risk factors: hiatal hernia, duodenogastric reflux,delayed acid clearance time, ↓lesp adult...
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Risk factors: hiatal hernia, duodenogastricreflux ,delayed acid clearance time,
↓LESp Adult disorder → 376 per 100000 Irreversible conditionM/F = 2/1
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Specialized columnar epithelium with goblet
cells (positive for Alcian blue in pH:2.5)
Absence of goblet cells is insufficient to make
a definitive diagnosis
“Barrett cytokeratin 7/20 pattern ”
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Negative for dysplasia
Indefinite for dysplasia
Low grade dysplasia
High grade dysplasia
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Surface maturation (low power)
Architecture (low power)
Cytologic features
Inflammation and erosions/ulcers
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Surface epithelium more mature than
underlying glands Normal architecture Nuclear stratification - ↑N/C, small nucleoli,
mitoses are normal in Deeper glands Nuclear polarity and, smooth outlines are
preserved in Deep and superficial
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Nuclear membrane irregularity,
hyperchromasia in Deep ,with normal maturation to surface
Active PMN infiltration
No polarity disturbance No architectural abnormality
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Extension of cytological abnormalities to
surface (at least focally)
No maturation to surface
Abundant inflammation, prominent nucleoli,
abnormal architectures and loss of polarity
are not LGD features .
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Prominent cytologic abnormalities
Markedly distorted glands
Little intervening lamina propria
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DNA content (flowcytometry)
P53 → progression
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