20 28 2016 07 01 chinese journal of tissue engineering research july 1, 2016 vol.20, no.28 4234 p.o....

�� 20 � � 28 � 20160701 �

Chinese Journal of Tissue Engineering Research July 1, 2016 Vol.20, No.28

P.O. Box 10002, Shenyang 110180 www.CRTER.org

4234

��

www.CRTER.org

��1990��

��

��

��

!"#��$�%&'(

)*+,-./012

3456789:

;?@AB�C#�

%��$�DE�C#�

F$��

��

��G

570208

��:R394.2

��:B

��:2095-4344

(2016)28-04234-09

��2016-04-06

�

��

�

��

�

��

�

��(�� 570208)

��. ��[J].�� 2016�20(28):4234-4242.

DOI: 10.3969/j.issn.2095-4344.2016.28.019 ORCID: 0000-0002-1918-8803(��)

��

��

�� !"#$��%&'

()*+(,-Karp./01'234�5*+"#�6789:;:?$�@A

"#�BC-01BCDEFG�HIJ8K�LMNOIP QR�NORSTNORU�VRW

XYOI�Z[�YO-

��\]A"#^��%_àb�cdef�abegh

i4LMNOjkRlbmn(opabRqrstRuvtw/ûvxyRz{R�NO^M|

l�)R�[N}~R�}~R3D�.�àb]cdY3"#àb

w�àb-

��

��01��"#}F��I��-*\��fm

01@A"#�}Fm�-àb3%�01 ¡¢-

��]%��01�àb%_£¤-

��¥¦stem cell, mesenchymal stem cells, preconditioning, homing, migration§3¨©ª«cd

"¬5 PubMed®¯¨© 2000° 1±@ 2015° 9±�)àb%��01�²

³�´µ+¶�·¸¹º 72»²³%_£¤-

�� \]A"#^��%_àb�¼½%P01@ !"#

¾&¿À"#}Fmn-"#àbÁ��BÂÃx�Ä�ÅÆÇÈLMNOÅ.m�¾

&%��01-��àb�ÉÊ[N}~R�NOËÌ.�¥��

�LMNO Q3mnÍ��BÇÈPÅÎ%A�01-̀ ab/3�ÏÐn

)ÑÒÓÎÔÕÖ×-

!"#�

��!"#!��!��!��!��!"#!��!��$%!&'(

)*+,-.

$�#�

��!"#!��

%&'(�

&'()*+,-.(811151)

��

��

��

��

��

�� !

"#�3D$%�&'�!

��()*+,-��

./01234

567839:

��;�

��

��?@!

"#�A;BC

DE!

FG��

��7H6I�,JK

��. ��

ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH

4235

www.CRTER.org

Wang Guo-ren, Studying

for master’s degree,

Physician, Department of

Urology, Affiliated Haikou

Hospital, Xiangya School

of Medicine, Central South

University, Haikou 570208,

Hainan Province, China

Corresponding author:

Bai Zhi-ming, M.D., Chief

physician, Professor,

Doctoral supervisor,

Department of Urology,

Affiliated Haikou Hospital,

Xiangya School of

Medicine, Central South

University, Haikou 570208,

Hainan Province, China

Preconditioning strategies for promoting mesenchymal stem cell homing

Wang Guo-ren, Bai Zhi-ming (Department of Urology, Affiliated Haikou Hospital, Xiangya School of

Medicine, Central South University, Haikou 570208, Hainan Province, China)

Abstract

BACKGROUND: Homing is the initial and key procedure of stem cells-based tissue restoration. Current

studies have shown that the inability to recruit bone marrow mesenchymal stem cells to target tissue with

high efficiency remains a significant barrier to tissue restoration. Preconditioning strategy provides a new

insight to promote stem cell homing.

OBJECTIVE: To review preconditioning strategies for promoting the homing of stem cells.

METHODS: In PubMed database, different combinations of terms from “stem cell, mesenchymal stem

cells, preconditioning, homing, migration” served as search terms to retrieve articles referring

preconditioning strategies for promoting mesenchymal stem cell homing published from January 2000 to

September 2015. According to the inclusion criteria, 72 articles were selected for final review.

RESULTS AND CONCLUSION: Pretreating target tissue or mesenchymal stem cells ahead of cell

transplantation, known as tissue preconditioning or cell preconditioning, prominently promotes the homing

of mesenchymal stem cells, therefore enhancing tissue restoration effect. Tissue preconditioning is

designed to up-regulate expression of chemokines by varying the local microenvironment, thereby

increasing homing ability of mesechymal stem cells. Mesenchymal stem cell preconditioning strategies, for

example, gene modification and cytokine induction, are mainly to up-regulate expression of chemokine

receptors on the surface of mesenchymal stem cells as effectors, and thus promote targeted cell homing.

Overall, preconditioning strategy will bring great hope to apply stem cell therapy into the clinic.

Subject headings: Mesenchymal Stem Cells; Transplantation; Tissue Engineering

Funding: the Natural Science Foundation of Hainan Province, China, No. 811151

Cite this article: Wang GR, Bai ZM. Preconditioning strategies for promoting mesenchymal stem cell

homing. Zhongguo Zuzhi Gongcheng Yanjiu. 2016;20(28):4234-4242.

0 �� Introduction

��

��

[1-3]

�� !"#

[4-6]

�$%

&��'(�)/�)*+,- !"#

[7-9]

./0�

��123*�� !"#�456,-

*7�89:;

[10]

.?@ABCD��

�� E�FG56�HI��B

JKL

[11-12]

MNOPQ

[13]

MNO��LR

[14]

MNO

STUVWX

[15-17]

.

YZ[�\]^_`4abcCD'BCD��

��defgh

[18]

��4"#\]

^M��\]^i�_`.jklab��

��\]^_`bmno.

1��Data and methods

1.1 ��

1.1.1 pqLrs PubMedLrs(http://www.ncbi.

nlm.nih.gov/pubmed/).

1.1.2 pqLrs�tu^v PubMedLrs�w

Bxyz�{|}~jLrs�jLr�.

1.1.3 pqMpq'pq� 4

Mpqno�j�jk

%nfpq�tuMpq�tu

�pq��f~�pq_

`.

��stem cell�mesenchymal stem cells�

preconditioning�homing�migration.

�� stem cell�preconditioning�

homing¡¢ stem cell�preconditioning�migration¡¢

mesenchymal stem cells � preconditioning �

homing¡¢ mesenchymal stem cells�preconditioning�

migration¡�£¤"bmpq.

��2000Z1¥�2015Z9¥.

1.2 ��

1.2.1 j¦t§ ¨�

��

�1�©ªbm.

1.2.2 j�¦t« ¬jkoc®¯'��

�M��U\]^_`l��°.±²³M

²r�´�jk.µ¤�¶·�jtuY¸¹@U

yzº»�j.

1.2.3 ¼½�j ¾¿À«1UÁÂDMÃ-

Dj.

1.2.4 �ÄÅÆ ÇÈQpqÉÊ162Ëj�ÌÍ

��. ��


4236

www.CRTER.org

��

�� !"#

$%&'()*+,-./012��34567

728��9�:;?�@ABC ��DE��

>?�@AF&��G&BCH6IJ�C�:

KL��G&BCMNOPQ�RQSTRUQ

VWXYQZ[(S[)Q\]^3_��`a�

��bcJ��3

2��Results �

2.1 �� d%efgh�ij

kfghO&��lmnokpqmnrstd

%efghuv5wxyz{|u�}~�

3Karp^

[10]

ij~fgh�z{�

�}|uz{�3

Lfgh�ij��5�ÚÛd%efgh�|u�:;�è�

�ÈÉ(green fluorescent proteinGFP)�³Â��

�y/ö÷CCL21®ö÷PBS��

z>?W+CCL21ö÷z|uyÜ/�GFP

+

g

��PubMed��

��162��

�� 109

��

��

��72

��stem cell, mesenchymal stem cells,

preconditioning, homing, migration

� 1 ��

� 2 ��

[28]

��. ��


4237

www.CRTER.org

h+� !r��³eghÌÆÂÃ1�é+w,-�d%

efghijn:~õ�O&3Zhang^

[38]

o&(

)é+~w,-õ�Ld%efghwdef

gÓKLhijNj��NR�wijV

�é+,-5NRz{§ghª«

��. ��


4238

www.CRTER.org

5ghW¬CXCR4¯ÄijxÅW¶®¯

kLd%efghij¢Ò.��¸¹Ô

:3d%efgh./0ïðíË³Â"°Qgh

ÂÃ±L^¤�®d%efghW¬ÀÁÂÃxÅ

¢£:rîÚÄW¶'õ�wij3

2.3.1 ³Â"° o&j²³j²�_´µô³

Â?@ÚÛd%efghW¬xÅ?mA

CXCR4W¶îÚ�d%efgh�ijW+�b

·�}õ�Ä�Nuv��NR6¸¢£3Chen

^

[46]

om+î¹>º3»��r³Â"°îÚ

CXCR1

[47]

QCCR1W¶

[48]

V}¶µJõ�d%e

fghij��3

¼ÀÁÂÃxÅd%efgh�gh½W¬

nW¶Ä:-gh|uÕp�

��. ��


4239

www.CRTER.org

hõö÷ij�3

Toma^

[64]

o&c¢£ÊøòÃùÅ�ú

eé+ûd%efghW¬®()GLfgh

é+�Qüª«§ýîô}�xy

2HÁ3Kokhuis^

[65]

o&)[\÷WGLfg

hé+w§ý !ÝÞ§ý�d%e

fghõ�Ä�yz{|�"#O&ABãV

�Âé+û�d%efghé+û[�5

�³þ�fgh�()*Â�£3

��.ïW3()$��¯��B

ã�mA�õ�t��Ä�¸¹Ô:kr

!d%efghwQ/�

[66]

3Wei^

[66]

o&.

ïW3()./0d%efgh5>Ögh

CXCR4¯SDF-1 mRNA?@îÚÅ|uABV�

d%efgh�|uWb·�SDF-1-CXCR4

F�ZAMD3100Þ./0ïðbc?G�

�@3

V!pAø./0ïðO&¸¹��:;�

�!È��P�ÄD3Ô/�0(õ./0

ïð��0�@3

��

��

� �!�� !"#��$%&'()*��

"�#$�+�,%&-./0)*�12��

%&'(��345678 CNKI 9:;�

?@AB 3CDE�

%&)*��7�1F!BG�HIJKG��L

MNOPQRS��

��+�TU��VWXYZ[�\�]3^�_

`Babc��\�]d��efgh�ijklmn

oijpqrs�tN6uv�&wxyz�{|Y}~�

#D��

��. ��


4240

www.CRTER.org

%&,-��345�6,��

4%&��

4 �� References

[1] Fuchs E, Segre JA. Stem cells: a new lease on life.

Cell. 2000;100(1):143-155.

[2] Horwitz EM, Le Blanc K, Dominici M, et al. Clarification

of the nomenclature for MSC: The International

Society for Cellular Therapy position statement.

Cytotherapy. 2005;7(5):393-395.

[3] Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria

for defining multipotent mesenchymal stromal cells.

The International Society for Cellular Therapy position

statement. Cytotherapy. 2006;8(4):315-317.

[4] Chamberlain G, Fox J, Ashton B, et al. Concise review:

mesenchymal stem cells: their phenotype, differentiation

capacity, immunological features, and potential for

homing. Stem Cells. 2007;25(11):2739-2749.

[5] Deak E, Seifried E, Henschler R. Homing pathways of

mesenchymal stromal cells (MSCs) and their role in

clinical applications. Int Rev Immunol. 2010;29(5):514-

529.

[6] Fong EL, Chan CK, Goodman SB. Stem cell homing in

musculoskeletal injury. Biomaterials. 2011;32(2):

395-409.

[7] Zhu XY, Lerman A, Lerman LO. Concise review:

mesenchymal stem cell treatment for ischemic kidney

disease. Stem Cells. 2013;31(9):1731-1736.

[8] Cashman TJ, Gouon-Evans V, Costa KD.

Mesenchymal stem cells for cardiac therapy: practical

challenges and potential mechanisms. Stem Cell Rev.

2013;9(3):254-265.

[9] Chou SH, Lin SZ, Kuo WW, et al. Mesenchymal stem

cell insights: prospects in cardiovascular therapy. Cell

Transplant. 2014;23(4-5):513-529.

[10] Karp JM, Leng Teo GS. Mesenchymal stem cell

homing: the devil is in the details. Cell Stem Cell. 2009;

4(3):206-216.

[11] Rombouts WJ, Ploemacher RE. Primary murine MSC

show highly efficient homing to the bone marrow but

lose homing ability following culture. Leukemia. 2003;

17(1):160-170.

[12] Phinney DG, Prockop DJ. Concise review: mesenchymal

stem/multipotent stromal cells: the state of

transdifferentiation and modes of tissue repair-current

views. Stem Cells. 2007;25(11):2896- 2902.

[13] Chen J, Li Y, Wang L, et al. Therapeutic benefit of

intravenous administration of bone marrow stromal

cells after cerebral ischemia in rats. Stroke. 2001;

32(4):1005-1011.

[14] Wu J, Sun Z, Sun HS, et al. Intravenously administered

bone marrow cells migrate to damaged brain tissue

and improve neural function in ischemic rats. Cell

Transplant. 2008;16(10):993-1005.

[15] Freyman T, Polin G, Osman H, et al. A quantitative,

randomized study evaluating three methods of

mesenchymal stem cell delivery following myocardial

infarction. Eur Heart J. 2006;27(9):1114-1122.

[16] Omori Y, Honmou O, Harada K, et al. Optimization of a

therapeutic protocol for intravenous injection of human

mesenchymal stem cells after cerebral ischemia in

adult rats. Brain Res. 2008;1236:30-38.

[17] Bai ZM, Deng XD, Li JD, et al. Arterially transplanted

mesenchymal stem cells in a mouse reversible

unilateral ureteral obstruction model: in vivo

bioluminescence imaging and effects on renal fibrosis.

Chin Med J (Engl). 2013;126(10):1890-1894.

[18] Yu SP, Wei Z, Wei L. Preconditioning strategy in stem

cell transplantation therapy. Transl Stroke Res. 2013;

4(1):76-88.

[19] Liu ZJ, Zhuge Y, Velazquez OC. Trafficking and

differentiation of mesenchymal stem cells. J Cell

Biochem. 2009;106(6):984-991.

[20] Chen FM, Wu LA, Zhang M, et al. Homing of

endogenous stem/progenitor cells for in situ tissue

regeneration: Promises, strategies, and translational

perspectives. Biomaterials. 2011;32(12):3189-3209.

[21] Vanden Berg-Foels WS. In situ tissue regeneration:

chemoattractants for endogenous stem cell

recruitment. Tissue Eng Part B Rev. 2014;20(1):28-39.

[22] Wynn RF, Hart CA, Corradi-Perini C, et al. A small

proportion of mesenchymal stem cells strongly

expresses functionally active CXCR4 receptor capable

of promoting migration to bone marrow. Blood. 2004;

104(9):2643-2645.

[23] Sharma M, Afrin F, Satija N, et al. Stromal-derived

factor-1/CXCR4 signaling: indispensable role in

homing and engraftment of hematopoietic stem cells in

bone marrow. Stem Cells Dev. 2011;20(6):933-946.

[24] Zhu H, Mitsuhashi N, Klein A, et al. The role of the

hyaluronan receptor CD44 in mesenchymal stem cell

migration in the extracellular matrix. Stem Cells. 2006;

24(4):928-935.

[25] Sackstein R, Merzaban JS, Cain DW, et al. Ex vivo

glycan engineering of CD44 programs human

multipotent mesenchymal stromal cell trafficking to

bone. Nat Med. 2008;14(2):181-187.

[26] Zhang A, Wang Y, Ye Z, et al. Mechanism of

TNF-α-induced migration and hepatocyte growth factor

production in human mesenchymal stem cells. J Cell

Biochem. 2010;111(2):469-475.

��. ��


4241

www.CRTER.org

[27] Ryu CH, Park SA, Kim SM, et al. Migration of human

umbilical cord blood mesenchymal stem cells

mediated by stromal cell-derived factor-1/CXCR4 axis

via Akt, ERK, and p38 signal transduction pathways.

Biochem Biophys Res Commun. 2010;398(1):105-110.

[28] Marquez-Curtis LA, Janowska-Wieczorek A.

Enhancing the migration ability of mesenchymal

stromal cells by targeting the SDF-1/CXCR4 axis.

Biomed Res Int. 2013;2013:561098.

[29] Gao H, Priebe W, Glod J, et al. Activation of signal

transducers and activators of transcription 3 and focal

adhesion kinase by stromal cell-derived factor 1 is

required for migration of human mesenchymal stem

cells in response to tumor cell-conditioned medium.

Stem Cells. 2009;27(4):857-865.

[30] Lee MJ, Jeon ES, Lee JS, et al. Lysophosphatidic acid

in malignant ascites stimulates migration of human

mesenchymal stem cells. J Cell Biochem. 2008;104(2):

499-510.

[31] Shang YC, Wang SH, Xiong F, et al. Wnt3a signaling

promotes proliferation, myogenic differentiation, and

migration of rat bone marrow mesenchymal stem cells.

Acta Pharmacol Sin. 2007;28(11):1761-1774.

[32] Ponte AL, Marais E, Gallay N, et al. The in vitro

migration capacity of human bone marrow

mesenchymal stem cells: comparison of chemokine

and growth factor chemotactic activities. Stem Cells.

2007;25(7):1737-1745.

[33] Ji JF, He BP, Dheen ST, et al. Interactions of

chemokines and chemokine receptors mediate the

migration of mesenchymal stem cells to the impaired

site in the brain after hypoglossal nerve injury. Stem

Cells. 2004;22(3):415-427.

[34] Sasaki M, Abe R, Fujita Y, et al. Mesenchymal stem

cells are recruited into wounded skin and contribute to

wound repair by transdifferentiation into multiple skin

cell type. J Immunol. 2008;180(4):2581-2587.

[35] Zhou SB, Wang J, Chiang CA, et al. Mechanical

stretch upregulates SDF-1α in skin tissue and induces

migration of circulating bone marrow-derived stem

cells into the expanded skin. Stem Cells. 2013;31

(12):2703-2713.

[36] Burks SR, Nguyen BA, Tebebi PA, et al. Pulsed

focused ultrasound pretreatment improves

mesenchymal stromal cell efficacy in preventing and

rescuing established acute kidney injury in mice. Stem

Cells. 2015;33(4):1241-1253.

[37] Wu S, Li L, Wang G, et al. Ultrasound-targeted stromal

cell-derived factor-1-loaded microbubble destruction

promotes mesenchymal stem cell homing to kidneys in

diabetic nephropathy rats. Int J Nanomedicine. 2014;9:

5639-5651.

[38] Zhang Y, Ye C, Wang G, et al. Kidney-targeted

transplantation of mesenchymal stem cells by

ultrasound-targeted microbubble destruction promotes

kidney repair in diabetic nephropathy rats. Biomed Res

Int. 2013;2013:526367.

[39] Oron U, Tuby H, Maltz L, et al. Autologous bone-marrow

stem cells stimulation reverses post-ischemic-

reperfusion kidney injury in rats. Am J Nephrol. 2014;

40(5):425-433.

[40] Tuby H, Maltz L, Oron U. Induction of autologous

mesenchymal stem cells in the bone marrow by

low-level laser therapy has profound beneficial effects

on the infarcted rat heart. Lasers Surg Med. 2011;

43(5):401-409.

[41] Aicher A, Heeschen C, Sasaki K, et al. Low-energy

shock wave for enhancing recruitment of endothelial

progenitor cells: a new modality to increase efficacy of

cell therapy in chronic hind limb ischemia. Circulation.

2006;114(25):2823-2830.

[42] Qiu X, Lin G, Xin Z, et al. Effects of low-energy

shockwave therapy on the erectile function and tissue of

a diabetic rat model. J Sex Med. 2013;10(3):738-746.

[43] Huang Z, Ma T, Ren PG, et al. Effects of orthopedic

polymer particles on chemotaxis of macrophages and

mesenchymal stem cells. J Biomed Mater Res A. 2010;

94(4):1264-1269.

[44] Gibon E, Yao Z, Rao AJ, et al. Effect of a CCR1

receptor antagonist on systemic trafficking of MSCs

and polyethylene particle-associated bone loss.

Biomaterials. 2012;33(14):3632-3638.

[45] Cao Z, Zhang G, Wang F, et al. Protective effects of

mesenchymal stem cells with CXCR4 up-regulation in

a rat renal transplantation model. PLoS One. 2013;

8(12):e82949.

[46] Chen W, Li M, Cheng H, et al. Overexpression of the

mesenchymal stem cell Cxcr4 gene in irradiated mice

increases the homing capacity of these cells. Cell

Biochem Biophys. 2013;67(3):1181-1191.

[47] Kim SM, Kim DS, Jeong CH, et al. CXC chemokine

receptor 1 enhances the ability of human umbilical

cord blood-derived mesenchymal stem cells to migrate

toward gliomas. Biochem Biophys Res Commun. 2011;

407(4):741-746.

[48] Huang J, Zhang Z, Guo J, et al. Genetic modification of

mesenchymal stem cells overexpressing CCR1

increases cell viability, migration, engraftment, and

capillary density in the injured myocardium. Circ Res.

2010;106(11):1753-1762.

[49] Meng F, Rui Y, Xu L, et al. Aqp1 enhances migration of

bone marrow mesenchymal stem cells through

regulation of FAK and β-catenin. Stem Cells Dev. 2014;

23(1):66-75.

��. ��


4242

www.CRTER.org

[50] Li P, Gao Y, Liu Z, et al. DNA transfection of bone

marrow stromal cells using microbubble-mediated

ultrasound and polyethylenimine: an in vitro study. Cell

Biochem Biophys. 2013;66(3):775-786.

[51] Shi M, Li J, Liao L, et al. Regulation of CXCR4

expression in human mesenchymal stem cells by

cytokine treatment: role in homing efficiency in

NOD/SCID mice. Haematologica. 2007;92(7):897-904.

[52] Fan H, Zhao G, Liu L, et al. Pre-treatment with IL-1β

enhances the efficacy of MSC transplantation in

DSS-induced colitis. Cell Mol Immunol. 2012;9(6):

473-481.

[53] Noiseux N, Borie M, Desnoyers A, et al.

Preconditioning of stem cells by oxytocin to improve

their therapeutic potential. Endocrinology. 2012;

153(11):5361-5372.

[54] Xinaris C, Morigi M, Benedetti V, et al. A novel strategy

to enhance mesenchymal stem cell migration capacity

and promote tissue repair in an injury specific fashion.

Cell Transplant. 2013;22(3):423-436.

[55] Zhu M, Feng Y, Dangelmajer S, et al. Human

cerebrospinal fluid regulates proliferation and

migration of stem cells through insulin-like growth

factor-1. Stem Cells Dev. 2015;24(2):160-171.

[56] Tsai LK, Leng Y, Wang Z, et al. The mood stabilizers

valproic acid and lithium enhance mesenchymal stem

cell migration via distinct mechanisms.

Neuropsychopharmacology. 2010;35(11):2225-2237.

[57] Kim YS, Noh MY, Kim JY, et al. Direct GSK-3β

inhibition enhances mesenchymal stromal cell

migration by increasing expression of β-PIX and

CXCR4. Mol Neurobiol. 2013;47(2):811-820.

[58] Najafi R, Sharifi AM. Deferoxamine preconditioning

potentiates mesenchymal stem cell homing in vitro and

in streptozotocin-diabetic rats. Expert Opin Biol Ther.

2013;13(7):959-972.

[59] Li S, Deng Y, Feng J, et al. Oxidative preconditioning

promotes bone marrow mesenchymal stem cells

migration and prevents apoptosis. Cell Biol Int. 2009;

33(3):411-418.

[60] Das R, Jahr H, van Osch GJ, et al. The role of hypoxia

in bone marrow-derived mesenchymal stem cells:

considerations for regenerative medicine approaches.

Tissue Eng Part B Rev. 2010;16(2):159-168.

[61] Liu H, Liu S, Li Y, et al. The role of

SDF-1-CXCR4/CXCR7 axis in the therapeutic effects

of hypoxia-preconditioned mesenchymal stem cells for

renal ischemia/reperfusion injury. PLoS One. 2012;

7(4):e34608.

[62] Hu X, Wei L, Taylor TM, et al. Hypoxic preconditioning

enhances bone marrow mesenchymal stem cell

migration via Kv2.1 channel and FAK activation. Am J

Physiol Cell Physiol. 2011;301(2):C362-372.

[63] Wei JF, Wei L, Zhou X, et al. Formation of Kv2.1-FAK

complex as a mechanism of FAK activation, cell

polarization and enhanced motility. J Cell Physiol. 2008;

217(2):544-557.

[64] Toma C, Fisher A, Wang J, et al. Vascular endoluminal

delivery of mesenchymal stem cells using acoustic

radiation force. Tissue Eng Part A. 2011;17(9-10):

1457-1464.

[65] Kokhuis TJ, Skachkov I, Naaijkens BA, et al. Intravital

microscopy of localized stem cell delivery using

microbubbles and acoustic radiation force. Biotechnol

Bioeng. 2015;112(1):220-227.

[66] Wei FY, Leung KS, Li G, et al. Low intensity pulsed

ultrasound enhanced mesenchymal stem cell

recruitment through stromal derived factor-1 signaling

in fracture healing. PLoS One. 2014;9(9):e106722.

[67] Huang CH, Chen MH, Young TH, et al. Interactive

effects of mechanical stretching and extracellular

matrix proteins on initiating osteogenic differentiation

of human mesenchymal stem cells. J Cell Biochem.

2009;108(6):1263-1273.

[68] Suhr F, Delhasse Y, Bungartz G, et al. Cell biological

effects of mechanical stimulations generated by

focused extracorporeal shock wave applications on

cultured human bone marrow stromal cells. Stem Cell

Res. 2013;11(2):951-964.

[69] Sheu JJ, Lee FY, Yuen CM, et al. Combined therapy

with shock wave and autologous bone marrow-derived

mesenchymal stem cells alleviates left ventricular

dysfunction and remodeling through inhibiting

inflammatory stimuli, oxidative stress & enhancing

angiogenesis in a swine myocardial infarction model.

Int J Cardiol. 2015;193:69-83.

[70] Huang X, Zhang F, Wang Y, et al. Design

considerations of iron-based nanoclusters for

noninvasive tracking of mesenchymal stem cell

homing. ACS Nano. 2014;8(5):4403-4414.

[71] Zhang Q, Nguyen AL, Shi S, et al. Three-dimensional

spheroid culture of human gingiva-derived

mesenchymal stem cells enhances mitigation of

chemotherapy-induced oral mucositis. Stem Cells Dev.

2012;21(6):937-947.

[72] Won YW, Patel AN, Bull DA. Cell surface engineering

to enhance mesenchymal stem cell migration toward

an SDF-1 gradient. Biomaterials. 2014;35(21):

5627-5635.

20 28 2016 07 01 chinese journal of tissue engineering research july 1, 2016 vol.20, no.28 4234 p.o....

Documents