10 years on the road to awesome! - cleantech...
TRANSCRIPT
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2015 LanzaTech. All rights reserved.
12 Years On the Road to Awesome! 2016 LanzaTech. All rights reserved.
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“The best way to predict the future is to invent it.”
Alan Kay
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What I CAN predict
linear circular
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Confidential
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Innovation, Strong Will and Regulation!
1950s 2013
5 Business Confidential
Los Angeles
London
Cuyahoga River
New Delhi
Lima
1969 2016
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4.3
Trillion tons lost 2003-2010
0.5inches
Added to global sea level
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A Carbon Smart World
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Gas Feed Stream
Gas Reception Compression Fermentation Recovery Product Tank
Recycling Carbon
Gas fermentation
technology converts C-
rich gases (CO, CO2) to
fuels and chemicals
Proprietary
Microbe
Performance milestones achieved and exceeded for >1000 hours at 0.3kMTA Potential Feedstocks
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Recycling Carbon Around the World
Caofeidian, China
16M
gallons/year
Gent, Belgium
21M
gallons/year
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From Mill to Wing
Ethanol
Chemical
Conversion Diesel
&
Jet Fuel
4,000 gallons of on-spec jet and 600 gallons of diesel produced Excellent analytical and Fit for Purpose results
Phase 1 Research Report Submitted $4M DOE Award to Build Demo
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Recycle Make
CCU
“CCS”
Enables the Circular Economy
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Building a Technology Platform
Gas Feed Stream
Gas Reception Compression Fermentation Recovery Product Tank
Hydrocarbon Fuels
Ethanol
Butanediol
Acrylonitrile Butadiene Styrene (ABS)
Nylon 6,6 (from Adiponitrile/HDMA)
Propanol Butanol
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LanzaTech’s Integrated Multi-Scale Platform
Industrial proven
host strain
Intellectual Property >200 granted patents on all aspects of process
Efficient genetic toolbox
Scalable reactor designs
Process optimization and scale up
Integrated models and algorithms
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Synthetic Biology to Improve Selectivity
Ethanol 2,3-BDO
Biomass
Acetate
Ethanol
Biomass Acetate
From Lab to Pilot in 1st Attempt!
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Inokuma et al., 2010, Improvement of isopropanol production by metabolically engineered Escherichia coli using gas stripping. J Biosci Bioeng, 110: 696-701.
Bes
t N
ati
ve P
rod
uce
r: C
. bei
jeri
nck
ii • Native Promoter
• Genome Expression
• Batch fed
• Pure Glucose
• Minimal medium
Bes
t En
gin
eere
d s
tra
in:
E. c
oli • High-cost
promoter
• Plasmid expression
• Batch fed
• Pure Glucose
• Complex medium
C. a
uto
eth
an
og
enu
m
• Low cost promoter
• Plasmid expression
• Continuous
• Waste steel mill gas
• Minimal medium
<0.1 g/L/h Stable < 3 days
0.67 g/L/h Stable <10
days
>2.5 g/L/h Stable >3 weeks
Isopropanol Production
Synthetic Biology to Develop New Products
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Fluctuations in price Predict 5-10 years down line
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Disrupting Market Cycles
DISRUPTION = 1) Rapid Reaction to Market Fluctuations 2) Feedstock ≠ Commodity
Same reactor Same operating
conditions
Same feedstock
“hardware”
“software”
improved efficiency, tolerance, ethanol only
new product molecule
Microbe 1.0
Microbe 1.1
Microbe 2.0
Ethanol
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1 Organism, over 20 Products…
Pyruvate
CO/CO2/H2
Acetyl-CoA
Fatty Acids,
Terpenoids
Aromatics
Ethanol
Succinate
Lactate
2,3-Butanediol
Biodiesel
3-Hydroxypropionate
Isopropanol
Acetone
3-Hydroxybutyrate
1,3-Butanediol
Joint development
Isobutene
1,3-Butadiene
2-Hydroxyisobutyrate
Branched-chain Amino Acids
Methyl Ethyl Ketone
2-Butanol
Acetoin
1,2-Propanediol
1-Propanol
Jet
Isoprene
Aromatics
Acetate
(R), (S), mixed isomers
(R), (S), mixed isomers
1-Butanol
Butyrate
(R,R), meso, mixed isomers
Valine, leucine, Isoleucine
(R), (S), mixed isomers
Benzoate (p-hydroxyl, 2-amino, dihydroxy),
salicylate
Farnesene
Mevalonate
FAEE, FABE
Citramalate
Long chain alcohols
Acetone
100% 1% Selectivity
Demonstrated over 30 new products directly from gas
PHB
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Jump to the Next Curve
We are the Next Curve
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Diffusion
Adapt and adopt from others
Continuous improvement
at scale
Crossing the Valley of Death
Technology Evolution
Ease
of
fun
din
g
Pilot and Demonstration
First Commercial
Applied R&D
Engineering Development
Discovery
Sustainable enterprise
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“There is only one way to avoid criticism: do
nothing, say nothing, and be nothing.”
Aristotle (384 - 322 BC)
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We all Need to be Superheros!