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; MEMORANDUM RECEIPT

TO:

SUBJECT:

I hereby ackcowledge receipt of the following:

Pltu• rttiU'lt....,_ __ algnH- COJJll••l of thh rtctlpt.

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~-------------------------------FORM NO. :U·Il MAR· 1!1U - · · _

DATE RECEIHO

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CERTIFICATE

May 24, 1954

'lhls is to certify that-I-have today received

Cashier's check No. 129758-ot--tlie Millll

in _the emount of $8,0_11.66.

May 24, 1954

This is to certify-that I have today reeeived

Cashier Is check No~ 129759 of -the

-- in the amount of ~320.46.-

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MEMORANDUM RECEIPT ' '

TO: - OATE

FROM:

SUBJECT:

I hereby acknowledge receipt of the following:

/l-1''" ,. .. ,,. 4" CHECK#l..22ZOIN THE AMOUNT OF" $.z.w.£" RECEIVED.

P1eaa• return __ ~· aignri cap~llu) of thh receipt _

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(2) •It. 1a herelJt Ctl"t.it1e4 t.hat. t.'ll• intoice a.ppliea t.o aubproJHt 2fJ \:Mer ProJ~t. ?·~J;!•l'P.J. which 1>1.8 dl.il.,y appf\ITe<t Al'.<i ~;a~ \hC! ;>rtJ,Ject. hA• -~ camecf cut 1n ucorcl&noe with t.>1• 'CC/r arr.vf8l'.dw:i t;o z;-.;1 cla~ l .tprl.ll9Sl v4d. t.t1e tiel lM'~~.-w.d~ to 'C·D/ A dat.od lJ A_prU 19Sl.

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Ma.7 18, 1954

IQvoice _-__ _

For 4enic-ea ••••••••••• $6,3)2.12

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ftOJM\ ICit&!RA, SubprojeCt 33-

UD4a'- tbe o~W'thorit)' gratecl 1D \M ~ d.ate4 13 Afril

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'?' DRA..~· J _· 10 Kq 19;,.

Project MKUL'l'RA-,- Subproject 28

. l. The purpoJ.., ot this project ia to provide fUnds for tbe at'Ud.y

- - ot drugs affect - ·- ·- --- the Depa.tlmeQt o~f __ _ Pb&rmacology at · .. Qi

~ )

- - - ---- ----

,.. 'l'be-. cost ot 1:111_!1:::-P!"()~-for a t~eriod of one year-'beg:lnnins Ill J'Une·l954 vil.l_'be:..$2,.,035.00~- n'fo -this~mt1st bec.:ad.d.ed a 4~ ~rvtc:e LJ __ charge to the_~. _ forits services., The total cost tor

the above period_Yi - exceed. 996.40 ·

u- - u 5. ~t~-n:.· .• lltltJM ~-Dr are· cleared TOP SECRET by tbe Af5eney Slld-are aware ot the sensitive nat~ ot ~this_V()t"k._ _______ _

APPROVED:

A~u Chief, C~cal DiVision, 'l'SS

APPROVil> FOR OBLIGATION or FONDS:

Attachment: Proposal

raded tor rH y ot:. 411-fP..

1977 4

BY•fitfi

...

-·~ -

. ~· ., ~:;.'; ~; ... .~,. . .... -·- ......

~~nt of Pharmacvi.olf

-(0 .. ~~~

Purpose: To st·lldy in a.n.i.mals and man the s~cif'ic effect ot central nervous

depressant drugs. .

This will be pursued under the tollow:ing headings:

a) Atropine""'like -central nervous system depressants. '

b) Other synthetic central nervous systen depressants. __ __ _

..:C) Ext-raction, identification ani pharmacological action of active principles~__::: fran plants .. -- -- - --· -

. d)- Effects or. these agents in echizoph_reni~~ -=::.-:.::

.. ·. : .... ':· . . ~ will have available SUfficient pharmacological;-psychological

am biochemical talent so that we wlll-be able to undertake as a major research effort~.

the study ~Jl animals and eventually normal man and schizophrenic patients the various "' synthetic chemicals.~ard plant=-ext.raot_s __ lfhich __ may be supplied-by industrial-and-other

research laboratories.

A biochemist will be employed part time to extract and identiiY active principles --. -· . ... . ·.- ... -.. . . .. . ~

!'rem various plants' the crude po"Nder ofwnich~shows definite phamaeological action.

These crude drugs and active principles will be assayed ~ the-pharmacologist. The

toxiei ty or potency will be determined and chronic toxicity experiMents in animals will ·

be undertaken to determine the __ safety of' the d~gs. __ These drugs will then be cautiously.

tested tor their effect in schizophrenic9, and will also be tested in normal human

vol,1nteers- for their peculiar _effect_ in __ man. __ The_ proje_ct therefore provides for pharm­

acological, eneymological, biochemical and psychological consUltants. 'lbese will all

be part. tiine, but will devote a defin.ite she.re of' their time to the pursuit of. this

research project, ·' f'ull time workwill be done by a fellcw in psychology arrl another

fellow in biochemistey-am. pharmacology.---------- -- -----

The e<s_uipnent needed will bef extraction-apparatus, fraction collect~rs, ph meters,

centrifuge and pr~paratory centrifuge. In addUion, we rill need certain psychometric . .. ·--testing equir.ment to supplement the material new available, Expenses and expendable- ... :.,; .;...:;..

-. -. .. ..... · ...

e .. '

suPPlies will be needed for modest stipen:is .for the htunan volunteers. These funds

-will also be used tor the purchase of solvents and other ehemie&ls•~-Travel is

'. i ·~

divided into two items:- The atterdanee at scientific meet1n£S~and_the __ need._!or c~c~-~~-~~·

travel funds to allow the drugs to be taken to

for initial testing•: This willcost. abaut_$100~00_per t~ip. and it is planned that

one trip p'3r month will be maia tor-this p~-li~~~

--, ----·~·· - -----·=-> e

Salaries tor ProtesSion&l Personnel -- - I 7 ,~oo.oo

FellOwships - _ __-- ____ _

1 - Bi®nemiJt.rr __ l~Perch-ology-----==-=---

Expend_a:,le-_Supplies --

Tr.vel ____ ~

Research Conterenc._..e=-_s_---_-___ _

TOTAL- --

to.UJ_A,Itf'flllll!lllfiJ.

2 52Sa00 , -. ------

21525.00- --

8,000~00

1,200.00

400.00.

$21,850.00

2,185.00-

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