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Page 1: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil
Page 2: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

IntroductionResults and Methodologies

Locating the Lesions Psychological Tests

Summary and Conclusions

Nicole Neil

Page 3: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Introduction

Page 4: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Subject Age of Injury Age at Test Source of InjuryBeth Birth 12 Hypoxia (birth trauma)

Jon 4 16 Hypoxia (convulsive seizures)

Kate 9 19 Hypoxia (seizures)

Mudra Bhatt

Page 5: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Hippocampal System

Episodic Memory

Hippocampal System

EpisodicMemory

SemanticMemory

SemanticMemory

Underlying Cortices

Nicole Neil

Page 6: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil
Page 7: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Methods Results

Volumetric Measurements

Hippocampus abnormally

small

T2 Relaxometry Remaining hippocampal

tissue severely compromised

Proton Magnetic Spectroscopy

Temporal Lobe normal

Molly O’Brien & James Guse

Page 8: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Parental Questionnaire Used Riverhead Mead Test to confirm

degree of impairment:

spatial temporal episodic

Molly O’Brien & James Guse

Page 9: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Copy of the Rey-Osterreith Complex Figure and 40-min delayed reproduction of it.

Normal control, copy and delayed reproduction by a typical 13-year-old.

Psychological TestsMolly O’Brien & James Guse

Page 10: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Molly O’Brien & James Guse

VIQ PIQ MQ

0

20

40

60

80

100

120Multiple IQ Comparisons

Beth

Jon

Kate

Normal

Standardized tests for IQ were done on all three children and compared to norms (green),

VIQ: Verbal Intellgence QuotientPIQ: PerformaceMQ:Memory Quotient

Page 11: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Molly O’Brien & James Guse

Working Memory

Combined foreward and reverse w.m. span

Normal

Kate

Jon

Beth

Working memory is at par with normal controls (green)!

Page 12: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Semantic (Intact)

Episodic (Damaged)

Verbal IQ Parent Report

Reading Comprehension Rey-Osterreith Complex Figure

Spelling* (exception Jon) Verbal Recall Tests

Richa SharmaMolly O’Brien & James Guse

Page 13: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil
Page 14: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Hippocampal System

Episodic Memory

Hippocampal System

EpisodicMemory

SemanticMemory

SemanticMemory

Underlying Cortices

Richa Sharma

Page 15: Introduction  Results and Methodologies  Locating the Lesions  Psychological Tests  Summary and Conclusions Nicole Neil

Richa Sharma