abba j. kastin, m.d

119
ABBA J. KASTIN, M.D. Professor and Endowed Chair, Pennington Biomedical Research Center Editor-in-Chief, Peptides Editor, Handbook of Biologically Active Peptides President, the International Neuropeptide Society EDUCATION A.B. Harvard College, 1956 M.D. Harvard Medical School, 1960 TRAINING 7/60 - 7/62 Residency in Medicine, Vanderbilt University Hospital 7/62 - 9/64 Clinical Associate, Endocrinology Branch, National Cancer Institute, National Institutes of Health 9/64 - 1/65 Special NIH Postdoctoral Fellow with Dr. Andrew V. Schally ACADEMIC APPOINTMENTS 7/61 - 7/62 Assistant, Department of Medicine, Vanderbilt University 1

Upload: roger961

Post on 24-Dec-2014

4.182 views

Category:

Documents


0 download

DESCRIPTION

 

TRANSCRIPT

Page 1: Abba J. Kastin, M.D

ABBA J. KASTIN, M.D.

Professor and Endowed Chair, Pennington Biomedical Research Center

Editor-in-Chief, Peptides

Editor, Handbook of Biologically Active Peptides

President, the International Neuropeptide Society

EDUCATION

A.B. Harvard College, 1956

M.D. Harvard Medical School, 1960

TRAINING

7/60 - 7/62 Residency in Medicine, Vanderbilt University Hospital

7/62 - 9/64 Clinical Associate, Endocrinology Branch, National Cancer Institute, National Institutes of Health

9/64 - 1/65 Special NIH Postdoctoral Fellow with Dr. Andrew V. Schally

ACADEMIC APPOINTMENTS

7/61 - 7/62 Assistant, Department of Medicine, Vanderbilt University

9/64 - 1/65 Assistant, Department of Medicine, Tulane University

1/65 - 7/66 Instructor, Department of Medicine, Tulane University

7/66 - 7/71 Assistant Professor, Department of Medicine, Tulane University

7/71 - 7/74 Associate Professor, Department of Medicine, Tulane University

7/74 - 7/04 Professor, Department of Medicine, Tulane University

7/86 - 7/04 Professor, Neuroscience Training Program, Tulane University

1

Page 2: Abba J. Kastin, M.D

7/86 – 9/06 Consulting Professor, Department of Psychology, University of New Orleans

8/04 - present Professor and Endowed Chair, Pennington Biomedical Research Center, Louisiana State University Systems

HOSPITAL APPOINTMENTS

Veterans Administration Hospital:

9/64 - 1/65 Medical Research Fellow

1/65 - 1/68 Clinical Investigator

7/66 - 1/68 Clinical Consultant in Endocrinology

1/68 - 7/04 Chief, Endocrinology Section

Charity Hospital:

7/66 - 7/69 Assistant Visiting Physician

7/69 - 7/79 Visiting Physician

7/79 - 7/89 Senior Visiting Physician

HONORARY DEGREES

1980 Doctorate (Honoris Causa), National University (Federico Villarreal) of Peru

1984 Doctorate of Science (Honoris Causa), University of New Orleans

2008 Doctorate (Honoris Causa), Uppsala University, Sweden

HONORARY SOCIETY MEMBERSHIPS

1966 La Societe de Dermo-Chimie

1970 Chilean Society of Endocrinology

1976 Philippine Society of Endocrinology and Metabolism

2

Page 3: Abba J. Kastin, M.D

1980 Peruvian Ob/Gyn Society

1980 Peruvian Endocrine Society

1980 Polish Endocrine Society

1984 Hungarian Endocrine Society

2006 Brazilian Society of Toxinology (SBTx)

2008 Indian Society for Comparative Endocrinology

AWARDS

1975 Federal Business Association "Eagle" Award and Key to the City of New Orleans

1975 Recipient (with Dr. A.V. Schally), Edward T. Tyler Fertility Award

1979 Copernicus Medal of the Medical Faculty of Krakow, Poland

1981 Distinguished Alumni Hall of Fame (First Annual Induction), Cleveland HeightsHigh School

1982 William S. Middletown Award

2001 Strand Award

2007 Honorary Professor, The Peking University Health Science Center

MISCELLANEOUS

1978 Most cited scientist list, Institute for Scientific Information, Current Contents, 7/10/78; Science 202: 296, 1978-top 300; Current Contents 10/12/81-top 100; The Scientist 3/19/90-top 100

1980 - presentFounding Editor-in-Chief, Peptides, an international journal

1980s – presentNominator: Japan Prize, Kyoto Prize, International Prize for Biology

3

Page 4: Abba J. Kastin, M.D

1993 - presentPresident, International Neuropeptide Society

2006 Editor, Handbook of Biologically Active Peptides. Elsevier, San Diego.

SPECIAL LECTURES

1984 XVI International Congress of the International Society of Psychoneuroendocrinology, Vienna, Austria

1984 International Symposium on Nonmammalian Peptides, Rome, Italy

1984 4th International Symposium on Psychoneuroendocrinology in Reproduction, Verona, Italy

1986 Talmage Lecture, 4th Annual Aspen Allergy Conference

1989 10th Annual Winter Neuropeptide Conference, Anniversary Decade (also Banquet Speaker, 1st Winter Conference)

1989-90 Welcome Visiting Professor (FASB), East Tennessee State University

1992 1st meeting of the International Society of Behavioral Neuroscience

1992 Inaugural Summer Neuropeptide Conference

1994 15th Anniversary Meeting of the Winter Neuropeptide Conference

1995 5th Anniversary Meeting of the Summer Neuropeptide Conference

1995 International Chronic Fatigue Syndrome Conference, Israel (summation)

2001 Joint meeting of European and American neuropeptide groups, Israel

2001 International Narcotic Research Conference, Helsinki

2004 Jim Flood Memorial Lecture, 15th Annual St Louis University Summer Geriatric Institute

2004 International Narcotics Research Conference, Sendai and Kyoto, Japan

2007 X International Union of Biochemistry and Molecular Biology, Salvador de Bahia, Brazil

4

Page 5: Abba J. Kastin, M.D

2007 Kalra Brain-Body Dialogue Lecture, University of Florida

ADVISORY BOARDS

7/74 - 7/77 National Pituitary Agency 1/78 - 12/81 National Association for Retarded Citizens

2/79 - 12/80 Food and Drug Association

7/84 - 12/95 Pre-reviewer in Endocrinology, Residency Review Committee for Internal Medicine, Accreditation Council for Graduate Medical Education

10/11/89 Congressional testimony, U.S. House of Representatives, representing American Federation for Clinical Research.

1/98 - 12/03 Self-Assessment Committee, AMA Accreditation Program (AMA).

1/98 - present Bar-Ilan University-Tel Hashomer Brain Research Center, Israel

EDITORIAL BOARDS

1/76-1/80 Journal of Clinical Endocrinology and Metabolism.

1/76-4/95 Brain Research Bulletin

1/77-12/95 Neuroscience and Biobehavioral Reviews 7/85- 1/01 New Trends in Experimental and Clinical Psychiatry

3/88-3/90 Progress in NeuroEndocrinImmunology

1/89-1/95 Pharmacology, Biochemistry and Behavior

1/90-1/95 Molecular and Cellular Neurosciences

1/93-1/95 Physiology and Behavior

1/94-12/04 Endocrine Practice

7/95-6/00 Neuroimmunomodulation

5

Page 6: Abba J. Kastin, M.D

7/96-12/00 Sulzberger & Graham Publishing, Ltd., Professional Books in Pharmacology, Neuroscience and Biomedical Sciences

1/99-present Hanwood Academic Publishers, Book Series: Nutrition, Brain, and Behavior

1/03-present Current Pharmaceutical Design

1/04-1/07 Medicinal Chemistry Reviews – Online

8/07-present Clinical Medicine: Endocrinology and Diabetes

TEACHING

1976-77 Distinguished Scientist Lecturer, Department of Anatomy, Tulane University School of Medicine

1977-1996 Outstanding Teacher Award, Tulane medical students’ Owl Club 1995 Guest of Honor, Research Day in Medicine, LSU Medical Center

1997 Visiting Senior Scientist, JSPS/NIH, Japan

SOCIETIES

1964 American Federation for Clinical Research

1965 The Endocrine Society

1965 American Association for Advancement of Science

1966 American Physiological Society

1967 Society for Experimental Biology and Medicine

1969 Society for Neuroscience

1970 International Society of Psychoneuroendocrinology

1972 International Society of Neuroendocrinology (Charter Member)

6

Page 7: Abba J. Kastin, M.D

1978 International Pigment Cell Society (Charter Member)

1990 American Peptide Society (Charter Member)

1990 American Geriatrics Society

1991 American Association of Clinical Endocrinology (Charter Member)

1992 International Behavioral Neuroscience Society (Council, 1992-1994; Fellow)

1993 The International Neuropeptide Society (President, 1993-present)

1994 Council of Biology Editors (Editorial Policy Committee, 1998-2001)

1995 American College of Endocrinology (Fellow)

CIVIC/COMMUNITY

Green Wave Masters Swim Club (President, 1978 – 1984)

Civic Symphony Orchestra of New Orleans (President, 1990; Chairman, Nominating Committee, 1991 – 2005)

Jewish Federation of Greater New Orleans (Board of Trustees, 1982 – 1988)

Harvard Club of Louisiana (President, 1991-1995; Chairman, Advisory Committee, 1996 – present)

Louisiana Philharmonic Orchestra (Advisory Board, 1997 – present)

Opéra Louisiane (Board of Directors, 2007 – present)

Baton Rouge Symphony Orchestra (Board of Directors, 2007 – present)

Visual Arts Visiting Committee, Loyola University, New Orleans (2004 – 2007)

Special Combined Music and Visual Arts Visiting Committee, Loyola University, New Orleans (2007 – present)

7

Page 8: Abba J. Kastin, M.D

FULL PAPERS

1. Kastin, A.J. and GOT. Ross. Melanocyte stimulating hormone (MSH) and ACTH activities of pituitary homografts in albino rats. Endocrinology 75: 187-191, 1964.

2. Kastin, A.J. and R.F. Gads. Skin graft challenge to pituitary transplants in the rat. Endocrinology 75: 457-460, 1964.

3. Kastin, A.J. and GT. Ross. Modified in vivo assay for MSH. Experiential 20: 461-464, 1964.

4. Gittes, R.F., A.J. Kastin, D.B. Geoff and A.F. Ketcham. Deficiency of effective histocompatibility antigens in pituitary and parathyroid tissue. Surgical Forum 15: 164-166, 1964.

5. Kastin, A.J., M.B. Lipsett, A.K. Ommaya and J.M. Moser. Asymptomatic hypernatremia: physiological and clinical study. Am. J. Med. 38: 306-315, 1965.

6. Douglas, G.W., A.J. Kastin and R.W. Huntington. Carcinoma arising in a retroperitoneal mullerian cyst, with widespread metastasis during pregnancy. Am. J. Ob. Gyn. 91: 210-216, 1965.

7. Paul, W.E., A.J. Kastin and W.D. Odell. The effect of ionizing radiation on melanocyte-stimulating and steroidogenic activities of corticotropin. Biochem. Biophys. Acta 100: 263-269, 1965.

8. Kastin, A.J. and G.T. Ross. MSH and ACTH activities in pituitaries of frogs with hypothalamic lesions. Endocrinology 77: 45-48, 1965.

9. Schally, A.V., C.Y. Bowers, A. Kuroshima, Y. Ishida, T.W. Redding and A.J. Kastin. Hormonal activities of beef and pig hypothalamus. Excerp. Med. Int. Cong. Series no. 87, pp. 275-283, Proc. XXIII International Congress of Physiological Sciences, 1965.

10. Kastin, A.J., A.V. Schally, H. Yajima and K. Kubo. Melanocyte stimulating hormone activity of synthetic MSH and ACTH peptides in vivo and in vitro. Nature 207: 978-979, 1965.

11. Kastin, A.J., A. Arimura and A.V. Schally. Topical absorption of polypeptide hormones with dimethylsulfoxide. Arch. Dermatol. 93: 471-473, 1966.

12. Gittes, R.F. and A.J. Kastin. Effects of increasing numbers of pituitary transplants in hypophysectomized rats. Endocrinology 78: 1023-1031, 1966.

13. Kastin, A.J. and A.V. Schally. In vivo assay for melanocyte lightening substances.

8

Page 9: Abba J. Kastin, M.D

Experientia 22: 389, 1966.

14. Schally, A.V., A.J. Kastin, J.F. Barrett, W.H. Carter, C.Y. Bowers and W.F. White. On vasodepressor activity in the hypothalamus. Biochem. Pharmacol. 15: 1805-1811, 1966.

15. Kastin, A.J. and A.V. Schally. MSH activity in pituitaries of rats treated with hypothalamic extracts. Gen. Comp. Endocrinol. 7: 452-456, 1966.

16. Schally, A.V. and A.J. Kastin. Purification of a bovine hypothalamic factor which elevates pituitary MSH levels in rats. Endocrinology 79: 768-772, 1966.

17. Kastin, A.J. and A.V. Schally. MSH activity in pituitary glands of rats treated with tranquilizing drugs. Endocrinology 79: 1018-1020, 1966.

18. Kastin, A.J., G.T. Ross and A.V. Schally. Controle hypothalamique de la secretion de MSH. Arch. Biochim. Cosmet. 9: 9, 1966.

19. Kastin, A.J. and A.V. Schally. Autoregulation of release of melanocyte stimulating hormone from the rat pituitary. Nature 213: 1238-1240, 1967.

20. Kastin, A.J. and A.V. Schally. MSH activity in pituitaries of rats treated with hypothalamic extracts from various animals. Gen. Comp. Endocrinol. 8: 344-347, 1967.

21. Kastin, A.J., T.W. Redding and A.V. Schally. MSH activity in rat pituitaries after pinealectomy. Proc. Soc. Exp. Biol. Med. 124: 1275-1277, 1967.

22. Schally, A.V., A.J. Kastin, T.W. Redding, C.Y. Bowers, H. Yajima and K. Kubo. Thyroid stimulating and pigmentary effects of synthetic peptides related to α-MSH and ACTH. Metabolism 16: 824-829, 1967.

23. Kastin, A.J., L. Barrett, S. Viosca, A. Arimura and A.V. Schally. MSH activity in rat pituitaries after stress. Neuroendocrinology 2: 200-208, 1967.

24. Kastin, A.J., A.V. Schally, S. Viosca, L. Barrett and T.W. Redding. MSH activity in the pituitaries of rats exposed to constant illumination. Neuroendocrinology 2: 257-262, 1967.

25. Schally, A.V., A.J. Kastin, W. Locke and C.Y. Bowers. Hypothalamic releasing and inhibiting factors. In: Hormones in Blood. C.H. Gray and A.L. Bacharach, eds., Academic Press, New York, 1: 491-525, 1967.

26. Schally, A.V., W. Locke, A.J. Kastin and C.Y. Bowers. Some aspects of neuroendocrinology. Yearbook of Endocrinology, pp. 5-29, 1967-68.

9

Page 10: Abba J. Kastin, M.D

27. Schally, A.V., A. Arimura, C.Y. Bowers, S. Sawano, A.J. Kastin, T.W. Redding, T. Saito, W.F. White and A.I. Cohen. Physiological and biochemical studies on some highly purified hypothalamic releasing factors. In: Pharmacology of Hormonal Polypeptides and Proteins. R. Back, R. Paoletti and L. Martini, eds., Plenum Press, pp. 158-166, 1968.

28. Schally, A.V., A. Arimura, C.Y. Bowers, A.J. Kastin, S. Sawano and T.W. Redding. Hypothalamic neurohumors regulating anterior pituitary function. Rec. Prog. Horm. Res. 24: 497-581, 1968.

29. Kastin, A.J., G. Gennser, A. Arimura, M.C. Miller and A.V. Schally. Melanocyte-stimulating and corticotrophic activities in human foetal pituitary glands. Acta Endocrinologica 58: 6-10, 1968.

30. Kastin, A.J., M.C. Miller and A.V. Schally. MSH activity in the rat pituitary after treatment with nembutal and morphine: A new bioassay for MSH-release inhibiting factor (MIF). Endocrinology 83: 137-140, 1968.

31. Kastin, A.J., S. Kullander, N.E. Borglin, K. Dyster-Aas, B. Dahlberg, D. Ingvar, C.E.T. Krakau, M.C. Miller, C.Y. Bowers and A.V. Schally. Extrapigmentary effects of MSH in amenorrheic women. Lancet 1: 1007-1010, 1968.

32. Schally, A.V. and A.J. Kastin. The present concept of the nature of hypothalamic hormones stimulating and inhibiting the release of pituitary hormones. Triangle 9: 19-25, 1969.

33. Kastin, A.J., A.V. Schally, S. Viosca and M.C. Miller. MSH activity in plasma and pituitaries of rats after various treatments. Endocrinology 84: 20-27, 1969.

34. Sandman, C.A., A.J. Kastin and A.V. Schally. Melanocyte-stimulating hormone and learned appetitive behavior. Experientia 25: 1001-1002, 1969.

35. Kastin, A.J., M.C. Miller and A.V. Schally. Modified in vitro assay for MSH. Experientia 25: 192-193, 1969.

36. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, C.Y. Bowers and A. Diaz-Infante. Stimulation of LH release in men and women by hypothalamic LH-releasing hormone purified from porcine hypothalami. J. Clin. Endocrinol. Metab. 29: 1046-1050, 1969.

37. Kastin, A.J. Neuroendocrine research in the Veterans Administration, Special report. January 29, 1969, part B.

38. Kastin, A.J., S. Viosca and A.V. Schally. Assay of mammalian MSH-release regulating factor(s). In: Hypophysiotropic Hormones of the Hypothalamus. J. Meites, ed., Williams and Wilkins, Baltimore, pp. 171-183, 1970.

10

Page 11: Abba J. Kastin, M.D

39. Dyster-Aas, K., A.J. Kastin, R.P. Vidacovich and A.V. Schally. Melanocyte-stimulating activity in serum and the aqueous flare response in rabbits. J. Endocrinol. 46: 285-286, 1970.

40. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, C.Y. Bowers and F. Gomez-Perez. Administration of LH-releasing hormone to selected subjects. Am. J. Ob. Gyn. 108: 177-182, 1970.

41. Gosbee, J.L., J. Kraicer, A.J. Kastin and A.V. Schally. A functional relationship between the pars intermedia and ACTH secretion in the Rat. Endocrinology 86: 560-567, 1970.

42. Schally, A.V. and A.J. Kastin. The role of sex steroids and hypothalamic LH-releasing hormone and FSH-releasing hormone in the regulation of gonadotropin secretion from the anterior pituitary gland. In: Advances in Steroid Biochemistry. M.H. Briggs, ed. Academic Press, New York, pp. 41-69, 1970.

43. Schally, A.V., A. Arimura, A.J. Kastin, J. Reeves, C.Y. Bowers, Y. Baba and W.F. White. Hypothalamic LH-releasing hormone: Chemistry, physiology and effect in humans. In: Mammalian Reproduction. H. Gibian and E.J. Plotz, eds., Springer-Verlag, Berlin, pp. 45-83, 1970.

44. Schally, A.V., A. Arimura, C.Y. Bowers, I. Wakabayashi, A.J. Kastin, T.W. Redding, J.C. Mittler, R.M.G. Nair, P. Pizzolato and A.J. Segal. Purification of hypothalamic releasing hormones of human origin. J. Clin. Endocrinol Metab. 31: 291-300, 1970.

45. Bowers, C.Y., A.V. Schally, D.S. Schalch, C. Gual, A.J. Kastin and K. Folkers. Activity and specificity of synthetic thyrotropin-releasing hormone in man. Biochem. Biophys. Res. Comm. 39: 352-355, 1970.

46. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, M.C. Miller and F. Flores. Increased release of LH after administration of LH-RH to men pretreated with clomiphene. J. Clin. Endocrinol. Metab. 31: 689-692, 1970.

47. Kastin, A.J., A.V. Schally, C. Gual and A.R. Midgley. Clinical studies with LH-releasing hormone. Acta Endocrinol Panam. 1: 147-153, 1970.

48. Gual, C., F. Flores, A.J. Kastin, A.V. Schally and A.R. Midgley. Valoracion de la funcion hipofisiaria en el humano mediante el empleo de hormonas liberadoras hipotalamicas (LH-RH). Reunion A.. Soc. Mex. Nutr. Endocrinol. 10: 331-340, 1970.

49. Sandman, C.A., A.J. Kastin and A.V. Schally. Behavioral inhibition as modified by melanocyte-stimulating hormone (MSH) and light-dark condition. Physiol. Behav. 6: 45-48, 1971.

11

Page 12: Abba J. Kastin, M.D

50. Schally, A.V., A. Arimura, A.J. Kastin, C.Y. Bowers, T.W. Redding, I. Wakabayashi, Y. Baba, R.M.G. Nair, J.F. Barrett and J.J. Reeves. Recent advances in hypothalamic hormones regulating pituitary function. In: Recent Advances in Endocrinology. E. Mattar, G. Mattar and V.H.T. James, eds., Excerp. Med. Int. Congr. Series no. 238, pp. 293-310, 1971.

51. Kastin, A.J. and A.V. Schally. Control of MSH release in mammals. In: Recent Advances in Endocrinology. E. Mattar, G. Mattar and V.H.T. James, eds., Excerp. Med. Int. Congr. Series no. 238, pp. 311-317, 1971.

52. Bowers, C.Y., A.V. Schally, A.J. Kastin, A. Arimura, D.S. Schalch, C. Gual, E. Castineda and K. Folkers. Synthetic thyrotropin-releasing hormone. Activity in men and women, specificity of action, inhibition by triiodothyronine, and activity orally. J. Med. Chem. 14: 477-481, 1971.

53. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, A. Arimura, M.C. Miller and A. Cabeza. Administration of LH-releasing hormone of human origin to man. J. Clin. Endocrinol. Metab. 32: 287-289, 1971.

54. Kastin, A.J., A. Arimura, A.V. Schally and M.C. Miller. Mass-action type, direct feedback control of pituitary MSH release. Nature 231: 29-30, 1971.

55. Sandman, C.A., P.M. Denman, L.H. Miller, J.R. Knott, A.V. Schally and A.J. Kastin. Electroencephalographic measures of melanocyte stimulating hormone activity. J. Comp. Physiol. Psychol. 76: 103-109, 1971.

56. Schally, A.V. and A.J. Kastin. Hypothalamic neuroendocrine mediators. Acta. Physiol. Polonica 22 (Suppl. 3): 5-19, 1971.

57. Kastin, A.J., A.V. Schally, C. Gual, A.R. Midgley, M.C. Miller and A. Cabeza. Dose response relationship of LH to LH-releasing hormone in man. J. Clin. Invest. 50: 1551-1553, 1971.

58. Kastin, A.J., A. Zarate, A.R. Midgley, E. Canales and A.V. Schally. Ovulation confirmed by pregnancy after infusion of porcine LH-RH. J. Clin Endocrinol. Metab. 33: 980-982, 1971.

59. Nair, R.M.G., A.J. Kastin and A.V. Schally. Isolation and structure of hypothalamic MSH release-inhibiting hormone. Biochem. Biophys. Res. Comm. 43: 1376-1425, 1971.

60. Kastin, A.J., A.V. Schally and S. Viosca. Inhibition of MSH release in frogs by direct application of L-prolyl-L-leucylglycinamide to the pituitary. Proc. Soc. Exp. Biol. Med. 137: 1437-1439, 1971.

12

Page 13: Abba J. Kastin, M.D

61. Kastin, A.J., L.H. Miller, D. Gonzalez-Barcena, W.D. Hawley, K. Dyster-Aas, A.V. Schally, M.L. Velasco-Parra and M. Velasco. Psycho-physiologic correlates of MSH activity in man. Physiol. Behav. 7: 893-896, 1971.

62. Schally, A.V., A. Arimura, A.J. Kastin, H. Matsuo, Y. Baba, T.W. Redding, R.M.G. Nair, L. Debeljuk and W.F. White. Gonadotropin-releasing hormone: one polypeptide regulates the secretion of LH and FSH. Science 173: 1036-1038, 1971.

63. Schally, A.V., A.J. Kastin and A. Arimura. Hypothalamic FSH and LH-regulating hormone: structure, physiology, and clinical studies. Fertil. Steril. 22: 703-721, 1971.

64. Anderson, M.S., C.Y. Bowers, A.J. Kastin, D.S. Schalch, A.V. Schally, P.S. Snyder, R.D. Utiger, J.F. Wilbur and A.J. Wise. Synthetic thyrotropin releasing hormone (TRH): a potent stimulator of thyrotropin secretion in man. N. Engl. J. Med. 285: 1279-1283, 1971.

65. Schally, A.V. and A.J. Kastin. Stimulation and inhibition of fertility through hypothalamic agents. Drug Therapy 1: 29-32, 1971.

66. Plotnikoff, N.P., A.J. Kastin, M.S. Anderson and A.V. Schally. DOPA potentiation by a hypothalamic factor, MSH release-inhibiting hormone (MIF). Life Sci. 10: 1279-1283, 1971.

67. Hollander, C.S., T. Mitsuma, A.J. Kastin, L. Shenkman, M. Blum and D.A. Anderson. Hypertriiodothyroninaemia as a premonitory manifestation of thyrotoxicosis. Lancet 2: 731-733, 1971.

68. Kastin, A.J. and A.V. Schally. MSH release in mammals. In: Pigmentation: Its genesis and biologic control. V. Riley, ed. Appleton-Century-Crofts, New York, pp. 215-223, 1972.

69. Kastin, A.J., A. Zarate, M.C. Miller, A. Hernandez-Ayup, K. Dyster-Aas, C. Gual and A.V. Schally. Anovulatory uterine bleeding after administration of MSH to women with secondary amenorrhea. J. Reprod. Fertil. 28: 185-189, 1972.

70. Kastin, A.J., A.V. Schally, D. Gonzalez-Barcena, D.S. Schalch and L. Lee. Different responses to two hypothalamic hormones in acromegalics. Arch. Int. Med. 130: 923-927, 1972.

71. Sandman, C.A., L.H. Miller, A.J. Kastin and A.V. Schally. A neuroendocrine influence on attention and memory. J. Comp. Physiol. Psychol. 80: 54-58, 1972.

72. Arimura, A., A.J. Kastin and A.V. Schally. Recent progress in physiological and clinical studies with LH- and FSH-releasing hormone. In: Gonadotropins. B. Saxena, C. Beling

13

Page 14: Abba J. Kastin, M.D

and H. Gandy, eds. John Wiley and Sons, Inc., New York, pp. 32-48, 1972.

73. Kastin, A.J., A.V. Schally, D.S. Schalch, S.G. Korenman, M.C. Miller, C. Gual and E. Perez-Pasten. Characterization of the hormonal responses to luteininzing hormone-releasing hormone (LH-RH) in prepubertal and adult subjects. Pediat. Res. 6: 481-486, 1972.

74. Denman, P.M., L.H. Miller, C.A. Sandman, A.V. Schally and A.J. Kastin. Electrophysiological correlates of melanocyte-stimulating hormone activity in the frog. J. Comp. Physiol. Psychol. 80: 59-65, 1972.

75. Gual, C., A.J. Kastin and A.V. Schally. Clinical experience with hypothalamic releasing hormones. Thyrotropin releasing hormone (TRH). Rec. Prog. Horm. Res. 28: 173-200, 1972.

76. Kastin, A.J., C. Gual and A.V. Schally. Clinical experience with hypothalamic releasing hormones. Luteinizing hormone-releasing hormone and other hypophysiotropic hormones. Rec. Prog. Horm. Res. 28: 201-227, 1972.

77. Schally, A.V. and A.J. Kastin. Hypothalamic releasing and inhibiting hormones. Gen. Comp. Endocrinol. Supplement 3: 76-85, 1972.

78. Schally, A.V., A. Arimura, A.J. Kastin, L. Debeljuk, H. Matsuo, Y. Baba, R.M.G. Nair and T.W. Redding. The hypothalamic hormone regulating LH and FSH secretion. In: Biology of Reproduction: Basic and Clinical Studies. J.T. Velardo and B.A. Kasprow, eds., Oxford Univ. Press, pp. 61-68, 1972.

79. Kastin, A.J., A.V. Schally, C. Gual and A. Arimura. Release of LH and FSH after administration of synthetic LH-releasing hormone. J. Clin. Endocrinol. Metab. 34: 753-756, 1972.

80. Schally, A.V., A.J. Kastin and A. Arimura. FSH-releasing hormone and LH-releasing hormone. In: Vitamins and Hormones. R.S. Harris, P. Munson, E. Diczfalusy and J. Glover, eds., Academic Press, New York, vol. 30, pp. 83-164, 1972.

81. Kastin, A.J. and A.V. Schally. The hypothalamus influences the menstrual cycle. Ob. Gyn. Suppl. to Medical World News, January, pp. 79-80, 1972.

82. Schally, A.V., A.J. Kastin and A. Arimura. The hypothalamus and reproduction. Am. J. Ob. Gyn. 114: 423-442, 1972.

83. Kastin, A.J., A.V. Schally, C. Gual, S. Glick and A. Arimura. Clinical evaluation in men of a substance with growth-hormone releasing activity in rats. J. Clin. Endocrinol. Metab. 35: 326-329, 1972.

14

Page 15: Abba J. Kastin, M.D

84. Plotnikoff, N.P., A.J. Kastin, M.S. Anderson and A.V. Schally. Oxotremorine antagonism by a hypothalamic hormone, melanocyte-stimulating hormone release-inhibiting factor, MIF. Proc. Soc. Exp. Biol. Med. 140: 811-814, 1972.

85. Kastin, A.J., S. Viosca, R.M.G. Nair, A.V. Schally and M.C. Miller. Interactions between pineal, hypothalamus, and pituitary involving melatonin, MSH-release inhibiting factor, and MSH. Endocrinology 91: 1323-1328, 1972.

86. Zarate, A., E. Canales, A.V. Schally, L. Ayala-Valdes and A.J. Kastin. Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatory infertility. Fertil. Steril. 23: 672-674, 1972.

87. Schalch, D.S., D. Gonzalez-Barcena, A.J. Kastin, A.V. Schally and L.A. Lee. Abnormalities in the release of TSH in response to thyrotropin-releasing hormone (TRH) in patients with disorders of the pituitary, hypothalamus, and basal ganglia. J. Clin. Endocrinol. Metab. 35: 609-615, 1972.

88. Nair, R.M.G., A.J. Kastin and A.V. Schally. Isolation and structure of another hypothalamic peptide possessing MSH-release inhibiting activity. Biochem. Biophys. Res. Comm. 47: 1420-1425, 1972.

89. Schally, A.V., A. Arimura and A.J. Kastin. The LH and FSH-releasing hormone. Proc. Symp. 4th International Congress of Endocrinology 273: 93-97, 1972.

90. Kastin, A.J., N.P. Plotnikoff, R.M.G. Nair, T.W. Redding and M.S. Anderson. MIF: Its pituitary and extra-pituitary effects. In: Hypothalamic Hypophysiotropic Hormones: Clinical and Physiological Studies. Excerp. Med. Int. Congr. Series no. 263., Amsterdam, C. Gual and E. Rosemberg, eds., pp. 159-166, 1972.

91. Zarate, A., E.S. Canales, A.V. Schally, A.J. Kastin and J. Soria. Induction of ovulation with synthetic luteinizing hormone-releasing hormone in suspected hypothalamic infertility. In: Hypothalamic Hypophysiotropic Hormones: Clinical and Physiological Studies. Excerp. Med. Int. Congr. Series no. 263., Amsterdam, C. Gual and E. Rosemberg, eds., pp. 251-253, 1972.

92. Gonzalez-Barcena, D., A.J. Kastin, A. Arimura, J.A. Bermudez, D. Lee, J. Ruelas and A.V. Schally. Effects of synthetic LH-RH administered by different routes. In: Hypothalamic Hypophysiotropic Hormones: Clinical and Physiological Studies. Excerp. Med. Int. Congr. Series no. 263., Amsterdam, C. Gual and E. Rosemberg, eds., pp. 291-298, 1972.

93. Bergada, G., R.E. Mancini. O. Vilar, M.A. Rivarola, J.C. Calamera, C. Bianculli, A.V. Schally and A.J. Kastin. Effect of chronic administration of synthetic LH-RH/FSH-RH

15

Page 16: Abba J. Kastin, M.D

on prepubertal boys and in hypogonadotropic hypogonadism. In: Hypothalamic Hypophysiotropic Hormones: Clinical and Physiological Studies. Excerp. Med. Int. Congr. Series no. 263., Amsterdam, C. Gual and E. Rosemberg, eds., pp. 299-301, 1972.

94. Dunn, J.D., A.J. Kastin, A.J. Carrillo and A.V. Schally. Additional evidence for dissociation of MSH and ACTH release. J. Endocrinol. 55: 463-464, 1972.

95. Kastin, A.J., R.H. Ehrensing, D.S. Schalch and M.S. Anderson. Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. Lancet 2: 740-742, 1972.

96. Dempsey, G.L., A.J. Kastin and A.V. Schally. The effects of MSH on a restricted passive avoidance response. Horm. Behav. 3: 333-337, 1972.

97. Nockton, R., A.J. Kastin, S.T. Elder and A.V. Schally. Passive and active avoidance responses at two levels of shock after administration of melanocyte-stimulating hormone. Horm. Behav. 3: 339-344, 1972.

98. Kastin, A.J. and A. Barbeau. Preliminary clinical studies with L-prolyl-L-leucyl-glycine amide in Parkinson's disease. Can. Med. Assoc. J. 107: 1079-1081, 1972.

99. Schally, A.V., A. Arimura and A.J. Kastin. Hypothalamic hormones and fertility. Proc. 3rd European Congress of Sterility, Athens, Greece, pp. 843-848, 1972.

100. Velasco, M., A.J. Kastin and D. Gonzalez-Barcena. Effects of melanocyte-stimulating hormone on the cortical somatic evoked responses in man. Neuropharmacology 11: 395-407, 1972.

101. Kastin, A.J. and A.V. Schally. Assay of MSH-releasing inhibiting factor (MIF). In: Peptide Hormones. S.A. Berson and R.S. Yalow, eds., North Holland Pub. Co., Amsterdam, pp. 422-427, 1973.

102. Schally, A.V., A. Arimura and A.J. Kastin. Hypothalamic releasing and inhibiting hormones. In: Biology Data Book. P.L. Altman and D.S. Dittmer, eds., Vol. 2, pp. 660-661, 1973.

103. Kastin, A.J., D. Gonzalez-Barcena, H. Friesen, L.S. Jacobs, D.S. Schalch, A. Arimura, W.H. Daughaday and A.V. Schally. Unaltered plasma prolactin levels in men after administration of synthetic LH-releasing hormone. J. Clin. Endocrinol. Metab. 36: 375-377, 1973.

104. Redding, T.W., A.J. Kastin, R.M.G. Nair and A.V. Schally. The distribution, half-life, and excretion of 14C and 3H-labeled L-prolyl-L-leucyl-glycinamide in the rat. Neuroendocrinology 11: 92-100, 1973.

16

Page 17: Abba J. Kastin, M.D

105. Arimura, A., M. Saito, Y. Yaoi, T. Kumasaka, H. Kato, T. Koyama, N. Nishi, A.J. Kastin and A.V. Schally. Comparison of the effects of subcutaneous and intravenous injection of synthetic LH-RH on serum LH and FSH levels in men. J. Clin. Endocrinol. Metab. 36: 385-388, 1973.

106. Kastin, A.J., L.H. Miller, R. Nockton, C.A. Sandman, A.V. Schally and L.O. Stratton. Behavioral aspects of MSH. Prog. Brain Res. 39: 461-470, 1973.

107. Plotnikoff, N.P., A.J. Kastin, M.S. Anderson and A.V. Schally. Deserpidine antagonism by a tripeptide, L-prolyl-L-leucylglycinamide. Neuroendocrinology 11: 67-71, 1973.

108. Schally, A.V., A. Arimura and A.J. Kastin. Hypothalamic regulating hormones. Science 179: 341-350, 1973.

109. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, M. Torres-Zamora, E. Perez-Pasten, A. Kato and A.V. Schally. Responses to thyrotropin-releasing hormone in patients with renal failure and after infusion in normal men. J. Clin. Endocrinol. Metab. 36: 117-120, 1973.

110. Schally, A.V., A.J. Kastin, A. Arimura, D. Coy, E. Coy, L. Debeljuk and T.W. Redding. Recent basic and clinical studies with luteinizing hormone-releasing hormone (LH-RH) and its analogues. J. Reprod. Fertil. Suppl. 20: 119-136, 1973.

111. Sandman, C.A., A.J. Kastin, A.V. Schally, J.W. Kendall and L.H. Miller. Neuroendocrine responses to physical and psychological stress. J. Comp. Physiol. Psychol. 84: 386-390, 1973.

112. Zarate, A., A.J. Kastin, J. Soria, E.S. Canales and A.V. Schally. Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in two brothers with hypogonadotropic hypogonadism and anosmia. J. Clin. Endocrinol. Metab. 36: 612-614, 1973.

113. Medeiros-Neto, G.A., S.P.A. Toledo, A.M. Pupo, M. Sucupira, F. Fraige-Filho, E. Mattar, A.J. Kastin and A.V. Schally. Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormonal deficiencies. J. Clin. Endocrinol. Metab. 37: 972-976, 1973.

114. Aldinger, E.E., W.D. Hawley, A.V. Schally and A.J. Kastin. Cardiovascular actions of melanocyte-stimulating hormone (MSH) in the dog. J. Endocrinol. 56: 613-614, 1973.

115. Kastin, A.J., G.D. Beach, W.D. Hawley, J.W. Kendall, M.S. Edwards and A.V. Schally. Dissociation of MSH and ACTH release in man. J. Clin. Endocrinol. Metab. 36: 770-772, 1973.

116. Carillo, A.J., A.J. Kastin, J.D. Dunn and A.V. Schally. MSH activity in plasma and

17

Page 18: Abba J. Kastin, M.D

pituitaries of rats with large hypothalamic lesions. Neuroendocrinology 12: 120-128, 1973.

117. Kastin, A.J., M.C. Miller, L. Ferrell and A.V. Schally. General activity in intact and hypophysectomized rats after administration of melanocyte-stimulating hormone (MSH), melatonin, and Pro-Leu-Gly-NH2. Physiol. Behav. 10: 399-401, 1973.

118. Stratton, L.O. and A.J. Kastin. Melanocyte-stimulating hormone in learning and extinction of two problems. Physiol. Behav. 10: 689-692, 1973.

119. Kastin, A.J., N.P. Plotnikoff, S. Viosca, M.S. Anderson and A.V. Schally. MSH-Release inhibiting factors: recent studies. Yale J. Biol. Med. 46: 617-622, 1973.

120. Nair, R.M.G., T.W. Redding, A.J. Kastin and A.V. Schally. Site of inactivation of MSH release-inhibiting hormone by human plasma. Biochem. Pharmacol. 22: 1915-1919, 1973.

121. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, J.A. Bermudez, D. Lee, A. Arimura, J. Ruelas, I. Zepeda and A.V. Schally. Synthetic LH-releasing hormone (LH-RH) administered to normal men by different routes. J. Clin. Endocrinol. Metab. 37: 481-484, 1973.

122. Kastin, A.J., A. Barbeau, R.H. Ehrensing, N.P. Plotnikoff and A.V. Schally. Melanocyte-stimulating hormone and the hypothalamic hormone which inhibits its release. In: Advances in Neurology. F.W. McDowell and A. Barbeau, eds., Raven Press, New York, Vol. 5, pp. 225-229, 1973.

123. Redding, T.W., A.J. Kastin, D. Gonzalez-Barcena, D.H. Coy, E.J. Coy, D.S. Schalch and A.V. Schally. The half-life, metabolism, and excretion of tritiated luteinizing hormone-releasing hormone (LH-RH) in man. J. Clin. Endocrinol. Metab. 37: 626-631, 1973.

124. Schally, A.V., A. Arimura, A.J. Kastin, T. Uehara, J. Takahara, D.H. Coy and E.J. Coy. Inhibition of the release of growth hormone In vitro by α-melanocyte-stimulating hormone. Biochem. Biophys. Res. Comm. 52: 1314-1319, 1973.

125. Sandman, C.A., W.D. Alexander and A.J. Kastin. Neuroendocrine influences on visual discrimination and reversal learning in the albino and hooded rat. Physiol. Behav. 11: 613-617, 1973.

126. Stratton, L.O., A.J. Kastin and W.P. Coleman. Activity and dark-preference responses of albino and hooded rats receiving MSH. Physiol. Behav. 11: 907-909, 1973.

127. Schally, A.V., A.J. Kastin, A. Arimura, D.H. Coy and J. Vilchez-Martinez. Potential role of hypothalamic hormones in fertility control. In: Regulation of Human Fertility. K.S.

18

Page 19: Abba J. Kastin, M.D

Moghissi and T.N. Evans, eds., Wayne State Univ. Press, pp. 115-131, 1973.

128. Zarate, A., J. Soria, E.S. Canales, A.J. Kastin and A.V. Schally. Pituitary FSH and LH reserve in women with isolated gonadotropin deficiency. Ob. Gyn. 42: 507-510, 1973.

129. Hall, R., G.M. Besser, A.V. Schally, D.H. Coy, D. Evered, D.J. Goldie, A.J. Kastin, A.S. McNeilly, C.H. Mortimer, C. Phenekos, W.M.G. Tunbridge and D. Weightman. Action of growth hormone-release inhibitory hormone in healthy men and acromegalics. Lancet 2: 581-584, 1973.

130. Woolf, P.D., D. Gonzalez-Barcena, D.S. Schalch, L.A. Lee, J.P. Arzac, A.V. Schally and A.J. Kastin. Lack of effect of steroids on thyrotropin-releasing hormone (TRH) mediated thyrotropin (TSH) release. Neuroendocrinology 13: 56-62, 1973-74.

131. Zarate, A., J. Soria, E.S. Canales, A.J. Kastin, A.V. Schally and R. Guzman Toledano. Pituitary response to synthetic luteinizing hormone-releasing hormone in Prader-Willi syndrome, prepubertal and pubertal children. Neuroendocrinology 13: 321-326, 1973-74.

132. Kastin, A.J., S. Viosca and A.V. Schally. Regulation of melanocyte- stimulating hormone release. In: Handbook of Physiology. E. Knobil and W.H. Sawyer, eds., Vol. 4, pp. 551-562, 1974.

133. Kastin, A.J., A.V. Schally, A. Zarate, A. Arimura, D. Gonzalez-Barcena, G. Medeiros-Neto and D.S. Schalch. Analysis of clinical studies with natural and synthetic LH-RH in man. Israel J. Med. Sci. 10: 1305-1310, 1974. Also In: Heterogeneity of Polypeptide Hormones. D. Rabinowitz and J. Roth, eds., Academic Press, New York, p. 123, 1974.

134. Kastin, A.J., A.V. Schally, A. Barbeau and R.H. Ehrensing. Endocrine and extra-endocrine studies of hypothalamic hormones in man. In: Recent Studies of Hypothalamic Function. K. Lederis and K.E. Cooper, eds., Karger, Basel, pp. 196-206, 1974.

135. Brown, G.M., I.V. Uhlir, J. Seggie, A.V. Schally and A.J. Kastin. Effect of septal lesions on plasma levels of MSH, corticosterone, GH, and prolactin before and after exposure to novel environment: role of MSH in the septal syndrome. Endocrinology 94: 583-587, 1974.

136. Schally, A.V., A. Arimura, A.J. Kastin, D.H. Coy, E.J. Coy, J. Vilchez-Martinez, R. Geiger, W. Konig and H. Wissman. Physiological, veterinary, and clinical effects of hypothalamic releasing hormones (RH), especially LH-RH. Pure Appl. Chem. 37: 315-328, 1974.

137. Kastin, A.J., W.D. Hawley, M.C. Miller, A.V. Schally and C. Lancaster. Plasma MSH and cortisol levels in 567 patients with special reference to brain trauma. Endocrinol. Exper. 8: 97-105, 1974.

19

Page 20: Abba J. Kastin, M.D

138. Zarate, A., E.S. Canales, J. Soria, L.S. Jacobs, W.H. Daughaday, A.J. Kastin and A.V. Schally. Gonadotropin and prolactin secretion in human pseudocyesis: effect of synthetic luteinizing hormone-releasing hormone (LH-RH) and thyrotropin releasing hormone (TRH). Ann. Endocrinol. 35: 445-450, 1974.

139. Zarate, A., E.S. Canales, J. Soria, A.J. Kastin, A.V. Schally and A. Gonzalez. Further observations on the therapy of anovulatory sterility with synthetic luteinizing hormone-releasing hormone. Fertil. Steril. 25: 3-10, 1974.

140. Zanartu, J., A. Dabancens, A.J. Kastin and A.V. Schally. Effect of synthetic hypothalamic gonadotropin releasing hormone in anovulatory sterility. Fertil. Steril. 25: 160-169, 1974.

141. Plotnikoff, N.P., F.N. Minard and A.J. Kastin. DOPA potentiation in ablated animals and brain levels of biogenic amines in intact animals after prolyl-leucylglycinamide. Neuroendocrinology 14: 271-279, 1974.

142. Ehrensing, R.H. and A.J. Kastin. Melanocyte-stimulating hormone-release inhibiting hormone as an anti-depressant: a pilot study. Arch. Gen. Psychiat. 30: 63-65, 1974.

143. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch and A.V. Schally. Differential effect of various doses of mestranol on the release of LH and FSH in response to LH-releasing hormone. Fertil. Steril. 25: 439-442, 1974.

144. Kastin, A.J., A.V. Schally, D. Gonzalez-Barcena, D.H. Coy and D.S. Schalch. Clinical comparison of natural LH-RH, synthetic LH-RH and two analogues of LH-RH. J. Clin. Endocrinol. Metab. 38: 801-804, 1974.

145. Kastin, A.J., G.L. Dempsey, B. LeBlanc, K. Dyster-Aas and A.V. Schally. Extinction of an appetitive operant response after administration of MSH. Horm. Behav. 5: 135-139, 1974.

146. Stratton, L.O. and A.J. Kastin. Avoidance learning at two levels of motivation in rats receiving MSH. Horm. Behav. 5: 149-155, 1974.

147. Arimura, A., A.J. Kastin, A.V. Schally, M. Saito, T. Kumasaka, T. Yaoi, N. Nishi and K. Ohkura. Immunoreactive LH-releasing hormone in plasma: midcycle elevation in women. J. Clin. Endocrinol. Metab. 38: 510-513, 1974.

148. Arimura, A., A.J. Kastin, D. Gonzalez-Barcena, G. Siller, R.E. Weaver and A.V. Schally. Disappearance of LH-releasing hormone in man as determined by radioimmunoassay. Clin. Endocrinol. 3: 421-425, 1974.

20

Page 21: Abba J. Kastin, M.D

149. Schally, A.V., A.J. Kastin and A. Arimura. The role of the hypothalamus in reproduction. Ciba Review, pp. 1-2, 1974.

150. Ehrensing, R.H., A.J. Kastin, D.S. Schalch, H. Friesen, R. Vargas and A.V. Schally. Affective state and thyrotropin and prolactin responses after repeated injections of thyrotropin-releasing hormone in depressed patients. Am. J. Psychiat. 131: 714-718, 1974.

151. Besser, G.M., C.H. Mortimer, D. Carr, A.V. Schally, D.H. Coy, D. Evered, A.J. Kastin, W.M.G. Tunbridge, M.O. Thorner and R. Hall. Growth hormone release inhibiting hormone in acromegaly. Brit. Med. J. 1: 352-355, 1974.

152. Gonzalez-Barcena, D., A.J. Kastin, D.H. Coy, S. Glick, D.S. Schalch, L.A. Lee, J.P. Arzac and A.V. Schally. Unaltered plasma GH levels in acromegalics and normal men and women after administration of (pyro)Glu-Ser-Gly-NH2, a proposed GH-releasing hormone. J. Clin. Endocrinol. Metab. 38: 1134-1136, 1974.

153. Kastin, A.J., C. Nissen, T.W. Redding, R.M.G. Nair and A.V. Schally. Delayed disappearance of 14C-labeled-Pro-Leu-Gly-NH2 from the blood of hypophysectomized rats. Neuroendocrinology 16: 36-42, 1974.

154. Mortimer, C.H., D. Carr, T. Lind, S.R. Bloom, C.N. Mallinson, A.V. Schally, W.M.G. Tunbridge, L. Yeomans, D.H. Coy, A.J. Kastin, G.M. Besser and R. Hall. Effects of growth hormone release inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients. Lancet 1: 697-701, 1974.

155. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, M.C. Miller, L. Lee, R. Rivas-Llamas and A.V. Schally. Response to LH-RH in women before and after treatment with prednisone. Int. J. Fertil. 19: 107-110, 1974.

156. Plotnikoff, N.P. and A.J. Kastin. Oxotremorine antagonism by prolyl-leucyl-glycine amide administered by different routes and with several anticholinergics. Pharmacol. Biochem. Behav. 2: 417-419, 1974.

157. Sandman, C.A., W. Beckwith, M.M. Gittis and A.J. Kastin. Melanocyte-stimulating hormone (MSH) and overtraining effects on extradimensional shift (EDS) learning. Physiol. Behav. 13: 163-166, 1974.

158. Redding, T.W., A.J. Kastin, D. Gonzalez-Barcena, D.H. Coy, Y. Hirotsu, J. Ruelas and A.V. Schally. The disappearance, excretion, and metabolism of tritiated prolyl-leucyl-glycinamide in man. Neuroendocrinology 16: 119-126, 1974.

159. Kastin, A.J., A. Arimura, D. Gonzalez-Barcena, D.H. Coy, M.C. Miller, N. Nishi, L. Lee,

21

Page 22: Abba J. Kastin, M.D

H. Duron-Huerta, D.S. Schalch and A.V. Schally. Increased potency of four analogues of LH-releasing hormone in man. Int. J. Fertil. 19: 202-206, 1974.

160. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, M.C. Miller, R. Henriquez-Espinoza and A.V. Schally. Response to LH-RH in men infused with theophylline. Int. J. Fertil. 19: 207-209, 1974.

161. Stone, S.C., F. Jaramillo, A.J. Kastin, A. Arimura, J.R. Vargas, A.V. Schally and R.P. Dickey. Effect of LH-RH on antibody formation, sperm count and plasma levels of gonadotropins and testosterone in normal men. Int. J. Fertil. 19: 192-196, 1974.

162. Plotnikoff, N.P. and A.J. Kastin. Pharmacological studies with a tripeptide, prolyl-leucyl- glycinamide. Arch. Int. Pharm. Therap. 211: 211-224, 1974.

163. Kastin, A.J., A.C. Paulsen, J. Zanartu and S.S.C. Yen. Hypothalamic control of reproduction. Contemp. Ob./Gyn. 3: 143-170, 1974.

164. Plotnikoff, N.P., A.J. Kastin and A.V. Schally. Growth hormone release inhibiting hormone: neuropharmacological studies. Pharmacol. Biochem. Behav. 2: 693-696, 1974.

165. Miller, L.H., A.J. Kastin, C.A. Sandman, M. Fink and W.J. Van Veen. Polypeptide influence on attention, memory, and anxiety in man. Pharmacol. Biochem. Behav. 2: 663-668, 1974.

166. Alford, F.O., S.R. Bloom, J.D.N. Nabarro, R. Hall, G.M. Besser, D.H. Coy, A.J. Kastin and A.V. Schally. Glucagon control of fasting glucose in man. Lancet 2: 974-976, 1974.

167. Besser, G.M., C.H. Mortimer, A.S. McNeilly, M.O. Thorner, G.A. Batistoni, S.R. Bloom, K.W. Kastrup, K.F. Hanssen, R. Hall, D.H. Coy, A.J. Kastin and A.V. Schally. Long term infusion of growth hormone releasing inhibiting hormone in acromegaly: effects on pituitary and pancreatic hormones. Brit. Med. J. 4: 622-627, 1974.

168. Bloom, S.R., C.H. Mortimer, M.O. Thorner, G.M. Besser, R. Hall, A. Gomez-Pan, V.M. Roy, R.C.G. Russell, D.H. Coy, A.J. Kastin and A.V. Schally. Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone. Lancet 2: 1106-1109, 1974.

169. Bermudez, J.A., A.J. Kastin, D.S. Schalch, D. Lee-Benitez, E. Perez-Pasten, D. Gonzalez-Barcena and A.V. Schally. Hormone response to synthetic LH-releasing hormone (LH-RH) in prepubertal, pubertal, and adult human males. Endocr. Res. Comm. 1: 477-493, 1974.

170. Zarate, A., E.S. Canales, J. Soria, A.J. Kastin, A.V. Schally and A. Gonzales. Induction of ovulation with synthetic luteinizing hormone-releasing hormone. In: Recent Progress

22

Page 23: Abba J. Kastin, M.D

in Reproductive Endocrinology. P.G. Crosignani and V.H.T. James, eds., Academic Press, London, pp. 811-826, 1974.

171. Zarate, A., E.S. Canales, A.V. Schally and A.J. Kastin. Clinical applications of synthetic releasing hormones: Utilization for diagnostic purposes. In: Biological and Clinical Aspects of Reproduction. VIII World cong. Fertil. Steril., Buenos Aires, Nov. 3-9, Excerp. Med. Int. Cong. Ser. No. 394, pp. 332-334, 1974.

172. Schally, A.V., A. Arimura, A.J. Kastin, D.H. Coy, E.J. Coy, L. Debeljuk, J. Vilchez-Martinez, T.W. Redding, T. Uehara, J. Takahara and W.H. Carter. Recent advances in the chemistry and physiology of hypothalamic hormones, especially the LH-releasing hormone. In: Some Aspects of Hypothalamic Regulation of Endocrine Functions. P. Franchimont, ed., F.K. Schattauer Verlag, Stuttgart, pp. 5-14, 1975.

173. Kastin, A.J., A. Arimura and A.V. Schally. Contributions of clinical studies with natural LH-RH to subsequent studies with the synthetic hormone. In: Some Aspects of Hypothalamic Regulation of Endocrine Functions. P. Franchimont, ed., F.K. Schattauer Verlag, Stuttgart, pp. 99-103, 1975.

174. Kastin, A.J., N.P. Plotnikoff, C.A. Sandman, M.A. Spirtes, R.M. Kostrzewa, S.M. Paul, L.O. Stratton, L.H. Miller, F. Labrie, A.V. Schally and H. Goldman. The effects of MSH and MIF on the brain. In: Anatomical Neuroendocrinology. W.E. Stumpf and L.D. Grant, eds. Karger, Basel, pp. 290-297, 1975.

175. Dupont, A., A.J. Kastin, F. Labrie, G. Pelletier, R. Puviani and A.V. Schally. Distribution of radioactivity in the organs of the rat and mouse after injection of 125I-α-melanocyte stimulating hormone. J. Endocrinol. 64:237-241, 1975.

176. Dupont, A., F. Labrie, G. Pelletier, R. Puviani, D.H. Coy, A.V. Schally and A.J. Kastin. Distribution of radioactivity in the organs of the rat and mouse after injection of L-[3H]prolyl-leucylglycinamide. J. Endocrinol. 64: 243-248, 1975.

177. Kastin, A.J., C.A. Sandman, L.O. Stratton, A.V. Schally and L.H. Miller. Behavioral and electrographic changes in rat and man after MSH. Prog. Brain Res. 42: 143-150, 1975.

178. Kastin, A.J., N.P. Plotnikoff, R. Hall and A.V. Schally. Hypothalamic hormones and the central nervous system. In: Hypothalamic Hormones, M. Motta, P.G. Crosignani and L. Martini, eds., Academic Press, New York, pp. 261-268, 1975.

179. Soria, J., A. Zarate, E.S. Canales, A. Ayala, A.V. Schally, D.H. Coy, E.J. Coy and A.J. Kastin. Increased and prolonged LH-RH/FSH-RH activity of synthetic [D-Ala-6, des-Gly-NH2]-LH-RH-ethylamide in normal women. Am. J. Ob. Gyn. 123: 145-146, 1975.

180. Gonzalez-Barcena, D., A.J. Kastin, D.H. Coy, D.S. Schalch, M.L. Vasconcelos, A.

23

Page 24: Abba J. Kastin, M.D

Gonzalez-Sanchez and A.V. Schally. Respuesta a la administracion aguda de la hormona hipotalamic inhibidora de la hormona de crecimiento y de un analogo en acromegalia. Arch Invest. Med. 6: 505-512, 1975.

181. Goldman, H., C.A. Sandman, A.J. Kastin and S. Murphy. MSH affects regional perfusion of the brain. Pharmacol. Biochem. Behav. 3: 661-664, 1975.

182. Spirtes, M.A., R.M. Kostrezewa and A.J. Kastin. MSH and MIF-1 effects on serotonin levels and synthesis in various rat brain areas. Pharmacol. Biochem. Behav. 3: 1011-1015, 1975.

183. Stratton, L.O. and A.J. Kastin. Increased acquisition of a complex appetitive task after MSH and MIF. Pharmacol. Biochem. Behav. 3: 901-904, 1975.

184. Sandman, C.A., J.M. George, J.D. Nolan, H. Van Riezen and A.J. Kastin. Enhancement of attention in man with ACTH/MSH 4-10. Physiol. Behav. 15: 427-431, 1975.

185. Kastin, A.J., T.W. Redding, R. Hall, G.M. Besser and A.V. Schally. Lipid mobilizing hormones of the hypothalamus and pituitary. Pharmacol. Biochem. Behav. 3, Suppl. 1: 121-126, 1975.

186. Zarate, A., E.S. Canales, H. Villalobos, J. Soria, L.S. Jacobs, A.J. Kastin and A.V. Schally. Pituitary hormonal reserve in patients presenting hyperprolactinemia, intrasellar masses, and amenorrhea without galactorrhea. J. Clin. Endocrinol. Metab. 40: 1034-1037, 1975.

187. Plotnikoff, N.P. and A.J. Kastin. GH-RIF, LH-RH, TRH, MIF-I, substance P, and angiotensin - central nervous system studies. In: Peptides: Chemistry, Structure and Biology. R. Walter and J. Meienhofer, eds., Ann Arbor Sci. Pub., pp 645-649, 1975.

188. Pelletier, G., F. Labrie, A.J. Kastin, D.H. Coy and A.V. Schally. Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of [3H]L-prolyl-leucylglycinamide. Pharmacol. Biochem. Behav. 3: 675-679, 1975.

189. Pelletier, G., F. Labrie, A.J. Kastin and A.V. Schally. Radioautographic localization of radioactivity in rat brain after intracarotid injection of 125I-α-melanocyte-stimulating hormone. Pharmacol. Biochem. Behav. 3: 671-674, 1975.

190. Plotnikoff, N.P. and A.J. Kastin. Neuropharmacology of hypothalamic releasing factors. Biochem. Pharmacol. 25: 363-365, 1976.

191. Besser, G.M., A.M. Paxton, S.A.N. Johnson, E.J. Moody, C.H. Mortimer, R. Hall, A. Gomez-Pan, A.V. Schally, A.J. Kastin and D.H. Coy. Impairment of platelet function by growth hormone release inhibiting hormone. Lancet 1: 1166, 1975.

24

Page 25: Abba J. Kastin, M.D

192. Gomez-Pan, A., W.M.G. Tunbridge, A. Duns, R. Hall, G.M. Besser, D.H. Coy, A.V. Schally and A.J. Kastin. Hypothalamic hormone interaction in acromegaly. Clin. Endocrin. 4: 455-460, 1975.

193. Kostrzewa, R.M., A.J. Kastin and M.A. Spirtes. α-MSH and MIF-I effects on catecholamine levels and synthesis in various rat brain areas. Pharmacol. Biochem. Behav. 3: 1017-1023, 1975.

194. Carr, D., A. Gomez-Pan, D.R. Weightman, V.C.M. Roy, R. Hall, G.M. Besser, M.O. Thorner, A.S. McNeilly, A.V. Schally, A.J. Kastin and D.H. Coy. Growth hormone-release inhibiting hormone: actions on thyrotropin and prolactin secretion after thyrotropin releasing hormone. Brit. Med. J. 3: 67-69, 1975.

195. Schalch, D.S., D. Gonzalez-Barcena, A.J. Kastin, L. Landa, L.A. Lee, M.T. Zamora and A.V. Schally. Plasma gonadotropins after administration of LH-releasing hormone in patients with renal or hepatic failure. J. Clin. Endocrinol. Metab. 41: 921-925, 1975.

196. Spirtes, M.A., N.P. Plotnikoff and A.J. Kastin. Effects of hypothalamic peptides on the brain. In: CNS and Behavioural Pharmacology. A. Airaksinen, ed., pp. 121-129, 1975.

197. Schally, A.V., A.J. Kastin and A. Arimura. The hypothalamus and reproduction. Am. J. Ob. Gyn. 122: 857-862, 1975.

198. Gonzalez-Barcena, D., A.J. Kastin, M.C. Miller, D.S. Schalch, D.H. Coy, A.V. Schally and A. Escalante-Herrera. Stimulation of LH release after oral administration of an analogue of LH-releasing hormone (LH-RH). Lancet 2: 1126-1128, 1975.

199. Plotnikoff, N.P., W.F. White, A.J. Kastin and A.V. Schally. Gonadotropin releasing hormone (GnRH): neuropharmacological studies. Life Sci. 17: 1685-1692, 1975.

200. Gomez-Pan, A., J.D. Reed, M. Albinus, B. Shaw, R. Hall, G.M. Besser, D.H. Coy, A.J. Kastin and A.V. Schally. Direct inhibition of gastric acid and pepsin secretion by growth-hormone release-inhibiting hormone in cats. Lancet 1: 888-890, 1975.

201. Kastin, A.J., C.A. Sandman and A.V. Schally. Effects of MSH on the brain. In: Unique Properties of Melanocytes, V. Riley, ed., S. Karger, Basel, Vol. 3, pp. 228-236, 1976.

202. Medeiros-Comaru, A.M., J. Rodrigues, L.C. Povoa, S. Franco, T. Dimetz, D.H. Coy, A.J. Kastin and A.V. Schally. Clinical studies with long acting superactive analogs of LH-RH in women with secondary amenorrhea. Int. J. Fertil. 21: 239-245, 1976.

203. Kastin, A.J., A.V. Schally, D. Gonzalez-Barcena, A. Zarate, M. Besser and R. Hall. Clinical studies with hypothalamic peptides. In: Basic Applications and Clinical Uses of

25

Page 26: Abba J. Kastin, M.D

Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopez del Campo, eds., Excerp. Med. Int. Cong. Ser. no. 374: 235-243, 1976.

204. Gonzalez-Barcena, D., A.J. Kastin, A. Escalente-Herrera, A. Gonzalez-Martinez, D.H. Coy and A.V. Schally. Long acting analogues of LH-RH. In: Basic Applications and Clinical Uses of Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopez del Campo, eds., Excerp. Med. Int. Cong. Ser. No. 374: 300-306, 1976.

205. Gomez-Pan, A., R. Hall, G.M. Besser, C.H. Mortimer, A.V. Schally, A.J. Kastin and D.H. Coy. Thyrotropin-releasing hormone: clinical studies. In: Basic Applications and Clinical Uses of Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopez del Campo, eds., Excerp. Med. Int. Cong. Series no. 374: 313-318, 1976.

206. Besser, G.M., R. Hall, C.H. Mortimer, A. Gomez-Pan, A.V. Schally, A.J. Kastin and D.H. Coy. Growth hormone release inhibiting hormone: actions on the pituitary. In: Basic Applications and Clinical Uses of Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopes del Campo, eds., Excerp. Med. Int. Cong. Series no. 374: 343-346, 1976.

207. Hall, R., A. Gomez-Pan, G.M. Besser, C.H. Mortimer, A.V. Schally, A.J. Kastin and D.H. Coy. The extra-pituitary actions of growth hormone-release inhibiting hormone. In: Basic Application and Clinical Uses of Hypothalamic Hormones. A.L. Charro-Salgado, R. Fernandez-Duranzo and J.G. Lopes del Campo, eds. Excerp. Med. Int. Cong. Series no. 374: 347-350, 1976.

208. Kastin, A.J., N.P. Plotnikoff, A.V. Schally and C.A. Sandman. Endocrine and CNS effects of hypothalamic peptides and MSH. In: Reviews of Neuroscience. S. Ehrenpreis and I.J. Kopin, eds., Raven Press, New York, pp. 111-148, 1976.

209. Kastin, A.J., C. Nissen, K. Nikolics, K. Medzihradszky, D.H. Coy, I. Teplan and A.V. Schally. Distribution of [3H]α-MSH in rat brain. Brain Res. Bull. 1: 19-26, 1976.

210. Barbeau, A., M. Roy and A.J. Kastin. Double-blind evaluation of oral L-prolyl- L-leucyl-glycine amide in Parkinson's disease. Can. Med. Assoc. J. 114: 120-122, 1976.

211. Barbeau, A. and A.J. Kastin. Polypeptide therapy in Parkinson's disease - A new approach. In: Advances in Parkinsonism, W. Birkmayer and O. Hornykiewicz, eds., Editiones Roche, Basel, pp. 483-487, 1976.

212. Stratton, L.O. and A.J. Kastin. Melanocyte-stimulating hormone and MSH/ACTH 4-10 reduce tonic immobility in the lizard. Physiol. Behav. 16: 771-774, 1976.

213. Schally, A.V., A.J. Kastin and D.H. Coy. LH-releasing hormone and its analogues: recent basic and clinical investigations. Int. J. Fertil. 21: 1-30, 1976.

26

Page 27: Abba J. Kastin, M.D

214. Cox, B., A.J. Kastin and H. Schnieden. A comparison between a melanocyte-stimulating hormone inhibitory factor (MIF-I) and substances known to activate central dopamine receptors. Eur. J. Pharm. 36:141-147, 1976.

215. Stone, S.C., R.P. Dickey, A.J. Kastin and A.V. Schally. LH-RH and steroid levels in normal ovulatory women. Ob. Gyn. 48: 146-149, 1976.

216. Schally, A.V., D.H. Coy and A.J. Kastin. Physiological and clinical effects of LH releasing hormone (LH-RH) and its analogs. In: Recent Advances in Human Reproduction. A. Campos da Paz, V.A. Drill, M. Hayashi, W. Rodrigues and A.V. Schally, eds. Excerp. Med. Int. Cong. Series no. 107: 73-78, 1976.

217. Zarate, A., A. Ayala, A.V. Schally, A.J. Kastin, E.S. Canales, D.H. Coy and E.J. Coy. The use of long-acting LH-RH analogs in the treatment of female infertility. In: Recent Advances in Human Reproduction. A. Campos da Paz, V.D. Drill, M. Hayashi, W. Rodrigues and A.V. Schally, eds., Excerp. Med. Int. Cong. Ser. No. 370: 106-109, 1976.

218. Forsbach, G., A. Ayala, A. Zarate, E.S. Canales, J. Soria, A.V. Schally, A.J. Kastin, D.H. Coy and E.J. Coy. Long-acting luteinizing hormone-releasing hormone (LH-RH) analogs in the treatment of female infertility. Arch. Invest. Med. 7: 43-48, 1976.

219. Plotnikoff, N.P. and A.J. Kastin. Neuropharmacological tests with α-melanocyte stimulating hormone. Life Sci. 18: 1217-1222, 1976.

220. Schally, A.V., D.H. Coy, A. Arimura, T.W. Redding, C.A. Meyers, J. Vilchez, E. Pedroza, A. Gordin, J. Molnar, A.J. Kastin, F. Labrie, R. Hall, A. Gomez-Pan and G.M. Besser. Structure-activity relationship of hypophysiotropic hormones. Proc. 5th Int. Cong. Endocrin., Excerp. Med. Int. Cong Ser. Vol. 1: 163-167, 1976.

221. Kastin, A.J., C.A. Sandman, L.H. Miller and A.V. Schally. Some questions related to MSH. Mayo Clin. Proc. 51: 632-636, 1976.

222. Kadowitz, P.J., B.M. Chapnick and A.J. Kastin. Comparison of α-MSH and several vasoactive substances on vascular resistance in the feline mesenteric vascular bed. Pharmacol. Biochem. Behav. 5: 219-221, 1976.

223. Beckwith, B.E., C.A. Sandman and A.J. Kastin. Influence of 3 short chain peptides (α-MSH, MSH/ACTH 4-10, MIF-I) on dimensional attention. Pharmacol. Biochem. Behav. 5, Suppl. 1: 11-16, 1976.

224. Miller, L.H., L.C. Harris, H. van Riezen and A.J. Kastin. Neuroheptapeptide influence on attention and memory in man. Pharmacol. Biochem. Behav. 5, Suppl. 1: 17-21, 1976.

27

Page 28: Abba J. Kastin, M.D

225. Sandman, C.A., J. George, B.B. Walker, J.D. Nolan and A.J. Kastin. Neuropeptide MSH/ACTH 4-10 enhances attention in the mentally retarded. Pharmacol. Biochem. Behav. 5, Suppl. 1: 23-28, 1976.

226. Panksepp, J., P. Reilly, P. Bishop, R.B. Meeker, T.R. Vilberg and A.J. Kastin. Effects of α-MSH on motivation, vigilance and brain respiration. Pharmacol. Biochem. Behav. 5, Suppl. 1: 59-64, 1976.

227. Stratton, L.O., C.A. Gibson, K.G. Kolar and A.J. Kastin. Neonatal treatment with TRH affects development, learning, and emotionality in the rat. Pharmacol. Biochem. Behav. 5, Suppl. 1: 65-67, 1976.

228. Ehrensing, R.H. and A.J. Kastin. Clinical investigations for emotional effects of neuropeptide hormones. Pharmacol. Biochem. Behav. 5, Suppl. 1: 89-93, 1976.

229. Christensen, C.W., C.T. Harston, A.J. Kastin, R.M. Kostrzewa and M.A. Spirtes. Investigations on α-MSH and MIF-I effects on cyclic AMP levels in rat brain. Pharmacol. Biochem. Behav. 5, Suppl. 1: 117-120, 1976.

230. Spirtes, M.A., N.P. Plotnikoff, R.M. Kostrzewa, C.T. Harston, A.J. Kastin and C.W. Christensen. Possible association of increased rat behavioral effects and increased striatal dopamine and norepinephrine levels during the DOPA-potentiation test. Pharmacol. Biochem. Behav. 5, Suppl. 1: 121-124, 1976.

231. Kostrzewa, R.M., M.A. Spirtes, J.W. Klara, C.W. Christensen, A.J. Kastin and T.H. Joh. Effects of L-prolyl-L-leucyl-glycine amide (MIF-I) on dopaminergic neurons. Pharmacol. Biochem. Behav. 5, Suppl. 1: 125-127, 1976.

232. Greenberg, R., C.E. Whalley, F. Jourdikian, I.S. Mendelson, K. Nikolics, D.H. Coy, A.V. Schally and A.J. Kastin. Peptides readily penetrate the blood-brain barrier: uptake of peptides by synaptosomes is passive. Pharmacol. Biochem. Behav. 5, Suppl. 1: 151-158, 1976.

233. Barbeau, A., M. Gonce and A.J. Kastin. Neurologically active peptides. Pharmacol. Biochem. Behav. 5, Suppl. 1: 159-163, 1976.

234. Goldman, H., E.B. Skelley, C.A. Sandman, A.J. Kastin and S. Murphy. Hormones and regional brain blood flow. Pharmacol. Biochem. Behav. 5, Suppl. 1: 165-169, 1976.

235. Gonzalez-Barcena, D., A.J. Kastin, D.S. Schalch, D.H. Coy and A.V. Schally. Prolonged elevation of luteinizing hormone (LH) after intranasal administration of an analogue of LH releasing hormone. Fertil. Steril. 27: 1246-1249, 1976.

236. Gomez-Pan, A., M.H. Snow, D.A. Piercy, V. Robson, R. Wilkinson, R. Hall, D.C.

28

Page 29: Abba J. Kastin, M.D

Evered, G.M. Besser, A.V. Schally, A.J. Kastin and D.H. Coy. Actions of growth hormone-release inhibiting hormone (somatostatin) on the renin aldosterone system. J. Clin. Endocrinol. Metab. 43: 240-243, 1976.

237. Kastin, A.J., B. Kuzemchak, R.G. Thompkins, A.V. Schally and M.C. Miller. Melanin in the rat brain. Brain Res. Bull. 1: 567-572, 1976.

238. Kastin, A.J., C. Nissen, A.V. Schally and D.H. Coy. Blood-brain barrier, half-time disappearance, and brain distribution for labeled enkephalin and a potent analog. Brain Res. Bull. 1: 583-589, 1976.

239. Marks, N., F. Stern and A.J. Kastin. Biodegradation of α-MSH and derived peptides by rat brain extracts, and by rat and human serum. Brain Res. Bull 1: 591-593, 1976.

240. Plotnikoff, N.P., A.J. Kastin, D.H. Coy, C.W. Christensen, A.V. Schally and M.A. Spirtes. Neuropharmacological actions of enkephalin after systemic administration. Life Sci. 19: 1283-1288, 1976.

241. Coy, D.H., A.J. Kastin, A.V. Schally, O. Morin, N.G. Caron, F. Labrie, J.M. Walker, R. Fertel, G.G. Berntson and C.A. Sandman. Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalin. Biochem. Biophys. Res. Commun. 73: 632-638, 1976.

242. Dunn, J.D., A.J. Kastin and A.J. Carrillo. Circadian variation in plasma melanocyte stimulating hormone activity in the rat. Int. J. Chronobiol. 4: 163-169, 1976.

243. Kastin, A.J., E.L. Scollan, M.G. King, A.V. Schally and D.H. Coy. Enkephalin and a potent analog facilitate maze performance after intraperitoneal administration in rats. Pharmacol. Biochem. Behav. 5: 691-695, 1976.

244. Schally, A.V. and A.J. Kastin. Hormones of the hypothalamus. La Recherche 7: 36-45, 1976.

245. Zarate, A., E.S. Canales, J. Soria, G. Forsbach, A.J. Kastin and A.V. Schally. Therapeutic use of gonadoliberin (FSH/LH-RH) in women. Fertil. Steril. 27: 1233-1239, 1976. Also In: Modern Trends in Infertility and Conception Control. E.E. Wallach and R.D. Kempers, eds., Williams and Williams Co., Baltimore, p. 203, 1979.

246. Sandman, C.A. and A.J. Kastin. Pituitary peptide influences on attention and memory. In: Neurobiology of Sleep and Memory. R.R. Drucker-Colin and J.L. McGaugh, eds., Academic Press, New York, pp. 347-360, 1977.

247. Kastin, A.J., L.H. Miller, C.A. Sandman, A.V. Schally and N.P. Plotnikoff. CNS and pituitary effects of hypothalamic peptides and MSH. In: Essays in Neurochemistry and

29

Page 30: Abba J. Kastin, M.D

Neuropharmacology. M.B.H. Youdim, W. Lovenberg, O.F. Sharman, J.R. Lagnado, eds., J. Wiley and Sons, New York, pp. 139-176, 1977.

248. Ehrensing, R.H. and A.J. Kastin. TRH: Clinical investigations for nonendocrine actions in man. In: Clinical Neuroendocrinology. L. Martini and G.M. Besser, eds., Academic Press, New York, pp. 133-142, 1977.

249. Kastin, A.J., A. Barbeau, N.P. Plotnikoff, A.V. Schally and R.H. Ehrensing. MIF-I: Actions in man. In: Clinical Neuroendocrinology. L. Martini and G.M. Besser, eds., Academic Press, New York, pp. 393-400, 1977.

250. Sandman, C.A., A.J. Kastin and L.H. Miller. Central nervous system actions of MSH and related pituitary peptides. In: Clinical Neuroendocrinology. L. Martini and G.M. Besser, eds., Academic Press, New York, pp. 443-469, 1977.

251. Sandman, C.A. and A.J. Kastin. Neuropeptide influences on behavior: a possible treatment for disorders of attention. In: Neuroregulation: Hypotheses about Psychiatric Disorders. J. Barchas, D.H. Hamburg and E. Usdin, eds., Oxford Univ. Press, New York, pp. 287-295, 1977.

252. Ehrensing, R.H., A.J. Kastin, P.F. Larson and G.A. Bishop. Melanocyte-stimulating hormone release-inhibiting factor-I and tardive dyskinesia. Dis. Nerv. Sys. 38: 303-307, 1977.

253. Ashton, H., J.E. Millman, R. Telford, J.W. Thompson, T.F. Davies, R. Hall, S. Shuster, A.J. Thody, D.H. Coy and A.J. Kastin. Psychopharmacological and endocrinological effects of melanocyte stimulating hormones in normal man. Psychopharmacology 55: 165-172, 1977.

254. Beckwith, B.E., C.A. Sandman, D. Hothersall and A.J. Kastin. Influence of neonatal injections of α-MSH on learning, memory and attention in rats. Physiol. Behav. 18: 63-71, 1977.

255. Sandman, C.A., J. George, T.R. McCanne, J.D. Nolan, J. Kaswan and A.J. Kastin. MSH/ACTH 4-10 influences behavioral and physiological measures of attention. J. Clin. Endocrinol. Metab. 44: 884-891, 1977.

256. Walker, M.J., G. Berntson, C.A. Sandman, D.H. Coy, A.V. Schally and A.J. Kastin. An analogue of enkephalin having a prolonged opiate-like effect in vivo. Science 196: 85-87, 1977.

257. Schally, A.V., D.H. Coy, A. Arimura, T.W. Redding, A.J. Kastin, J. Vilchez-Martinez, E. Pedroza, A. Gordin, J. Molnar, C.A. Meyers, F. Labrie, R. Hall, D. Reed, A. Gomez-Pan and G.M. Besser. Hypothalamic regulatory hormones and their synthetic analogs. In:

30

Page 31: Abba J. Kastin, M.D

Proceedings of the Vth International Symposium on Medicinal Chemistry, Paris, July 19-22, 1976. J. Mathieu, ed., Elsevier Scientific Pub. Corp., Amsterdam, pp. 1-9, 1977.

258. Beckwith, B.W., R.K. O'Quin, M.S. Petro, A.J. Kastin and C.A. Sandman. The effects of neonatal injections of α-MSH on the open field behavior of juvenile and adult rats. Physiol. Psychol. 5: 295-299, 1977.

259. Coy, D.H., P. Gill, A.J. Kastin, A. Dupont, L. Cusan, F. Labrie, D. Britton and R. Fertel. Synthetic and biological studies on unmodified and modified fragments of human ß-lipotropin with opioid activities. In: Peptides, M. Goodman and J. Meienhoffer, eds., Wiley and Sons, New York, pp. 107-110, 1977.

260. Schally, A.V., A.J. Kastin and A. Arimura. Hypothalamic hormones: the link between brain and body. Am. Sci. 65: 712-719, 1977.

261. Miller, L.H., A.J. Kastin and C.A. Sandman. Psychobiological actions of MSH in man. In: Melanocyte Stimulating Hormone: Control, Chemistry and Effects. Frontiers of Hormone Research, Vol. 4. F.J.H. Tilders, D.F. Swaab and T.B. Greidanus, eds., Karger, Basel, pp. 153-161, 1977.

262. Geiger, R., J. Sandow and A.J. Kastin. Synthesis and properties of (11-serine) α-melanotropin. Hoppe-Seyler's Z. Physiol. Chem. 358: 1475-1481, 1977.

263. Plotnikoff, P.J. and A.J. Kastin. Neuropharmacological review of hypothalamic releasing factors. In: Neuropeptide Influences on the Brain and Behavior. L.H. Miller, C.A. Sandman and A.J. Kastin, eds., Raven Press, New York, pp. 81-107, 1977.

264. Sandman, C.A., L.H. Miller and A.J. Kastin. Introduction: Perspectives on the behavioral effects of the neuropeptides. In: Neuropeptide Influences on the Brain and Behavior. L.H. Miller, C.A. Sandman and A.J. Kastin, eds., Raven Press, New York, pp. 1-9, 1977.

265. Miller, L.H., S.C. Fischer, G.A. Groves, M.E. Rudrauff and A.J. Kastin. MSH/ACTH 4-10 influences on the CAR in human subjects: a negative finding. Pharmacol. Biochem. Behav. 7: 417-419, 1977.

266. Walker, J.M., C.A. Sandman, G.G. Berntson, R.F. McGivern, D.H. Coy and A.J. Kastin. Endorphin analogs with potent and long-lasting analgesic effects. Pharmacol. Biochem. Behav. 7: 543-548, 1977.

267. Gonzalez-Barcena, D., A.J. Kastin, D.H. Coy, K. Nikolics and A.V. Schally. Suppression of gonadotropin release in man by an inhibitory analogue of LH-releasing hormone. Lancet 2: 997-998, 1977.

268. Porter, J.R., A.J. Kastin, G. Pelle-Day and R.G. Tompkins. Regional in vitro uptake of a

31

Page 32: Abba J. Kastin, M.D

synthetic [3H]-labeled-melanin into rat brain. Brain Res. Bull. 2: 401-404, 1977.

269. Grynbaum, A., A.J. Kastin, D.H. Coy and N. Marks. Breakdown of enkephalin and endorphin analogs by brain extracts. Brain Res. Bull. 2: 479-484, 1977.

270. Marks, N., F. Stern, A.J. Kastin and D.H. Coy. Degradation of delta sleep inducing peptide (DSIP) and its analogs by brain extracts. Brain Res. Bull. 2: 491-493, 1977.

271. Schally, A.V., D.H. Coy, A. Arimura, J. Vilchez, T.W. Redding and A.J. Kastin. Survey of the structure synthesis and biological activity of hypothalamic releasing and inhibiting hormones. In: Hypothalamic Hormones - Chemistry, Physiology and Clinical Applications. D. Gupta and W. Voelter, eds., Verlag Chemie, pp. 1-12, 1978.

272. Ehrensing, R.H. and A.J. Kastin. Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-I) in depression. Am. J. Psychiat. 135: 562-566, 1978.

273. Kastin, A.J., C.A. Sandman, A.V. Schally and R.H. Ehrensing. Clinical effects of hypothalamic-pituitary peptides upon the central nervous system. In: Clinical Neuropharmacology. H.L. Klawans, ed., Raven Press, New York. 3: 133-152, 1978.

274. Christensen, C.W., M.A. Spirtes, R.M. Kostrzewa and A.J. Kastin. Neuropharmacological aspects of hypothalamic peptides and alpha-MSH. In: Current Studies of Hypothalamic Factors. Vol. 1 - Hormones. K. Lederis and W.L. Veale, eds., S. Karger, Basel, pp. 182-191, 1978.

275. Sandman, C.A. and A.J. Kastin. A behavioral strategy for the CNS actions of the neuropeptides. In: Current Studies of Hypothalamic Factors. Vol. 2 - Metabolism and Behaviour. W.L. Veale and K. Lederis, eds., S. Karger, Basel, pp. 163-174, 1978.

276. Schally, A.V., D.H. Coy, A. Arimura, T.W. Redding, A.J. Kastin, C. Meyers, J. Seprodi, R. Chang, W.-Y. Huang, K. Chihara, E. Pedroza, J. Vilchez and R. Millar. Hypothalamic peptide hormones and their analogues. In: Pharmacology of the Hypothalamus, B. Cox, I.D. Morris and A.H. Weston, eds., McMillan Press, London, pp. 161-206, 1978.

277. Spirtes, M.A., C.W. Christensen, C.T. Harston and A.J. Kastin. α-MSH and MIF-I effects on cGMP levels in various rat brain regions. Brain Res. 144: 189-193, 1978.

278. Britton, D.R., R. Fertel, D.H. Coy and A.J. Kastin. The effect of enkephalin and endorphin analogs on receptors in the mouse vas deferens. Biochem. Pharm. 27: 2275-2277, 1978.

279. Veith, J.L., C.A. Sandman, J.M. Walker, D.H. Coy and A.J. Kastin. Systemic administration of endorphins selectively alters open field behavior of rats. Physiol. Behav. 20: 539-542, 1978.

32

Page 33: Abba J. Kastin, M.D

280. Kastin, A.J., D.H. Coy, A.V. Schally and L.H. Miller. Peripheral administration of hypothalamic peptides results in CNS changes. Pharmacol. Res. Commun. 10: 293-312, 1978.

281. Kastin, A.J., D.H. Coy, Y. Jacquet, A.V. Schally and N.P. Plotnikoff. CNS effects of somatostatin. Metabolism 27 (Suppl. 1): 1247-1252, 1978.

282. Coy, D.H., A.J. Kastin, M.J. Walker, R.F. McGivern and C.A. Sandman. Increased analgesic activities of a fluorinated and a dimeric analogue of [D-Ala-2]-methionine enkephalinamide. Biochem. Biophys. Res. Commun. 83: 977-983, 1978.

283. Kanade, A., A.E. Ruiz, K. Tornyos, I. Wakabayashi and A.J. Kastin. Panhypopituitarism and anemia secondary to traumatic fracture of the sella turcica. J. Endocrin. Invest. 1: 263-268, 1978.

284. Olson, R.D., A.J. Kastin, G.F. Michell, G.A. Olson, D.H. Coy and D.M. Montalbano. Effects of endorphin and enkephalin analogs on fear habituation in goldfish. Pharmacol. Biochem. Behav. 9: 111-114, 1978.

285. Kostrzewa, R.M., A.J. Kastin and S.K. Sobrian. Potentiation of apomorphine action in rats by L-prolyl-L-leucyl-glycine amide. Pharmacol. Biochem. Behav. 9: 375-378, 1978.

286. Redding, T.W., A.J. Kastin, K. Nikolics, A.V. Schally and D.H. Coy. Disappearance and excretion of labeled α-MSH in man. Pharmacol. Biochem. Behav. 9: 207-212, 1978.

287. Kastin, A.J., E.L. Scollan, R.H. Ehrensing, A.V. Schally and D.H. Coy. Enkephalin and other peptides reduce passiveness. Pharmacol. Biochem. Behav. 9: 515-519, 1978.

288. Olson, R.D., A.J. Kastin, D. Montalbano-Smith, G.A. Olson, D.H. Coy and G.F. Michell. Neuropeptides and the blood-brain barrier in goldfish. Pharmacol. Biochem. Behav. 9: 521-524, 1978.

289. Olson, G.A., R.D. Olson, A.J. Kastin, F.X. Castellanos, M.T. Kneale, D.H. Coy and R.H. Wolf. Behavioral effects of D-Ala2-ß-endorphin in squirrel monkeys. Pharmacol. Biochem. Behav. 9: 687-692, 1978.

290. Kastin, A.J., D.H. Coy, A.V. Schally and C.A. Meyers. Activity of VIP, somatostatin and other peptides in the mouse vas deferens assay. Pharmacol. Biochem. Behav. 9: 673-676, 1978.

291. Sandman, C.A. and A.J. Kastin. Interaction of α-MSH and MIF-I with D-amphetamine on open-field behavior of rats. Pharmacol. Biochem. Behav. 9: 759-762, 1978.

33

Page 34: Abba J. Kastin, M.D

292. Kastin, A.J. CNS actions of various hypothalamic-pituitary peptides in animals and man. Neurosci. Res. Prog. Bull. 16: 328-332, 1978.

293. Kastin, A.J., C.A. Sandman, N.P. Plotnikoff, D.H. Coy, R.D. Olson, A.V. Schally and L.H. Miller. Central nervous system effects of MSH and hypothalamic peptides. In: Clinical Psychoneuroendocrinology in Reproduction. L. Carenza, P. Pancheri and L. Zichella, eds., Academic Press, New York, pp. 47-56, 1978.

294. Panksepp, J., T. Vilberg, N.J. Bean, D.H. Coy and A.J. Kastin. Reduction of distress vocalization in chicks by opiate-like peptides. Brain Res. Bull 3: 663-667, 1978.

295. Marks, N., A.J. Kastin, F. Stern and D.H. Coy. Metabolism of potent enkephalin analogs (FK 33-823, D-Ala2, pentafluorophenylalanine-4-enkephalinamide and a dimer of D-Ala2- enkephalin) and D-amino acid substituted derivatives of human ß-endorphin. Brain Res. Bull. 3: 687-690, 1978.

296. Kastin, A.J., C. Nissen, A.V. Schally and D.H. Coy. Radioimmunoassay of DSIP-like material in rat brain. Brain Res. Bull 3: 691-695, 1978.

297. Coy, D.H., A.J. Kastin and N.P. Plotnikoff. Etudes biologiques faites avec les encephalines, les endorphins et leurs analogues. Ann. Anesth. Franc. 19: 373-378, 1978.

298. Schally, A.V., A. Arimura, D.H. Coy, A.J. Kastin, C.A. Meyers, T.W. Redding, K. Chihara, W.Y. Huang, R.C.C. Chang, E. Pedroza and J. Vilchez-Martinez. Hypothalamic hormones regulating pituitary (and other) functions: their physiology and biochemistry as well as recent studies with their synthetic analogues. In: Central Regulation of the Endocrine System. K. Fuxe, T. Hokfelt and R. Luft, eds., Plenum Press, New York, pp. 9-29, 1978.

299. Kastin, A.J., D.H. Coy, R.D. Olson, J. Panksepp, A.V. Schally and C.A. Sandman. Behavioral effects of the brain opiates enkephalin and endorphin. In: Central Nervous System Effects of Hypothalamic Hormones and Other Peptides. R. Collu, A. Barbeau, J.R. Ducharme, J.-G. Rochefort, eds., Raven Press, New York, pp. 273-281, 1979.

300. Schally, A.V., A.M. Medeiros-Comaru and A.J. Kastin. Hormonas hipothalamicas y su aplicacion en la pratica medica. Tribuna Medica 16: 2, 1979.

301. Kastin, A.J., R.D. Olson, A.V. Schally and D.H. Coy. CNS effects of peripherally administered brain peptides. Life Sci. 25: 401-414, 1979.

302. Schally, A.V., D.H. Coy, C.A. Meyers and A.J. Kastin. Hypothalamic peptide hormones: Basic and clinical studies. In: Hormonal Proteins and Peptides. C.H. Li, ed., Academic Press, New York, pp. 1-54, 1979.

34

Page 35: Abba J. Kastin, M.D

303. Wass, J.A.H., G.M. Besser, A. Gomez-Pan, M.F. Scanlon, R. Hall, A.J. Kastin, D.H. Coy and A.V. Schally. Comparison of long-acting analogues of luteinizing hormone releasing hormone in man. Clin. Endocrinol. 10: 419-430, 1979.

304. Kostrzewa, R.M., J.C. Hardin, R.L. Snell, A.J. Kastin, D.H. Coy and F. Bymaster. MIF-I and postsynaptic receptor sites for dopamine. Brain Res. Bull. 4: 657-662, 1979.

305. Olson, G.A., R.D. Olson, A.J. Kastin, M.T. Green, R. Roig-Smith, C.W. Hill and D.H. Coy. Effects of an enkephalin analog on complex learning in the rhesus monkey. Pharmacol. Biochem. Behav. 11: 341-345, 1979.

306. King, M.G., A.J. Kastin, R.D. Olson and D.H. Coy. Systemic administration of Met-enkephalin, [D-Ala2]-Met-enkephalin, ß-endorphin, and [D-Ala2]-ß-endorphin: effects on eating, drinking, and activity measures in rats. Pharmacol. Biochem. Behav. 11: 407-411, 1979.

307. Sandman, C.A., R.F. McGivern, C. Berka, M. Walker, D.H. Coy and A.J. Kastin. Neonatal administration of ß-endorphin produces “chronic” insensitivity to thermal stimuli. Life Sci. 25: 1755-1760, 1979.

308. Kastin, A.J., B. Kuzemchak, A.V. Schally and M.W. Eggert. Rat brain melanin at different ages and after various treatments. Brain Res. Bull. 4: 793-797, 1979.

309. Olson, R.D., A.J. Kastin, G.J. LaHoste, G.A. Olson and D.H. Coy. Possible non-narcotic component to action of opiate peptides on tonic immobility. Pharmacol. Biochem. Behav. 11: 705-708, 1979.

310. Kastin, A.J., M.T. Jemison and D.H. Coy. Analgesia after peripheral administration of enkephalin and endorphin analogues. Pharmacol. Biochem. Behav. 11: 713-716, 1979.

311. Kastin, A.J., C. Nissen, A.V. Schally and D.H. Coy. Additional evidence that small amounts of a peptide can cross the blood-brain barrier. Pharmacol. Biochem. Behav. 11: 717-719, 1979.

312. Kastin, A.J., R.D. Olson, R.H. Ehrensing, M.C. Berzas, A.V. Schally and D.H. Coy. MIF-I's differential actions as an opiate antagonist. Pharmacol. Biochem. Behav. 11: 721-723, 1979.

313. King, B.M., F.X. Castellanos, A.J. Kastin, M.C. Berzas, M.D. Mauk, G.A. Olson and R.D. Olson. Naloxone-induced supression of food intake in normal and hypothalamic obese rats. Pharmacol. Biochem. Behav. 11: 729-732, 1979.

314. Nance, D.W., D.H. Coy and A.J. Kastin. Experiments with a proposed anorexigenic tripeptide: pyro-Glu-His-Gly-OH. Pharmacol. Biochem. Behav. 11: 733-735, 1979.

35

Page 36: Abba J. Kastin, M.D

315. Kostrzewa, R.M., Fukushima, H., C.T. Hartson, K.W. Perry, R.W. Fuller and A.J. Kastin. Striatal dopamine turnover and MIF-I. Brain Res. Bull. 4: 799-802, 1979.

316. Huang, W.Y., R.C.C. Chang, A.J. Kastin, D.H. Coy and A.V. Schally. Isolation and structure of pro-methionine-enkephalin, a new potential enkephalin precursor from porcine hypothalami. Proc. Natl. Acad. Sci. 76: 6177-6180, 1979.

317. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiates: through 1978. Neurosci. Biobehav. Rev. 3: 285-299, 1979.

318. Schally, A.V., A.M. Comaru-Schally, J. Zadina and A.J. Kastin. LH-RH and its stimulatory and inhibitory analogues: clinical studies. In: Psychoneuroendocrinology in Reproduction. L. Zichella and P. Pancheri, eds., Elsevier Press, Amsterdam, pp. 9-18, 1979.

319. Kastin, A.J., R.H. Ehrensing, D.H. Coy, A.V. Schally and R.M. Kostrzewa. Behavioral effects of brain peptides, including LH-RH. In: Psychoneuroendocrinology in Reproduction. L. Zichella and P. Pancheri, eds., Elsevier Press, Amsterdam, pp. 69-80, 1979.

320. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. The opioid neuropeptides enkephalin and endorphin and their hypothesized relation to pain. In: Pain: Meaning and Management. W.L. Smith, S.C. Gross and H. Merskey, eds., Spectrum Pub., New York, p. 21, 1980.

321. Schally, A.V., T.W. Redding, R.C.C. Chang, A. Arimura, W.Y. Huang, D.H. Coy, C.A. Meyers, E. Pedroza, A.J. Kastin and C. Turkelson. Chemistry and physiology of hypothalamic hormones. In: Polypeptide Hormones. R.F. Beers, Jr. and E.G. Bassett, eds., Raven Press, New York, pp. 169-184, 1980.

322. Kastin, A.J., J.E. Zadina, D.H. Coy, A.V. Schally and C.A. Sandman. Hypothalamic peptides affect behavior after systemic injection. In: Polypeptide Hormones. R.F. Beers, Jr. and E.G. Bassett, eds., Raven Press, New York, pp. 223-234, 1980.

323. Olson, R.D., A.J. Kastin, G.A. Olson and D.H. Coy. Behavioral effects after systemic injection of opiate peptides. Psychoneuroendocrinology 5: 47-52, 1980.

324. Kastin, A.J., R.H. Ehrensing, R.D. Olson, A.V. Schally and D.H. Coy. Neurological effects of MIF-I, MSH, and opiate peptides in clinical studies. Int. J. Neurol. 14: 205-209, 1980.

325. Kastin, A.J., A.V. Schally and R.M. Kostrzewa. Possible aminergic mediation of MSH release and of the CNS effects of MSH and MIF-I. Fed. Proc. 39: 2931-2936, 1980.

36

Page 37: Abba J. Kastin, M.D

326. Kastin, A.J., L.A. Wade, D.H. Coy, A.V. Schally and R.D. Olson. Peptides and the blood-brain barrier. In: Brain and Pituitary Peptides. W. Wuttke, A. Weindl, K.H. Voigt and R.R. Dries, eds., Munich, Karger, pp. 71-78, 1980.

327. Kastin, A.J., G.A. Olson, C.A. Sandman, D.H. Coy, A.V. Schally and R.D. Olson. Brain opiates affect behavior after systemic injection. In: Growth Hormone and Other Biologically Active Peptides. A. Pecile and E.E. Muller, eds., Excerpta Med., Amsterdam, pp. 201-206, 1980.

328. Miller, L.H., G.A. Groves, M.J. Bopp and A.J. Kastin. A neuroheptapeptide influence on cognitive functioning in the elderly. Peptides 1: 55-57, 1980.

329. O'Steen, W.K. and A.J. Kastin. Relationship of melanocyte-stimulating hormone to photoreceptor damage. Peptides 1: 19-22, 1980.

330. Yehuda, S., J. Zadina, A.J. Kastin and D.H. Coy. D-amphetamine-induced hypothermia and hypermotility in rats: changes after systemic administration of ß-endorphin. Peptides 1: 179-185, 1980.

331. Mauk, M.D., G.A. Olson, A.J. Kastin and R.D. Olson. Behavioral effects of LH-RH. Neurosci. Biobehav. Rev. 4: 1-8, 1980.

332. LaHoste, G.J., G.A. Olson, A.J. Kastin and R.D. Olson. Behavioral effects of melanocyte stimulating hormone. Neurosci. Biobehav. Rev. 4: 9-16, 1980.

333. Yehuda, S., A.J. Kastin and D.H. Coy. Antagonistic actions of MIF-I on the hypothermia and hypomotility induced by ß-endorphin or morphine. Int. J. Neurosci. 11: 317-320, 1980.

334. Ehrensing, R.H. and A.J. Kastin. Effects of MIF-I and TRH on the brain. In: Hormones and the Brain. D. de Wied and P.A. van Keep, eds., MIP Press, Lancaster, pp. 155-165, 1980.

335. Kastin, A.J., G.A. Olson, A.V. Schally and D.H. Coy. DSIP-More than a sleep peptide? Trends Neurosci. 3: 163-165, 1980.

336. Hanker, J.P., J. Knippenberg, A.J. Kastin, E.J. Wickings, A.V. Schally, D.H. Coy and H.P.G. Schneider. Gonadotropin release during repeated administration of D-Leu6 des Gly10- LH-RH-EA at different stages of the menstrual cycle and in functional amenorrhea. Int. J. Fertil. 25: 7-17, 1980.

337. Davis, K.L., A.J. Kastin, B.A. Beilstein and A.L. Vento. MSH and MIF-I in animal models of tardive dyskinesia. Pharmacol. Biochem. Behav. 13: 37-40, 1980.

37

Page 38: Abba J. Kastin, M.D

338. Coy, D.H. and A.J. Kastin. Tyrosine-modified analogs of methionine-enkephalin and their effects on the mouse vas deferens. Peptides 1: 175-177, 1980.

339. Schally, A.V., R.C.C. Chang, W.-Y. Huang, D.H. Coy, A.J. Kastin and T.W. Redding. Isolation, structure, biological characterization, and synthesis of ß-[Tyr9] melanotropin-(9-18) decapeptide from pig hypothalami. Proc. Natl. Acad. Sci.USA 77: 3947-3951, 1980.

340. Schally, A.V., A.M. Comaru-Schally and A.J. Kastin. Present status of the use of LH-RH and its analogs in the diagnosis and therapy of infertility. In: The LH Releasing Hormone. C. Beling and A. Wentz, eds., Masson Pub. Co., New York, pp. 1-13, 1980.

341. Kastin, A.J. and A.V. Schally. Early clinical studies with LH-RH. In: The LH Releasing Hormone. C. Beling and A. Wentz, eds., Masson Pub. Co., New York, pp.15-20, 1980.

342. Yehuda, S. and A.J. Kastin. Interaction of MIF-I or α-MSH with D-amphetamine or chlorpromazine on thermoregulation and motor activity of rats maintained at different ambient temperatures. Peptides 1: 243-248, 1980.

343. Yehuda, S., A.J. Kastin and D.H. Coy. Thermoregulatory and locomotor effects of DSIP: paradoxical interaction with D-amphetamine. Pharmacol. Biochem. Behav. 13: 895-900, 1980.

344. Yehuda, S. and A.J. Kastin. Peptides and thermoregulation. Neurosci. Biobehav. Rev. 4: 459-471, 1980.

345. Sandman, C.A., B.E. Beckwith and A.J. Kastin. Are learning and attention related to the sequence of amino acids in ACTH/MSH peptides? Peptides 1: 277-280, 1980.

346. Kastin, A.J., R.M. Kostrzewa, A.V. Schally and D.H. Coy. Neonatal administration of Met-enkephalin facilitates maze performance of adult rats. Pharmacol. Biochem. Behav. 13: 883-886, 1980.

347. Coy, D.H. and A.J. Kastin. Structure-CNS activity studies with the enkephalins. Pharmacol. Ther. 10: 657-668, 1980.

348. Kastin, A.J., M.D. Mauk, A.V. Schally and D.H. Coy. Unusual dose-related effect of an endorphin analog in a complex maze. Physiol. Behav. 25: 959-962, 1980.

349. Kastin, A.J., D.H. Coy, A.V. Schally and J.E. Zadina. Dissociation of effects of LH-RH analogs on pituitary regulation and reproductive behavior. Pharmacol. Biochem. Behav. 13: 913-914, 1980.

38

Page 39: Abba J. Kastin, M.D

350. Kastin, A.J., S.P. Lawrence and D.H. Coy. Radioimmunoassay of MIF-1/Tyr-MIF-1-like material in rat pineal. Pharmacol. Biochem. Behav. 13: 901-905, 1980.

351. Kastin, A.J., C. Nissen, J.E. Zadina, A.V. Schally and R.H. Ehrensing. Naloxone-like actions of MIF-1 do not require the presence of the pituitary. Pharmacol. Biochem. Behav. 13: 907-912, 1980.

352. Kastin, A.J., A. Arimura, D. Gonzalez-Barcena, J. Fishback, A.V. Schally and D.H. Coy. Dynamics of injected somatostatin in blood of patients with hepatic failure and acromegaly. Peptides 1: 257-259, 1980.

353. McGivern, R.F., J.M. Harris, N. Yessaian, A.J. Kastin, D.H. Coy, C.A. Sandman and E.P. Noble. Antagonism of ethanol induced sleep-time by α-MSH, MSH/ACTH 4-10 and naloxone. Substance and Alcohol Actions/Misuse 1: 335-342, 1980.

354. LaHoste, G.J., R.D. Olson, G.A. Olson and A.J. Kastin. Effects of pavlovian conditioning and MIF-1 on the development of morphine tolerance in rats. Pharmacol. Biochem. Behav. 13: 799-804, 1980.

355. Olson, R.D., A.J. Kastin, T.K. von Almen, D.H. Coy and G.A. Olson. Systemic injections of gastro-intestinal peptides alter behavior in rats. Peptides 1: 383-385, 1980.

356. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiates: 1979. Peptides 1: 365-379, 1980.

357. Olson, R.D., A.J. Kastin, G.A. Olson, B.M. King, T.K. von Almen, M.C. Berzas, M.L. Ibanez and D.H. Coy. MIF-1 suppresses deprivation-induced fluid consumption in rats. Peptides 1: 353-357, 1980.

358. Gonzalez-Barcena, D., H. Trevino Ortiz, F. Gordon, A.J. Kastin, D.H. Coy and A.V. Schally. Influence of LH-RH agonists and antagonists on gonadotropin release in humans. Int. J. Fertil. 25: 185-189, 1980.

359. Canales, E.S., H. Montvelinsky, A. Zarate, A.J. Kastin, D.H. Coy and A.V. Schally.Suppressive effect of an inhibitory LHRH analog on the gonadotropin release to LHRH in normal women. Int. J. Fertil. 25: 190-192, 1980.

360. Canales, E.S., H. Montvelinsky, MA. E. Fonseca, A. Zarate, A.J. Kastin, D.H. Coy and A.V. Schally. The use of a potent stimulatory LHRH analog (D-Trp-6, LHRH) in the induction of ovulation. Int. J. Fertil. 25: 193-197, 1980.

361. Kastin, A.J., J.E. Zadina and A.V. Schally. Foundations of the clinical use of LHRH: early studies with the porcine hypothalamic Hormone. Materia Medical Polona 12: 33, 1980.

39

Page 40: Abba J. Kastin, M.D

362. Hudson, R., A. King, G. Singer, A. Tucker, D.H. Coy and A.J. Kastin. Schedule-induced self-injection of enkephalin and heroin by the rat. In: Problems in Pain. C. Peck and M. Wallace, eds., Pergamon Press, pp. 73-77, 1980.

363. Meyers, C.A., A.J. Kastin, A.V. Schally and D.H. Coy. Use of the mouse vas deferens assay to evaluate the action of somatostatin peptides on gastric acid secretion. Digestion 21: 21-24, 1981.

364. Kastin, A.J., R.D. Olson, E. Fritschka and D.H. Coy. Neuropeptides and the blood-brain barrier. In: Cerebral Microcirculation and Metabolism. J. Cervos-Navarro and E. Fritschka, eds., Raven Press, New York, pp. 139-145, 1981.

365. Walker, J.M., G.G. Berntson, C.A. Sandman and A.J. Kastin. Induction of analgesia by central administration of Org 2766, an analog of ACTH 4-9. Eur. J. Pharm. 69: 71-79, 1981.

366. Sandman, C.A. and A.J. Kastin. Intraventricular administration of MSH induces hyperalgesia in rats. Peptides 2: 231-233, 1981.

367. Ehrensing, R.H., A.J. Kastin and A.V. Schally. Behavioral and hormonal effects of prolonged high doses of LHRH in male impotency. Peptides 2, Suppl. 1: 115-121, 1981.

368. Kastin, A.J., W.A. Banks, N. Marks and R.D. Olson. Dissociative effects of CNS peptides with some unusual applications of RIA. In: Physiological Peptides and New Trends in Radioimmunology. Ch. A. Bixollon, ed., Elsevier, Amsterdam, pp. 89-99, 1981.

369. Sandman, C.A., A.J. Kastin and A.V. Schally. Neuropeptide influences on the central nervous system: A psychobiological perspective. In: Neuroendocrine Regulation and Altered Behaviour. P.D. Hrdina and R.L. Singhal, eds., Croom Helm Ltd., pp. 4-27, 1981.

370. Olson, R.D., A.J. Kastin, G.A. Olson and D.H. Coy. Behavioural modulation by systemic administration of enkephalins and endorphins. In: Neuroendocrine Regulation and Altered Behaviour. P.D. Hrdina and R.L. Singhal, eds., Croom Helm Ltd., pp. 142-150, 1981.

371. Kastin, A.J., G.A. Olson, C.A. Sandman and R.E. Ehrensing. Possible role of peptides in senile dementia. In: Strategies for the Development of an Effective Treatment for Senile Dementia. T. Crook and S. Gershon, eds., Mark Powley Associates, pp. 139, 1981.

372. Kastin, A.J., R.D. Olson, C.A. Sandman, A.V. Schally and D.H. Coy. Multiple independent actions of neuropeptides on behavior. In: Endogenous Peptides and Learning

40

Page 41: Abba J. Kastin, M.D

and Memory Processes. J.L. Martinez, R.A. Jensen, R.B. Messing, H. Rigter and J.L. McGaugh, eds., Academic Press, New York, pp. 563-577, 1981.

373. Sandman, C.A. and A.J. Kastin. The influence of fragments of the LPH chains on learning, memory and attention in animals and man. Pharmacol. Ther. 13: 39-60, 1981.

374. Sankar, R., F.R. Domer and A.J. Kastin. Selective effects of α-MSH and MIF-1 on the blood-brain barrier. Peptides 2: 345-347, 1981.

375. Miller, L.H., A.J. Kastin, M. Hayes, A. Sterste, J. Garcia and D.H. Coy. Inverse relationship between onset and duration of EEG effects of six peripherally administered peptides. Pharmacol. Biochem. Behav. 15: 845-848, 1981.

376. Olson, R.D., R.C. Fernandez, A.J. Kastin, G.A. Olson, S.W. Delatte, T.K. von Almen, D.G. Erickson, D.C. Hastings and D.H. Coy. Low doses of naloxone and MIF-1 peptides increase fluid consumption in rats. Pharmacol. Biochem. Behav. 15: 921-924, 1981.

377. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiates: 1980. Peptides 2: 349-369, 1981.

378. Kastin, A.J., L.C. Honour and D.H. Coy. Kyotorphins affect aversive pecking in chicks. Physiol. Behav. 27: 1073-1076, 1981.

379. Kastin, A.J., C. Nissen and D.H. Coy. DSIP-like immunoreactivity in the developing rat brain. Brain Res. Bull. 7: 687-690, 1981.

380. Kastin, A.J., P.F. Castellanos, W.A. Banks and D.H. Coy. Radioimmunoassay of DSIP-like material in human blood: possible protein binding. Pharmacol. Biochem. Behav. 15: 969-974, 1981.

381. Kastin, A.J., C. Nissen and D.H. Coy. Permeability of the blood-brain barrier to DSIP peptides. Pharmacol. Biochem. Behav. 15: 955-959, 1981.

382. Kastin, A.J., S.P. Lawrence and D.H. Coy. Radioimmunoassayable N-Tyr-MIF-1-like activity in rat brain is increased by pinealectomy. Brain Res. Bull. 7: 697-702, 1981.

383. Kastin, A.J., L.C. Honour and D.H. Coy. Effects of MIF-1 and three related peptides on reserpine-induced hypothermia in mice. Pharmacol. Biochem. Behav. 15: 983-985, 1981.

384. Moldow, R.L., A.J. Kastin, C.S. Hollander, D.H. Coy and C.A. Sandman. Brain ß-endorphin-like immunoreactivity in adult rats given ß-endorphin neonatally. Brain Res. Bull. 7: 683-686, 1981.

385. Luciano, M.G., J.E. Zadina, A.J. Kastin and D.H. Coy. Mu and delta opiate receptors in

41

Page 42: Abba J. Kastin, M.D

rat brain are affected by GTP but not by MIF-1. Brain Res. Bull. 7: 677-682, 1981.

386. Zadina, J.E., A.J. Kastin, L.A. Fabre and D.H. Coy. Facilitation of sexual receptivity in the rat by an ovulation-inhibiting analog of LHRH. Pharmacol. Biochem. Behav. 15: 961-964, 1981.

387. Sander, G.E., T.D. Giles, A.J. Kastin, A.C. Quiroz, A. Kaneish and D.H. Coy. Cardiopulmonary pharmacology of enkephalins in the conscious dog. Peptides 2: 403-407, 1981.

388. Davis, B.M., G.M. Brown, M. Miller, H.G. Friesen, A.J. Kastin and D.L. Davis. Effects of cholinergic stimulation on pituitary hormone release. Psychoneuroendocrinology 7: 347-354, 1982.

389. Kastin, A.J., R.D. Olson, C.A. Sandman, D.H. Coy, J.E. Zadina and R.H. Ehrensing. CNS actions of peripherally administered peptides: some unresolved issues. In: Changing Concepts of the Nervous System. A.R. Morrison and P.L. Strick, eds., Academic Press, New York, pp. 757-768, 1982.

390. Olson, R.D., A.J. Kastin, G.A. Olson and D.H. Coy. Central nervous system effects after systemic injection of opiate peptides. In: Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications. N.S. Shah and A.G. Donald, eds., Plenum Press, pp. 6l-74, l982.

391. Olson, G.A., A.J. Kastin, D.H. Coy and R.D. Olson. Systemic injections of enkephalins and endorphins alter behavior. In: Analgesia by Peridural and Spinal Opiates. A.L. Cools and G.M.M. Nijhuis, eds., pp. 63-73, 1982.

392. Kastin, A.J., D.H. Coy, A.V. Schally and R.D. Olson. Dissociative actions of peptides on the brain. In: Functional Regulation at the Cellular and Molecular Levels. R.A. Corradino, ed., Elsevier, pp. 91-103, 1982.

393. Sander, G., T. Giles, A. Kastin, A. Kaneish and D. Coy. Leucine-enkephalin: reversal of intrinsic cardiovascular stimulation by pentobarbital. Eur. J. Pharmacal. 78: 467, 1982.

394. Ehrensing, R.H. and A.J. Kastin. MIF-1 and regulation of the hypothalamic-pituitary-

adrenocortical system in depression. In: Biological Markers in Psychiatry and Neurology. E. Usdin and I. Handin, eds., Pergamon Press, New York, pp. 299-305, 1982.

395. Clarkson, D.B., B.M. King, R.C. Hemmer, G.A. Olson, A.J. Kastin and R.D. Olson. Naloxone decreases consumption of liquid and solid sucrose in vagotomized rats. Physiol. Behav. 29: 927-930, 1982.

396. Ehrensing, R.H., G.F. Michell and A.J. Kastin. Similar antagonism of morphine analgesia

42

Page 43: Abba J. Kastin, M.D

by MIF-1 and naloxone in Carassius auratus. Pharmacol. Biochem. Behav. 17: 757-761, 1982.

397. Banks, W.A., A.J. Kastin and D.H. Coy. Delta sleep-inducing peptide crosses the blood-brain-barrier in dogs: some correlations with protein binding. Pharmacol. Biochem. Behav. 17: 1009-1014, 1982.

398. Kastin, A.J., C. Nissen and R.D. Olson. Failure of MIF-1 or naloxone to reverse ischemic- induced neurologic deficits in gerbils. Pharmacol. Biochem. Behav. 17: 1083-1085, 1982.

399. Kastin, A.J., W.A. Banks, P.F. Castellanos, C. Nissen and D.H. Coy. Differential penetration of DSIP peptides into rat brain. Pharmacol. Biochem. Behav. l7: 1187-l191, l982.

400. Zadina, J.E., A.J. Kastin, E.F. Krieg and D.H. Coy. Characterization of binding sites for N-Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) in rat brain. Pharmacol. Biochem. Behav. l7: 1193-1198, l982.

401. Kastin, A.J. and L.A. Fabre. Limitations to effect of α-MSH on permeability of blood-brain barrier to IV 99mTc-pertechnetate. Pharmacol. Biochem. Behav. l7:1199-1201, l982.

402. Kastin, A.J., L.C. Honour, J. Sueiras-Diaz and D.H. Coy. Opposite effects of CRF and ACTH on reserpine-induced hypothermia. Pharmacol. Biochem. Behav. l7: l203-l206, l982.

403. Hemmer, R.C., G.A. Olson, A.J. Kastin, J.H. McLean and R.D. Olson. Effects of naloxone and its quaternary form on fluid consumption in rats. Pharmacol. Biochem. Behav. l7: l287-l290, l982.

404. Sander, G.E., A.J. Kastin and T.D. Giles. MIF-1 does not act like naloxone in antagonizing the cardiovascular activity of leucine-enkephalin in the conscious dog. Pharmacol. Biochem. Behav. 17: l301-l303, l982.

405. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiates: l981. Peptides 3: l039-l072, l982.

406. Kastin, A.J., A.V. Schally, G.A. Olson and D.H. Coy. Early questions involving hypothalamic peptides. In: The Anterior Pituitary Gland. A.S. Bhatnagar, ed., Raven Press, pp. 55-59, l983.

407. Kastin, A.J., W.A. Banks, J.E. Zadina and M. Graf. Brain peptides: the dangers of constricted nomenclatures. Life Sci. 32: 295-30l, l983.

43

Page 44: Abba J. Kastin, M.D

408. Kastin, A.J. and C.A. Sandman. Possible role of peptides in mental retardation. In: Curative Aspects of Mental Retardation: Biomedical and Behavioral Advances. F.J. Menolascino, R. Neman, J.A. Stark, eds. Paul H. Brookes Publishing Co., Inc. pp. l47-l64, l983.

409. Banks, W.A., A.J. Kastin and D.H. Coy. Delta sleep-inducing peptide (DSIP)-like material is absorbed by the gastrointestinal tract of the neonatal rat. Life Sci 33: l587-l597, l983.

410. Kastin, A.J., H. Vaudry, J.E. Zadina and R.D. Olson. MIF-l, Tyr-MIF-l, and MSH: control of MSH release and extra-pigmentary effects. Amer. Zool. 25: 55l-558, l983.

411. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: l982. Peptides 4: 563-576, l983.

412. Tonon, M.C., P. Leroux, P. Saulot, H. Vaudry, D.H. Coy and A.J. Kastin. Effect of Tyr-Pro-Leu-Gly-NH2 on melanotropin-stimulating hormone release in the frog and rat. Gen. Comp. Endocrinol. 52: l7-22, l983.

4l3. Banks, W.A. and A.J. Kastin. Aluminium increases permeability of the blood-brain barrier to labelled DSIP and ß-endorphin: possible implications for senile and dialysis demenita. Lancet pp. l227-l229, l983.

4l4. Banks, W.A. and A.J. Kastin. CSF-plasma relationships for DSIP and some other neuropeptides. Pharmacol. Biochem. Behav. l9: l037-l040, l983.

4l5. Hayashi, T., A.J. Kastin, D.H. Coy and R.D. Olson. Tyr-MIF-l affects passive avoidance behavior but not motor activity in rats. Brain Res. Bull. ll: 659-662, l983.

4l6. Olson, G.A., R.D. Olson, A.J. Kastin and D.H. Coy. Endogenous opiate systems may modulate learning and memory. In: Psychoneuroendocrine Dysfunction. N.S. Shah and A.G. Donald, eds., Plenum Press, pp. 279-292, l984.

4l7. Kastin, A.J., R.D. Olson, G.A. Olson and D.H. Coy. Effects of hypothalamic peptides on behavior. In: The Hypothalamus. J.R. Givens, ed. Year Book Medical Publisher, Inc., pp. 29l-301, l984.

4l8. Feldman, S.C. and A.J. Kastin. Localization of neurons containing immunoreactive delta sleep-inducing peptide in the rat brain: an immunocytochemical study. Neuroscience 11: 303-3l8, l984.

4l9. Marks, N., M.J. Berg, A.J. Kastin and D.H. Coy. Evidence for conversion of N-Tyr-MIF-l into MIF-l by a specific brain aminopeptidase. Neurochem. Int. 6: 347-353, l984.

44

Page 45: Abba J. Kastin, M.D

420. Graf, M.V. and A.J. Kastin. Delta-sleep-inducing peptide (DSIP): a review. Neurosci. Biobehav. Rev. 8: 83-93, l984.

421. Kastin, A.J., J.E. Zadina, W.A. Banks and M.V. Graf. Misleading concepts in the field of brain peptides. Peptides 5 (Suppl. 1): 249-253, l984.

422. Banks, W.A., A.J. Kastin, E.G. Biglieri and A.E. Ruiz. Primary adrenal hyperplasia: a new subset of primary hyperaldosteronism. J. Clin. Endocrinol. Metab. 58: 783-785, l984.

423. Banks, W.A., A.J. Kastin and D.H. Coy. Evidence that [125I]N-Tyr-delta sleep-inducing peptide crosses the blood-brain barrier by a non-competitive mechanism. Brain Res. 30l: 20l-207, l984.

424. Graf, M.V., C.A. Hunter and A.J. Kastin. Presence of delta-sleep-inducing peptide-like material in human milk. J. Clin. Endocrinol. Metab. 59: l27-l32, l984.

425. Graf, M.V., A.J. Kastin., D.H. Coy and J.E. Zadina. DSIP reduces amphetamine-induced hyperthermia in mice. Physiol. Behav. 33: 29l-295 l984.

426. Vilberg, T.R., J. Panksepp, A.J. Kastin and D.H. Coy. The pharmacology of endorphin modulation of chick distress vocalization. Peptides 5:823-827, l984.

427. Kastin, A.J., G.A. Olson, J.E. Zadina and R.D. Olson. Disparate effects of peripherally administrated endorphins and enkephalins in laboratory animals. In: Central and Peripheral Endorphins. E.E. Muller and A.R. Genazzani, eds., Raven Press, New York, pp. 99-l08, l984.

428. Graf, M.V. and A.J. Kastin. DSIP-like material exists in peripheral organs of rats in large dissociable forms. Proc. Soc. Exp. Biol. Med. l77: l97-204, l984.

429. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: l983. Peptides 5: 975-992, l984.

430. Fischman, A.J., A.J. Kastin and M.V. Graf. HPLC shadowing: artifacts in peptide characterization monitored by RIA. Peptides 5: l007-l0l0, l984.

431. Graf, M.V., A.J. Kastin and A.J. Fischman. DSIP occurs in free forms in mammalian plasma, human CSF, and urine. Pharmacol. Biochem. Behav. 21: 76l-766, l984.

432. Kastin, A.J., J. Dickson and A.J. Fischman. DSIP-like material in brain parts of rats running a complex maze. Physiol. Behav. 33: 427-431, l984.

433. Fischman, A.J., A.J. Kastin and M.V. Graf. Circadian variation of DSIP-like material in

45

Page 46: Abba J. Kastin, M.D

rat plasma. Life Sci. 35: 2079-2084, l984.

434. Kastin, A.J., D.A. Abel, R.H. Ehrensing, D.H. Coy and M.V. Graf. Tyr-MIF-l and MIF-l are active in the water wheel test for antidepressant drugs. Pharmacol. Biochem. Behav., 21: 767-771, l984.

435. Hayashi, T., A.F. Fischman, A.J. Kastin and D.H. Coy. Some analogs of Tyr-MIF-l affect passive avoidance behavior but not motor activity in rats. Pharmacol. Biochem. Behav. 21: 809-812, l984.

436. Kastin, A.J., E. Stephens, R.H. Ehrensing and A.J. Fischman. Tyr-MIF-l acts as an opiate antagonist in the tail-flick test. Pharmacol. Biochem. Behav. 21: 937-941, l984.

437. Banks, W.A. and A.J. Kastin. A brain-to-blood carrier-mediated transport system for small, N-tyrosinated peptides. Pharmacol. Biochem. Behav. 21: 943-946, l984.

438. Kastin, A.J., P.F. Castellanos, A.J. Fischman, J.K. Proffitt and M.V. Graf. Evidence for peptide aggregation. Pharmacol. Biochem. Behav. 21: 969-973, l984.

439. Ehrensing, R.H., A.J. Kastin and G.F. Michell. Antagonism of morphine analgesia by prolyl-leucyl-glycinamide (MIF-l) in humans. Pharmacol. Biochem. Behav. 21: 975-978, l984.

440. Zadina, J.E. and A.J. Kastin. A rapid filtration method for receptor binding: characterization with mu and delta opiate receptors. Pharmacol. Biochem. Behav. 21: 947-95l, l984.

441. Feldman, S.C. and A.J. Kastin. The distribution of neurons containing delta sleep-inducing peptide in the hippocampal formation. Brain Res. Bull. l3: 833-837, l984.

442. Graf, M.V., A.J. Kastin and G.A. Schoenenberger. Delta-sleep inducing peptide and two of its analogs reduce nocturnal increase of N-acetyltransferase activity in rat pineal gland. J. Neurochem. 44: 629-632, l985.

443. Banks, W.A. and A.J. Kastin. Aluminum alters the permeability of the blood-barrier to some non-peptides. Neuropharmacology. 24: 407-412, l985.

444. Graf, M.V., A.J. Kastin and A.J. Fischman. Interaction of arginine vasopressin and corticotropin releasing factor demonstrated with an improved bioassay. Proc. Soc. Exp. Biol. Med. l79: 303-308, l985.

445. Kastin, A.J., J.E. Zadina, C.A. Sandman and R.D. Olson. Perinatal injections of opiate and other peptides exert long-term effects. In: Endorphins, Neuroregulators and Behaviour in Human Reproduction. P. Pancheri, L. Zichella and P. Falaschi, eds.,

46

Page 47: Abba J. Kastin, M.D

Excerpta Med. (Amsterdam) Cur. Clin. Prac. Ser. 26: 16-22, l985.

446. Banks, W.A. and A.J. Kastin. The aluminum-induced increase in blood-brain barrier permeability to delta-sleep inducing peptide occurs throughout the brain and is independent of phosphorus and acetylcholinesterase levels. Psychopharmacology 86: 84-89, l985.

447. Graf, M.V., A.J. Kastin, D.H. Coy, A.J. Fischman. Delta-sleep-inducing peptide reduces CRF-induced corticosterone release. Neuroendocrinology 4l: 353-356, l985.

448. Banks, W.A. and A.J. Kastin. Peptides and the blood-brain barrier: lipophilicity as a predictor of permeability. Brain Res. Bull. l5: 287-292, l985.

449. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: l984. Peptides 6: 769-79l, l985.

450. Banks, W.A., A.J. Kastin and J.K. Selznick. Modulation of immunoactive levels of DSIP and blood-brain barrier permeability by lighting and diurnal rhythm. J. Neurosci. Res. l4: 347-355, l985.

451. Banks, W.A., A.J. Kastin and E.A. Michals. Transport of thyroxine across the blood-brain barrier is directed primarily from brain to blood in the mouse. Life Sci. 37: 2407-2414, l985.

452. Zadina, J.E. and A.J. Kastin. Interactions between the antiopiate Tyr-MIF-l and the mu opiate morphiceptin at their respective binding sites in brain. Peptides 6: 965-970, l985.

453. Kastin, A.J., E. Stephens, J.E. Zadina, D.H. Coy and A.J. Fischman. Tyr-MIF-l, identified in brain tissue, and its analogs are active in two models of antinociception. Pharmacol. Biochem. Behav. 23: l045-l049, l985.

454. Olson, G.A., S.W. Delatte, A.J. Kastin, J.H. McLean, D.F. Phillpott and R.D. Olson. Naloxone and fluid consumption in rats: Dose-response relationships for l5 days. Pharmacol. Biochem. Behav. 23: l065-l068, l985.

455. Banks, W.A. and A.J. Kastin. Aging and the blood-brain barrier: changes in the carrier-mediated transport of peptides in rats. Neurosci. Lett. 6l: l7l-l75, l985.

456. Zadina, J.E., A.J. Kastin, D.H. Coy and B.A. Adinoff. Developmental, behavioral, and opiate receptor changes after prenatal or postnatal β-endorphin, CRF, or Tyr-MIF-l. Psychoneuroendocrinology l0: 367-383, l985.

457. Banks, W.A. and A.J. Kastin. Permeability of the blood-brain barrier to neuropeptides: the case for penetration. Psychoneuroendocrinology l0: 385-399, l985.

47

Page 48: Abba J. Kastin, M.D

458. Graf, M.V., A.J. Kastin and A.J. Fischman. The natural occurrence and some extra-sleep effects of DSIP. In: Endogenous Sleep Substances and Sleep Regulation. S. Inoue and A.A. Borbely, eds., Japan Scientific Societies Press, Tokyo: VNU Science Press BV Utrecht, The Netherlands, pp. 155-l65, l985.

459. Galina, Z.H. and A.J. Kastin. MIF-l antagonizes warm-, but not cold-water stress-induced analgesia: dissociation from immobility. Peptides 6: 1109-1112, l985.

460. Olson, G.A., M.F. Pignatiello, A.J. Kastin, B.F. Geiger and R.D. Olson. Lesions in ventromedial hypothalamus or amygdala do not affect naloxone's suppression of water consumption. Physiol. Behav. 36: 967-970, l986.

461. Coy, D.H. and A.J. Kastin. Structure-CNS activity studies with the enkephalins. In: Neuropeptides and Behavior. D. de Wied, W.H. Gispen and Tj.B. van Wimersma Greidanus, eds., Pergamon Press, Oxford, pp. 385-396, l986.

462. Miller, L.H., B.A. Turnbull, A.J. Kastin and D.H. Coy. Sleep-wave activity of a delta sleep-inducing peptide analog correlates with its penetrance of the blood-brain barrier. Sleep 9: 80-84, l986.

463. Kastin, A.J., T.D. Giles and J.C. Dickson. Immunoreactive plasma concentrations of an endogenous antiopiate are higher in spontaneously hypertensive rats than in Wistar-Kyoto rats. Hypertension 8: l98-202, l986.

464. Kastin, A.J., R.H. Ehrensing, C. Hara and D.H. Coy. Parallel behavioral and EEG studies of the CNS effects of MSH in animals and humans. In: Central Actions of ACTH and Related Peptides. D. de Wied and W. Ferrarri, eds., Liviana Press, Padova, pp. l47-l52, l986.

465. Graf, M.V., A.J. Kastin and G.A. Schoenenberger. Delta sleep-inducing peptide in spontaneously hypertensive rats. Pharmacol. Biochem. Behav. 24: l797-l799, l986.

466. Hara, C. and A.J. Kastin. Acute administration of MIF-l or Tyr-MIF-l inhibits haloperidol- induced catalepsy in rats. Pharmacol. Biochem. Behav. 24: l785-l787, l986.

467. Banks, W.A. and A.J. Kastin. Aging, peptides, and the blood-brain barrier: implications and speculations. In: Treatment Development Strategies for Alzheimer's Disease. T. Crook, R. Bartus, S. Ferris and S. Gershon, eds., pp. 245-265, l986.

468. Zadina, J.E., W.A. Banks and A.J. Kastin. Central nervous system effects of peptides, l980-l985: a cross-listing of peptides and their central actions from the first six years of the journal Peptides. Peptides 7: 497-537, l986.

48

Page 49: Abba J. Kastin, M.D

469. Zadina, J.E. and A.J. Kastin. Neonatal peptides affect developing rats: β-endorphin alters nociception and opiate receptors, corticotropin-releasing factor alters corticosterone. Devel. Brain Res. 29: 2l-30, l986.

470. Banks, W.A., A.J. Kastin, D.H. Coy and E. Angulo. Entry of DSIP peptides into dog CSF: Role of physicochemical and pharmacokinetic parameters. Brain Res. Bull. 17: 155-158, l986.

471. Hara, C. and A.J. Kastin. Biphasic effects of MIF-1 and Tyr-MIF-1 on apomorphine-induced sterotypy in rats. Pharmacol. Biochem. Behav. 25: 757-761, 1986.

472. Banks, W.A., A.J. Kastin, A.J. Fischman, D.H. Coy and S.L. Strauss. Carrier-mediated transport of enkephalins and N-Tyr-MIF-1 across blood-brain barrier. Am. J. Physiol. 251: E477-E482, 1986.

473. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1985. Peptides 7: 907-933, 1986.

474. Galina, Z.H. and A.J. Kastin. Minireview: Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1. Life Sci. 39: 2153-2159, 1986.

475. Pretorius H.T., A.J. Kastin and W.A. Banks. Binding of Tyr-MIF-1 to isolated brain capillaries. Brain Res. Bull. 17: 829-831, 1986.

476. Zadina, J.E. and A. J. Kastin. Interactions of Tyr-MIF-1 at opiate receptor sites. Pharmacol. Biochem. Behav. 25: 1303-1305, 1986.

477. Graf, M.V. and A. J. Kastin. Delta sleep-inducing peptide (DSIP): an update. Peptides 7: 1165-1187, 1986.

478. Banks, W.A. and A. J. Kastin. Modulation of the carrier-mediated transport of the Tyr-MIF-1 across the blood-brain barrier by essential amino acids. J. Pharmacol Exp. Ther. 239: 668-672, 1986.

479. Zadina, J.E. and A.J. Kastin. Multi-independent actions of peptides in the brain: LHRH, MIF-1 and CRF. Amer. Zool. 26: 951-964, 1986.

480. Kastin, A.J., R.D. Olson, J.E. Zadina and W.A. Banks. Relationship of clinical to basic research with peptides as illustrated by MSH. In: Neural and Endocrine Peptides and Receptors. T.W. Moody, ed., Plenum Press, New York, pp. 645-652, 1986.

481. Moldow, R.L., A.J. Kastin, M. Graf and A. J. Fischman. Stress mediated changes in hypothalamic corticotropin releasing factor-like immunoreactivity. Life Sci. 40: 413-418, 1987.

49

Page 50: Abba J. Kastin, M.D

482. Sandman, C.A. and A.J. Kastin. Behavioral actions of ACTH and related peptides. In: Hormonal Proteins and Peptides. C.H. Li, ed., Academic Press, Inc., Orlando, pp. 147-171, 1987.

483. Kastin, A.J., Z.H. Galina, A. Horvath and R.D. Olson. Some principles in the peptide field. J. Allergy Clin. Immunol. 79: 6-11, 1987.

484. Kastin, A.J. and J.C. Dickson. Hypophysectomy increases Tyr-MIF-1-like immunoreactivity in rat plasma. Neuroendocrinology 45: 177-181, 1987.

485. Galina, Z.H. and A.J. Kastin. Tyr-MIF-1 attenuates antinociceptive responses induced by three models of stress-analgesia. Br. J. Pharmacol. 90: 669-674, 1987.

486. Zadina, J.E., A.J. Kastin, P.K. Manasco, M.F. Pignatiello and K.L. Nastiuk. Long-term hyperalgesia by neonatal ß-endorphin and morphiceptin is blocked by neonatal Tyr-MIF-1. Brain Res. 409: 10-18, 1987.

487. Kastin, A.J., R.H. Ehrensing, W.A. Banks and J.E. Zadina. Possible therapeutic implications of the effects of some peptides in the brain. Prog. Brain Res. 72: 223-234, 1987.

488. Kastin, A.J., J.E. Zadina, R.H. Ehrensing and D. Schwartzenburg. MIF-1 and Tyr-MIF-1 can act differently from amitriptyline in an animal modelof depression. New Trends Exp. Clin. Psychiat. 3: 49-58, 1987.

489. Banks, W.A. and A.J. Kastin. Saturable transport of peptides across the blood-brain barrier. Life Sci. 41: 1319-1338, 1987.

490. Kastin, A.J. and R.D. Olson. Melanocyte-stimulating hormone (MSH). In: Encyclopedia of Neuroscience. G. Adelman, ed., Birkhauser Inc., Boston, pp. 622-623, 1987.

491. Kastin, A.J. and R.H. Ehrensing. Neuropeptides, MIF-1/Tyr-MIF-1. In: Encyclopedia of Neuroscience. G. Adelman, ed., Birkhauser Inc., Boston, pp. 838-839, 1987.

492. Kastin, A.J. and J.E. Zadina. Peptides, multiple independent actions. In: Encyclopedia of Neuroscience. G. Adelman, ed., Birkhauser Inc., Boston, pp. 936-937, 1987.

493. Kastin, A.J. and W.A. Banks. Peptides and the blood-brain barrier. In: Encyclopedia of Neuroscience. G. Adelman, ed., Birkhauser, Inc., Boston, pp. 937-938, 1987.

494. Kastin, A.J. and M.V. Graf. Delta sleep-inducing peptide (DSIP). In: Encyclopedia of Neuroscience. G. Adelman, ed., Birkhauser, Inc., Boston, pp. 1106-1107, 1987.

50

Page 51: Abba J. Kastin, M.D

495. Miller, L.G. and A.J. Kastin. MIF-1 and Tyr-MIF-1 augment GABA-stimulated benzodiazepine receptor binding. Peptides 8: 751-755, 1987.

496. Banks, W.A., A.J. Kastin and E.A. Michals. Tyr-MIF-1 and met-enkephalin share a saturable blood-brain barrier transport system. Peptides 8: 899-903, 1987.

497. Miller, L.G., A.J. Kastin and D.J. Greenblatt. Tyr-MIF-1 augments benzodiazepine receptor binding in vivo. Pharmacol. Biochem. Behav. 28: 521-524, 1987.

498. Banks, W.A., A.J. Kastin, A. Horvath and E.A. Michals. Carrier-mediated transport of vasopressin across the blood-brain barrier of the mouse. J. Neurosci. Res. 18: 326-332, 1987.

499. Barrera, C.M., A.J. Kastin and W.A. Banks. D-[Ala1]-peptide T-amide is transported from blood to brain by a saturable system. Brain Res. Bull. 19: 629-633, 1987.

500. Miller, L.G., A.J. Kastin and R.B. Roy. Effects of Tyr-MIF-1 and MIF-1 at the GABAA

receptor chloride channel site. Brain Res. Bull. 19: 743-745, 1987.

501. Strimas, J.H., D.S. Chi and A.J. Kastin. Brain peptide reverses effect of morphine on human lymphocytes. Peptides 8: 1165-1167, 1987.

502. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1986. Peptides 8: 1135-1164, 1987.

503. Galina, Z.H. and A.J. Kastin. Differential activity of the endogenous antiopiate Tyr-MIF-1 after various intensities of stress. Neurosci. Lett. 84: 312-316, 1988.

504. Banks, W.A., A.J. Kastin and B.J. Nager. Analgesia and the blood-brain barrier transport system for Tyr-MIF-1/enkephalins: evidence for a dissociation. Neuropharmacology 27: 175-179, 1988.

505. Banks, W.A., A.J. Kastin and M.B. Fasold. Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium, and albumin. J. Pharmacol. Exp. Ther. 244: 579-585, 1988.

506. Banks, W.A. and A.J. Kastin. Peptides and the senescent blood-brain barrier. Neurobiol. Aging 9: 48-49, 1988.

507. Fischman, A.J., A.J. Kastin, M.V. Graf and R.L. Moldow. Constant light and dark affect the circadian rhythm of the hypothalamic-pituitary-adrenal axis. Neuroendocrinology 47: 309-316, 1988.

508. Banks, W.A. and A.J. Kastin. Twenty-one hormones fail to inhibit the brain to blood

51

Page 52: Abba J. Kastin, M.D

transport system for Tyr-MIF-1 and the enkephalins in mice. J. Pharm. Pharmacol. 40: 289-291, 1988.

509. Iyer, K.S., G.A. Marks, A.J. Kastin and S.M. McCann. Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat. Proc. Nat. Acad. Sci. USA 85: 3653-3656, 1988.

510. Banks, W.A. and A.J. Kastin. Interactions between the blood-brain barrier and endogenous peptides: Emerging clinical implications. Am. J. Med. Sci. 31: 459-465, 1988.

511. Kastin, A.J., J.E. Zadina, G.A. Olson and W.A. Banks. Considerations regarding some peptides involved in biorhythms, reproduction, stress, and pineal function. In: Biorhythms and Stress in the Physiopathology of Reproduction. P. Pancheri and L. Zichella, eds., Hemisphere Publishing Corporation, New York, pp. 11-19, 1988.

512. Zadina, J.E. and A.J. Kastin. Developmental and long-term effects of perinatal stress and peptides released during stress. In: Biorhythms and Stress in the Physiopathology of Reproduction. P. Pancheri and L. Zichella, eds., Hemisphere Publishing Corporation, New York, pp. 485-491, 1988.

513. Pulvirenti, L. and A.J. Kastin. Blockade of brain dopamine receptors antagonizes the anti- immobility effect of MIF-1 and Tyr-MIF-1 in rats. Eur. J. Pharmacol. 151: 289-292, 1988.

514. Graf, M., A.J. Fischman, A.J. Kastin and R.L. Moldow. Circadian variation in response to CRF-41 and AVP. Am. J. Physiol. 255: E265-E271, 1988.

515. Banks, W.A., A.J. Kastin, C.M. Barrera and D.A. Durham. Movement of peptides between the blood and the central nervous system: a brief perspective. European Conference Biotechnology; Scientific, Technical and Challenges: Verona, Italy, pp. 135-140, 1988.

516. Banks, W.A. and A.J. Kastin. Peptides and the blood brain barrier: penetration and modulating influences. In: Peptide and Amino Acid Transport Mechanisms in the Central Nervous System. L. Rakic, D.J. Begley, H. Davson and B.V. Zlokovic, eds., Stockton/MacMillan Press, New York, pp. 21-32, 1988.

517. Pulvirenti, L. and A.J. Kastin. Naloxone, but not Tyr-MIF-1, reduces volitional ethanol drinking in rats: correlation with degree of spontaneous preference. Pharmacol. Biochem. Behav. 31: 129-134, 1988.

518. Miller, L.G., A.J. Kastin, R.B. Roy, A. Gaver, A.J. Fischman and A. Horvath. Structural specificity of MIF-1 and Tyr-MIF-1 in augmenting GABA-stimulated benzodiazepine

52

Page 53: Abba J. Kastin, M.D

receptor binding. Res. Commun. Chem. Pathol. Pharmacol. 62: 365-368, 1988.

519. Banks, W.A., T.L. Trentman, A.J. Kastin and Z.H. Galina. The general anesthesia induced by various drugs differentially affects analgesia and its variability. Pharmacol. Biochem. Behav. 31: 397-403, 1988.

520. Banks. W.A., A.J. Kastin, M.B. Fasold, C.M. Barrera and G. Augereau. Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier. Brain Res. Bull. 21: 881-885, 1988.

521. Pulvirenti, L. and A.J. Kastin. MIF-1 reduces stress-induced eating in rats. New Trends Exp. Clin. Psychiat. 4: 229-233, 1988.

522. Banks, W.A., A.J. Kastin, T.L. Trentman, H.S. Haynes, B.G. Johnson and Z.H. Galina. Mediation of serotonin-induced analgesia by the 5HT2 receptor in the pentobarbital anesthetized mouse model. Brain Res. Bull. 21: 887-891, 1988.

523. Horvath, A. and A.J. Kastin. Isolation of tyrosine-melanocyte-stimulating hormone release-inhibiting factor 1 from bovine brain tissue. J. Biol. Chem. 264: 2175-2179, 1989.

524. Beckwith, B.E. and A.J. Kastin. Central actions of melanocyte- stimulating hormone (MSH). In: Peptide Hormones: Effects and Mechanisms of Action. A.N. Vilar and P.M. Conn, eds., CRC Press, 1: 195-218, 1989.

525. Zadina, J.E., A.J. Kastin, L.J. Ge, H. Gulden and K.J. Bungart. Chronic, but not acute, administration of morphine alters antiopiate (Tyr-MIF-1) binding sites in rat brain. Life Sci. 44: 555-561, 1989.

526. Banks, W.A. and A.J. Kastin. Inhibition of the brain to blood transport system for enkephalins and Tyr-MIF-1 in mice addicted or genetically predisposed to drinking ethanol. Alcohol. 6: 53-57, 1989.

527. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1987. Peptides 10: 205-236, 1989.

528. Kostrzewa, R.M., T.G. White, J.E. Zadina and A.J. Kastin. MIF-1 attenuates apomorphine stereotypies in adult rats after neonatal 6-hydroxydopamine. Eur. J. Pharmacol. 163: 33-42, 1989.

529. Pignatiello, M.F., G.A. Olson, A.J. Kastin, R.H. Ehrensing, J.H. McLean and R.D. Olson. MIF-1 is active in a chronic stress animal model of depression. Pharmacol. Biochem. Behav. 32: 737-742, 1989.

530. Banks, W.A. and A.J. Kastin. Effect of neurotransmitters on the system that transports

53

Page 54: Abba J. Kastin, M.D

Tyr-MIF-1 and the enkephalins across the blood-brain barrier: a dominant role for serotonin. Psychopharmacology. 98: 380-385, 1989.

531. Kastin, A.J., L.G. Miller and D.S. Schwartzenburg. MIF-1 and Tyr-MIF-1 fail to alter benzodiazepine-induced hypothermia. Pharmacol. Biochem. Behav. 33: 261-263, 1989.

532. Banks, W.A. and A.J. Kastin. Aluminum-induced neurotoxicity: alterations in membrane function at the blood-brain barrier. Neurosci. Biobehav. Rev. 13: 47-53, 1989.

533. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1988. Peptides 10: 1253-1280, 1989.

534. Banks, W.A., A.J. Kastin and D.A. Durham. Bidirectional transport of interleukin-1 alpha across the blood-brain barrier. Brain Res. Bull. 23: 433-437, 1989.

535. Barrera, C.M., W.A. Banks and A.J. Kastin. Passage of Tyr-MIF-1 from blood to brain. Brain Res. Bull. 23: 439-442, 1989.

536. Kastin, A.J., D. Schwartzenburg, L. Tsui, L.G. Miller, G.A. Olson and R.D. Olson. Differential effects of Tyr-MIF-1 and naloxone in two animal models involving benzodiazepine. Brain Res. Bull. 23: 443-446, 1989.

537. Chi, D.S., J.H. Strimas and A.J. Kastin. In vitro studies of Tyr-MIF-1 with human lymphocytes. Brain Res. Bull. 23: 549-552, 1989.

538. Banks, W.A. and A.J. Kastin. Quantifying carrier-mediated transport of peptide from the brain to the blood. Methods Enzymol. P. M. Conn, ed., Academic Press, San Diego, 168: 652-660, 1989.

539. Miller, L.G., A.J. Kastin and R.B. Roy. MIF-1 and Tyr-MIF-1 augment muscimol- stimulated chloride uptake in cerebral cortex. Brain Res. Bull. 23: 413-415, 1989.

540. Zadina, J.E., A.J. Kastin and L.-J. Ge. Tyr-MIF-1 binding in brain is not altered by ligands selective for the GABAA/benzodiazepine receptor. Neurosci. Lett. 110: 143-147, 1990.

541. Kastin, A.J., W.A. Banks and J.E. Zadina. Hormones and messenger peptides in normal brain function. In: Principles and Practice of Endocrinology and Metabolism. K.L. Becker, ed., J.B. Lippincott Co., Philadelphia, pp. 1474-1479, 1990.

542. Kastin, A.J., W.A. Banks and J.E. Zadina. A decade of changing perceptions about neuropeptides. Ann. NY Acad. Sci. 579: 1-7, 1990.

543. Banks, W.A. and A.J. Kastin.Editorial Review: Peptide transport systems for opiates

54

Page 55: Abba J. Kastin, M.D

across the blood-brain barrier. Am. J. Physiol. 259: E1-E10, 1990.

544. Sandman, C.A. and A.J. Kastin. Neuropeptide modulation of development and behavior: implications for psychopathology. In: Application of Basic Neuroscience to Child Psychiatry. S.I. Deutsch, A. Weizman and R.Weizman, ed., Plenum Press, New York, pp. 101-124, 1990.

545. Zadina, J.E., S.L. Chang, L.-J. Ge, A.J. Kastin and R.E. Harlan. Downregulation of mu opiate receptors by morphine and presence of Tyr-MIF-1 binding sites in SH-SY5Y human neuroblastoma cells. In: New Leads in Opioid Research. J.M. van Ree, A.H. Mulder, V.M. Weigant and T.B. van Wimersma Greidanus eds., Excerpta Medica, Amsterdam, pp.151-153, 1990.

546. Banks, W.A. and A.J. Kastin. Uptake of peptides containing Tyr-Pro by human and mouse erythrocytes. Biochem. Pharmacol. 40: 607-614, 1990.

547. Zadina, J.E., A.J. Kastin, L.-J. Ge and V. Brantl. Hemorphins, cytochrophins, and human ß-casomorphins bind to antiopiate (Tyr-MIF-1) as well as opiate binding sites in rat brain. Life Sci. 47: PL25-PL30, 1990.

548. Banks, W.A. and A.J. Kastin. Exchange of peptides between the circulation and the nervous system: role of the blood-brain barrier. In: Circulating Regulatory Factors and Neuroendocrine Function. J.C. Porter and D. Jezova, eds., Plenum Press, New York, pp. 59-69, 1990.

549. Banks, W.A., A.V. Schally, C.M. Barrera, M.B. Fasold, D.A. Durham, V.J. Csernus, K. Groot and A.J. Kastin. Permeability of the murine blood-brain barrier to some octapeptide analogs of somatostatin. Proc. Natl. Acad. Sci. USA. 87: 6762-6766, 1990.

550. Horvath, A. and A.J. Kastin. Evidence for presence of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) in human brain cortex. Int. J. Pept. Protein Res. 36: 281-284, 1990.

551. Banks, W.A., A.J. Kastin, E.A. Michals and C.M. Barrera. Stereospecific transport of Tyr-MIF-1 across the blood-brain barrier by peptide transport system-1. Brain Res. Bull. 25: 589-592, 1990.

552. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1989. Peptides 11: 1277-1304, 1990.

553. Zadina, J.E., A.J. Kastin, L.-J. Ge and V. Brantl. Casomorphin-related peptides bind to non-opiate (Tyr-MIF-1) sites as well as opiate receptors in brain. In: ß-Casomorphins and Related Peptides. F. Nyberg and V.Brantl, eds., Uppsala, Sweden, pp 61-63, 1990.

554. Miller, L.G. and A.J. Kastin. MIF-1 and Tyr-MIF-1 do not alter GABA binding on the

55

Page 56: Abba J. Kastin, M.D

GABAA receptor. Brain Res. Bull. 25: 917-918, 1990.

555. Krowicki, Z.K. and A.J. Kastin. Effects of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on GH, LH, prolactin, FSH, and TSH secretion in rats with and without morphine. Neuropeptides 18: 41-47, 1991.

556. Britton, J.R. and A.J. Kastin. Biologically active polypeptides in milk. Am. J. Med. Sci. 301: 124-132, 1991.

557. Banks, W.A. and A.J. Kastin. Leucine modulates peptide transport system-1 across the blood-brain barrier at a stereospecific site within the central nervous system. J. Pharm. Pharmacol. 43: 252-254, 1991.

558. Banks, W.A. and A.J. Kastin. Regulation of the passage of peptides across the blood-brain barrier. In: Peptides, Peptoids and Proteins. P.D. Garzone, W.A. Colburn and M. Mokotoff, eds., pp. 148-153, 1991.

559. Durham, D.A., W.A. Banks and A.J. Kastin. Carrier-mediated transport of labeled oxytocin from brain to blood. Neuroendocrinology 53: 447-452, 1991.

560. Banks, W.A. and A.J. Kastin. Blood to brain transport of interleukin links the immune and central nervous systems. Life Sci. 48: PL117-PL121, 1991.

561. Barrera, C.M., A.J. Kastin, M.B. Fasold and W.A. Banks. Bidirectional saturable transport of LHRH across the blood-brain barrier. Am. J. Physiol. 261: E312-E318, 1991.

562. Kastin, A.J., J. Seligson, J.H. Strimas and D.S. Chi. Failure of Met-enkephalin to enhance natural killer cell activity. Immunobiology 183: 55-68, 1991.

563. Banks, W.A., Kastin, A.J. and C.M. Barrera. Delivering peptides to the central nervous system: dilemnas and strategies. Pharm. Res. 8: 1345-1350, 1991.

564. Kastin, A.J., M.A. Pearson and W.A. Banks. EEG evidence that morphine and an enkephalin analog cross the blood-brain barrier. Pharmacol. Biochem. Behav. 40: 771-774, 1991.

565. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1990. Peptides 12: 1407-1432, 1991.

566. Banks, W.A., A.J. Kastin, C.M. Barrera and L.M. Maness. Lack of saturable transport across the blood-brain barrier in either direction for ß-amyloid (Alzheimer's disease protein). Brain Res. Bull. 27: 819-823, 1991.

567. Barrera, C.M., W.A. Banks, M.B. Fasold and A.J. Kastin. Effects of various reproductive

56

Page 57: Abba J. Kastin, M.D

hormones on the penetration of LHRH across the blood-brain barrier. Pharmacol. Biochem. Behav. 41: 255-257, 1991.

568. Banks, W.A., L. Ortiz, S.R. Plotkin and A.J. Kastin. Human interleukin (IL) 1α, murine IL-1α and murine IL-1ß are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 259: 988-996, 1991.

569. Banks, W.A. and A.J. Kastin. The interleukins-1α, -1ß, and -2 do not acutely disrupt the murine blood-brain barrier. Int. J. Immunopharmacol. 14: 629-636, 1992.

570. Zhang, X.-Y, J.E. Zadina, M. Ehrlich and A.J. Kastin. Tyr-MIF-1, but not MIF-1 or morphine, decreases cyclic AMP-dependent protein kinase activity extracted from HeLa cells. Mol. Cell. Neurosci. 3: 348-353, 1992.

571. Banks, W.A. and A.J. Kastin. Human interleukin-1α crosses the blood-testis barriers of the mouse. J. Androl. 13: 254-259, 1992.

572. Banks, W.A. and A.J. Kastin. Bidirectional passage of peptides across the blood-brain barrier. Prog. Brain Res. 91: 139-148, 1992.

573. Zadina, J.E., A.J. Kastin, D. Kersh and A. Wyatt. Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonist in the guinea pig ileum. Life Sci. 51: 869-885, 1992.

574. Banks, W.A. and A.J. Kastin. Exchange of peptides between the central nervous system and the blood. Chimicaoggi 10: 38-40, 1992.

575. Erchegyi, J., A.J. Kastin, J.E. Zadina, Qiu, X.-D. Isolation of a heptapeptide Val-Val-Tyr-Pro-Trp-Thr-Gln (valorphin) with some opiate activity. Int. J. Pept. Protein Res. 39: 477-484, 1992.

576. Erchegyi, J., A.J. Kastin and J. Zadina. Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1). Peptides 13: 623-632, 1992.

577. Petersheim, M., R.L. Moldow, H.N. Halladay, A.J. Kastin and A.J. Fischman. Conformational studies of N-Tyr-MIF-1 in aqueous solution by 1H nuclear magnetic resonance spectroscopy. Int. J. Pept. Protein Res. 40: 41-48, 1992.

578. Kostrzewa, R.M., R. Brus, D.H. Coy, H. Criswell. P.S. Coogan and A.J. Kastin. D-Ala2,F5

Phe4-dynorphin amide, an opiate with analgesic and toxic properties. Pol. J. Pharmacol. Pharm. 44: 109-120, 1992.

579. Zlokovic, B.V., W.A. Banks, H. Elkadi, J. Erchegyi, J.B. Mackic, J.G. McComb and A.J. Kastin. Transport, uptake and metabolism of blood-borne vasopressin by the blood-brain

57

Page 58: Abba J. Kastin, M.D

barrier. Brain Res. 590: 213-218, 1992.

580. Banks, W.A., A.J. Kastin and J.B. Jaspan. Orally administered cyclo(His-Pro) reduces ethanol-induced narcosis in mice. Pharmacol. Biochem. Behav. 43: 939-941, 1992.

581. Banks, W.A., A.J. Kastin, S. Radulovic, F.K. Conley, D.L. Johnson and A.V. Schally. Selective uptake of the somatostatin analog RC-160 across the blood-brain tumor barrier of mice with KHT sarcomas. Anti-Cancer Drugs 3: 513-518, 1992.

582. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1991. Peptides 13: 1247-1287, 1992.

583. Kastin, A.J., L. Fabre, M.M. Brown and R.D. Olson. Age- and sex-related changes in Tyr-MIF-1-like immunoreactivity in rat plasma. Neuroendocrinology 56: 902-906, 1992.

584. Erchegyi, J., J.E. Zadina, X.-D. Qiu, D.C. Kersh, L.-J. Ge, M.M. Brown and A.J. Kastin. Structure-activity relationship of analogs of the endogenous brain peptides Tyr-MIF-1 and Tyr-W-MIF-1. Pept. Res. 6: 31-38, 1993.

585. Zadina, J.E., S.L. Chang, L.-J. Ge and A.J. Kastin. Mu opiate receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp. Ther. 265: 254-265, 1993.

586. Hackler, L., A.J. Kastin, J. Erchegyi and J.E. Zadina. Isolation of Tyr-W-MIF-1 from bovine hypothalami. Neuropeptides 24: 159-164, 1993.

587. Kostrzewa, R.M. and A.J. Kastin. Tyr-MIF-1 attenuates development of tolerance to spiperone-induced catalepsy in rats. Brain Res. Bull. 31: 707-712, 1993.

588. Malin, D.R., J.E. Zadina, J.R. Lake, R.B. Rogillio, T.M. Benson, L.S. Corriere, B.P. Handunge and A.J. Kastin. Tyr-MIF-1 precipitates abstinence syndrome in morphine-dependent rats. Brain Res. 610: 169-171, 1993.

589. Kastin, A.J., L. Fabre, W.A. Banks and J.E. Zadina. Uptake, content, regulation of plasma concentrations, and binding of Tyr-MIF-1 by the adrenals. Neuroendocrinology. 57: 541-549, 1993.

590. Banks, W.A., A.J. Kastin, V. Akerstrom and J.B. Jaspan. Radioactively iodinated cyclo(His-Pro) crosses the blood-brain barrier and reverses ethanol-induced narcosis. Am. J. Physiol. 26: E723-E729, 1993.

591. Zadina, J.E., A.J. Kastin, V. Kenigs, C. Bruno and L. Hackler. Prolonged analgesia after intracerebroventricular Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Neurosci. Lett. 155: 220-222, 1993.

58

Page 59: Abba J. Kastin, M.D

592. Banks, W.A. and A.J. Kastin. The potential for alcohol to affect the passage of peptide and protein hormones across the blood-brain barrier: a hypothesis for a disturbance in brain-body communication. NIAAA Research Monograph 23: 401-411, 1993.

593. Banks, W.A., A.J. Kastin and C.A. Ehrensing. Endogenous peptide Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1) is transported from the brain to the blood by peptide transport system-1. J. Neurosci. Res. 35: 690-695, 1993.

594. Banks, W.A., A.J. Kastin, G.A. Olson and R.D. Olson. Permeability of the blood-brain barrier and blood-testis barrier to LH, FSH, and albumin in younger and older mice. Neuroendocrinol. Lett. 15: 177-181, 1993.

595. Banks, W.A., A.J. Kastin, G. Komaki and A. Arimura. Pituitary adenylate cyclase activating polypeptide (PACAP) can cross the vascular component of the blood-testis barrier in the mouse. J. Andrology 14: 170-173, 1993.

596. Banks, W.A. and A.J. Kastin. Peptide binding in blood and passage across the blood-brain barrier. In: Proceedings of the International Symposium on Blood Binding and Drug Transfer. J.P. Tillement, H. Eckert, E. Albengres, J. Barre, P. Baumann, F. Belpaire and M. Lemaire, eds., Editions Fort et Clair, Paris pp. 223-241, 1993.

597. Gutierrez, E.G., W.A. Banks and A.J. Kastin. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J. Neuroimmunol. 47: 169-176, 1993.

598. Banks, W.A. and A.J. Kastin. Measurement of transport of cytokines across the blood-brain barrier. In: Neurobiology of Cytokines, Part A., P.M.Conn and E.B. De Souza, eds., Academic Press, San Diego, 16: 67-77, 1993.

599. Harrison, L.M., J.E. Zadina, W.A. Banks and A.J. Kastin. Effects of neonatal treatment with Tyr-MIF-1, morphiceptin, and morphine on development, tail flick, and blood-brain barrier transport. Dev. Brain Res. 75: 207-212, 1993.

600. Banks, W.A., A.J. Kastin and E.G. Gutierrez. Interleukin-1α in blood has direct access to cortical brain cells. Neurosci. Lett. 163: 41-44, 1993.

601. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1992. Peptides 14: 1339-1378, 1993.

602. Banks, W.A., A.J. Kastin, G. Komaki and A. Arimura. Passage of pituitary adenylate cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-38

across the blood-brain barrier. J. Pharmacol. Exp. Ther. 267: 690-696, 1993.

603. Banks, W.A. and A.J. Kastin. Physiological consequences of the passage of peptides

59

Page 60: Abba J. Kastin, M.D

across the blood brain barrier. Rev. Neurosci. 4: 365-372, 1993.

604. Banks, W.A. and A.J. Kastin. Opposite direction of transport across the blood-brain barrier for Tyr-MIF-1 and MIF-1: comparison with morphine. Peptides 15: 23-29, 1994.

605. Kastin, A.J., K. Hahn, J. Erchegyi, J.E. Zadina, L. Hackler, M. Palmgren and W.A. Banks. Differential metabolism of Tyr-MIF-1 and MIF-1 in rat and human plasma. Biochem. Pharmacol. 47: 699-709, 1994.

606. Waguespack, P.J., W.A. Banks and A.J. Kastin. Interleukin-2 does not cross the blood-

brain barrier by a saturable transport system. Brain Res. Bull. 34: 103-109, 1994.

607. Maness, L.M., A.J. Kastin, J.T. Weber, W.A. Banks, B.S. Beckman and J.E. Zadina. The neurotrophins and their receptors: structure, function, and neuropathology. Neurosci. Biobehav. Rev. 18: 143-159, 1994.

608. Hackler, L., A.J. Kastin and J.E. Zadina. Isolation of a novel peptide with a unique binding profile from human brain cortex: Tyr-K-MIF-1 (Tyr-Pro-Lys-Gly-NH2). Peptides 15: 945-950, 1994.

609. Kastin, A.J., W.A. Banks, K. Hahn and J.E. Zadina. Extreme stability of Tyr-MIF-1 in CSF. Neurosci. Lett. 174: 26-28, 1994.

610. Banks, W.A. and A.J. Kastin. Effects of aluminum on blood-brain barrier structure and function. Life Chemistry Reports 11: 141-149, 1994.

611. Banks, W.A., A.J. Kastin, H.M. Sam, V.T. Cao, B. King, L.M. Maness and A.V. Schally. Saturable efflux of the peptides RC-160 and Tyr-MIF-1 by different parts of the blood-brain barrier. Brain Res. Bull. 35: 179-182, 1994.

612. Ahmed, B., A.J. Kastin, W.A. Banks and J.E. Zadina. CNS effects of peptides: a cross-listing of peptides and their central actions published in the journal Peptides, 1986-1993. Peptides 15: 1105-1155, 1994.

613. Zadina, J.E., L.M. Harrison, L.-J. Ge, A.J. Kastin and S.L. Chang. Differential regulation of mu and delta opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp. Ther. 270: 1086-1096, 1994.

614. Banks, W.A., A.J. Kastin and C.A. Ehrensing. Blood-borne interleukin-1α is transported across the endothelial blood-spinal cord barrier of mice. J. Physiol. 479.2: 257-264, 1994.

615. Ehrensing, R.H., A.J. Kastin, G.F. Wurzlow, G.F. Michell and A.H. Mebane. Improvement in major depression after low subcutaneous doses of MIF-1. J. Affect.

60

Page 61: Abba J. Kastin, M.D

Disord. 31: 227-233, 1994.

616. Harrison, L.M., A.J. Kastin, J.T. Weber, W.A. Banks, D.L. Hurley and J.E. Zadina. The opiate system in invertebrates. Peptides 15: 1309-1329, 1994.

617. Banks, W.A., A.J. Kastin and E.G. Gutierrez. Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci. Lett. 179: 53-56, 1994.

618. Maness, L.M., W.A. Banks, M.B. Podlisny, D.J. Selkoe and A.J. Kastin. Passage of human amyloid ß-protein 1-40 across the murine blood-brain barrier. Life Sci. 55: 1643-1650, 1994.

619. Kastin, A.J., W.A. Banks, R.D. Olson and J.E. Zadina. Novel concepts from novel peptides. Ann. NY Acad. Sci. 739: 1-10, 1994.

620. Jaspan, J.B., W.A. Banks and A.J. Kastin. Study of passage of peptides across the blood-brain barrier: biological effects of cyclo(His-Pro) after intravenous and oral administration. Ann. NY Acad. Sci. 739: 101-107, 1994.

621. Banks, W.A. and A.J. Kastin. Brain-to-blood transport of peptides and the alcohol withdrawal syndrome. Ann. NY Acad. Sci. 739: 108-118, 1994.

622. Gergen, K.A., S.L. Chang, Y.F. Niu, A.J. Kastin and J.E. Zadina. Expression of the FOS proto-oncogene protein in brain after icv administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Peptides 15: 1505-1511, 1994.

623. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1993. Peptides 15: 1531-1556, 1994.

624. Kastin, A.J., K. Hahn, W.A. Banks and J.E. Zadina. Delayed degradation of Tyr-MIF-1 in neonatal rat plasma. Peptides 15: 1561-1563, 1994.

625. Zadina, J.E., A.J. Kastin, L. Hackler and S.L. Chang. Cyclic analogues of Tyr-W-MIF-1 with prolonged analgesic activity and potency comparable to DAMGO and morphine. Peptides 15: 1567-1569, 1994.

626. Zadina, J.E., A.J. Kastin, L.-J. Ge and L. Hackler. Mu, delta, and kappa opiate receptor binding of Tyr-MIF-1 and of Tyr-W-MIF-1, its active fragments, and two potent analogs. Life Sci. 55: PL461-PL466, 1994.

627. Gutierrez, E.G., W.A. Banks and A.J. Kastin. Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier. J. Neuroimmunol. 55: 153-160, 1994.

628. Hackler, L., M.E. Carey and A.J. Kastin. Enhanced isolation of Tyr-MIF-1 from fresh

61

Page 62: Abba J. Kastin, M.D

human brain cortex. Brain Res. Bull. 36: 109-111, 1995.

629. Kastin, A.J., L. Fabre, W.A. Banks, L. Hackler and J.E. Zadina. Increase in plasma Tyr-MIF-1-like immunoreactivity after hypophysectomy is robust and reversible by corticosterone. Neuropeptides 28: 65-71, 1995.

630. Banks, W.A. and A.J. Kastin. Blood-brain permeability: pharmacological implications with special emphasis on peptides. In: Pharmacokinetics. P. G. Welling and F. L. Tse, eds., Marcel Dekker, Inc., New York, 67: 119-138, 1995.

631. Kastin, A.J., K. Hahn, J.E. Zadina, W.A. Banks and L. Hackler. Melanocyte- stimulating hormone release-inhibiting factor-1 (MIF-1) can be formed from Tyr-MIF-1 in brain mitochondria but not in brain homogenate. J. Neurochem. 64: 1855-1859, 1995.

632. Banks, W.A. and A.J. Kastin. Regional variation in transport of pancreatic polypeptide across the blood-brain barrier. Pharmacol. Biochem. Behav. 51: 139-147, 1995.

633. Bollinger, J.E., J.T. Mague, W.A. Banks, A.J. Kastin and D.M. Roundhill. Lipophilic hexadentate aluminum complexes of new phenolate-derivatized cyclohexanetriamine ligands and their effect on the peptide transport system (PTS-1). Inorg.Chem. 34: 2143-2152, 1995.

634. Zadina, J.E., A.J. Kastin, L.M. Harrison, L.-J. Ge and S.L. Chang. Opiate receptor changes after chronic exposure to agonists and antagonists. Ann. NY Acad. Sci. 757: 353-361, 1995.

635. Kastin, A.J., W.A. Banks, B. Ahmed and J.E. Zadina. Influence of hormones and messenger peptides on normal brain function. In: Principles and Practice of Endocrinology & Metabolism. K.L. Becker, ed., J.B. Lippincott, Philadelphia, pp. 1682-1691, 1995.

636. Banks, W.A. and A.J. Kastin. Permeability of the blood-brain barrier to melanocortins. Peptides 16: 1157-1161, 1995.

637. Banks, W.A., D.J. Wustrow, W.L. Cody, M.D. Davis and A.J. Kastin. Permeability of the blood-brain barrier to the neurotensin8-13 analog NT1. Brain Res. 695: 59-63, 1995.

638. Banks, W.A., S.R. Plotkin and A.J. Kastin. Permeability of the blood-brain barrier to soluble cytokine receptors. Neuroimmunomodulation 2: 161-165, 1995.

639. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1994. Peptides 16: 1517-1555, 1995.

640. Banks, W.A., A.J. Kastin, L.M. Maness, W, Huang and J.B. Jaspan. Permeability of the

62

Page 63: Abba J. Kastin, M.D

blood-brain barrier to amylin. Life Sci. 57: 1993-2001, 1995.

641. Maness, L.M., W.A. Banks, J.E. Zadina and A.J. Kastin. Selective transport of blood-borne interleukin-1α into the posterior division of the septum of the mouse brain. Brain Res. 700: 83-88, 1995.

642. Banks, W.A., A.J. Kastin and P. Zatta. The blood-brain barrier in aluminum toxicity and Alzheimer's disease. In: Non-neuronal Cells in Alzheimer's Disease. P. Zatta and M. Nicolini, eds., World Scientific Publishing Co. Pte. Ltd., Singapore, pp. 1-12, 1995.

643. Banks, W.A., A.J. Kastin and R.D. Broadwell. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation 2: 241-248, 1995.

644. Banks, W.A. and A.J. Kastin. Peptide transport system-1. In: New Concepts of a Blood-Brain Barrier. J. Greenwood, D. Begley, M.B. Segal and S. Lightman (Eds.) Plenum Press, p. 111-117, 1995.

645. Maness, L.M., W.A. Banks, J.E. Zadina and A.J. Kastin. Periventricular penetration and disappearance of ICV Tyr-MIF-1, DAMGO, tyrosine, and albumin. Peptides 17: 247-250, 1996.

646. Banks, W.A. and A.J. Kastin. Reversible association of the cytokines MIP-1α and MIP-1β with the endothelia of the blood-brain barrier. Neurosci. Lett. 205: 202-206, 1996.

647. Banks, W.A., A.J. Kastin, W. Huang, J.B. Jaspan and L.M. Maness. Leptin enters the brain by a saturable system independent of insulin. Peptides 17: 305-311, 1996.

648. Gergen, K., J.E. Zadina, A.J. Kastin and D. Paul. Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by α2-adrenoceptors. Eur. J. Pharmacol. 298: 235-239, 1996.

649. Martins, J.M., A.J. Kastin and W.A. Banks. Unidirectional specific and modulated brain to blood transport of corticotropin-releasing hormone. Neuroendocrinology 63: 338-348, 1996.

650. Kastin, A.J., J.E. Zadina, R.D. Olson and W.A. Banks. The history of neuropeptide research: version 5.a. In: Neuropeptides: Basic and Clinical Advances. J.N. Crawley and S. McLean, eds., Ann. NY Acad. Sci., New York. 780: 1-18, 1996.

651. Bollinger, J.E., W.A. Banks, A.J. Kastin and D.M. Roundhill. Iron-59 complexes of lipophilic hexadentate phenolate-derivatized cyclohexanetriamine ligands. Inorganic Chimica Acta 242: 201-204, 1996.

652. Plotkin, S.R., W.A. Banks and A.J. Kastin. Comparison of saturable transport and

63

Page 64: Abba J. Kastin, M.D

extracellular pathways in the passage of interleukin-1α across the blood-brain barrier. J. Neuroimmunol. 67: 41-47, 1996.

653. Zadina, J.E., D. Paul, K.A. Gergen, L.-J. Ge, L. Hackler and A.J. Kastin. Binding of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2) and related peptides to μ1 and μ2 opiate receptors. Neurosci. Lett. 215: 65-69, 1996.

654. Cashion, M.F., W.A. Banks and A.J. Kastin. Sequestration of centrally administered insulin by the brain: effects of starvation, aluminum, and TNF-α. Horm Behav. 30: 280-286, 1996.

655. Pan, W.H., W.A. Banks, M.K. Kennedy, E.G. Gutierrez and A.J. Kastin. Differential permeability of the BBB in acute EAE: enhanced transport of TNF-α. Am. J. Physiol. 34: E636-E642, 1996.

656. Banks, W.A. and A.J. Kastin. Passage of peptides across the blood-brain barrier: pathophysiological perspectives. Life Sci. 59: 1923-1943, 1996.

657. Olson, G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1995. Peptides 17: 1421-1466, 1996.

658. Bollinger, J.E., W.A. Banks, A.J. Kastin, M.J. Welch and D.M. Roundhill. Biodistribution of the lipophilic complexes 59Fe(RsalH2)3tach (R=H, NO2 and OMe) and 68Ga(NO2salH2)3tach. Nucl. Med. Biol. 23: 645-652, 1996.

659. Banks, W.A., L.M. Maness, M.F. Banks and A.J. Kastin. Aluminum-sensitive degradation of amyloid β-protein1-40 by murine and human intracellular enzymes. Neurotoxicol. Teratol. 18: 671-677, 1996.

660. Banks, W.A., A.J. Kastin, L.M. Harrison and J.E. Zadina. Perinatal treatment of rats with opiates affects the development of the blood-brain barrier transport system PTS-1. Neurotoxicol. Teratol. 18: 711-715, 1996.

661. Banks, W.A., M.B. Fasold and A.J. Kastin. Measurement of efflux rates from brain to blood. In: Methods in Molecular Biology, Neuropeptide Protocols. G.B. Irvine and C.H. Williams, eds., Humana Press Inc., Totowa, NJ, Vol. 73, pp. 353-360, 1997.

662. Banks, W.A., A.J. Kastin and S.I. Rapoport. Permeability of the blood-brain barrier to circulating free fatty acids. In: Handbook of Essential Fatty Acid Biology: Biochemistry, Physiology and Behavioral Neurobiology. S. Yehuda, D.I. Mostofsky, eds., Humana Press, Totowa, NJ, pp. 3-14, 1997.

663. Shayo, M., R.N. McLay, A.J. Kastin, and W.A. Banks. The putative blood-brain barrier transporter for the β-amyloid binding protein apolipoprotein J is saturated at

64

Page 65: Abba J. Kastin, M.D

physiological concentrations. Life Sci. 60: PL115-PL118, 1997.

664. Zadina, J.E., L. Hackler, L.-J. Ge and A.J. Kastin. A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386: 499-502, 1997.

665. Martins, J.M., W.A. Banks and A.J. Kastin. Acute modulation of the active carrier-mediated brain-to-blood transport of corticotropin-releasing hormone. Am. J. Physiol. 272: E312-E319, 1997.

666. Plotkin, S.R., W.A. Banks, P.J. Waguespack and A.J. Kastin. Ethanol alters the concentration of Met-enkephalin in brain by affecting peptide transport system-1 independent of preproenkephalin mRNA. J. Neurosci. Res. 48: 273-280, 1997.

667. Banks, W.A and A.J. Kastin. The role of blood-brain barrier transporter PTS-1 in regulating concentrations of methionine enkephalin in blood and brain. Alcohol 14: 237-245, 1997.

668. Maness, L.M., W.A. Banks and A.J. Kastin. Investigation of blood-brain barrier penetration and central nervous system distribution of peptides and proteins by in vivo autoradiography. STP Pharma Sciences 7: 12-16, 1997.

669. Pan, W., W.A. Banks and A.J. Kastin. Permeability of the blood-brain and blood-spinal cord barriers to interferons. J. Neuroimmunol. 76: 105-111, 1997.

670. Kastin, A.J., R.D. Olson, J.M. Martins, G.A. Olson, J.E. Zadina and W.A. Banks. Chronic fatigue syndrome: possible integration of hormonal and immunological observations. In: Chronic Fatigue Syndrome. S. Yehuda and D.I. Mostofsky, eds., Plenum Press, New York, p. 161-192, 1997.

671. Champion, H.C., J.E. Zadina, A.J. Kastin, L. Hackler, L.-J. Ge and P.J. Kadowitz . The endogenous mu-opioid receptor agonists endomorphins 1 and 2 have novel hypotensive activity in the rabbit. Biochem. Biophys. Res. Commun. 235: 567-570, 1997.

672. Pan, W., W.A. Banks and A.J. Kastin. Blood-brain permeability to ebiratide and TNF in acute spinal cord injury. Exp. Neurol. 146: 367-373, 1997.

673. Banks, W.A., A.J. Kastin and V. Akerstrom. HIV-1 protein GP120 crosses the blood-brain barrier: role of adsorptive endocytosis. Life Sci. 61: PL119-PL125, 1997.

674. Banks,W.A., A.J. Kastin, L.M. Maness, M.F.Banks, M. Shayo and R.N.McLay. Interactions of β-amyloids with the blood-brain barrier. In: Cerebrovascular Pathology in Alzheimer’s Disease. J.C. de la Torre and V. Hachinski, eds., Ann NY Acad. Sci., New York, 826: 191-199, 1997.

65

Page 66: Abba J. Kastin, M.D

675. Banks, W.A. and A.J. Kastin. Relative contributions of peripheral and central sources to levels of IL-1α in the cerebral cortex of mice: assessment with species-specific enzyme immunoassays. J. Neuroimmunol. 79: 22-28, 1997.

676. Pan,W., J.E. Zadina, R.E. Harlan, J.T. Weber, W.A. Banks and A.J. Kastin. Tumor necrosis factor-α: a neuromodulator in the CNS. Neurosci. Biobehav. Rev. 21: 603-613, 1997.

677. McLay, R.N., S.M. Freeman, R.E. Harlan, C.F. Ide, A.J. Kastin and J.E. Zadina. Aging in the hippocampus: interrelated actions of neurotrophins and glucocorticoids. Neurosci. Biobehav. Rev. 21: 615-629, 1997.

678. Banks, W.A., J.B. Jaspan and A.J. Kastin. Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays. Peptides 18: 1257-1262, 1997.

679. Champion, H.C., J.E. Zadina, A.J. Kastin, L. Hackler, L.-J. Ge and P.J. Kadowitz. Endomorphin 1 and 2, endogenous ligands for the μ-opioid receptor, decrease cardiac output, and total peripheral resistance in the rat. Peptides 18: 1393-1397, 1997.

680. Banks, W.A., J.B. Jaspan, W. Huang and A.J. Kastin. Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin. Peptides 18: 1423-1429, 1997.

681. McLay, R.N., W.A. Banks and A.J. Kastin. Granulocyte macrophage-colony stimulating factor crosses the blood-testis barrier in mice. Biol. Reprod. 57: 822-826, 1997.

682. McLay, R.N., M. Kimura, W.A. Banks and A.J. Kastin. Granulocyte macrophage-colony-stimulating factor crosses the blood-brain and blood-spinal cord barriers. Brain 120: 2083-2091, 1997.

683. Banks, W.A., J.B. Jaspan and A.J. Kastin. Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin. Peptides 18: 1577-1584, 1997.

684. Hackler, L., J.E. Zadina, L.-J. Ge and A.J. Kastin. Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex. Peptides 18: 1635-1639, 1997.

685. Martin-Schild, S., J.E. Zadina, A.A. Gerall, S. Vigh and A.J. Kastin. Localization of endomorphin-2-like immunoreactivity in the rat medulla and spinal cord. Peptides 18: 1641-1649, 1997.

686. Olson,G.A., R.D. Olson and A.J. Kastin. Endogenous opiates: 1996. Peptides 18: 1651-1688, 1997.

66

Page 67: Abba J. Kastin, M.D

687. Martins, J.M., W.A. Banks and A.J. Kastin. Transport of CRH from mouse brain directly affects peripheral production of β-endorphin by the spleen. Am. J. Physiol. 273:E1083-E1089, 1997.

688. Champion, H..C., J.E. Zadina, A.J. Kastin and P.J. Kadowitz. The endogenous μ-opioid agonists, endomorphin 1 and 2, have vasodilator activity in the hindquarters vascular bed of the rat. Life Sci. 61: PL409-PL416, 1997

689. Plotkin, S.R., W.A. Banks and A.J. Kastin. Enkephalin, PPE mRNA, and PTS-1 in alcohol withdrawal seizure-prone and -resistant mice. Alcohol 15: 25-31, 1998.

690. Kastin, A.J., K. Hahn, W.A. Banks and J.E. Zadina. Regional differences in the metabolism of Tyr-MIF-1 and Tyr-W-MIF-1 by rat brain mitochondria. Biochem. Pharmacol. 55: 33-36, 1998.

691. Higashida, H., N. Hoshi, R. Knijnik, J.E. Zadina and A.J. Kastin. Endomorphins inhibit high-threshold Ca2+channel currents in rodent NG108-15 cells overexpressing μ-opioid receptors. J. Physiol. 507: 71-75, 1998.

692. Harrison, L.M., A.J. Kastin and J.E. Zadina. Differential effects of endomorphin-1, endomorphin-2, and Tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 19: 749-753. 1998.

693. Harrison, L.M., A.J. Kastin and J.E. Zadina. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp.Ther. 284: 611-617, 1998.

694 Banks, W.A., V. Akerstrom and A.J. Kastin. Adsorptive endocytosis mediates the passage of HIV-1 across the blood-brain barrier: evidence for a post-internalization coreceptor. J. Cell Sci. 111: 533-540, 1998.

695. Pan, W., W.A. Banks and A.J. Kastin. Permeability of blood-brain barrier to neurotrophins. Brain Res. 788: 87-94, 1998.

696. Banks, W.A. and A.J. Kastin. Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylin. Peptides 19: 883-889, 1998.

697. Champion, H.C., J.E. Zadina, A.J. Kastin and P.J. Kadowitz. Endomorphin 1 and 2 have vasodepressor activity in the anesthetized mouse. Peptides 19: 925-929, 1998.

698. Banks, W.A., A.J. Kastin and A. Arimura. Effect of spinal cord injury on the permeability of the blood-brain and blood-spinal cord barriers to the neurotropin PACAP. Exp. Neurol. 151: 116-123, 1998.

67

Page 68: Abba J. Kastin, M.D

699. Banks, W.A., A.J. Kastin and C.A Ehrensing. Diurnal uptake of circulating interleukin-1α by brain, spinal cord, testis and muscle. Neuroimmunomodulation 5: 36-41, 1998.

700. Maness, L.M., A.J. Kastin and W.A. Banks. Relative contributions of a CVO and the microvascular bed to delivery of blood-borne IL-1α to the brain. Am J. Physiol. 275: E207-E212, 1998.

701. Czapla, M.A., H.C. Champion, J.E. Zadina, A.J. Kastin, L. Hackler, L.-J. Ge and P.J. Kadowitz. Endomorphin 1 and 2, endogenous μ-opioid agonists, decrease systemic arterial pressure in the rat. Life Sci. 62: PL175-PL179, 1998.

702. Champion, H.C., T.J. Bivalacqua, D.G. Lambert, S.M. McWilliams, J.E. Zadina, A.J. Kastin and P.J Kadowitz. Endomorphin 1 and 2, the endogenous μ-opioid agonists, produce biphasic changes in systemic arterial pressure in the cat. Life Sci. 63: PL131-PL136, 1998.

703. Champion, H.C., T.J. Bivalacqua, D.E. Friedman, J.E. Zadina, A.J. Kastin and P.J. Kadowitz. Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat. Peptides 19: 1595-1602, 1998.

704. Harrison, L.M., A.J. Kastin and J.E. Zadina. Opiate tolerance and dependence: receptors, G-proteins, and antiopiates. Peptides 19: 1603-1630, 1998.

705. Maness, L.M., A.J. Kastin, C.L. Farrell and W.A. Banks. Fate of leptin after intracerebroventricular injection into the mouse brain. Endocrinology 139: 4556-4562, 1998.

706. Martin-Schild, S., A.A. Gerall, A.J. Kastin and J.E. Zadina. Endomorphin-2 is an endogenous opioid in primary sensory afferent fibers. Peptides 19: 1783-1789, 1998.

707. Olson, G.A., R.D. Olson, A.L. Vaccarino and A.J. Kastin. Endogenous opiates: 1997. Peptides 19: 1791-1843, 1998.

708. Pan, W., W.A. Banks, M.B. Fasold, J. Bluth and A.J. Kastin. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37: 1553-1561, 1998.

709. Martin-Schild, S., A.A. Gerall, A.J. Kastin and J.E. Zadina. Differential distribution of endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent. J. Comp. Neurol. 405: 450-471, 1999.

710. Kastin, A.J and V. Akerstrom. Nonsaturable entry of neuropeptide Y into brain. Am. J.

68

Page 69: Abba J. Kastin, M.D

Physiol. 276: E479-E482, 1999.

711. Pan, W. and A.J. Kastin. Penetration of neurotrophins and cytokines across the blood-brain/blood-spinal cord barrier. Adv. Drug Delivery Rev. 36: 291-298, 1999.

712. Kastin, A.J. and V. Akerstrom. Orexin A but not orexin B rapidly enters brain from blood by simple diffusion. J. Pharmacol. Exp. Ther. 289: 219-223, 1999.

713. Banks, W.A., A.J. Kastin, J.M. Brennan and K.L. Vallance. Adsorptive endocytosis of HIV-1 gp120 by blood-brain barrier is enhanced by lipopolysaccharide. Exp. Neurol. 156: 165-171, 1999.

714. Cashion, M.F., W.A. Banks, K.L. Bost and A.J. Kastin. Transmission routes of HIV-1 gp120 from brain to lymphoid tissues. Brain Res. 822: 26-33, 1999.

715. Pan, W., A.J. Kastin, L.M. Maness and J.M. Brennan. Saturable entry of ciliary neurotrophic factor into brain. Neurosci. Lett. 263: 69-71, 1999.

716. Pan, W., A.J. Kastin, R.L. Bell and R.D. Olson. Upregulation of tumor necrosis factor α transport across the blood-brain barrier after acute compressive spinal cord injury. J. Neuroscience 19: 3649-3655, 1999.

717. Kastin, A.J., C.A. Sandman, G.A. Olson and R.D. Olson. Melanocyte-stimulating hormone (MSH) and its analogs. In: Encyclopedia of Neuroscience, 2nd Ed., G.A. Adelman and G.H. Smith, eds. Elsevier Science, Amsterdam, pp. 1125-1126, 1999.

718. Kastin, A.J., W.A. Banks and W. Pan. Peptides and cytokines cross the blood-brain barrier. In: Encyclopedia of Neuroscience, 2nd Ed., G.A. Adelman and G.H. Smith, eds. Elsevier Science, Amsterdam, pp. 1607-1608, 1999.

719. Kastin, A.J., R.H. Ehrensing and J.E. Zadina. The Tyr-MIF-1 family of peptides. In: Encyclopedia of Neuroscience, 2nd Ed., G.A. Adelman and G.H. Smith, eds. Elsevier Science, Amsterdam, pp. 2082-2083, 1999.

720. McLay, R.N., S.M. Freeman, R.E. Harlan, A.J. Kastin and J.E. Zadina. Tests used to assess the cognitive abilities of aged rats: their relation to each other and to hippocampal morphology and neurotrophin expression. Gerontology 45: 143-155, 1999.

721. Sakurada, S., J.E. Zadina, A.J. Kastin, S. Katsuyama, T. Fujimura, K. Murayama, M. Yuki, H. Ueda and T. Sakurada. Differential involvement of μ-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception. Eur. J. Pharmacol. 372: 25-30, 1999.

722. Banks, W.A., R.N. McLay, A.J. Kastin, U. Sarmiento and S. Scully. Passage of leptin across the blood-testis barrier. Am. J. Physiol. 276: E1099-E1104, 1999.

69

Page 70: Abba J. Kastin, M.D

723. Banks, W.A., A.J. Kastin and W. Pan. Uptake and degradation of blood-borne insulin by the olfactory bulb. Peptides 20: 373-378, 1999.

724. Nores, W.L., R.D. Olson, G.A. Olson, A.L. Vaccarino, R.L. Bell, J.E. Zadina and A.J. Kastin. Tyr-W-MIF-1-induced conditioned place preference. Peptides 20: 479-484, 1999.

725. Bell, R.L., A.L. Vaccarino, R.D. Olson, G.A. Olson, W.L. Nores, J.G. Cambre, J.E. Zadina and A.J. Kastin. Tolerance and morphine-induced cross-tolerance are shown to Tyr-W-MIF-1 analgesia. Peptides 20: 971-978, 1999.

726. Pan, W. and A.J. Kastin. Entry of EGF into brain is rapid and saturable. Peptides 20: 1091-1098, 1999.

727. Pan, W., A.J. Kastin, W.A. Banks and J.E. Zadina. Effects of peptides: a cross-listing of peptides and their central actions published in the journal Peptides from 1994 through 1998. Peptides 20: 1127-1138, 1999.

728. Maresh, G.A., A.J. Kastin, T.T. Brown, J.E. Zadina and W.A. Banks. Peptide transport system-1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either. Brain Res. 839: 336-340, 1999.

729. Kastin, A.J. and V. Ackerstrom. Entry of CART into brain is rapid but not inhibited by excess CART or leptin. Am. J. Physiol. 277: E901-E904, 1999.

730. Pan, W., K. Vallance and A.J. Kastin. TGFα and the blood-brain barrier: accumulation in cerebral vasculature. Exp. Neurol. 160: 454-459, 1999.

731. Kastin, A.J., W. Pan, L.M. Maness and W.A. Banks. Peptides crossing the blood-brain barrier: some unusual observations. Brain Res. 848: 96-100, 1999.

732. Kastin, A.J. Multiple direct actions of peptides on the CNS. Brain Res. Bull. 50: 361-362, 1999.

733. Zadina, J.E., S. Martin-Schild, A.A. Gerall, A.J. Kastin, L. Hackler, L.-J. Ge and X. Zhang. Endomorphins: novel endogenous μ-opiate receptor agonist in regions of high μ-opiate receptor density. Ann. NY Acad. Sci. 897: 136-144, 1999.

734. Champion, H.C., T.J. Bivalacqua, J.E. Zadina, A.J Kastin and P.J. Kadowitz. Vasodilator responses to the endomorphin peptides, but not nociceptin/OFQ, are mediated by nitric oxide release. Ann. NY Acad. Sci. 897: 165-172, 1999.

735. Kelly, J.P., G. Nicolau, A. Redmond, B.E. Leonard, J. Noble, L. Sverdlov, R. Molinar, A.J. Kastin, R.H. Ehrensing and J.P. Feigher. The effect of treatment with a new

70

Page 71: Abba J. Kastin, M.D

antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. J. Affect. Disord. 55: 231-236, 1999.

736. Kastin, A.J., W. Pan, L.M. Maness, R.J. Koletsky and P. Ernsberger. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides 20: 1449-1453, 1999.

737. Vaccarino, A.L., G.A. Olson, R.D. Olson and A.J. Kastin. Endogenous opiates: 1998. Peptides 20: 1527-1574, 1999.

738. Kastin, A.J., V. Akerstrom, L. Hackler and J.E. Zadina. Phe13,Tyr19-Melanin-concentrating hormone and the blood-brain barrier: role of protein binding. J. Neurochem. 74: 385-391, 2000.

739. Pan W., A.J. Kastin and J.M. Brennan. Saturable entry of leukemia inhibitory factor from blood to the central nervous system. J. Neuroimmunol. 106: 172-180, 2000.

740. Kastin, A.J. and V. Akerstrom. Fasting, but not adrenalectomy, reduces transport of leptin into the brain. Peptides 21: 679-682, 2000.

741. Kastin, A.J. and V. Akerstrom. Mahogany (1377-1428) enters brain by a saturable transport system. J. Pharmacol. Exp. Ther. 294: 633-634, 2000.

742. Maness, L.M., W.A. Banks and A.J. Kastin. Persistence of blood-to-brain transport of leptin in obese leptin-deficient and leptin receptor-deficient mice. Brain Res. 873: 165-167, 2000.

743. Soignier, R.D., A.L. Vaccarino, A.M. Brennan, A.J. Kastin and J.E. Zadina. Analgesic effects of endomorphin-1 and endomorphin-2 in the formalin test in mice. Life Sci. 67: 907-912, 2000.

744. Somogyvari-Vigh, A., W. Pan, D. Reglodi, A.J Kastin and A. Arimura. Effect of middle cerebral artery occlusion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat. Regul. Pept. 91: 89-95, 2000.

745. Pan, W. and A.J. Kastin. Interactions of IGF-1 with the blood-brain barrier in vivo and in situ. Neuroendocrinology 72: 171-185, 2000.

746. Sakurada, S., T. Hayashi, M. Yuki, T. Fujimura, K. Murayama, A. Yonezawa, C. Sakurada, M. Takeshita, J.E. Zadina, A.J. Kastin and T. Sakurada. Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone. Brain Res. 881: 1-8, 2000.

747. Kastin, A.J. and W. Pan. Dynamic regulation of leptin entry into brain by the blood-brain

71

Page 72: Abba J. Kastin, M.D

barrier. Reg. Pep. 92: 37-43, 2000.

748. Kastin, A.J., V. Akerstrom and L. Hackler. Agouti-related protein (83-132) aggregates and crosses the blood-brain barrier slowly. Metabolism 49: 1444-1448, 2000.

749. Feighner, J.P., R.H. Ehrensing, A.J. Kastin, B.E. Leonard, L. Sverdlov, G. Nicolau, A. Patel, J. Hlavka, H. Abajian and J.F. Noble. A double-blind, placebo-controlled, efficacy, safety, and pharmacokinetic study of INN 00835, a novel antidepressant peptide, in the treatment of major depression. J. Affect. Disord. 61: 119-126, 2000.

750. Plotkin, S.R., W.A. Banks, L.M. Maness and A.J. Kastin. Differential transport of rat and human interleukin-1α across the blood-brain barrier and blood-testis barrier in rats. Brain Res. 881: 57-61, 2000.

751. McLay, R.N., A.J. Kastin and J.E. Zadina. Passage of interleukin-1β across the blood-brain barrier is reduced in aged mice: a possible mechanism for diminished fever in aging. Neuroimmunomodulation 8: 148-153, 2000.

752. Kastin, A.J., V.A. Akerstrom and W. Pan. Activation of urocortin transport into brain by leptin. Peptides 21: 1811-1818, 2000.

753. Wilson, A.M., R.D. Soignier, J.E. Zadina, A.J. Kastin, W.L. Nores, R.D. Olson and G.A. Olson. Dissociation of analgesic and rewarding effects of endomorphin-1 in rats. Peptides 21: 1871-1874, 2000.

754. Vaccarino, A.L. and A.J. Kastin. Endogenous opiates: 1999. Peptides 21: 1975-2034, 2000.

755. Kastin, A.J., V. Akerstrom, L. Hackler and W. Pan. Adrenomedullin and the blood-brain barrier. Horm. Metab. Res. 33: 19-25, 2001.

756. Pan, W. and A.J. Kastin. Changing the chemokine gradient: CINC1 crosses the blood-brain barrier. J. Neuroimmunol. 115: 64-70, 2001.

757. Kastin, A.J., W. Pan, J.E. Zadina and W.A. Banks. The endocrine brain. In: Principles and Practice of Endocrinology and Metabolism, edited by K.L. Becker, Philadelphia: Lippincott Williams & Wilkins, 2001, pp. 1611-1615.

758. Kastin, A.J. and V. Akerstrom. Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice. Neuroendocrinology 73: 237-242, 2001.

759. Kastin, A.J. and V. Akerstrom. Pretreatment with glucose increases entry of urocortin into mouse brain. Peptides 22: 829-834, 2001.

72

Page 73: Abba J. Kastin, M.D

760. Pan, W. and A.J. Kastin. Diurnal variation of leptin entry from blood to brain involving partial saturation of the transport system. Life Sci. 68: 2705-2714, 2001.

761. Plotkin, S.R., W.A. Banks, C.S. Cohn and A.J. Kastin. Withdrawal from alcohol in withdrawal seizure-prone and -resistant mice: evidence for enkephalin resistance. Pharmacol. Biochem. Behav. 68: 379-387, 2001.

762. Maresh, G.A., L.M. Maness, J.E. Zadina and A.J. Kastin. In vitro demonstration of a saturable transport system for leptin across the blood-brain barrier. Life Sci. 69: 67-73, 2001.

763. Pan, W., A.J. Kastin, L. Gera and J.M Stewart. Bradykinin antagonist decreases early disruption of the blood-spinal cord barrier after spinal cord injury in mice. Neurosci. Lett. 307: 25-28, 2001.

764. Smith, R.R., S. Martin-Schild, A.J. Kastin and J.E. Zadina. Decreases in endomorphin-2-like immunoreactivity concomitant with chronic pain after nerve injury. Neuroscience 105: 773-778, 2001.

765. Kastin, A.J., K. Hahn and J.E. Zadina. Regional differences in peptide degradation by rat cerebral microvessels: A potential novel regulatory mechanism for communication between blood and brain. Life Sci. 69: 1305-1312, 2001.

766. Kastin, A.J., M.B. Fasold, R.R. Smith, K.A. Horner and J.E. Zadina. Saturable brain-to-blood transport of endomorphins. Exp. Brain Res. 139: 70-75, 2001.

767. Pan, W. and A.J. Kastin. Increase in TNF transport after SCI is specific for time, region, and type of lesion. Exp. Neurol. 170: 357-363, 2001.

768. Kastin, A.J., V. Akerstrom, and L.M. Maness. Chronic loss of ovarian function decreases transport of leptin into mouse brain. Neurosci. Lett. 310: 69-71, 2001.

769. Sakurada, S., T. Hayashi, M. Yuhki, T. Orito, J.E. Zadina, A.J.Kastin, T. Fujimura, K. Murayama, C. Sakurada, T. Sakurada, M. Narita, T. Suzuki, K. Tan-no, and L.F. Tseng. Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse. Eur. J. Pharmacol. 427: 203-210, 2001.

770. Feighner, J.P., R.H. Ehrensing, A.J. Kastin, A. Patel, L. Sverdlov, J. Hlavka, H.B. Abajian, J.F. Noble and G. Nicolau. Double-blind, placebo-controlled study of INN 00835 (netamiftide) in the treatment of outpatients with major depression. Int. Clin. Psychopharmacol. 16: 1-8, 2001.

771. Gozes, I., D.E. Brenneman, P. Geppetti, A.J. Kastin, R.E. Mains, T.W. Moody, K.

73

Page 74: Abba J. Kastin, M.D

Seroogy, A.D. Spier, and M. Zimmermann. Neuropeptides: brain messengers of many faces. Trends in Neurosci. 24: 687-690, 2001.

772. Banks, W.A., B.M. King, K.N. Rossiter, R.D. Olson, G.A. Olson, and A.J. Kastin. Obesity-inducing lesions of the central nervous system alter leptin uptake by the blood-brain barrier. Life Sci. 69: 2765-2773, 2001.

773. Kastin, A.J., V. Akerstrom, and W. Pan. Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides 22: 2127-2136, 2001.

774. McLay, R.N., W. Pan, and A.J. Kastin. Effects of peptides on animal and human behavior: a review of studies published in the first twenty years of the journal Peptides. Peptides 22: 2181-2255, 2001.

775. Vaccarino, A.L. and A.J. Kastin. Endogenous opiates: 2000. Peptides 22: 2257-2328, 2001.

776. Kastin, A.J., V. Akerstrom, and L. Hackler. Food deprivation decreases blood galanin-like peptide and its rapid entry into the brain. Neuroendocrinology 74: 423-432, 2001.

777. Pan, W. and A.J. Kastin. Upregulation of the transport system for TNFα at the blood-brain barrier. Arch. Physiol. Biochem. 109: 350-353, 2001.

778. Pan, W., G. Cornelissen, F. Halberg, and A.J. Kastin. Circadian rhythm of tumor necrosis factor α uptake into mouse spinal cord (Selected Contribution). J. Appl. Physiol. 92: 1357-1362, 2002.

779. Kastin, A.J., M.B. Fasold, and J.E. Zadina. Endomorphins, Met-Enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system. Drug Metab. Disp. 30: 231-234, 2002.

780. Pan, W. and A.J. Kastin. TNFα transport across the blood-brain barrier is abolished in receptor knockout mice. Exp. Neurol. 174: 193-200, 2002.

781. Kastin, A.J., V. Akerstrom, and W. Pan. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J. Molec. Neurosci. 18: 7-14, 2002.

782. Kastin, A.J. and V. Akerstrom. Differential interactions of urocortin/corticotropin-releasing hormone peptides with the blood-brain barrier. Neuroendocrinology 75: 367-374, 2002.

783. Wang, Q.P., J.E. Zadina, J.-L.Guan, A.J. Kastin, H. Funahashi, and S. Shioda. Endomorphin-2 immunoreactivity in the cervical dorsal horn of the rat spinal cord at the electron microscopic level. Neuroscience 113: 593-605, 2002.

74

Page 75: Abba J. Kastin, M.D

784. Sakurada, S., T. Hayashi, M. Yuhki, T. Fujimura, K. Murayama, A. Yonezawa, C. Sakurada, M. Takeshita, T. Sato, J.E. Zadina, A.J. Kastin, and T. Sakurada. Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone. Peptides 23: 895-901, 2002.

785. Pan, W., B. Solomon, L. M. Maness, and A.J. Kastin. Antibodies to β-amyloid decrease the blood-to-brain transfer of β-amyloid peptide. Exp. Biol. Med. 227: 609-615, 2002.

786. Kastin, A.J., W. Pan, V. Akerstrom, L. Hackler, C. Wang, and C.M. Kotz. Novel peptide-peptide cooperation may transform feeding behavior. Peptides 23: 2189-2196, 2002.

787. Pan, W., L. Zhang, J. Liao, B. Csernus, and A.J. Kastin. Selective increase in TNFα permeation across the blood-spinal cord barrier after SCI. J. Neuroimmunol. 14: 111-117, 2003.

788. Pan, W., A.J. Kastin, T. Rigai, R. McLay, and C.G. Pick. Increased hippocampal uptake of tumor necrosis factor α and behavioral changes in mice. Exp. Brain Res. 149: 195-199, 2003.

789. Kastin, A.J., and V. Akerstrom. Entry of exendin-4 into brain is rapid but may be limited at high doses. Int. J. Obes. 27: 313-318, 2003.

790. Wang, Q.-P., J.E. Zadina, J.-L. Guan, A.J. Kastin, and S. Shioda. Electron microscopic examination of the endomorphin 2-like immunoreactive neurons in the rat hypothalamus. Brain Res. 969: 126-134, 2003.

791. Kastin, A.J., V. Akerstrom, and W. Pan. Glial cell line-derived neurotrophic factor does not enter normal mouse brain. Neurosci. Lett. 340: 239-241, 2003.

792. Kastin, A.J. and W. Pan. Feeding peptides interact in several ways with the blood-brain barrier. Curr. Pharm. Des. 9: 789-794, 2003.

793. Pan, W. and A.J. Kastin. Interactions of cytokines with the blood-brain barrier: Implications for feeding. Curr. Pharm. Des 9: 827-831, 2003

794. Kastin, A.J., V. Akerstrom, and W. Pan. Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier. Mol. Brain Res. 114: 168-171, 2003.

795. Kastin, A.J., V. Akerstrom, L. Hackler, and W. Pan. Different mechanisms influencing permation of PDGF-AA and PDGF-BB across the blood-brain barrier. J. Neurochem 87: 7-12, 2003.

75

Page 76: Abba J. Kastin, M.D

796. Kastin, A.J., V. Akerstrom, and W. Pan. Circulating TGF-β does not cross the intact blood-brain barrier. J. Molec. Neurosci. 21: 43-48, 2003.

797. Kastin, A.J., and W. Pan. Peptide transport across the blood-brain barrier. In: Peptide Transport and Delivery into the Central Nervous System, edited by Laszlo Prokai and Katalin Prokai-Tatrai, Basel, Switzerland: Birkhäuser Verlag, 2003, pp 79-100.

798. Pan, W., B. Csernus, and A.J. Kastin. Upregulation of p55 and p75 receptors mediating TNF α transport across the injured blood-spinal cord barrier. J. Molec. Neurosci. 21: 173-184, 2003.

799. Kastin, A.J., and W. Pan. Brain influx of endogenous peptides affecting food intake. In: Blood-Spinal Cord and Brain Barriers in Health and Disease, edited by Hari Shanker Sharma and Jan Westman, San Diego, California: Elsevier, 2004, pp 57-62.

800. Pan, W., and A.J. Kastin. Transport of cytokines and neurotrophins across the blood-brain barrier and their regulation after spinal cord injury. In: Blood-Spinal Cord and Brain Barriers in Health and Disease, edited by Hari Shanker Sharma and Jan Westman, San Diego, California: Elsevier, 2004, pp 395-407.

801. Kastin, A.J., Victoria Akerstom, and Weihong Pan. Neuregulin 1-β1 enters brain and spinal cord by receptor-mediated transport. J. Neurochem. 88: 965-970, 2004.

802. Pan, W., and A.J. Kastin. Polypeptide delivery across the blood-brain barrier. Current Drug Targets - CNS & Neurological Disorders. 3: 131-136, 2004.

803. Somogyvari-Vigh, A., A.J. Kastin, J. Liao, J.E. Zadina, and W. Pan. Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells. Exp. Brain. Res. 156: 224-230, 2004.

804. Kastin. A.J. Editorial: Twenty-five years of peptides. Peptides 25: 315-317, 2004.

805. Pejovic V, V.Soskic, W. Pan, A.J.Kastin. Brain proteome of mice lacking the receptors for tumor necrosis factor α. Proteomics, 4: 1461 - 1464, 2004

806. Pan W, V. Akerstrom, J. Zhang, V. Pejovic, A.J. Kastin. Modulation of feeding-related peptide/protein signals by the blood-brain barrier. J. Neurochem. 90: 455 - 461, 2004

807. Pan W, A.J. Kastin. Why study transport of peptides and proteins at the neurovascular interface. Brain Res. Rev. 46: 32 - 43, 2004

808. Pan, W., A.J. Kastin, T.C. Zankel, P. van Kerhof, T. Terasaki, and G. Bu. Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. J. Cell Sci. 117: 5071-5078, 2004.

76

Page 77: Abba J. Kastin, M.D

809. Yu, Y., A. Jawa, W. Pan, and A.J. Kastin. Effects of peptides, with emphasis on feeding, pain, and behavior: A 5-year (1999-2003) review of publications in Peptides. Peptides 25: 2257-2289, 2004.

810. Kastin, A.J. and W. Pan. Targeting neurite growth inhibitors to induce CNS regeneration. Curr. Pharm. Des. 11: 1247-1253, 2005.

811. Xiang, S., W. Pan, and A.J. Kastin. Strategies to create a regenerating environment for the injured spinal cord. Curr. Pharm. Des. 11: 1267-1277, 2005.

812. Ding, Y., A.J. Kastin and W. Pan. Neural plasticity after spinal cord injury. Curr. Pharm. Des. 11: 1441-1450, 2005.

813. Pan, W., Y. Yu, C.M. Cain, F. Nyberg, P.O. Couraud, and A.J. Kastin. Permeation of growth hormone across the blood-brain barrier. Endocrinology 146: 4898-4904, 2005.

814. Pan, W., A.J. Kastin, Y. Yu, C.M. Cain, T. Fairburn, A.M. Stütz, C. Morrison, and G. Argyropoulos. Selective tissue uptake of AgRP (82-131) and its modulation by fasting. Endocrinology 146: 5533-5539, 2005.

815. Pan, W., Y. Yu, F. Nyberg, and A.J. Kastin. Growth hormone, insulin, and insulin-like growth factor-1: Do they interact at the blood-brain barrier? In: The Somatotropic Axis in Brain Function, edited by Fred Nyberg, San Diego, California: Elsevier, 2006, pp 75-79.

816. Pan, W., Y. Ding, Y. Yu, H. Ohtaki, T. Nakamachi, and A.J. Kastin. Stroke upregulates TNFα transport across the blood-brain barrier. Exp. Neurol. 198: 222–233, 2006.

817. Pan, W., H. Tu, and A.J. Kastin. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides 27: 911-916, 2006.

818. Kastin, A.J. & W. Pan. Editorial: Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity? Endocrinology 147: 2086-2087, 2006.

819. Pan, W, X. Xiang, H. Tu, and A.J. Kastin. Cytokines interact with the blood-brain barrier. Chapter 11, in: The Blood-brain Barriers: From Ontogeny to Artificial Interfaces. Volume I, Dermietzel R, Spray DC and Nedergaard M ed., Winheim, Germany: Wiley-VCH, 2006, pp 247-264.

820. Yu, Y., A.J. Kastin, and W. Pan. Reciprocal interactions of insulin and IGF-I in receptor-mediated transport across the blood-brain barrier. Endocrinology 147: 2611-2615, 2006.

77

Page 78: Abba J. Kastin, M.D

821. Pan W., C. Cain, Y. Yu, and A.J. Kastin. Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury. J. Neuroimmunol. 174: 119-125, 2006.

822. Pan, W, Y. Yu, R. Yemane, C. Cain, C. Yu, and A.J. Kastin. Permeation of hepatocyte growth factor across the blood-brain barrier. Exp. Neurol. 201: 99-104, 2006.

823. Yu, C., A.J. Kastin, Y. Ding, and W. Pan. Gamma glutamyl transpeptidase is a dynamic indicator of endothelial response to stroke. Exp. Neurol. 203: 116-122, 2007.

824. Tu, H., A.J. Kastin, and W. Pan. CRH-R1 and CRH-R2 are both trafficking and signaling receptors for urocortin. Mol. Endocrinol. 21: 700-711, 2007.

825. Pan, W. and A.J. Kastin. Mahogany, blood-brain barrier, and fat mass surge in AVY mice. Int. J Obes. 31: 1030-1032, 2007.

826. Tu, H., W. Pan, L. Feucht, and A.J. Kastin. Convergent trafficking pattern of leptin after endocytosis mediated by ObRa – ObRd. J Cell Physiol. 212: 215-222, 2007.

827. Pan W, A.J. Kastin, J. Daniel, C. Yu, L.M. Baryshnikova, and C.S. von Bartheld. TNF trafficking in cerebral vascular endothelial cells. J Neuroimmunol 185: 47-56, 2007.

828. Yu, C., A.J. Kastin, H. Tu, and W. Pan. Opposing effects of proteasomes and lysosomes on LIFR: modulation by TNF. J Mol Neurosci 31:80-89, 2007.

829. Pan, W., M. Barron, H. Hsuchou, H. Tu, and A.J. Kastin. Increased leptin permeation across the blood-brain barrier after chronic alcohol ingestion. Neuropsychopharmacology, in press, 2007.

830. Tu, H., A.J. Kastin, C. Bjørbæk, and W. Pan. Urocortin trafficking in cerebral microvessel endothelial cells. J Mol Neurosci. 31: 171-82, 2007.

831. Pan, W. and A.J. Kastin. Adipokines and the blood-brain barrier. Peptides 28: 1317-1330, 2007.

832. Yu, C., A.J. Kastin, and W. Pan. TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression. J Cell Physiol. 213: 161-6, 2007.

833. Pan, W. and A.J. Kastin. Peptide/polypeptide transport in the central nervous system. In: Handbook of Neurochemistry and Molecular Neurobiology: Neural Membranes and Transport. Lajtha, A. and Reith, E.A., eds, New York: Springer, 2007, pp 406-422.

834. Pan, W., H. Tu, C. Yu, H. Hsuchou, Y. Yang, and A.J. Kastin. Differential role of TNF receptors in cellular trafficking of intact TNF. Cell Physiol. Biochem. 20: 559-568, 2007.

78

Page 79: Abba J. Kastin, M.D

835. Yu, C., W. Pan, H. Tu, S. Waters, and A.J. Kastin. TNF activates p-glycoprotein in cerebral microvascular endothelial cells. Cell Physiol. Biochem. 20: 853-858, 2007.

836. Pan, W., H. Hsuchou, and A.J. Kastin. Nesfatin-1 crosses the blood–brain barrier without saturation. Peptides 28: 2223-2228, 2007.

837. Hsuchou, H., Pan, W., and A.J. Kastin. The fasting polypeptide FGF21 can enter brain from blood. Peptides 28: 2382-2386, 2007.

838. Pan, W. and A.J. Kastin. From MIF-1 to endomorphin: the TYR-MIF-1 family of peptides. Peptides, 28: 2411-2434, 2007.

839. Pan, W. and A.J. Kastin. Tumor necrosis factor and stroke: role of the blood-brain barrier. Prog. Neurobiol. 83: 363-374, 2007.

79