARF6. PLOS One, 8: e69356, 2013 891. Hsuchou H, Wang Y, Cornelissen-Guillaume GG, Kastin AJ, Jang E, Halberg F, Pan W.

Diminished leptin signaling can alter circadian rhythm of metabolic activity and feeding. J Applied Physiol, 115: 995-1003, 2013

892. Wang Y, Kastin AJ, Hsuchou H, He J, Pan W. Obesity changes sleep architecture and

neurobehavior: minimal role of leptin. J Mol Neurosci, 51: 1038-45, 2013 893. Mishra PK, Hsuchou H, Ouyang S, Kastin AJ, Wu X, Pan W. Loss of astrocytic leptin

signaling worsens experimental autoimmune encephalomyelitis. Brain Behav Immunity, 34:98-107, 2013

894. Hsuchou H, Kastin AJ, Pan W. Fibroblast growth factor 19 and the blood-brain barrier.

Fluids and Barriers of the CNS, 10: 32, 2013. doi: 10.1186/2045-8118-10-32, PMID 24176017

895. Pan W, Kastin AJ. Leptin: a biomarker for sleep disorders? Sleep Med Rev, 18: 263-70,

2014 896. Ouyang S, Hsuchou H, Kastin AJ, Wang Y, Yu C, Pan W. Diet-induced obesity

suppresses expression of many proteins at the blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism, 34: 43-51, 2014

897. Ouyang S, Hsuchou H, Kastin AJ, Mishra PK, Wang Y, Pan W. Leukocyte infiltration

into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling, Brain, Behav, Immuity, 40:61-73, 2014

84

898. He J, Wang Y, Kastin AJ, Pan W. Increased sleep fragmentation in experimental autoimmune encephalomyelitis. Brain, Behav, Immuity, 38:53-8, 2014

899. He J, Kastin AJ, Wang Y, Pan W. Sleep fragmentation has differential effects on obese

and lean mice. J Mol Neurosci, 55:644-52, 2015 900. He J, Hsuchou H, He Y, Kastin AJ, Pan W. Sleep restriction impairs blood-brain barrier

function. J Neurosci, 34(44):14697-706, 2014 901. Pan W, Kastin AJ. Can sleep apnea cause Alzheimer's disease? Neurosci Biobehav Rev,

47C:656-669 902. He J, Hsuchou H, He Y, Kastin AJ, Mishra PK, Fang J, Pan W. Leukocyte infiltration

across the blood-spinal cord barrier is modulated by sleep fragmentation in EAE mice. Fluids and Barriers of the CNS, 11(1):27. doi: 10.1186/2045-8118-11-27, 2014

903. Wang Y, Hsuchou H, He Y, Kastin AJ, Pan W. Role of astrocytes in leptin signaling. J

Mol Neurosci, in press 904. Pan W, Kastin AJ. The Blood-Brain-Barrier: Regulatory Roles in Wakefulness and

Sleep. Committed to the Neuroscientist. 2015.