TBILISIJUNE 5-7, 2019

PROGRAM OF THE CONFERENCE

University Clinic9 Tsinandali St, Tbilisi

XVI th INTERNATIONAL SCIENTIFIC CONFERENCE

«HAEMATOPOIESIS IMMUNOLOGY»

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ORGANIZER

GUEST EXPERT

Federal State Budgetary Institute «N. N.Blokhin National Medical Research Center of Oncology» of Ministry of Health of Russian Federation

George Janossy

Moderator of the Conference Professor, Academician of Hungarian Academy of Sciences (UK)

Nikolay N.Tupitsyn

Сhairman. Professor, Honored Scientist of Russia Head of Haematopoiesis Immunology Laboratory Federal State Budgetary Institute «N.N. Blokhin National Medical Research Center of Oncology» Ministry of Health of the Russian Federation (Russia)

Bovin Nikolay

Ph. D., Professor Department of chemical biology of glycans and lipids Institute Bioorganic chemistry. M.M. Shemyakin and Y.A. Ovchinnikov Russian Academy of Sciences (Russia)

Berksoy Sahin

MD, Professor. He is a member of several national and international societes including the Turkish Society of Medical Oncology, the National Society of Hematologists,and the Society of European Bone Marrow Transplantation (Turkey)

Dvirnykh Valentina

MD, PhD, Head, Centralized Clinical Diagnostics Laboratory, Doctor, Clinical Diagnostics Laboratory, National Medical Research Center for Hematology (Russia)

Drokova Darya

Doctor, Clinical Laboratory Diagnostics (flow cytometry), National Medical Research Center for Hematology (Russia)

Gale Robert

Professor, MD PhD, DSc(hc), FACP, FRSM (New York)

Falaleeva Natalya

MD, Head of the Department of drug treatment of malignant tumors mrnts them. A. F. Tsyba –branch of «NMITS radiology» of the Ministry of health of Russia (Russia)

Grivtsova Ludmila

Head of the Department of laboratory medicine mrnc. A. F. Tsyb – branch fgbu «SMRC radiology» of Ministry of health of Russia, D. SC.N. (Russia)

Galili Uri

Professor, Rush University Medical Center, Chicago (USA)

N.N.BLOKHINCRC

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GUEST EXPERT

Huflejt Margaret

Ph.D, Adjunkt, Medical Faculty of University of Rzeszow University of Rzeszow Centre for Innovative Research in Medical and Natural Sciences (Poland)

Guvenc Birol

MD, Professor. He is a founding member and the acting president of the Hematology Specialist Association and member of many international societes including the American Society of Hematology (Turkey)

Jurisic Vladimir

MD, PhD is a professor for Physiopathology at University of Kragujevac, Faculty of Medical Sciences (Serbia)

Joosse Simon

PhD, Research group leader University Medical Center Hambug-Eppendorf (Germany)

Kosorukov Vyacheslav

Ph.D. Adjunkt, Deputy Director for research – Director of the research Institute of experimental diagnosis and therapy of tumors Federal State Budgetary Institute «N.N. Blokhin National Medical Research Center of Oncology» Ministry of Health of the Russian Federation (Russia)

Kadagidze Zaira

MD, Professor, Leading Research Scientist, Laboratory of Clinical Immunology of Tumors Federal State Budgetary Institute «N.N. Blokhin National Medical Research Center of Oncology» Ministry of Health of the Russian Federation (Russia)

Naskhletashvili David

PhD, medical oncologist, neuro-Oncology, oncologist of the highest category Federal State Budgetary Institute «N.N. Blokhin National Medical Research Center of Oncology» Ministry of Health of the Russian Federation (Russia)

Leone Kevin

PhD, Laboratorio DME-CTC Istituto Oncologico Veneto IRCCS c/o Istituto di Ricerca Pediatrica (Italy)

Vorotnikov Igor

Professor, Нead of the Surgical Department №5 breast tumors research Institute of clinical Oncology Federal State Budgetary Institute «N.N. Blokhin National Medical Research Center of Oncology» Ministry of Health of the Russian Federation (Russia)

Rossi Jean-Francois

MD, PhD, Professor. Member of 7 international scientific societies and the Scientific Advisory Board of the Castleman Disease Collaborative Network (CDCN) (France)

Frenkel Marina

MD, Professor, Leading researcher Haematopoiesis Immunology Laboratory Federal State Budgetary Institute «N.N. Blokhin National Medical Research Center of Oncology» Ministry of Health of the Russian Federation (Russia)

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PROGRAM

June 5, 2019

Registration

14.00–14.20Opening CeremonyWelcoming address Professor Professor George Janossy, Professor NikolayTupitsyn

GENERAL TUMOR-IMMUNOLOGYChairpersons: Professor George Janossy, Professor Zaira Kadagidze, Professor George Jurisic

14.20–14.40 Predictors of the clinical use of check points inhibitors of immunity Professor Zaira Kadagidze

14.40–15.10 Immunotherapy of sarcomasProfessor Robert Gale

15.10–15.30 Thrombosis in hematological malignancies: from bench to bedsideProfessor Jean-Francois Rossi

15.30–15.45 NK cell function in myelomaVladimir Jurisic

15.45 – 16.00 The potential of tumor neoantigens in immunotherapy of oncological diseasesVyacheslav Kosorukov

16.00–16.10 Immunoregulatory supressor T-cells in lymphoprolipherative disordersEugenya Kuzmina, T.Yu.Mushkarina, T.V.Konstantinova, S.V.Shakhtarina

16.10–16.20 Integral immunohematologic parameters in Hodgkin’s lymphomaTatyana Mushkarina*, E.G.Kuzmina, T.V.Konstantinova, T.I.Bogatyreva, L.Yu.Grivtsova

16.20–17.20

SEMINAR «TOWARDS THE PROTOCOL OF SARCOMAS IMMUNE THERAPY WITH ALLOGENEIC BONE MARROW (BASED on N.N.TRAPEZNIKOV-G.I.DEICHMAN DATA)»

Chairman: Professor Robert Gale Participants: Kapitolina Melkova, Oleg Rukavitsyn, George Janossy, Tatiana Gorbunova, Igor Vorotnikov, Nikolay Tupitsyn

17.20–17.30 Discussion

June 6, 201909.00–10.00 Registration

STEM CELLSChairpersons: Professor Marina Frenkel, Professor Birol Guvench, Professor Oleg Rukavitsyn

10.00–10.20 Stem cells – targets of hemoblastosesProfessor Marina Frenkel

10.20–10.40 What is ApheresisProfessor Birol Guvench

10.40–11.00 Subpopulations of mobilized autologous and allogeneic hematopoietic stem cells: transplantation in oncological practiceLudmila Grivtsova

11.00–11.20 Tumor stem cellsSvetlana Chulkova

11.20–11.35 COFFE BREAK

* Young scientist

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PROGRAM

IMMUNODIAGNOSTICS IN ONCOHAEMATOLOGYChairpersons: Professor Jean-Francois Rossi, Professor Nikolay Tupitsyn,

Professor George Janossy, Professor Vladimir Jurisic

11.35–11.50 Dendritic cell Immunothe rapy; Cancer VaccineProfessor Ali Unal

11.50–12.00 Blastik plasmacytoid dendritic cell neoplasm. Presentation of clinical reportsDarya Drokova*

12.00–12.10Genomic alteration in CIITA frequent in mediastinal large B-cell lymphoma and notspecified for multiple myeloma Anna Sergeyeva*

12.10–12.20 The role of determining CD117 in the diagnosis of acute myeloid leukemia in childrenAlexandra Palladina*

12.20–12.35 Systemic mastocytosis diagnostics principals. Clinical case reportValentina Dvirnykh

12.35–12.45 Diagnosis of angioimmunoblastic T-cell lymphoma using flow cytometryElena Rybkina*

12.45–12.55 Features of AML diagnosis with monocytic differentiationKira Matokhina*

SOLID TUMORS:IMMUNE DIAGNOSIS, IMMUNE STADING, IMMUNE THERAPYChairpersons:Professor Robert Gale, Professor Igor Vorotnikov,

Professor Jean-Francois Rossi, Kapitolina Melkova, PhD

12.55–13.15 Tumor cell dissemination and liquid biopsy for cancer diagnosisSimon Joosse

13.15–13.35 Second opinion in oncological diagnosing. Possibilities of Gemotest Medical laboratoryRimma Boyko

13.35–13.50 Immunotherapy in metastatic colorectal cancerProfessor Sahin Berksoy

13.50–14.50

SEMINAR «IMMUNE ADJUVANTS IN IMMUNOTHERAPY OF CANCER PATIENTS – POLYOXODONIUM AS AN EXAMPLE»

Chairman: Professor Nikolay Tupitsyn, Professor Jean-Francois Rossi, Ludmila Komarova • Farkhad Shamilov «Strategy of immune adjuvants in oncology»• Jean-Francois Rossi «Influence of polyoxidonium on breast cancer patient’s immune system»• Nikolay Tupitsyn «Main subpopulations of bone marrow cells and TILs which are the targets of polyoxidonium»• Yana Vishnevskaya «Morphological basis of tumor pathomorphosis induced by polyoxidonium»

14.50–15.00Circulating tumor cells in patients with stage II–III breast cancerValery Ponomarev*, O.A. Chernysheva, S.B. Polikarpova, A.Yu. Suvorov, V.Yu. Kirsanov, E.A. Bogush, D.A. Goryainov, A.A. Ofosuakh, N.N. Tupitsyn

15.00–15.30 LUNCH

* Young scientist

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PROGRAM

15.30–15.45 Disseminated tumor cells in patients with luminal breast cancer are promising markers of prognosisDenis Ryabchikov

15.45–16.00 Immunotherapy in the treatment of patients with melanoma with metastases in the brainDavid Naskhletashvili

16.00–16.10 The clinical significance of the repertoire of NK cells in cancer patientsKapitolina Melkova, Zhanna Sharoyan

16.10–16.25 Bone marrow transplantation in Georgia. Review on situation before and after BMT in GeorgiaNino Sharashenidze

16.25–16.35 Bone marrow in patients with follicular lymphomaNatalya Falaleeva

16.35–16.50 Lymphocyte subpopulations of bone marrow in children with small-round cell sarcomasOlga Kolbatskaya

16.50–17.00 Detection of PD-L1-positive CTCs: standardizing a PD-L1 assayKevin Leone*

17.00–17.10 Discussion

18.30 Welcome reception

June 7, 2019

09.00–10.00 Registration

TUMOR-ASSOCIATED GLYCANS AND ANTI-GLYCANSChairpersons: Professor Nikolay Bovin, Professor Uri Galili, Professor Margaret Huflejt

10.00 – 10.20 The true specificity of human antibodies known as «anti-TNProfessor Nikolay Bovin

10.20–11.05 Autologous antitumor vaccines using alpha-gal glycolipidsProfessor Uri Galili

11.05–11.35 Glyco-Immuno-Oncology: from diagnosis to treatment opportunitiesMargaret Huflejt

11.35–11.55 Human anti-LeC antibodiesNadezhda Shilova

11.55–12.55

SEMINAR «POSSIBILITIES OF GLYCAN AND ANTI-GLYCAN-BASED IMMUNE DIAGNOSIS AND IMMUNE THERAPY»

Chairmen: Professor Uri Gallili, Professor Robert Gale, Professor George Janossy, Professor Jean-Francois Rossi, Professor Nikolay Bovin, Professor Margaret Huflejt, Professor Igor Vorotnikov, Vyacheslav Kosorukov, Ph), David Naschletashvili, PhD, Maxim NikulinMain topics: flow cytometry-based diagnosis of anti-glycans in human sera, natural antibodies or hybridoma produced monoclonal antibodies etc.

12.55–13.10 General Discussion

Conference closing remarks

* Young scientist

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GENERAL SPONSORBioLine LLCAddress: Russia, 197101, St. Petersburg, Pinsky per, 3, lit. A Tel.: +7 (812) 320-49-49E-mail: main@bioline.ruWebsite: www.bioline.ru

BioLine company specializes in equipping laboratories with flow cytometry, cytogenetics, immunohistochemistry and molecular diagnostics and presents complex solutions for oncology and oncohematology.

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NPO Petrovax Pharm is a Russian full-cycle biopharmaceutical company focusing on R&D and manufacture of innovative im-munobiological medical products.The company has a successful 20-year experience on the pharmaceutical market. NPO Petro-vax Pharm’s product portfolio includes only innovative pharmaceuticals and vaccines manufactured based on in-house R&D results and in partnership with the leading domestic and foreign companies. NPO Petrovax Pharm has more than 20 patents for new molecules and manufacturing technologies. The company’s major activities include the development and manufacture of influenza vaccines and immunobiological products as well as manufacture of a pneumococcal vaccine, innovative throm-bolytics. The company’s manufacture is fully compliant with the Russian and international GMP standards and ISO:9001. NPO Petrovax Pharm has more than 600 highly skilled employees. NPO Petrovax Pharm is part of Interros Group.

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FOR NOTES

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FOR NOTES

© BD, 2017. Все права защищены. BD и логотип BD являются товарными знаками Becton, Dickinson and Company. 22885-MC7729

ПРОТОЧНЫЕ ЦИТОФЛУОРИМЕТРЫ BD BIOSCIENCES — ЛУЧШЕЕ РЕШЕНИЕ ДЛЯ ВАШЕЙ ЛАБОРАТОРИИ.

40 ЛЕТ ДОВЕРИЯ в различных сферах применения:

» ВИЧ/СПИД» Онкогематология» Иммунология

» Научные исследования» Промышленность» Биотехнологии

© BD, 2017. Все права защищены. BD и логотип BD являются товарными знаками Becton, Dickinson and Company. 22885-MC7729

ПРОТОЧНЫЕ ЦИТОФЛУОРИМЕТРЫ BD BIOSCIENCES — ЛУЧШЕЕ РЕШЕНИЕ ДЛЯ ВАШЕЙ ЛАБОРАТОРИИ.

40 ЛЕТ ДОВЕРИЯ в различных сферах применения:

» ВИЧ/СПИД» Онкогематология» Иммунология

» Научные исследования» Промышленность» Биотехнологии