1 polymeric nanoparticles in drug delivery: overcoming barriers to reach the market viii jornadas de...
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VIII Jornadas de Aplicaciones Industriales de la Nanotecnología
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Polymeric nanoparticles in drug delivery: overcoming
barriers to reach the market
VIII Jornadas de Aplicaciones Industriales de la Nanotecnología
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A drug delivery company
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Polymeric nanoparticles
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Business model
Basic Nanoscience Research
Application Development
Preclinical Studies Clinical Studies Commercial Product
Nanomedicine application in development
Nanomedicine Clinical Investigations
Commercial Nanomedicine Products
LABORATORY MARKET
Licensing
Co-development
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Key points to overcome the barrier
EFFICACY AND
SAFETY
COMPETITIVE ADVANTAGE
INTELLECTUAL PROPERTY
REGULATORY ISSUES
SCALE-UP AND PRICE
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Polymeric nanotechnology for drug delivery
Superior product benefit
Increased bioavailability
Controlled release
Enhanced solubility
Robust stability profile
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Favorable conditions for collaboration
Intellectual property rights until 2032
PCT/EP2012/056900Nanoparticles comprising esters of poly (methyl vinyl ether-co-maleic anhydride) and uses thereof
PCT/EP2013/052795Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof
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Smooth regulatory pathway
All excipients are GRAS listed
Very well known excipients: water, ethanol , propylene glycol...
Widely used in a diverse range of pharmaceutical formulations
GRAS: Generally Recognized as Safe
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Easy and cost-effective production
No volatile organic solventsAvoids the use of special equipment and techniques
Production using standard processes of solution preparation
Low cost of goods ensures excellent profit margin
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Successful case 1: minoxidil
Minoxidil Hair Loss
Treatment
Irritant excipient
Patent protected
Easy development
Low price
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Successful case 1: minoxidil
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Successful case 2: mucosal vaccination
Nano-vaccine for aquiculture
No marketed product
Vaccination by
immersion bath
Suitable for food use
Patent protected
Low price
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Successful case 2: mucosal vaccination
Mucosal immunization with antigens-loaded nanoparticles induces long lasting immunity
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To take home
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Contact details
• Controlled releasing of molecules
• Enhancing of residence time
• Drug targeting
• Drug isolation from incompatible excipients
• Increasing bioavailability of hydrophobic or hydrophilic molecules
• Improving stability
• Increasing drug solubility
• PK modification
LET US HELP YOU IN…
Ricardo Palacios, PhD, MBABusiness Development Director
www.bionanoplus.com Plaza Ceín, 5 Nave 14B | Polígono industrial
Mocholí31110 Noaín – Navarra | SPAIN