© peter menzel humanizing not mechanizing...who first global forum on medical devices, bangkok,...

Future of Health Technology

Future of Health Technology Institutewww.fhti.org

© 2010, FHTI.

Humanizing not MechanizingSeptember 9, 2011

WHO First Global Forum on Medical Devices, Bangkok, Thailand

Renata G. Bushko, [email protected]

Future of Health Technology Institute

© Peter Menzel

First Global Forum on Medical Devices

© 1996-2010, FHTI. All Rights Reserved.

“By analogy to the successful effort to put man on the moon, we should aim at chromallocyte landing on the liver by 2039 which would commemorate 70th anniversary of man landing on the Moon. We should have a dream with a deadline of 2039.”Fight for Chromallocyte, in “Strategy for the Future of Health”, Ed. R. Bushko, IOS Press 2009

Dream with a DeadlineDream with a Deadline

© R. Freitas



INSPIRATIONINSPIRATION•• Inspiration from space to achieve impossible for the Inspiration from space to achieve impossible for the

““benefit of the mankindbenefit of the mankind””::Fight for Chromallocyte and Space ElevatorFight for Chromallocyte and Space Elevator

INCUBATIONINCUBATION•• Importance of setting goalsImportance of setting goals

•• Strategy equations and megaStrategy equations and mega--trendstrends

•• PublicPublic--Private Health Revolution: Private Health Revolution:

Empowering consumers and especially women Empowering consumers and especially women

•• Examples: sociometers, $2 eye exam, 100Examples: sociometers, $2 eye exam, 100--fold cost fold cost reduction in Malaria /HIV testing, caring agents; reduction in Malaria /HIV testing, caring agents;

autonomous learning robots; cellularautonomous learning robots; cellular--camera; camera;

mosquitoes fighting malariamosquitoes fighting malaria

•• Electricity generation through Electricity generation through ……dancingdancing

INSIGHT INSIGHT -- WHA resolution 60.29WHA resolution 60.29•• Improved access, quality and use of medical devicesImproved access, quality and use of medical devices

Future of Health Technology:Future of Health Technology:

Humanizing not MechanizingHumanizing not Mechanizing



From Space Elevator to Cancer TreatmentFrom Space Elevator to Cancer Treatment

� Carbon Nanotubes have been classified by FDA as medical devices

�Soluble in water

�Thermal conductivity linear with concentration and temperature

�Can be targeted towards specific cancers

�Cancer therapeutics – market worth $35B in 2003 and projected to be $60B in 2010 (Pharmaceutical Business Review)



Future of Health Technology InstituteFuture of Health Technology Institute since 1996since 1996

Brings Together Creative Minds for Annual Brings Together Creative Minds for Annual

Future of Health Technology SummitFuture of Health Technology Summit™™ to:to:

� Stop disease before it even begins

� Stop suffering before tears occur

� Stop symptoms before they hurt

� Stop medical errors and aging before they kill

� Stop Cyborgs before….they control us….Future of Health Technology Institute tries to achieve this by:

� Addressing health crisis as an international emergency

� Thinking about long-term global future on an on-going bases

� Giving power to the consumer

� Managing randomness in technology creation & adoption process

� Designing healthcare with caring machines



Future of Health Technology Award Future of Health Technology Award –– FHT2011 9/26FHT2011 9/26--27/201127/2011

Reduce suffering, save lives, extend human potential with technology

Third nanotech-made diamond eye to see the future, wings to be inspired…



IT + MD + Medicine = ITicine

Mechanical Engineering

Electrical Engineering

Computer Science

Molecular Biology

Chemistry

Genetic Engineering

Nanotechnology

Mathematics

Biology

Future = CONVERGENCELife Science + Computer Science

Medical Devices + Communications Technololgies/IT

ArchitecturePhysics

Material Science

Genomics

Proteomics

Power to the Consumer



The following 32 diseases related to genes on chromosome 11:autism (neurexin 1) [1]aniridiaacute intermittent porphyria

ataxia-telangiectasiabeta-ketothiolase deficiency

beta thalassemiabladder cancer

breast cancercarnitine palmitoyltransferase I deficiencyCharcot-Marie-Tooth disease

Charcot-Marie-Tooth disease, type 4Denys-Drash syndrome

familial Mediterranean feverHereditary angioedema [[2]] Jacobsen syndrome

Jervell and Lange-Nielsen syndromeMeckel syndrome

methemoglobinemia, beta-globin typemultiple endocrine neoplasia type 1

Hereditary Multiple ExostosesNiemann-Pick diseasenonsyndromic deafness

nonsyndromic deafness, autosomal dominantnonsyndromic deafness, autosomal recessive

porphyriaRomano-Ward syndromesickle cell anemia

Smith-Lemli-Opitz syndrometetrahydrobiopterin deficiency

Usher syndromeUsher syndrome type I

WAGR syndrome

Geno-Socionome:Molecular to Behavioral Mapping

© Alex Pentland

Epigenetics, Hunger and Econo-Spiritual Growth



© 1999, R. Kurzweil, The Age of Spiritual Machine

$1,000 OF COMPUTING BUYS

Smart computersSmart computers



Future of Health Technology- Move to Wellness Model



Track the social signals exchanged in telephone conversations –

Attitudes

Interest

Distress

Power to the consumer:PersonalHIS

© 2010, FHTI.

.

Shared decision making



Crowd Farms would make use of the endless human movementsharnessing this power source to create electricity

© Graphic / MIT School of Architecture and Planning

The Land of Giants

“idea from an ingenious little device by

Thomas Edison. When visitors came to his

house, they passed through a turnstile that

pumped water into his holding tank,"

“MIT student T. Jusczyk’s stool exploits the passive act of sitting to generate power. The weight of the body on the seat causes aflywheel to spin, which powers a dynamo that, in turn, lights four LEDs”



2 billion people have

refractive errors

© 2010, Renna Bushko© 2010, MIT Media Lab

© 2010, MIT Media Lab

$2 Health Technology to Save your Sight153 million do not know they need glasses – 87% of them in developing countries

Resesrch by Vitor Pamplona, Ankit Mohan, Manuel Oliveira, Ramesh Raskar

Paper Accepted for ACM SIGGRAPH 2010

© 2010, MIT Media Lab



Lab on the cell phone : 100 times reduction in cost of Malaria and HIV testing

CD4-count machines, which determine the suitability of HIV -positive patients for antiretroviral treatment, cost too much around $20,000.

© 2010, Henry Young

LUCAS: Lens-less, ultra-wide-field cell-monitoring array platform based on shadow imaging -UCLA professor Aydogan Ozcan.



© 2010, Northwestern University, Relational Agents Group,

Professor Tim Bickmore

Smart Relational Agents Technology Agent, 74%

Doctor or

Nurse, 10%

Either, 16%



Intelligent Caring Agents – empowering women PersonalHIS

Personal StatusMonitoring

AI/NLP

Access to Global DBs



Robotic and nano-surgery: towards autonomous medical devices

© R. Freitas

© R. Freitas

© 2010, Renna Bushko

© David Gracias, John Hopkins

© Leong, Randall, Benson, Bassik, Stern, Gracias, PNAS 106:703-708 (2009)



© Sheila Kennedy

Carbon nanotubes in fabric – electronic fabric with built in antennas, sensors, and tiny batteries to power communication equipment. • 20 times a tough as steel•17 times as tough as bullet prove vest•4 times tougher as spider silk

© Sheila Kennedy

Light for 1.6 billion people without electricity -

alternative glowing films applied to walls and

ceilings - healthy light departing from the bulb

culture....



By 2020 depression will be the highest ranking cause of disease.By 2020 depression will be the highest ranking cause of disease.

Goal: ongoing monitoring of Goal: ongoing monitoring of mentalmental health status health status

Depression meter



Revolution in Public Health “Using Reality Mining to Improve Public Health and Medicine”by Alex Pentland …in Strategy for the Future of Health, R. Bushko IOS 2009

Instead of this:

You can use this:

So: we can `x-ray’ entire organizations and regions with Reality Mining

Massive behavioral realMassive behavioral real--time monitoring time monitoring ––mobility, speech patterns, socialization patterns mobility, speech patterns, socialization patterns ––diagnostic of depression, diabetesdiagnostic of depression, diabetes……immediate action possible immediate action possible



Mosquitoes totally resistant to malaria – new way to fight the disease…

Scientists created a gene that kills the disease inside the mosquitoes themselves. DNA injected to mosquito eggs. According to Michael Riehle from University of Arizona US, genes kill 100 percent of the malaria inside the engineered mosquitoes.

At the dawn of the 21st century, malaria kills at least 1 million people a year while roughly 2 million children die from diarrheal diseases annually.



Massive low-cost Immuno-signaturing :Neal WoodburyASU

© 2010 Benjamin Miller

Porous silicon sensors which color changes as a function of what’s in the pores - a molecule from a disease-causing organism. Can be incorporated into bandages

New type of silicon sensor able to detect single viruses

- only 4/1000ths of a millimeter across



The way forward to ensure improved access, quality and use of medical devices (WHA resolution 60.29):

Form nonprofit medical device companies just like Dr. Hale’s nonprofit pharma company, to work on most pressing problems not addressed by established industry and involve local communities – create jobs.

After five years, Hale’s company will bring to market its first affordable drug: a cure for Kala Azar, a parasitic disease that kills two hundred thousand people a year; Next goal: secretory diarrhea, a deadly disease that kills more than 1.6 million children in the developing world each year is the

Massive hiring of mathematicians to work on complexity and reliability theory and implementation both in current manufacturing process and in the use of devices in medicine.

Massive consumer education campaign in use of PERSONAL Medical devices to prepare for SELF-CARE era.



SimulationSimulationActualActual

Digital Medical Training and Clinical Trials with Quantum ComputDigital Medical Training and Clinical Trials with Quantum Computers ers

AR Goggle

Haptic Device

Marker

© Peter Haddawy



© Marco/Harvard, diamond from Apollo

Diamond, Cooperative work between Harvard

and Apollo Diamond,

Similar type of array will be used in diamond nano cameras

Nano-sensing: Diamond cellular-cameraProfessor Ron Walsworth – Harvard University Department of Physics

Scanning the magnetic activity of billions of individual nuclei.

The new diamond-based magnetic sensor could enable novel forms of imaging, marrying NMR's noninvasive nature with atomic-scale spatial resolution.



““Evidence from several countries shows that tremendous improvemenEvidence from several countries shows that tremendous improvement in healthcare t in healthcare

outcomes at costs dramatically less than US or similar healthcaroutcomes at costs dramatically less than US or similar healthcare systems is achievable e systems is achievable

by proactively delivering healthcare by proactively delivering healthcare through a system of young women who visit every through a system of young women who visit every family in the country several times per year.family in the country several times per year.

Such young women in desperate need of jobs already can collect hSuch young women in desperate need of jobs already can collect health information, ealth information, deliver contextdeliver context--dependent advice, and perhaps most importantly dependent advice, and perhaps most importantly serve as frontserve as front--line triage line triage

for the rest of the healthcare system.for the rest of the healthcare system.The successes demonstrated by such `three tier' systems The successes demonstrated by such `three tier' systems -- proactive home visit, health proactive home visit, health

clinic, and hospitalclinic, and hospital -- can be further augmented by using the world's first ubiquitous can be further augmented by using the world's first ubiquitous sensor sensor

technology: cell phones. technology: cell phones.

Today's phones track mobility, speech patterns, and socializatioToday's phones track mobility, speech patterns, and socialization patterns n patterns -- information information proven to be diagnostic of many of the world's most important diproven to be diagnostic of many of the world's most important diseases of (diabetes, seases of (diabetes,

depression, etc)...and collect images suitable for telemedicine.depression, etc)...and collect images suitable for telemedicine. By managing and analyzing By managing and analyzing

the information collected by these ubiquitous sensors the information collected by these ubiquitous sensors -- a process called `reality mining'a process called `reality mining'--we can dramatically improve disease detection and track treatmenwe can dramatically improve disease detection and track treatment efficacy.t efficacy.”” Professor Professor

Alex (Sandy) Pentland Alex (Sandy) Pentland

That process is also called personal health informatics, selfThat process is also called personal health informatics, self--analytics, or selfanalytics, or self--monitoring. monitoring. Some consumers will be able to do reality mining themselves whilSome consumers will be able to do reality mining themselves while others will subscribe to e others will subscribe to

RM services and will relay on caring machines and automated trigRM services and will relay on caring machines and automated triggers. gers.

SelfSelf--reflection may also lead to more selfreflection may also lead to more self--realization and increased sense of purpose that realization and increased sense of purpose that

will significantly decrease depression rates due to overwhelmingwill significantly decrease depression rates due to overwhelming feeling of insignificance. feeling of insignificance. Caring for each other in a new way may give jobs and sense of puCaring for each other in a new way may give jobs and sense of purpose to millions.rpose to millions.



2003 50th anniversary of DNA

discovery

First mechanosynthesis – key manufacturing technology to

build chromallocyte [8]

2007 The first technical description of a cell repair nanorobot ever

published: Robert A. Freitas Jr., “The Ideal Gene Delivery

Vector: Chromallocytes, Cell Repair Nanorobots for

Chromosome Replacement Therapy,” Journal of. Evol.

Technology, June 2007. [3]

2008

Direct experiments to build and validate several of

mechanosynthesis tooltips. Seminal paper: Robert A.

Freitas Jr., Ralph C. Merkle, “A Minimal Toolset for

Positional Diamond Mechanosynthesis,” J. Comput. Theor.

Nanosci. 5 (May 2008) [9]

2009 40th Anniversary of Man

landing on the Moon

Nanofactory Collaboration active: coordinate a combine

experimental and theoretical R&D program to design and

construct the first working diamondoid nanofactory [10]


landing on the Moon

Demonstrating diamond mechanosynthesis in practice

2022 Building Nanofactory

2027 Building Prototypes of simple nanorobots (eg. Respirocyte)


landing on the Moon

Manufacturing of diamondoid medical nanorobots for life

extension


landing on the Moon

Building chromallocyte (extremely sophisticated and

complex nanorobot) and landing on a human liver –

First in vivo liver chromosome replacement.2069 100th Anniversary of

Man landing on the

Moon

Broad use of chromallocytes: Our biological age restored

once a year to a more or less constant physiological age

that we select.

Dream with a Deadline: Dream with a Deadline:

Broad use of Chromallocytes on Broad use of Chromallocytes on

100100thth Anniversary of Man Landing on the Moon in 2069Anniversary of Man Landing on the Moon in 2069

Fight for Chromallocyte, in “Strategy for the Future of Health”, Ed. R. Bushko, IOS Press 2009

© peter menzel humanizing not mechanizing...who first global forum on medical devices, bangkok,...

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