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EU-funded health research activities against TB: FP6 actions and

perspectives toward FP7

EU-funded health research activities against TB: FP6 actions and

perspectives toward FP7

DG Research - European Commission

22 MARCH 2007

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FP6 Tools and Instruments

Project funding:focus on product development pipeline

Large consortia: basic and preclinical research up to early human testing (10 M€ / 10+ partners / 5 y) Number of TB Projects: 3

Small-scale, high risk projects (1-2 M€ / 2-3 years / young researchers/ SMEs) Number of TB Projects: 19

Programme funding: EDCTP Focus on phase II-III clinical trials

Coordination of national research programmes on PRDs

Independent legal entity

Strategy for Poverty Related Diseases (PRD)

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Overall Research Strategy

of the 6th Framework Programme to confront

HIV/AIDS, Malaria and Tuberculosis

Pre-clinical

Discovery

Genomics

• Vaccines (NoE)

• Microbicides (IP)

• Therapy Trials in Europe

•Drugs (IP)

• Vaccines (IP/NoE)•Biology and

Pathology (NoE)

EUROPEAN DEVELOPING COUNTRIES CLINICAL TRIALS PARTNERSHIP (EDCTP)

Clinical Trials(Phase II/III)

HIGH RISK PROJECTS (STREPS)DEFINED SUPPORTING ACTIVITIES (SSA)

•Vaccines (IP)

•Drugs (IP)

HIV/AIDS Malaria TB

CROSS-CUTTING TOPICS: Mucosal vaccines for PRD (IP)

Neonatal vaccination strategies for PRD

Early human testingSOME STRUCTURING CAs, SSAs ?

NEW INSTRUMENTS

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Distribution of EC funding to PRD during FP6 (2002-2006)

Disease distribution

TB24%

Malaria25%

HIV/AIDS51%

Product distribution

Vaccines43%

Microbici6%

Treatm.48%

Diagnost3%

TB funding: 61 M€

Discovery Translational research

Clinical (incl. EDCTP)

Total

(%)

87 M€

(19%)

134 M€

(29%)

237 M€

(52%)

458 M€

(100%)

(EDCTP not included) (EDCTP not included)

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FP7 2007 –2013 Specific Programmes

Ideas – Frontier Research

Capacities – Research Capacity

People – Marie Curie Actions

Cooperation – Collaborative research

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Cooperation: Collaborative research in FP7

Thematic Priorities1. Health2. Food, agriculture, fisheries and biotechnology3. Information and communication technologies4. Nanosciences, nanotechnologies, materials

and new production technologies5. Energy6. Environment (including climate change)7. Transport (including aeronautics)8. Socio-economic sciences and the humanities9. Security 10. Space

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Collaborative researchin the Health theme

Main policy drivers: Improving health of European citizens

Increasing competitiveness of European health-related industries and businesses

Addressing European and global health issues, including emerging epidemics

• Budget: €6.1 billion over 7 years (2007-2013)

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First calls of FP7

1st FP7 workprogramme: 22 Dec 2006

Deadline 1: 19 April 2007

Deadline 2: 18 September 2007

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Infectious Diseases: Continuity of Challenges in

FP7Longer duration - larger budget

Continuity from FP6 (pipeline approach)

• Focus on product development

• Focus on collaborative research

• Focus on global health problems

Create Partnerships

• Between scientists from different disciplines

• Between scientists from different countries

• Between different sectors: Industry-academia

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Topics from first calls Health

HIV/AIDS, malaria and tuberculosis (1)

Topics for first call (19 April 2007):

• Highly innovative approaches for research into host-pathogen interaction in tuberculosis (FRP).

• Development of fast tests for the diagnosis of Multi-Drug-Resistant strains of HIV, malaria and tuberculosis and of latent tuberculosis infection (LTBI) (FRP).

• Paediatric formulations of drugs against HIV/AIDS, malaria and tuberculosis (CA or SA).

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Topics from first callsHealth

HIV/AIDS, malaria and tuberculosis (2)

Topics for second call (18 September 2007):

•European network for study and clinical management of TB drug resistance (IP)

SICA topics for second call (18 September 2007):

• Highly innovative research in HIV/AIDS, malaria and tuberculosis between Indian and European partners. Targeted Region: India. Other ICPCs are also encouraged to join (FRP).

• Coordination of European research activities with global initiatives, including Public-Private Partnerships. Targeted Regions: ICPC (CA or SA).

• Next generation of researchers for HIV/AIDS, malaria, tuberculosis and neglected infectious diseases. Targeted Regions: ICPC (CA or SA).

ICPC: International Cooperation Partner Countries

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Information &useful addresses

•National Contact Points: www.cordis.lu/fp6/lifescihealth

•ERC webpage: http://erc.europa.eu

•The Health Directorate – Director: Dr O. Quintana-Trias: octavi.quintana-trias@ec.europa.eu

• TB research: Hannu Lång: hannu.laang@ec.europa.eu

• Infectious Diseases unit http://ec.europa.eu/research/health/poverty-diseases/index_en.html

• Framework Programme 7: http://cordis.europa.eu/fp7