11092015 - p.biofarmasetika - perhitungan farmakokinetik
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7/21/2019 11092015 - P.biofarmasetika - Perhitungan Farmakokinetik
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Non-Compartmental Analysis of Plasma Data after Intravenous
Time Unit h Method Linear TrapezoidalConc Unit μg/ml Analyst Byantari Prameswari NyomanDose !" Date !#$"%$$%&Dose Unit mg Time $'(')(*$
Time Conc ln(C) AUC AUMC R#+" !'+,) *+!#&!!&'', $'+'!""&*,)) *+#&" %#+&!&",""')
$ $+)$ !+&!*)&&#,#, !"+!)#&*,)) $#+'!" %#+&'$*#&$#)*
$+" $'+#, !+)''#'',$$ **+'*#&*,)) !#+,,$!" %#+&""#"$&$,
! ,+& !+#,)&*'$$" *+&"#"&*,)) *#+#*," %#+&,*&&&,&'*
* ,+! $+&"$*#)!! ')+"#"&*,)) '+&*," %#+&,!&')$&
' "+', $+)&&!,)$)' "!+&"""&*,)) ,#+,&," %#+&,)*$#,*$&
" "+$, $+)'!,!)" "+!,""&*,)) &'+))!" %#+&,"$"&,*'$
) '+#* $+*&*,))*,) )!+,""&*,)) $$&+),," %#+&*'$'*&'!
, !+,! $+###)*$#* ))+!"#"&*,)) $'$+!," %#+&&$*&&!#,*
!+)$ #+&"&*"#!!$* )+&$""&*,)) $)$+!'," %#+&&&'*$,$'
$! $+,* #+"'$!$'#" ,,+"&""&*,)) !''+"!," %#+&!,#)$$&*
$) $+') #+*,'*)'*", *+&,""&*,)) **!+,),"!' #+"& %#+"!,)*!,'!$ &!+$,""&*,)) '!+',"
PK Solver 2.0
0 5 10 15 20 25
0
5
10
15
20
25
30
Time (h)
C o n c e n t r a t i o n ( μ g / m l )
10
100
C o n c e n t r a t i o n ( μ g / m l )
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0 5 10 15 20 25
0.1
1
Time (h)
0 5 10 15 20 25
0.1
1
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100
Time (h)
C
o n c e n t r a t i o n ( μ g / m l )
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Bolus Input
Ra!" #arameter Unit $al%e#+"$,",,') Lam-da.z $/h #+#,#,"$"
#+,'))&$$)& t$/! h ,+$*'&!&!)
#+&#*&"&"$)$ Tma h #+"
#+&'!!)##'&* Cma μg/ml !'+,)
#+&*&#"$&#! C# μg/ml *!+&'!*,"#),!
#+&'"*,&,"! Clast.o-s/Cma #+#!*!,")$
#+&'$$!*#* AUC #%t μg/ml0h &!+$,""&*,))
#+&",&*" AUC #%in1.o-s μg/ml0h &+!)))',!"'
#+&,,$)*$'! AUC #%t/#%in1.o-s #+&*!)&&)*$"
#+&)&&$!!* AUMC #%in1.o-s μg/ml0h2! ,$,+'"#,*),!,$
#+&*$'!!)** M3T #%in1.o-s h ,+!"&),'")
4z.o-s 5mg6/5μg/ml6 &'+$#)'',"''Cl.o-s 5mg6/5μg/ml6/h +*',&'&'*"'
4ss.o-s 5mg6/5μg/ml6 )#+)#*"#,#"!$
30
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30
30
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Sample Data for Non-Compartmental Analysis of Plasma Data
Time Unit hConc Unit μg/ml Analyst Byantari Prameswari NyomanDose !" Date !#$"%$$%&Dose Unit mg Time $'('"($#
Time Conc#+" !'+,)
$ $+)$
$+" $'+#,
! ,+&
* ,+!
' "+',
" "+$,
) '+#*
, !+,!
!+)$
$! $+,*
$) $+')!' #+"&
PK Solver 2.0
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fter Intravenous Bolus Input
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t Cp ln Cp AUC
0 3.486 1.2487549471 2.31225
0.75 2.68 0.9858167945 0.62375
1 2.31 0.8372475245 0.9575
1.5 1.52 0.4187103349 0.62752 0.99 -0.0100503359 0.745
3 0.5 -0.6931471806 0.375
4 0.25 -1.3862943611 0.32
6 0.07 -2.6592600369
AuC 0-ta 5.961
slope -0.65267265
intercept 1.248680958
Cp0= 3.485742082
AuC tak hina !0.07 " slope# -0.10725AuC ta-tak hina 6.068251
AuC $otal
%osis 10000 &ilira& Cl '()k
'( 2868.829582 &ililiter -1.872407
2.868829582 *
+ = AuC ,ral " AuC ' ) % !'# " % !,# )100
0
-3
-2.5
-2
-1.5
-1
-0.5
0
0.5
1
1.5
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AuC inus ti(ak (i&asukkin
1 2 3 4 5 6 7
/!# = - 0.6998613611 1.4664989399 = 0.9976315655
Chart $itle
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a(ar ,at (ala& las&a terha(ap aktu
t !a&#a(ar !u"&l#
:uspensi ,ral neksi ntra;ena ln :uspensi ,ral
0 0 6.135889222 <rr502
0.5 2.75 5.31 1.01160091171 6.24 4.62 1.8309801824
1.5 8.5 4.02 2.1400661635
2 9.81 3.5 2.2834022736
3 7.43 2.65 2.0055258587
4 5.6 2.01 1.7227665977
6 3.19 1.16 1.1600209168
8 1.91 0.66 0.6471032421
>ioa;ailailitas !+# 0.7995359797 + = AuC ,ral " AuC
C ?at Akti/ 100 &"&l50 &"&l
%osis neksi ' 2 &l
:uspensi ,ral 2 s(t 10
,A* @$A'<@A
:lope ,ral -0.2689158389 :lope '
ntercept ,ral 2.7901252857 ntercept '
Cp 0 ,ral 0 Cp 0 '
k 0.2689158389 0.2784125415
AuC 0-ta 39.535 19.7789723055
AuC tak hina 0.2603044889 0.2514254553
AuC ta-tak hina 39.2746955111 19.5275468502
'( %'"0B 32.5951125848
Cl %'"0B -9.0748881355
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ln ' AuC ,ral AuC '
1.81415501 0.6875 2.861472
1.66959184 2.2475 2.48251.53039471 3.685 2.16
1.3912819 4.5775 1.88
1.25276297 8.62 3.075
0.97455964 6.515 2.33
0.69813472 8.79 3.17
0.14842001 5.1 1.82
-0.4155154 -7.64 -2.64
AuC 0-ta 39.535 19.77897
' ) % !'# " % !,# )100
&l
-0.2784125
1.81415501
6.13588922
0 1 2 3 4 5
-1
-0.5
0
0.5
1
1.5
2
2.5
/!# = - 0.2778240768 1.809690149 = 0.9999842469
/!# = - 0.1343017738 2.0366640331 = 0.3549140249
Chart $itle
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6 7 8 9
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@atakan status ioeki;alensi (ari ketia se(iaan kapsul ui !kapsul AD >D (an C# t
:uect
AUC !u"&l .a&#
apsul A apsul > apsul C apsul :$%
1 14.1 19.1 9.6 15.8
2 20.2 20 10.6 19
3 19 17.5 14.6 19.34 13.2 20.3 13.1 18.4
5 13.5 17.3 10.4 17.2
6 17.9 17.4 8.3 16.5
7 12.4 17.2 14.5 17.9
8 15.8 16.9 11.4 17.5
:uect AUC !u"&l .a&#
apsul A +A apsul > +> apsul C +C
1 14.1 89.24051 19.1 120.886076 9.6 60.759492 20.2 106.3158 20 105.263158 10.6 55.78947
3 19 98.4456 17.5 90.6735751 14.6 75.64767
4 13.2 71.73913 20.3 110.326087 13.1 71.19565
5 13.5 78.48837 17.3 100.581395 10.4 60.46512
6 17.9 108.4848 17.4 105.454545 8.3 50.30303
7 12.4 69.27374 17.2 96.0893855 14.5 81.00559
8 15.8 90.28571 16.9 96.5714286 11.4 65.14286
+ ata - ata 89.03421 103.230706 65.03861
:+ 14.9665 9.49569571 10.33253
:+ 5.291459 3.35723541 3.6531
C* / + E :/ ta 79.0069 96.8687452 58.11598
99.06153 109.592667 71.96124
riteria ioeki;alensi C* 80-125
sehina pro(uk > ioeki;alen (enan :$%
untuk pro(uk A ti(ak isa lansun (ikatakan $%A >,<'A*<@ !&en(ekati 80
&enurut usp sarat sa&pel untuk ui ioeki;alen seanak 24 sa&pel
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erha(ap se(iaan stan(ar !:$%#
apsul :$%
15.819
19.3
18.4
17.2
16.5
17.9
17.5
FFFF kriteria ioeki;alensi
a 0D05 1.895
#D &aka (ilakukan pena&ahan u&lah susta