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S08MITTEO 8Y OAT£ • VOUCHER NO. 2•12
ACCOUNTING BY INDIVIDUAL ' MWI.~-------t .._ FOR ADVA"CE. PER 100 OF ACCOUNT lNG
FROM ITO £ NOTE: Folio• ln.tt'uctlou on 1/.ever•• 1 1<J6':t · ".ft. Jbltft~ ., 1. CASH ON HAND 8£GI,.HING Of PERIOD S ~ -~-. 5, EXPENSES THIS PERIOD: ---'--------------~~------ol.. 2. OUTSTANDING ADVA,.CES BEGINNING OF PEIIIOD v,.'tL~'=8'f:"R11 ! DATE , DESCRIPTION AMOUNT 1
~ 3, f. :CE I PT!I ''HI 5 PER I 00 r ' • Sea &~'b!l.ebed I
......... 'if( .. 'i.~I~T OATE DESCR I PT I ON CC!rtU.toa't1aa !.71 _n"'CJ 0 C0 4 I tJ/tl. -..... J\ee:t; '2'litLft
I ~-•. ••• • •• .. ...•. '''II • .• I ' ...... . •. . ,.
I I 1 • '! I TOTAL EXPENSES I~~,..,..
. e. R~FUNDEO,IHO~wnH 111 ' lcAis"' 1 cone• ! lMo"u ooou , II 1 1 1. f>UTSifl'lr>tD~N~ 1\0VANCES•I EN~ OFI!I'~RIOD I(Att~och li•HnO ' . !i
I e. ~As~!' 0!'111 ~A~ol ~No I oF•: fER too' o~:· 8ALA~C~II ol'£ ADVANC~~ ' 11
"· TOTAL TO ACCOUNT FOR • m NM.- 9. ! 1 ji!lr jll I!! I 1 I !!l~pJALjl ACCOtm~O fOR' 1 j1 lrll! 1 j ' 1 I'M .Nn~
I CERTIFY FUNDS ARE AVA IL'A9LE ' 'i I i IIi APPROVED ! Iiiii ,il li I I lr II' )rj ', 'li ~ljicf'l~t:~ri/~ha:fJ:! jl:~': ", ""pend~~iur~•: 'J'; ~ted I her~o.n """ Olli.IG.REF. NO. CHARGI! !':AN 1\CCOUNT HO.,il' OAT£ I' I 'i ISIGNATt,J!Uo!IO['I.ArPIF!OViriNG·I'OrFIIC;ERI i'''l J(> jlft~ll"'rtlaflh~en·~·! .,.,,..,LIJIJ;rt;
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DATE 1, , siGNATURE OF .'lUTHORitz tNG oH I CEll ' 1 ce:. !'IT 1Ft EO FOR PAYM ••. ENT OR CREO[IT ! ·' d i's 11
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1 • 1 1 i, I , , SPACE BELOW [F.OR' EXCLUSIVE USE OF OFFICE OF F[INANCEII '/"1 i I I ! •1, 'i '"
OESCR I PT 1,0!1· Ill. I. OTHER IICCOU,NTS 13• 33 I I u-:~~. 1"0·!. I ·z~ 47:[ ! 48· ~0 I !It. 54 ! i 55· el!l .. !. .Ill?· 70 l:7t .ieo!! i !
. 1 ,,· 28• 33 S't'ATIION ••! •Ol!Lirol ;119, CA cosT • FAN I ! 'I .OBJECT AMOUNT ' ::·
1 IIi , !. ·i/ ,,., u. i I ,cool~l.'l!l .~I! REF' lr-tO. PAY 011 GENERAl. Acc;ouNT SYMII01. 1. lc~Ass , 1 ', ••• 1 , 1 !il
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FORM 282 oes:>I.ETr ~UYIOUI : (."'!'CftfT .1
IORO'UP I I (t•UJ 4•1!15 EDITIONS 1 ~~ T i BIC<'L"I>.I>I ...... OIAU~:!:'!'""""• I !
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1 July 1960 1 October 1960, 1 January 196\ _________ _ 1 April 1961:
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Date Wtlaled: _ .tlllt ~~
Date Expb•t: Nov_embtL 196l_
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Purpou: To d...mnp _tiloanay and pba.nnacodjiWnlc tecWquu in tile -------fiel4~c•zYili~08Y--i_~i_ed-tnllle RB eh~mlw -ag~fPt:OS!a.lll•- u--
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ACCOUNTING BY INDIVIDUAL FOR ADVANCE
SUBMITTED
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fJ4J.,l.ti8 JAN l~ 66
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Thh covers the ~>~;r19'd _septe11l~l' 1»1963,~to A:uguet 31,, 1965.
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0-\uc.ndtna--11\\in~red- · AHTOErlU l01} !!z!!t\!• !Jicumbr&nc._!::-~ _Bilinee- : ••
PetiOt\Mll $ 2;114-;U $ 2;114'-;U $ i •·0. _____ - $ •_0• A.t~odatac!, Antttantt: ___ :__.:: _:__~-~ ____ __ : ~ _
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151 ol Total BudgetJ To C«tr Indtreet_Coflt~-,:2;749:S6----~t-;Jli9.56 _____ · .o ... ~--::.-:-:--::;-~:_--=-- ..-o;
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-~.... Ditr=; tebruux. a&, 1963
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·'. -, _· I. . _ _ o?a::..a.dd&$io?al.--'l$.fttdnal-ReP§rt,- dated=!.~§.§J?tember-. ___ u _____ .. -.,.._
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letter· of:_l~ DeJ:fiftb_e_r 1962. /tJVC'tCG # 3 __ · _ --- '· ··· · .~-_____ _ It is my undoeteta.nding=that no oili~fiscalrepprts _need· to: be aubmi tted. ·
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Project Title:
f j (
Principal Inveatlgt.tor: ~Pb.t>. • lroteuor ~nd Head ~f the_Departfiilt\t of l'b«t'lNlceu_t_k(ll_4Uld_Me_d_~tna_l_~~t_nnr, -~lle~ -of-~tmicy; ---- · -
Date: August 31, 1963
l'enonnel; Associates, Asaiatanti~&~COilSult:anu
Supplies and Materials
Equipment
Trawl
Subtotals
_ §Rropriat~ out•tandtns __ l]ne~~r~<L
P~fs-... Encurabranees _aalanees
$ 4,420~36- -$ 4,420.J6 -- $ •0• ---$ - •O•
s;o:s3~ 14----,-;os3 .. 14 .. o.. ..:-·0· 7;316~63 ____ --- 7-$-316.63 __ _,~0 .. -- ------- ------
l,Uo;ss
71 of Personnel Budget; tp cove..--------__ -_ 309-;:43 R.et.• Soc. Sec ... Iu~=~~
309.43 ·0· _•0·
/
15'4 of Entire Budget; to ~ovn _________ 2;l49-;56--2-;749.56 · ____ •0• I.ndirect Costa
Total [i(aosp.oq D)::Oso.oo - i: ;o·~:~ :: r: : .o; : .... ill- - ..... -
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?udg-2't Report on Resea.rch Project ~'.l"9'"'<:,rted -. - .. -- "
b7 the :at-:t
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Project Title: The Synthesis and Biochel'lic~l-::.EXal,iitit>n~C>LP~ot_en tial Psychopha.nT.acologic~l-:: ::--, Agents,
P:ri.ncipal Investigator:.-...· . . .- . - ?h.il,, ~rofessor. and Hea4 of the Department or---:c-~-c~~d-?:ed~cal.Chem:ustry, CoJlege__of~Enarm~r.y. --=-~-~~---· _
• Date: ~ray 31, 1962
Item
011tstanding Encumbrances
Unenc.\unbered Balance-=~~ - - _...--
Personnel: Associates, Assista.!"t & Ccnsultants---$---T,-SOQ-•Oo- =~=~$~~499 .98- -- $ - -0------$ 7 ;000.02 -
Supplil6's and }hterials
R • ... .,.,qu1.pmen"
Tra.-'lcl
4, 745.00
-- -----$5,b29.)5- - $2.tt:.6J;Jl_ $- 9,912~ 78.
7% of Personnel Bud(;et; to cover----Ret.·Soc.Sec.·Ins.
lS% of Entire Budget; to cover Indirect Costs
Total
2 -'H-o-~6 --------A19-6r' J t l}.;~ .... - ------~-----=- __ -- -~-- ...... - - • ;)
. . .
$21;080,00 $6,284,00 $2 ,L63 .n---- $12,332.69
by th ·at
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Budget_ Report ~Yn-Rese-arch- Project -- Su -of' ted-=-'-=-·:- -:----- --
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Project Title: The Synthesis and Biocl"l_emical Evalu~tion of Pot:ent~aLE_sychopharmaco~l)gical Agents.
Principal Investigator:
c Date: August 31, 1963
Personnel: Associ~tes, Assistants_&~Cpnsu1~~~ts
Supplies and Materials
Equipment
Travel
Subtotal:
7% of Persor.ne 1 Budget; to=cover_::_ ____ _ Ret.• Soc. Sec. - In$.~- _
• , Professor ami~Read- pf -the _))epartment -of '---=~~~~-~c-~ -
nd-Medicinal Chemistry, College_()f _ ~h!!l'!nacy;
Outsta-rr9_1ng-Un~mcumb~red-~opriatio&--Payme~~ Encumbrances Balances u-
.--
$ -4,420.36 $ -4,420.36 $ ~9- $
7;316;63~-
1;230--;-88
];316.63 - - ·0-:_- ---
1; 230-.;-8_8 __ -----'•0.._-__
$
309.43 --_ ----309.43 -~o~--_---__
.Q ..
-0-
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--o-
15% of Entire Budget; to cover------- --~-;-2,7~9.-56-~--2,749.56--- -aIndirect Costs
-0~
Total
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Date~i:Dbi'UQ__HG4.._____: -- ··-··
BIIUYIOIW.~ .ICTIYITIEfLSUPPOaT-Branch BB i Category~il!Ji~!!~J:~f~~}fol ___ l(attrll{i"c--~-c~-- -{!I~)
SJiDtheala aocS evalva~loo-of ~teatUal--peye}lOpJiU.;
Project Title a~olOilcjl=c~fti'~_Item Ciassificaf10n · VllelJDif~--
Project Crypto : BULTaA ~- --~-=-crypto-classificatiolk----llfiiiU.aMified., __ _
Type of Contract- -= -~ J..&; ~--•-. Date Initiated=.l~J=a&l-~ __ i ----------·---
Completion.· Date===,_3(E~J..964~.:~--·
Purpose: Bluelda..t1b1l.Qf-11Ue-rrelattoNihtpj-betw••n aolecular--con.---· atltutlO.o ktul blologleal nrsponee-of ;c}),tJai~a_t_~OIIpounda of--~~ luterest_w-_.Iml~ · ~ - - --- - -
Status: Teratnal_tearot--a tiastc btocbttw.lcat: l'eau~~~_;---:::-~Jr bUt-tho tlul::-phu~a of t-ife~researcll baa bee;a-cospl_eted ·and~ the~-report• au1.1iiltted~. ~aepo~ta relating to floal-pb~lr-ot t" coatra~_t_ w1_ll:::~_l'~~·-1ved upoD coapl.tioo-; - - -
Requirement: lllternallt geHrated-ln TSD bJ qeed :for_spo<:ial-liiolo~-lcallractlve coep®nda and baste iritoNatton of their -charaeterlzatlon;-- --
/0'/-/0
REVISED
Date".· 5 ·September 1963
BEHAVIORAL-ACTIVITIES SUPPOR.'l':-:---- -----·--Branc~BB .· Category Behavioral-Control Materials -- . _('{Ia_i_-
Synthes_i_s-and evaluation (formerly '\"b) ' _ of ~otential PSl~hophar~ ·~
Project Title maci:>'lii€:ical ·comJ20Unas-c-jt;~classificatfon-~ ! Uno_l.As!tified-
Project Crypto MKtffi'!!_A-- -~--- Cfypto Classificatioll..-!-... Unclassified
Branch Project NQ·----=-N:,;;.:;A~-·---·-'Proj~'~ Eng;neer ~ ..
Contractor~---- I ---~~----·~·--· .~.:--~--~-----i-==-:.~ ·/3_--
Contract No __ JIKULTRA_.#~09 - -- N~A; __ Task N<>.~----.:.:..:..~..;._...;.,;_........__
N;A~-Type of Contract.._ __ ._..:=;.:;;_,_, ........ ...,. Date Initiated
Cost _ _,;_. ____ ...;$.:;.;;2;..:l:..;~o..::9:...;;2..,.3;...:.~2~0.:;.....__ __
Pu.rpose:
Status:
Elueidatio_n_Qf.=-Interrelationships between_Jil~lecular constitution an.d-bl-ologfcar-response-of :ch.em_i_cal~ccompounds of ind!r_e.st to TSD~------ ·
I I !
Requirement: Internally genet·ated in TSD by need for special biolog....; ically~ctive compounds and oasic informatiQn_o~their character_.i..~_a_tj_<)n. - ~ -- - _-- ~---- · -- ----
/C>7-/I. ...
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Ttlis-----:is_just a brief not--e-t--o-let I have::_,._ece_i~ea t~~~~~-~~~~~~~~~
By A i r::.Ma LL
1 :e:,:
J une_____U~J 9 6 2
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Project Title a The SynthesiS end Biochemical- Evaluatlonot Poten~iaLPaycltophannacologiul-- --Agtnts. · ··· · --
Principal Invest.igat.ora ~Ph.D., Professor and Head of_tl'l~-nep~rtA.ent. _o_t_ ______ _ ~ and Medical Chemistry, Colle&• _of Ph_al'l1\aCl.•==-~-:-
Da.t.ea J.tay )1, 1962
lt.em --Personnel& .
outstanding uneneWilbered EneWl1branees~- suan.ee-=-
Assoehtea 1 Auistant I£J~onsulMn_tL___~_J)~QQ_.OO ____ $-_4~·98_-_$ ..o- . $ 7 1()QQ~92 ----S1lpplles and Materials ))890~~ 1)749.)0::_=_::_::_--:_-=~));SQ ________ 21_1<>_?;64_
Equipmel\t 21146.14._ 2 h29.6l- -- -- - 169;QS . ' ------ ---------- -
'l'nvel 11670,00 -- -----ljO));?y:=-__ c-:-__ ~~ 6)6~07 --
--=-~~ ..... 3-__::<_!~-----
Subtotal• $17, 805.~·~llh_,_____-------=-$~S"; 429. >S~ =~l?~ ,_k6l !_)J.~:-;:=:(_911'1.~~1~-- ~--
7f. ot Personnel BudgetJ '~e._.._r ______ S~2=--S~;_.._oo-:__ __ __.) ...... S~· oo-.-_ ----o .. Ret,..Soc.Sf>f.l .... w.
490.00
15% ot Fntl.r~.j Budget; w.eover:---Indireet :}Ost.s
'l'ot.al
t ?- --
.fl
21749.S6 ar9--;~s-- ____ -o .. ______ _},?2_2;n--
94 ......
- ·-_ -- ------- -_- -.
/0 9-1"3
RECEIP'l'---
Receipt ia hereby ackno~ledged~fo!_ the- folloWing tvo checks:
("\)
\"" -~
-~
REQUEST FOR ADVAHCE OF FUNDS
PVRI'OSE
SECRET (When Filled Zn)
Ad't'UCe to ICJLtM 109 XaY. 3 f:rA" act1nt;y ·~ 1>7 AC/'tS::> oo a. X>eceal.ber 19(52. tor tb1JI 84~ vUl. be 1Jl ~- vltb Attacb!l!!!!!!llt A ~ JCIDI:J:M Piac:al J\DDeX.
AcCOUD.tiD&
'l"be eMck abanld lie t~ 'tO "':SD/1!111>, ~ TSD/brliJ.&et Otncer. DO later t.ball
! : !,'
26 X>eceDber 1,962. ······ -------T1 z~""ji!:ij~~iii~"i•_"i~1t;i;, •n•i.J.fi-.Jiil7J_I~1U:,_JiJt!";_r~·-;;;:. _.,;;_;;;, .. ;;;};-:-_ 7.r.,::~•t:K~••:;: .• :: .... :;<1.,:;:.....,;;:;:
1
,:::: •• :-:;.b;::,:: ... ::u"btllwJ..:: •• :-::j.,.=,:-:,.:-:,;-: . ..o:::-::u.,:-;:,.~.,::.-:.11104::-::-.,~.:-:./un-:-:d-.,.-:-,-,,n-.,-.. -.... -.-.,.--:.,~-"':-:~-.. -:-, .. -,-.,~---J
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CosCA~c:Oulit::.:..._·, _3_1_2_S_•lJ_9_0_~l_9<:e_~·· ~--
Daw. :itemarks_r.:tld_R.eferenc_es ·-- Obligations ' Obligations Unliquidated Incurred __ i Liquidated -- ·Balance
:5 DEC. I«ULTU Sub-p~j-=----.109 --lut)i f} ---- -
21,080.00 21,~0.00 l. 1.?60: -
~-("Aj~AQ ---'-'~ ~.R j_'f_.:j_ 10 J.I.CJ~J 1D 18f'i'~'i J-v,A~ ~3-~ . :;u. r 3..3."dlJ
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... ~~~----,~~~_~\4~~~ ---~~~--·-~--.--- ~
·A
I 4- DEC .~;,l
SECRET (Whe~ Filled In)
REQUEST FOR ADVAMCE OF FUNDS ::t I I GN Att&ebe4 PQWD.t tnetJ J21 I Veatc!llt I
\ PURPOSE " I),. 0 ....... M.w.rlCe to llBU.'tM 109 lilY· 3 '.tor eet1vit)' approved 'b1 N:/'I:'SD em. t. !)~comber 1962·
'.tor 1'J'WJ a&VIIItCI v1ll. be 1Jl ~ v1 'tb. Attacblllmt. A ot tttm:ral F1ao&l ~x. AceOIID.tUg
~== 281
!2Mt cbldc: ecul4 be '.t~ to 'I:'S'D/JWIJ11 tbl"CU8b fJ:SD~t Ott1cer, DO later theD 26 ~1" l.g62.
U9E PREVIOUS tO.YtONs. .. SECRET . ...... ~
109-
Authorttation #c3_
·. /OY-16
DP.An -------- -
l5_NQ'lember_l9Q2_ __
l.__TM p'!J."PP_!~ ottbiS subproJect 1S to }'ronde 1\Ulds for·- -
the conUuuation of a study of-potential P8Yc40Pha~£2!£s!~~!-~---
agentSi -xn-part1cular;--stud1es vill 'be-directed--:_to the_du~id&110il~-
of 1nterre-la!.J_Qnsbips between molecular-consti_t_U__tiOb.-and. b1olog1~e&~l ____ _
responee._ StUdies vilroe conducted into the: biochemical _cbe.ra.c- __
terititi<rs=ot c~rU1n t~ll~ of Chemical moietiu-=whicb are_ 9t-in_- _
terest_to 'l'SD~lLi_n carmng_J>Ut its pr~gr&~_on=-the_deye_l_ppclle11~_2f __
means to_control_Hu~ln Behavior.
2.__Tlle_attached~get-1nd_1ca~-rtne--extent of the investi-
gations tb&t will re -carried out under the direction_of_D~_. ______ _
v.-~-n _f!l~1_!~~1_e_s available at
tunds_~for _tb18~project vnr be transferred us.ing _the
as a cutout. ;
· 3i:-'fne~s-tudies being _carried ou_t-under _this subp!".Q.Ject-vere
originally pl&.llned to cover a-period-of approxime.tely t1ve years
based UP9~ t~~-a tts,ched_-proposal ~However-, "';he _change in emph"'-e:s=1=-=s=------
._
of the· present_TSD_ {)_r_Oj!8!"1 requil"~s tbat _these planlJ-be al~~~~ ~---- ----
cons1derably. __ ~-~~(1nv_e_e~!sat1on has therefore .as«~~~~~ pro"'~
duce as_many__JI._qt.1\~l~-!:tto!·1 ~Ill- c~~d!J~~~poss!,'ble durin& the ___ ---
next yeal"c_SJlcLa_ls6~ to--consider tbis_k_s_ the ti~l.c year-of _the
project.-. For-=- this- reason-the attaclled budget be.s_been=-s_®..l~d __ _
dow f,r0111-::..the_or_tginal estimate of $29,578~00uto_$2l1o8o.OO.
The lower.:..Ugurereflects mostly lowred persoJilneLeosts_ _
occasioned o:fthe-simplerdevelopme-nun-aetivit.ies-nov pla=n=n....,e.:-d~·---
1+. 'tbe cost ot-tblspro~-ror a Jteriod; ot.::.one_year vill---:--
not exceed.~$2I,@-:-oo-to~wlCh-wst.-be-added ~e four_ ~r-cent ,
tee tQ_the~ing t_he total ~ount_~l1923-:;-_20. _ . _______ -
Cbarges_::_shOUTd:'be made a~inst Allotment- No. 3.125·139")-3902;~-., • " • .. ~· • '-. "1. ,~
. ·~. ,. ~ . requires that the
~submit to them a S\UiliDal'Y accounting :on~an-:annual~'t>asis--:-
- of alLmonies:.r~_cei ved -ri'Ointhe--Also, ~expended_ f\lnds_ vlll
be returned._by _t.lle--as--8-oon-as· posslble-upoQ- the·· close _______ .~- -=:-----.:
of the-=-gre.nt_- year. --- - · ----- --- ------- -- :
6-;-:-::::-A requirement tor a six months' ififo~mal accounting on - -. ~"-·-- - --· ~-·--· ~--·- _, .. - '.
the p.rt_of~tbe::::-pri(lc_!pal_!_n_vestigato_r ;s wa1y-ed. ___ _-=.:_ _ _:_ _______ __
7.;- It-is not- e.ntici~ted ~that-any-permanent_equi~nt will-
be needed for tb18 progl'am. --
.. . .. . . . ~ ___J ~ • • ~ .k •
.... . . . . ~
-~·-~----!
·.
8. · In3Q!Ulect1on-v1 th traverunder ·this Pr<?Ject1 1 t is
agreed thAt tbe A.g~cy v1_u· accept- th~c-travel do~umentation_ar1d __
accounting whicn conform v1 th the practices of the
9·' n-18 a~ed that ~chnieal----z"ep<:)rts retle~tillg--=...__·=------
progre s s-=--O.t~t=h=e _.re._..,..s,..e ..... ar.._c=li.._~~p-=-ro='gr"""· --=am=--=-:sb=-:a=l=l-._b.._e:__:s._.-u...-_bmi=· :_jt,ted _a:t.::_~ tua].ly____ _
acceptaolecin~t~e=rv~a=l=s~·~-----------------
10.- All ~rsonnel~e-cted With the-pla.nnin~UHl~ mon•_
itol'ing- ot_::_tbU_ program-possess TOP-SECm-.a.geney s~<LU!'J._t~=~ - - -
approva~====----------------------------
Attachment: --Pr9~sal;-::-:-&-:-;!;;:;:Ud:;-;-::g-=-et~·-:-::-===-::::-------_ -__ - __ --___ -_ .:________
Distributi®. --=-~~ ~ -=-=-======== Original only_
BIOLOGICAL !RANCH
PROPOSED RESEARCH- PROJECr-•
Project Title: The=Syntheds and Biochemical Evaluation of PotentiaLl'sy~hoph<l;nl~c_o-
log ica l-Ag~~~~~ " : ___ b : · :__ · _ _ _ _ _: :__ _ Principal Investigator:-~ Ph. D., Professor a~d~Head.:.of_:the-'Department -
~al and Medicinal Chemistry, c_o_l_l_e_g_e of __ Pha_r;.~ macy,*
For the past sever.aLyears, _ the~applicant has be-en--enga-ged· in-research-::invJ)lYing·:::::_ (I) the synthesis oLorgarti~enntie-s-having potential effects upon the-central rH!t"•=vous system, and (II,-the evaluation ofconne•>cions-between the::::.cheml._c_d-and ph~tm&-.. _ codynamic properties_:_oLl:nes_e_<:~oJ,JndS::~e~app!!cii:rt~_i_!J primarrty=trn:erested in the fundamental st:ud~of.:r:ela~t.l.Qffshigs~between molecular constitution_an_d_Q..i~hemi~---=--cal response, and is_ part icularlt=-~Q.I\.c:erned with the effecLo.LgrB._d.JJ.al_c_haJ'lges_in · the chemical structure=oLs~_Jh~_tin_-_c __ nt-HTesypo_n-i.sorat-~ecd ~n,~~stei.s-. -',I!le rea• . ·
. to (A)_reports_submitte_d_~ar_lier_to the _ I-· B ... ___ '"' · · 1-7, and (B) published acco\)nts 8-l9fo_t"_~upple-m-ental_info~i0ation_-. ---=_=--c----
The applicant plans_t_O_c_o.nttnuJLb..iS=tnv-estigation in accordance-with-:the principles set forth ia the cite~.OOununications, Sp~Ci.fi~~).!y, l't~ _iptends=-to:':c:-_________ _
1. Synthesize severaLsetie.S~~o_r_ru~w compounds patterned after~(a) organic amino---known to affect.::the_central nervous SY.!ti~. an~-(~)-Iiioie.ties_:_acknowledged as substrates in enzym~--:-sy~~etn_s inrplicat~d~in- the phitmacodynamics _of-::comp~g_u:_n_dsc~PC).SS~s.,.~sing psychopharmacologi(.ai::-pi.Pperties. The member con:.poun<i_s-of :each series will-u -be designed with.:.gtadual __ changes in-their c:9nstit~t_ign, or-physie~lprop-ertfes;--or both; furtbennore,;::.~hey..:..~tll. 'be_ p].~nn_e_<f 'i_n )_uch ~ _11)anner..:.that_pote_nUa1 _ _!i_i_fJ~-~- ·rences in the' interaction between the me.mher conipounds of a given-synthetic~·seriesC"-_ and a given ertzyme:..may_b_e-=-int:e_rpJ.st~L!JL..t~~!;-~f __ ~_<>,ll_cepts c reasonably well estab· 1 ished in coneemp()H!"Y the_or_e_t icaJ,. cll.e1llisf_ry~=~.:.c~--:-' -:
2. Study the effect....:_of-'1h-ese-entitie-suupon= (a)- isola-tedemzyme-::-prepa.ratiQn_suJ>jtli~Y~d to be associated--'ll.itb_brain-function, and Q>_)__2_ther _p_!ausible bioche,mi~ 1 $yst_emt:~_._ ___ _:_-
3. Explore relatlonships between-the biochen1ical activity-of each series of-derivatives, and the successiv-e=:ehanged.n_ tb~ -chemi~aJ~and physical characteriB_t_~s of the - · member compounds •.
At present, our synthetic work-is centered around series-qf arylalkylaminoalkylaceta•- . mides, and pyridine..._and piperidinecarboxamid€s which couJd be visualized as moieties derived from the psychotomimetic-molecule LSD-(s-eeFigure$ r,- II,- III- and IV; other series have been planned),
Concurrently, the completed COmpounds are being evaloat:ed ·in isolated cholinesterase systems in which LSD has shown-remarkable specifiCity. OUr manometric-procedures
*Effective July 1,.1960 (on-leave of absence July 1, 1960 through June-30, 1961),
.-- ~--
~' // ' (/ ~ • rl I 11 ,,, ,.., ; ,..
/ '~ / '- '/ HN Y ,..
I I 1.:-_:-.. ::J
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, H~ I ·---:.1 ----- ' ' /, v!
LSD.
N ~ N ~H_i~~-=~~-:-~~=~=---- ~~~~ -- ~·- -~- b Hi
A---
0 -c-.c-N""R H2 H~2--'~R ______ __
-· -"11~~--__"111111111111111
FTGURE I.
........ 0 "'<)
' ~
S U B S T ll T U T f 0 A R Y L A L K Y L AM I ~ 0 P R 0 P I 0 N A M I 0 E A N A L 0 G U E S
0 "' II r.211 s
~:,' ";• C-Nr . ' • 'c211 s
N LSD • CH3.
9' ~ ~11 •/
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'ti' ~ ~ ~
--------------~:----~------------~~------~
Page Four .
-'t-
_.__
I 1
. -w rL~-_ ·-. ~-~____;__=_-~
.,_,_ .... ----
-$it-
l
I o P- -z..:...---
O~H····. -•II ,-----
.......... o-Il: ,CH3-c..:.N'- -' -··
CH_3 .. --------=-
0 - ~ 11. ,..c2lts
~ : C~N~Cl!!_s .. '--~-~
-c.-N, ______ _ ! c2~s ·------
F I GURE--rv-·-·- ···- ·· · - - --. -. --- ---- --
Page Six \
yield very precise m~surements of activity-in isolated pseudo• and acetyl~llolinesterase systems, and enal>le_3l~ ~9-=evali.Jate the significance of even~minc:rr_v_~r_ia_Hons in activity due to small constitutio11alchanges in~a se-ries· o~_molec~u_l~~.--=--=--=- ~~--~
- - --- -' -
We are aware of the fact::.that: the_effec-tivenen-of-a-psychoph~rmacological agent-!!! vitro cannot be interprete.::l_a,s.:...!tyj:dence for-· the inVolvement o~~the=-specific enz}'llle -in the mechanism of psy~hotomimettc-tesponses.-Yet even with:aut conclusive causal connect ion, this approach may-fu'<fntsn=va-tual>le {[\format ion-on' the- natl.l~e .c:>.f p_!ycho• .c.
pharmacological agenta=~c--c --- --- -------
**~-------------
It is felt that this' inv.es_tigation may yield (a) information assis.Ung:_the eludda--------
tion of interrelationships_-:.l>etween_mo1ecll1ar~conTtituUon anq biologi~d.tEtSpQnse, (b) better insight into_:_the_i>~t2cliem~1li cfiaract.:_eristic-s arid ~herapcll\lt..l~po_~_e.1ltialf.;;-~ --~c=--ties of certain type~=of=molf!_t.ilfs-,=-(c} ~everal seHes-of-ne.w.organt<;-cO!npounds~ario~~-~ ~=···-_information about their~ phy~ic-!!_1_ characteris-ti-cs, and (d) da~a=-s.1.1pp:lementin.g our knowledge of the neuroch.em_t.ca i ~ processes~a-ss-ocntedwith-the: attion:-c>f.=psychop'flaima- -~--cological agents. - -
***
The refe10ences cited in.::.the-=-f_ifst paragraph· of theoutlinea rdis_te..d _o_q__t~~ ~!1~~~..:-=c_: ing page.
January 22, 1960
cc:
-. Page Seyen
·- 6
Chern., 11: 799, ,1956.--_:::-:_-:::~ I
9. . .., ·"'"' "' ~ . ,~
~ "'~ '" .. ·' Org. Chern., 21: 805, _1956.
10. Org. Criem., 21: 958,~-1956:
~-~~--~~--~~~~
23: :1577 ~-1958.~-~ - __ -_ -
J,! Org; Chem.--,--=-23: -2005-;-1958.--
15 fharm;-Assoc., Sci. Ed.,
16
17 1922, 1959 •.
18 stry, J. me~. pharm•-Chem.,-2:- in press,
19. ... "" .. -.:- ,_..- ~ . . . .
. -- ;;, ' . . . . . med. pharm. Chern., 2: in press,~l960. -
-------~---_!_l_:l'_f..-_Z--
•
BY THE AT (Dee
Project Tit I e: The_Synthesis_and B iochemrcar Eva I uat i on_of __ eoteRt_ia I Psychophat'nlaCQ_I og ica I Agents~
Principal Investigator:--. -. .-. ·~ .. -. -:o·:-~- P. rof.·~.sso~~and Ch-airma~.-- --- ----, -~~eot __ of __ P_h_armaceut 1 cal and Mede-
ciila_LCJ1~mi_-s_tJ'y, -~gJJ~g~ Q_f~ Pharmacy"--- ____ . _. ___ _
Personnel (Associates, Assistants-and Con-sultants)
Supp I i es and Materia Is__ _ __ - -
Travel
SUBTOTAL
7% of Personna I Budget ($---:::-_l?t,OOo,OO ··,);-to cover-----, retirement, etc. ___ _
SUBTOTAL II
15% of Subtotal II ($-i8:33Ci:~~-}; to cover participation in-indirect costs
.TOTAL
***-------
Checks sliould be-payable to the
May 31, 1962
$ :_ -~lQ®.-!96.~~~~~~; $ ·c·- ,. . ... ·-·-- -·- --- -,
.. 11,89<>."------$' 600.00 :·· ..
s - · -840~oo..:. ·-- -· $; i8i~3Q;4~~:-=-=----
1!"'-2~14&(0··-.- -_·
$- 2~~-~.oo~~--~---
•
<n_ >
Project Title
Project Crypto_ ~- Ccypto Class,ificatio:t - Uac1MtU't .... I4-~----~----------~-~~~~.~,.L· __ ~-- '
Purpfw~:
Status:
\
-'
~-~~·---------------------lot•naU1 ~·rated ill 'MD \J $1J-t6 tor ·~~!" W9lot.lcaU1
utift ~~· e:4 'bU1e-lrd'ORA\l~ oa t~J.r_d'Ai~t:et11&1!~~:_ \
f
May __ 31, _ _L96~
\ I certain I y~e~njoy~_d 't-alking-t-o-you-this morn-i-ngr•·======~
for you~c_onYimi ence-,----1 am- enc I osi ng~a--qopy_:=of __ tbe .. proposed_budget for the next--gra-nt~-per i ¢d _(December I, 1962~th_r_ough- November 30:;-1963). - ·· - --, .
With the very test regar_ds,
Enclosure __ By Air Mai I
\ \ ~.-:--::----:-- ---:-:--:-:-::-----
\ I
--~- r ... ----~·-·"=··"· ..... \.../
P.S.:: My home address
1862 AMERICA'S LAND-GRANT UNIVERSITIES CELEBRATE A CENTURY OrSERVICE 962--
. ~
TO THE (De
May 31, 1962
/0?-/1
$ 3,000.00
**X-~--~~-----
.•
First Year:
Survey-ot~rontsifil- compoonds .. :
Literature r~vuw- --- ----------------.~urce~semirla~------·-· . .,...._. 4uggestions -- ·· .
Effects to be~scre-ened:= ----·----. ----=-- -convulsants --an..tic~6ltwls_a_n.t:s=-~--------------,
/0?-·/f
speoifit;-art.erial...:.oil.a_t_ors~c.Qr\d.l".i~.Q.l".s~n.J,iserotonin_efteot.~::.-=~~-- -eholineeterase-1nhioftors sympa thomi.rtl.etio~M.t'.as~.tb~ime tic
BllDGE'l'---=.Dli'l'IAL~STAFF' -- !!I"
Neurologist .:.=?r-incipal_in'iestigat~r _______________ . Clinical pba.~acologtst·--~-:--:c---:-:-~--=----= -- --------Research asststants~·=~=~==o=====~~~=~ Statistic.\.an eervices._(par_t, __ titne) ~ -:: 0 -:....~-=-~~ _ Resident asslgnments=-(B:::.mo • ..:$)00/mo;)- -~ --- --
Equipment and supp).~:==~=.~~. __ ~_~·=~~-~--~-~~~~~~~=~ e.g. calculator,- camera., n
E.E.G.cservtce,---computor-service
'l'ravel
T~l~~---·· ____ _
$ 3,000 ___c
l.L,ooo 10,000 . l-2oo~------
2!1ioo--~
4,000
600 ~=~c:=c~- ~ -
$35.,200
To the budget figures must-be added 7% of personnel budget tor retire• ment .and 15% or overall-costs-torO'i/erhead. - ·· · ~--,
Second Year: --Trials o! Mil COJQpounds ____ _
Screening potentially valuableeffeoti
Chronic toJd.ci t)'_i~n_:::,"=··=a:"."n'""'im.,..:a=l"""s'=. =========================== Hunan trials - double_bnna-an~/o_r concurre11t. trialS:--:
psychological.f!ffeots · -- --a utonomio=eff_~t.s anticonvulsant ~~""~---~---~---~----------------.C---------------~----~--------- --=-- :
/07-1(
antispa_smodt'<L -::-- -~:::--~-_-=_- -_---------:----_-- -~;
antichoUnesteras_e_(limited, on myasthenia gr:avis-=pa_ti~nt~). ___ _ ant.iserotonin- (ttoluster 11-headaches)- --- -~~
Neurologist - 'rincipa£r=-t...._n"::":v::":e::st::=i._.,g,>'"'a':::"'t=or"======== Clinical phannacologl:S' __ _ ____ _ ___ _ _ Experimental psychologist __ Research assistants-S taUs tic ian sentcesi~::==================:::::::::.:: Clerlc-sta tisti~ian. -------
--------------~~--~
Resident_ assigrunen.t.s --- ---------- ----
Travel
(+ 7% pe~~~nn~!~for retirement) ( +15%-:-overall- tor-=:OfefheC.a) __:__~_
$-),000 llil@. ~ -- .. . -• -__ -_-- __ .. __ . 1a.;ooo- ----- ------lo;soo 1;200 __ _ ),QOO __ _ 3,600
$50,700
It may be advisable also_to-consider the adcition--or a basic phartna• cologist to t.he swt-iii secona (or third) year.
. ..
March-9, · 1962 =- c=
- . !
Enclosed-is:the·c~Jmt...lhtiV~~aj\nual expendi~ure report -~-on your~grant~tQ_Qr._~_-··._ _ . • Th_is is f~r~the_perio~~ ~ July 1, 1960,-to:Nov~~~--:--c=.:=----=
Yours=.very_trJJ_ly •
..,L __ ~--~----U-~c~--·
1862 AMERICA'S LAND-GRANT UNIVERSITIES -cELEBR,4TE A-CENTURY OF SERVICE
--1
"~ g;·-
.. ,
1962
I
Budget Report.on--ResearchcProject~
. (Ju ly~l, _l960~through~Uovembedo,---i 96-t)
Froject Title: The Synthesis-.:md--Biochemic<!l-Evalua-tion-of Potential Psychopharmacological-:-: -A~~s -
Frincipal Investigate!:
Date: November 30, 1961
Personnel:
C...~~~~-~"---~~ -~~ ••• fl'Fh.D., Frofessor and Head 'of::-tne_Department=Of~::.~-~=c:cc~
cal C. and.·J£:e-dicina E=Chemistry,~College-of- Pharma-cy _ _: _ __::::__::_~~
Outstanding~UnencT.Imoered _ Appropri-ation-Paymellli: Er,cumbrances Balance
Principal Investigator· $_3,000~00 • $ 3,-0oo;ooAssociates, Assistants & Consultants- 1 ,-07]~QO~--~-_::_~:_l)0_7~~J)0-=
$ -Q- - -- ---- $ - -0-~-----o- --- ----~----- --~ -o-=~~~---==~
Supplies and Materials
Equipment
Travel
·Subtotal:
7% of Per so nne 1 Budget; t :> cover __ _ Ret.•Soc.Sec.-Ins.
15% of Entire audget; to cover Indirect Costs
Total:
I have exn,n:;.:;:;d. i;r.d a_?p:.·cvl:'i t~1~ sub.:nitted expendi tiil'·33. ·
D1te:·
-Q-
6,324~93 ~-;-3c2~93_. .... -e-~~~~- -0-·~~~=
581-;;570-'-'--- 5Sl~5T -o-~~~~ -0----_ -. -_-~----
$18,__QI15~5-~$18,045";'6'5 .. $ --e-~~~. c$- -o-- ---
. -~ 2,7_49.56c~--c ::2,7.:+9.56-: •' -0-~--~~~~--o-~~~
$?1 ,080.~2-l-.080.00~
J!I)V,_L_
--------=====~-------- ·~---:::$=·=0-=-::·· =--=--=--=-c·=·o ==$=-=0-==- ------
;:
. /0 ?-·· 2o
29_:_MarclCI962. _
MEMORANDJJM_FOR:TneRecord
SUBJE:CT= MKl.JLTR:A, Subpj'()je_c~ 109;-Cost of Equipment-EJ<:ce~~ed BudgetEifimate-----~--
t;--=_The~B-~(lg-et Proposal !or- Subproject 109; ---dated---~=- --~- -~~-~-~~-~
2.2 JanuaryJ960, !lad !_P_roposed figure of $S. 000-:-j)<Lfor _ ___ ____ _ supplies=an:d materials.- There was no anticipation of any~·--- · equipP1ent~---------------------------
2~~- An ac~c_QW\ting ~eport has beeri rec-eive~d~f~o~r';: -~th~e::·======== period_LlUl'tJ9bJLt}rougb. __ 3Q_-lfQ.Y~ml:!~_r 1961. ! Ttiis report _ n _u_
refie<;ted expenditure~_-()r$1, 661~ 55 !o~ suppl.i,es~and materialS,: and $6, 324~93 for eqUipment.-TKes-e-amount$-exceeded the __ figure-s in-the original proposed oudgeC
3,___c:__This_ecquipment was expendable and tlie_expendi=;.~-~-~--~--~~ tures have-the~appr_()'{_al __ ()(J'SD/RB as being essential for:_~-~------=-------the successful=<:ompl~tioxi--or the ·research wor:k-that_was _____________ _ conducted;:_ - --- -- - -- - - -
....-:;' . ~.- .... : . ~ . ;.
. . . • ' ·\ •••.• '!' .• · .. ' . \. ;, "'
' - ~. . '~ . ._ ~ . ~ . ' ~
·chiet=, · TSIY/Research Branch-"--- -
..... ~{- ~ . . .... ';'" -~ ..
c --- v Enclo_~ .. ec: ..._.._, f'h• D.
I _I
----------~~\
Objecrc~ ··==="="=
Date Remarks_Md_R~~J.Inces--- ~ -- Obligations~ Obligations Unliquidated
Incurred Liquidated BalL'lCG
(' f.;ry} 193\ .<:i.fb 16<1 --------- - -- ----
~· --- - . gs. '-'~J,. :u, ~tJ'.J&~6 -
16 NO\ ~ U61 a h. ,.1.. ~.:r"./Jzc. -
"' , ,
• -<" --
-
.
~-
==--"- .
----- . ..
: -
.
~ -~~
--
. I -
(Wlien In}
ATTENTION
SUBJ£CT
APPROV.:.<:D li'GR OBLIGATION OF FUNDS:
Dint:l:ib1.1t:ic>~:
O!'igin~.1 ~y Add.l"ess;;ls 1 -~TSD/FASS Z -cTSD/RB ____ _
).
- . ,- . t .• :- "r~: · ··.
..
. I
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"t --- ~
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VIA
SUBJECT
U_Novcmbo r 1?41
;=-TSDJnUd~et O!itcer __ ...
: ---MKULTRA;::-S®pl:ojcd }(l9, tnvotc« No.~ ..... 1Jt~tmOt1t_!i_o~:::.U~:S•U3G•l90Z.=-~~~-
l. In vOle e:-l'to. lc.ovenng tlt.c-a.i>~vo-£ubproJQS!_b_ ~t;taeh.ad.--PaymQ.-~~-shoul<lJa--r~dJ.r cas !OllO"Wt! - --. -· -----
Ca•h!.~t-'.i~~~~~. r·~.--nx-~-$l4. 08\)._QJ, , dr&v:.u..:® . _ ___ _ £_ ____ : Cash!- 63. ~v. d.t·awn-
oa
l._::_P_teaii"_!t)_nf&.Jd thi-ch.e~ka to Chief, :TSD/~ii"-rcb. -Br&nclt "t1,r®ah_T§D/Budaet-6iitcer -by Z& November 1961.
3; _ Th.li liTllnar li\"'I'Oi~-.,-.-- How~Yer, sil\~6 it 1• antieipatod that &.dt1itiow.LL!ua.d§_\rlU bt-obUga_t~d foz t.Ms p~j~k tb-o iUes ~b.ould ilot· ~'J e.toted ..
t 0' tf RECEIPT 1\
\
-... ~ . "'- ~ I I 1 ' : ': ~ '< ... ' •
. . . _:. -·. . ~ . . ~
SUBJECT __ c -=-=-=~----=-: MKUl4TaA«Si.\Spi'OJect-l~t. _Lh~ce t{o. ~Al.!Orininf_No.-:__U~S:~U_90•39QZ;------:-
t.: JnyQleLNo~l_e_O'Ltr11\8_1M:~yo e~f>ptoJ~~_!_~ ~t_t_~~h•d·----==-=-____ _ Paymont -~~4 be ll\•4• at follows:
C&tb:fot_•. ,_,.~l·-41'&\W.
-_.-m_~t·t:rt $9&J. 30-;-:--4i'J.~i\-~ -
(_
pa.yal>l• to
L-Pio&se to~1"4-il'1e eheelte-to-Cblil, 'tSD/.Rtuarck __ Branch Utr&.i&!l TSD/DUd•tt Ofllcetl'_l)y _2_~~~~~·~ttl,bar_l96L---:_-=--:-_--=----:--- --
),. Tlil• lla ~11Avolc6. Ho"fitW~,., ali\ce U t; antldp&t~~---that addillOMllU:'lds wlln>o=ol)ll~ttd-£o.r thi• proJe<:tl" tlle llhn thould not ho cl()sOd. .
Attachmw:. Invoice It Co:rtlftc&Uon•
DtetrlbtttioaL ---:~~-- . i-J ___ . .• 1 J, Odg. Ol 2,. AddieUO>& ------------·---,,-,->~-, _. tif'1
. ~ -" ~~ t ' I
_ J __ .. ~TSD/F AS .. s=---::__ :__:_ ___ ~~-f"J'_.-_~-;.;'J-J'_"" VZ - TSD/RB ___________ -- -- -- -v ·· -- -
\ .. c !NVOlCE-- . ===~~
CERi!F'lCAT'lONS' -·-·
.,.._ --- ·- - .• .., - • i.J:i ·~ ~ t... .;; .•• . n . t: _ t=l-1 _. .,. 7: _ • ~~ U) :_~ !~t l-~>tl'lllo'; ~__,);'U,".;,'!;d !b-~ .... th~.;<l i~ kA~iC~,.:.!!J._ - \t.P•)~};l~g. t.~
s~b~ p~~j""d N!i~ !~J~"'--c=- d_ ~U<Ut;TRA-;;-];~~t-p~Tfu~M~ ~i.~ ~~~1~r.~~t~.if1~ _ it~M ,aG'_n•"'t·~.c~ t;,!~ fl!':~~Jt. ~~~tc~mp.li::-ih!l!;d lli ~(;(;'t;fd;u~&<!! ~,a;'i.f,h m1::t~~1 ~.~f'~{'·~ m>':n'f~-~ t~-~~ l& .u..-jt<!il.ti:<i -6-~~n~ t:!' tb:: P·~-Yt.''H!nh ~i~d rtt~i!iiptos •~->G:n tn~ it\ TSDIRR, r:\n.t ~'t'!-.o bill h jtt!St %r.d t:~©Jt'tl'd .. ,'!JM!Jb;,l.t p;lym~~t ih.rtl~~i-}:~g t.i'-n y "1;~. b-e.::t> .. tn-.\.•i.;t;.,- -
•' ~.) !'! ~"' b(!r'~:by {:~t1.l'J:t~d t~,?\ t tl:?J.~ ltw(",!t;?1 ~pplhlil t.o St.ibf'J'(~j~~t ~.~.1Q,2..;;;-d ~~~Kt;L-rll..t\ ~t~.,.d.t ~,.J ti·uly 4ppu:o,~·~d .. :<tnd th..'!t \h"-' pt·ejtl:·~.t l.j bdt:~~ ~"'-t!i~-1 o;"•\1,~ i~ --~:~·vH·~.n'-:~ with t.h~ mN:n~,t>~d,:.m t~f U AptU ti'J"~l h~r,< 1~~ .)C~ t9 tt;~ t>D/ A,, ~n4 the t'.Jii.,~;tt·:l!~~n ·of H,.b ~?--ilh~uity lr;, .iJ'~1b~~~~·~t1lf.
.'f;sr:n~a i.t~~i.-.. ... -
-:=R,.~~:,;.o..-·~~ ...... ~ ..... -~·...-j,\"JL .. ~~,;;..-..,.., •. -~•J.....llt.:>~
R~-"lr'~t·dt t}:it:'!'.~tt.·t' .
1
/0'1-2 .. 1
' D R A,F_c::T_:~~=-~~=~-=---
Z_Novemb_er_l9_21 _
MEMORANDUM FOR:- THE RECORD
SUBJECT :c=MKU~TR.A,-Subproject 109 ---
l. Tliepul'p~li~f of this-subproject is to pr_o_vide_!und=s"'---=!o_.._r=-------~
the continuation o£ a.:-_study of I)ote~tial psychopha,rmacological =-c==-:c=-
agents .• In particular:;=-studies-w·UrbTdirected to_the_el\i~i!iati(.)n_ --:--:-_:___-
of interrelationship§J)_~tween molecular constitu.tion_and biologi_c~! _ - ------------- - - -- - -- . - --
response.-Studies willb-e-<:onducted into the biC:chemical:c_b.a.r~c-C..~e""'lL_l>. \, , ,,. , - , - ,
teristics-.OLce:ttaJn types -o~~i._~-!~s wh3~h_ ~:: f>£ intete_S_t__to_:_-______ -.---'0~ · r. , ' · r""- - _ _ ___ • _ - {A. - _- .~ ..... ~~}):,.,-, '-~"-v..·"'f 1 ; ... -
TSD/RB~'-1N_'::'''~vJ'-"-~~r-V\ ..v'~ {H~~_,~ _ N.;.---'""- ___________ ( _________________ ._ __ _
.,. ....... ~ -{;c-c.-v--~~ 't..~~ 41 .. ~.-r- t ;
l:-- The __ at~cll_ed Budget ind.idlfes the extent o£ the inv~sti--or or:-~_C ________ _ --~-
_!a~ilitJes availaole at the The
.· . . . ..... . · .. -.. " ":·:
funds f<)r_this_pri>j~ct_will_'b~rran:1fei'red-,rsiz;~~~e~. ', - ·- __ ~"., __ ··._ ;;;; -· )_,.
as a cutout./fror administrative - . : -~ : • "'· • •• ~ ~ ~. • • ~ • .,.'o t - •
purposes in this project, the salary of lhe princripal investigator, . (, ------- -------
Dr._ ___ ~ill be c_arrie~~s ~-sep~rate budget item-and will_b_e __ _
paid directly_ to hi_mJ>Y the cutout.
~·~-
/07-2..1
~- The-cost of-tnispr9gramfor a period,of one_year~wtllnoe~:=~~=~~-= __ .2.1
1 o~C?;..r~:_:= __________ --- - - --- - - -
exceed $lf. oso:-oo-to which must be addedthefour_per=cent fee~-t-o _tl'l_e _ ~ ,_,,ql-1,1--0 .. . ..
.,,u ............ ~~:: the total arnount-$2-5-;~~3".-zu._:C""h~a~rg-;;:'e~_s~_~~~~~~
! ~.~The requires that t'tle -~- ----
~ubmit to them a summary accounting on_a~_annuaLb~asisL__~~~~
of all monies__r_ec.eive.d::_l~_m_t.b&.,, Also, unexp_~n_c\~A.J\ihAscc-VYj._g
be retur · s soon as pos sibl~ up~l). t}\e_ clg~e_()!__
the grant year.
f.:, y A re-qilire~menCf9_r._:_a._six months • infor_mal accounting~~_-
~ on the part of the Pl'iilcipal)nv_~stiga~~F=-if!_W<\iY_ed.~ c_-----"-----""------'-'-----~'---'
1 £_ It is not_anticipM~<!_t_l\_M_:(r\y_p~t_lll_an_e~t equiprn~nt will~---~=
be neededfor_this_program.
(b ( In connf.lction. with_tr_ay_d_under thii-p:roject, it is agreed
that the Agency wilt=acceprthe travel documentaUon-:and accounting=~~~;~~~~~;~~~
which collforllf"Witlllhe:'EfrTctiees~of the~~~~~~ 01 "' It is_a.greed that technical report~rreflectiifgctheP!':Ogress------::
of the research progratn~shall_b~submitted at_mutually acceptable-:: _
intel'vals.
P.'f: AlLP~E!~nnel connected with the plannlng and monitoring
of this program po-ssess T()P-~~ECRE_':['~~g_ency ~~curity_approvaJ.
!L1! Tllis_pr_oiectwilrb~lassHied after it leaves the
<:. _____ _
TSD/Research~B~anch~----------
APPROV OF FUN ~\---~-=~===,==-=~------
i ttq'{, Date: G "9
" --,..:...-.~~ ----------. ----; I
Atta~hment:
ProposaL&::.B_udget
Distribution·~::__· _c______:c_:~
Original only---------
·~----------~----------~---------------------------------~
BY THE AT (0
/01-2.f
Project Tit I e: ~'·The-'...Syn~nesJ~~•m([]~loc:::liem i caCEvaluoti on~:.o_f_l'ot--.ent La 1_~=~~ = Psy~hopharmaco I og L<Lal=_,&.gent~;~=-:-=:-~ ____ , ·
-- -- --
Ph. 0., Profe&so~n_d___H_e_a_d_of- -- -- ---------------of Pharmaceut i cat- and_Med ic i_-__~ _ _-_ __ _
.---.---Coli ege of--:-Pfi'armacy. _ ~c- ·~ ..
Personnel (Associates,_Assist~ntsaf'\d Consultants)
Supp I i e s and N ater i a I s'---·-·· -_-··_· ___________ · _-_--_· _·-______ _
Travel
SUBTOTAl
7% of Personnel Budget_($ 13;ooo-:-oo); to cover retiremer~t, etc.:
SUBTOTAl II
15% of Subtotal II ($~18~~30:44); to cover participation in indirect-costs
TOTAl
*** -- -
Checks should be payable_to_th
October 2, 1961
"" t._ . • •.
cc . . . • '• • • ,I' • ,. ·, "'
. . . . . _· ... '
$-; 12~000. 00---
$~-4,890~44-
6oo.oo--·
t. 840.00
$ 18,330.-44
'· !- 2.749.52
$ 21,080,00
TO THE (Oe
October 2, 1961!
$ 3,ooo;oo
. -
ATTENTION
SUBJECT
.~ .. i- .,4!11.-~~~--"-~~
...,, ~..:..t ""··' •.• ~ .... ~" J...
subproject's e::~p.::-m.Gc~ ~-n~hotilli!. bQ-~htl.l".&•ld to cost c~n.t<:<r aulil)?J•S90J . ------,--..... -~.-~~~~""''=:::" --;oo ~--~-~-
APPROVED FOR-OBLIGA'H.ON __ OF FuNDS:
A-,.
_'* ______ ...,... __ ..... ~------...-----__...-.-~ ---------------lteoaarch Dir"OC"~n.::- __
Di:Jt~ibll~:io~o
O·r~gin~-l ;:.t 2 ~~ 4\d·dress:2 ~
J~nuary~,_l961 ---
~~:~;_:~~~p~~~e~~;~ ~~~~ -~i~i:\~p;;~-... a nual_ -_: : _ -,_,,_c-. .
' - - ---
S inc~_re 1 y:_y_our_s, -~ __
c L
•• - -- nnnnUU-UUU • •
Enclosur-e - -==~--~- --------
De. tel December ~1, 1960. ·
ITEM APPRQfalA1'10N PA :tMENTS
Penonnol-Principal Invest.igator:c~oo~-~ $~· .~3,000-;00~~$.=1 t500,00 $ ~-- -0- . $ ~1,?00.00 ~-
Associates, Assistants and_-c._· _ ___c~~~:;;;--~~===-----c--Oonsulta.nt.s: 9,000,00 l,OOOoOO -G 8,0.00_.,0,(L__.:.-_:c-~-~~-
Sttpplies and ).fs.terials: : 4,890.44 13. ')Q,_--_-__ _
Travel:
SUBTOTAL:
7% of Personnel Budget; . to~~ ~ cover insurance, . retirO"!'--=-~-~-~~ ment, etc.t
600.00
·,
e<1o.oo _ ~l7§.oO---====· -e-- - ~~-~665.00
1~ of Entire Budget; to-:-=:=:--~ .. ~-~-··--~-~~~~~~-~~~___:_ cover participation in. ____ _ i ndireot. costs: ~~.1..72t.:.2r~9~;?..!5f>~.-~. :_:~_.-..,..--~4~2k.i".;;;•-5?;l9!.;; .. ~---_::---·· _. .;-~G.:-~~~@., 32:7 ;97 ---.. · -. -~
'roT.AL:
ce Dr
,.,. ,0 ~.,_II :
,.
I ;
$ 21;oso.qg ·$ :i_.i232;1~~~'"$~~:::.;;. -o- u $ 17!847~83-::=--=-~~-=---~- _
li'l'l-1-
s-.,• ·- • ~ • . ' .. ·,
'. :: I ' \ .... ~
'•. • a .,. • ~ •
~·' ~ ....... ·:~! .~ . . . , ..
, : . ' ·'· . . .. 0 Adm, Assto=to the-Vice ... PresidenL~~~
c-------- -Tbe {iYst~nterlygrant-in-ald ~he.ck{Ot Ut~-~
researclLshould be forwarded. Each quarterly payment is $~Quarterly_p_o!'f!!!enta are-due on-July 1, 1960; Oc~oher l,--lj~Q; Ja-nuary 1, 1961; anct::At>:tif1, !91>!_. ___ - - - ; ---- -- "-
Date Remarks_arul References_-__ _:__ ---
··-
IZT.t
Obj~t ~lass --~--
Obligations Obligations Tn"""""" -- Liquidated
Unliquidated Balance
i '
' . (
W£l&ORANDUM-FORI CQJdPTROLLER
A'l'fEHTION---=:---:- r-'f'lwce Dlvlil.-i---~------\
SUBJECT•
Ot.dtl' tile &au.HUyj~_~H lo ·~· w~~aadlim d&tH
u Afrllt;n -trom tile J)_c.lJ~Jb•_~_l)(~. a~ tu .... _toa of tfall --
a•tll••lty J&::.t\\bu\oeat 11.\~~rao4a~ ~~~project lq9 llit 'tieea
&.Pfl'OVH u.4_$1l, 9U.l0of-tlit ove'l'•all-PJ>jjed ltlKULTlrA-foadt
~ . . .. . , . -.. .. ,, ' . . : ~ . . , .
~ - . - ~ .,_ .. · Cblef _
T~1/Chemlcal DlYlaloa
APPltOVED.::.J"Oa::.OltLlOATION -------Of' rUNDSt·=-=-~=
...,___ ... ~c_..,_, __ ~ -~---=--
' .A.t!!'-.~t:)t.;C~~~:G GfrlC!:R: -
'f<;.EI
Date: _______ :_·9-~9-~~0 ~~~~~======~===
Dhtrtbu\loo: _ _ _ Odl It 2 .!" Addreuee
1 • TSS/0-C_-__ ---~-TSS/F ASB '-··-
----
z_,. TSS~D
TSS/CD/~19 Feb 60)
.•
'\
VIA
SUBJECT
1-TSD/81ldgit-o-=---tll_c_e=-"----
LMKU_LTRA, S~\ptojiet f109. lav~tlce 11 AllotmeAl OS~5~100, .. 90l
1. !Av•le•-fl-cOYerlc& tile ab-ove t~,&bpr-ojed llittacb.ri. ___ _ Paymeot allolald .be ·mu.-a.-foUows: · -----
C&tld~e-amo\Jnt-ot $1l;oao;oo;.~ dra-.. __
oaa~_E :
&mOGI\t of $8~)-; lO, d~&WO R =--~-=.::::-:::___
- J. Pleaae::_fowi&'fi ctie cb.ecka to Chief, TStf/lhuarcb Bj'&Acll lhro-aib. TSD/B"<Ijlt Offlcei' bylS -Auiilit 1960;-= _-· ·_:
l. Tbli h a RMl-lAvolce. Howevtr, 1lcce lt-l.::.aatldp~~·tt--.-.. ----- -thai additlooa' l\itidl wlllbe ol>lli.iti<lfortbh pro]«t,--~h• filn ebo.UCic-- - · ao.t be clot ed. ·
. ' ' !~ . . ... ~· . .- ._
r ....... ~, • I!• • - r "·"' ~
Cfild ___ _ T .SD/Ru eucb- Braacb
Att&clu'nent; Iavolee k ce.-tUlcatton•
Dlltrlbattoo: Orlg. L I • Adclru ue ___________ _
/~SD/FASS-z • TSD/RB-::-_--------
RECEIPT
·-- - -·- _"., __ .
l'A9gllttJ160~==- -
WEWORANDUM J'Olh~ CHl~F i FINANCE DIVISION - ·
VIA
SUBJECT
1 TSD/8.adaet Officer
F).U<UL1'8A. SvbptoJI-d 11091-l"~otce_f_l __ ~ -AllotsneDt osu•to~-.,oa
l. kvoicell c~e.rli-g: theabOv-.--.Qbprojed ,. ·~tac1t.ed.-------Paymeot ehnl• be A'-1~41-~~ toliowit-: · · :
~:-· ;;o••t of $ll0 010~0~, • ..,..,
~T&mOISGI of $a4S. Z004raw• o~
UA"W'&WO. to th
J. Pleat.- lol'w&rcl the cllecki to Chief,- TSD/R.enarcll lli&:Gcll
throu,ll TSD/1!\\cla•' _9ff!~_•r 'tiyls-Aui\lar-1960. :
s. Thlt h-a floal-lO.volce. Ho1frevll'l tlace lt h::.&QJlclpatccJ-- - -- ----that aUlUooal_fGii4t_'4dll 'H obll&atcafor Uah project,; the tllelehould -- ~ --aot b-e doted.' -
1
- -
II
Attaetmlenh : lnYOICI • Certlfl~~tlODI _
:DlatrllHltloa: Orlg .. • I ~ Addu_ne•-·· --------- ----- ----- ,
1 .. TSDIFASS~ z-TSD1~B====·================~
--~--------~·~ ___ .._... ____ _
·8mRfT::_ _______ _
INYOICE ______ ~ __
For Servlcu
···········-~·-·····················~···~~
CERTIFICATIONS==- :
(1) lt ll bereby cetU.!lid:::-ttiaCtlilrlL_ll'lY_olc.-Jj app!Y!Ill to SubproJ•"]L~--109 ol MKULTBA,-tb&t-~doimaoce 11 latllfaetory, t~at urvlcu_are _ belns accompl-lhed_~l_o __ at_c_o_rdi-ClC._vd_tQ_a_n~f~---•BJ~••~'otl, thAt_&_ ---- ----deta!led aaeftda::_oLth:e_~~erite a~d Jijcelpte li on fireili~_TSD/RB, that tblt bill It Ju•l and_cor_1'.e_c:_t_and_t_ba1_~yment thereof ba-t-not yet beea____ - --made.
Ctilef, TSD1Reuarcb Brandl
Date:
U) It h bueby::certU'itCitnat _tbllln\'olce appllu to Sgl)pro)!_~~~J_Qt__ ol MKULTRA 'Wblcb-wa• duly appr~,~<l_;~ !llcS)~-~~tlje fifoJect It belol---------=- ==- ---=-canted out lo · ac_(~Ldance witb ttl~ memofindum-ot'_U_ Apl'_l!_lcl~~_f_r~_ _ __ ______ _ tha DCl to the DDJ A, -~nd-ttii iX.te-ndon of lbh autho~ltyJn_ IU~!~qut(lt -~ memoranda.
Ruearch Director ____ _
Dat•=----------------------~~~~~~~----~
I.
I
ATTENTION _______ a_fili_u~•-IUvlilji ~==-~
SUBJEC'f_
'.:..."
Ull4er_tlle_a.llta..t_ny_&rwt4 lata•• Wiiiioru4omure~r:-~:-=~-===-=-~-
u Aprll ltn -from ,_...- DCllo tile DD/ A, u4 tke ~txtecalloa ot '~' __ _
a.utlo~lty la.au~lt:(otat mem.oraoaa,- Ssltprojtct 109 _bt \tta _ _ -
a~sn:ovecl aa4 $1J;tu-;H of_j_-~_,n•tr•al[l!.l'•J~d-~KULTl\7,-ftack«_e-::- __
APPROVED.:.r..oa:..ODLlOA't.lQN - ---- ------OF FUNDSt~~~ _-
----
R.eeeaJ'ca Dl·udor - -- ---
Date: ---~--------------~---------
DhtrlWloa: _______ _ Orla &.: 1 • Ad4reiue __ _
1 .- TSS/OC_____ __ - ---1 • TSS/F ASB -_--_ ~-
z i;=TSS/CD~----A- -- ---------- . TSS/CD/c-. (lfFeb 60)-
T$8/ Cflemlcal Dlvleloa - -
,. -. · ...
D R A F T ~=- := -_ 19 Feb-ruary 1960 __
SUBJECT
studies wilLb_e~dlicfct_e_d to the eluCidation of inter-re-lationships------~---~~~c~--
between moiecular::_co_nstitut_ion and biologi~al r~upqns e-.-studies
' as a cut out. ' ) '
3.~The~cost or thiS-progi'~afi'\for_~-~~l'_~od ofone·year will not :tif.O<;O,J_I) __ ___ __ _ _ _ . -~ ...
exceed $Z.Y, 080. oo-to which must be added-Ufefour-per cent fee to the ---~- '!~ ~, )<.J$ ... <,) - -
~nakl[lg_t_h-~j~t~~~-;~~~-n-t~$i~,' ~i3-i;o. _ Ch-arg-es-should
be made against_AllQ.tln_eJ1LN_o-;_:~-?~5·:l(J0?;,.-:}90Z'~ · ·
. · • 4. Tb-e....-..eq~h~t the .......... ~_-. subrnit to-them a summary accountl~g-_o~~_n_ aJ~p:ua:tJ:>.asis_oJ-~~--
·.
all monies_r_eceiy_ed from the Fund. _A~~. __ un~xp~nde<! _funds -.viU
be returned_by-the as soon as possible-~lpon the close
of the grant~year;
5. _-A reqt~ire!Uent_ for~a~si)( ffi()nths• in£orrna.Laccount_ing
on the part _ofthe p~i_ncipa.l investigator is waiv~d;-="---=--c=-~
[6. It is not ·anticip~ted-fffianype-i'nYanent _eql!!p_m~t _will~-- -
be needed_for-_this_progra.m.y-
7.- In_~_Qnneclton w1th-tra.vel under thi~ project, j_t_ !~~greed
that the Agency-will accept_ tne tuv_el-doctimentation and.::.acCQ\ln~ing-~
whieb con!ormwith the ractices-o
S.~~It--:is agreed that technical reports reflecting-the prog!_ess _
of the research program shaU-besubmitted at tnutually~c-~p1.!!:>1~;~- -
intervals •- ___ _
9. All p~rsonnelconnected ·with: (he pJatlning and -::m-onitoring~-~=- c_c--
of this program-poness-TOP-SECRET7"gency·security appr_0\'_~1._ ~---
10.-- Tllis project will b-e unclassified-after_it_leay~-~.Jhe _______ _
APPROVED-FOR--__-OBLIGATION OF FUNDS::----=--=--=--c=-
Date: .
Attachment: Proposal &
1~7'-1
:-:.
Project Title: The Sy-utheds an~}tiQ_c}lemt~rEValuanon -or Potential Payg!l<:>PJla.rma-cological Agents.-~ ~Q-_-_--_--_:-_:_-:-~_-·- ~. -.- ---- -
Principal Investigator:-~:!>•., Professor and ~~.d-Q.ft.he De~rt.~nt;==---==-=~-~ and Medicinal Chemiatry 1 College_ of _ ----
Personnel -
Fharuat~·~·*-------------------
PrincipaLin'i.es_t_t~~t~or~~~--~~~---------Assooiates, Assistants and Consultants
Supplies and Materia 1 ... -__________ ___:__:_ ______ ____:-=-~::.:..:..:...:__:::_:=.:..::::::::..::.::....:..:
Travel
7% of Personnel Budget-=-{$-12,000.00); to cover insurance, retirement
1 social security,-etc._.. ________ _
l~ of Entire Budget ($ 17,600.()0); to cover :participation in indirect costs
TOTAL
*** .
Checks should be pa1able to
January 22, 1960
cc
* Effective July 1, l96o
$~31000.00 $- 9,ooo-.oo------ -
$ c~5,000~0Q
$-~--600-:oo
840.00,-
$ ~ 2 , 640. oo----- --• ~ -----
"' ~21=080 .oo-- - --'P , ..... .
ProJect. Title: The Szn\h•lla-w Btoohellioal fialUatlOJrot-htential_h)'chophal"'l&• ·· coloct_oal As•ntl. ______ ---· · · · · -- -- - - : - ~~---
.:D. 1
P'l'OftiiOI' aM. ~834. of -t.hT l>epaftlw_n.t _ _ .ma~LOtlllUC&J. ~-!l•~!_~~l Chtll11t17, College of- ---c---=.._
hHOAMl •
Pti:t..:mt.07• * --- -- --:---=--_ - - -
Pl'inclpe.l 1DY_tat1~t'OI'- -----~-
AAIOC1&tta,-AeaiataDta aO!-consUltante
SUpplill and Mattl'tal•==~-=c . :r. ______ _
Yranl
7~ of Personnel Bu4glt_($_l.?,OOO.OO) J to oour sneul"&llo.e, ret.ireunt 1 eootal ueur1t7 '-~~to. -
1~ of :Intire Budget (f_J.T;liOO.OO); to cover part1oip&t1~· tn indirect coats
tOTAL
... -=-----
00
.,
! 3,000~00 • 91000 .oo-----
* ,,ooo~oo L ~.oo
t 17;600.oo----
• - -- 840~00-
! 2!64o.oo
• 21,080,00-
.. G
l . ..
/07-J.t;
Project Title: The Synthesis_and ~ioc.Mrrii.~~l-_]va!\la.~ion ()f Pote,ntiaLPsy~hopharma~ cological.:_Agents ~ cc. _____ ~-- _C . - . :
Principal Investigator: ........-... . .D., Professor and Hea:d-:::of~he Department ~~and z.tedicinal ChEllll_i~try,-College of
Personnel •
Phar!llaty,. * -.-.. -·~----~-~-
Principal Investigator ~--- _ Associates,· AssistantS.-and Consultants
Supplies and Materials ·
Travel
SUBTOTAL
7'7:-·of Personnel Budget ($~2;-QOo-:-Og)f-to~c.S>\'_e_r insurance, retirement, social security,-etc~
15% of Entire Budget ($ 17;600~00);fo .. cover participati-on in indirect costs
TOTAL
***-
Checks should be payab lL.t<Lt
January 22, 1960
cc
$=- 3-;-ooo~oo · $ - 9 J 0.90_!()9
$-s;ooo~oo
$. 600~_00==~--.... -_ -.
$ 17;600~00
$ 840~QQ __ _
~640~oo- ----- ·
$ 21;-080~00
..
* Effective July 1, 1960 (on leave of absence CJu1y 1,•1960 thrqugh June 30, 1961)
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