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ISSN 0036-807514 AUGUST 1992VOLUME 257NUMBER 5072
AMERICANASSOCIATION FOR THEADVANCEMENT OFSCIENCE
IEWS & COMMENT _ _ PERSPECTIVES
Fetal Transplants Show PromiseThe Tissue Bank's Shaky Underpinnings
Chemistry Curricula Edge Towarda New World
NSF Holds Plan Close to Its Vest
Mitochondrial Eve: Wounded, But NotDead Yet
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Reading the Bones for Modem Human Origins
RESEARCH NEWS
Huge Impact Tied to Mass Extinction i 878
Getting Some "Backbone":
How lMHC Binds Peptides
Microgravity Materials Science Strives toStay in Orbit
Possible Evolutionary Role Explored for"Jumping Genes"
Science Innovation '92:The San Francisco Sequel
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Intermolecular InteractionsW. Klemperer
Splicing Takes a HollidayJ. A. Steitz
ARTICLESThe Nature of the Metal-Metal Bondin Bimetallic Surfaces
J. A. Rodriguez and D. W. Goodman
PATENT POLICYGenes, Patents, and Product 903DevelopmentR. S. Eisenberg
Genome Research: Fulfilling thePublic's Expectations for Knowledge andCommercializationR. G. Adler
Patents on Random ComplementaryDNA Fragments?T. D. Kiley
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DEPARTMENTSTHIS WEEK IN SCIENCE 857
EDITORIAL 859Science Is Great, But Scientists Are Still People:A. Komberg
LETTERS 860Drugs from Third World Plants: I. S. JohnsonoComputing in Science: J. Ross * Condom Use: F.L. Sonenstein * NSF and Duplicate Grant Submis-sions: D. Jaron * Combating Epidemic Cholera:R. A. Finkelstein * Nucleoside DiphosphateKinase: Conclusions Withdrawn: P. A. Randazzo,R. A. Kahn, J. K. Northrup
SCIENCESCOPE
RANDOM SAMPLESBush Administration Weighs in on AIDSSocieties Sound Alarm on Biodiversity, etc.
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BOOK REVIEWS 981The Code of Codes, reviewed by B. D. Davis *
Everyday Cognition in Adulhood and Late Life, T. A.
Salthouse * Andean Magrtism and Its TectonicSetting, B. S. Singer * Vignettes: Tales ofInvention* Books Received
PRODUCTS & MATERIALS 987
_AAAS Board of Directors -BoardIof Reviewing Editors_
Leon M. LedermanRetiring President,Chairman
F. Sherwood RowlandPresident
Eloise E. ClarkPresident-elect
Mary Ellen AveryFrancisco J. AyalaRobert A. Frosch
Florence P. HaseltineAlan SchriesheimJean'ne M. ShreeveChang-Lin TienWarren M. Washington
William T. GoldenTreasurer
Richard S. NicholsonExecutive Officer
John AbelsonFrederick W. AltDon L. AndersonStephen J. BenkovicDavid E. BloomFloyd E. BloomHenry R. BourneJames J. BullKathryn CalameC. Thomas CaskeyDennis W. Choi
John M. CoffinBruce F. EldridgePaul T. EnglundRichard G. FairbanksDouglas T. FearonHarry A. FozzardVictor R. FuchsTheodore H. GeballeMargaret J. GellerJohn C. GerhartRoger 1. M. Glass
Stephen P. GoffCorey S. GoodmanStephen J. GouldIra HerskowitzEric F. JohnsonStephen M. KosslynMichael LaBarberaCharles S. Levings Ill
Harvey F. LodishRichard LosickAnthony R. Means
Mortimer MishkinRoger A. NicollWilliam H. Orme-Johnson Ill
Stuart L. PimmYeshayau PockerDennis A. PowersRalph S. QuatranoV. RamanathanErkki RuoslahtiRonald H. SchwartzTerrence J. Sejnowski
Thomas A. SteitzRichard F. ThompsonRobert T. N. TjianEmil R. UnanueGeerat J. VermeijBert VogelsteinHarold WeintraubZena WerbGeorge M. WhitesidesOwen N. WitteKeith Yamamoto
SCIENCE * VOL. 257 * 14 AUGUST 1992
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COVERComputer simulation of a molecular beam of the ben-zene-water dimer. The sizable penetration of the vander Waals surfaces, depicted by the dotted surfaces inthe bottom right corner (light blue for water and pink forbenzene), illustrates the hydrogen bond interaction of
water with the benzene t electron cloud. See page 942and the Perspective on page 887. [Computer graphics:Geoffrey A. Blake and Siddharth Dasgupta. Production:Mario Blanco and Carolynn Sherby, Molecular SimulationsInc.]
RESEARCH ARTICLES IEI
Crystal Structures of Two Viral Peptides F 919in Complex with Murine MHC Class I H-2KbD. H. Fremont, M. Matsumura, E. A. Stura,P. A. Peterson, I. A. Wilson
Emerging Principles for the Recognition F 927of Peptide Antigens by MHC Class I MoleculesM. Matsumura, D. H. Fremont, P. A. Peterson,I. A. Wilson
REPORTSA Lunar Occultation of the Dust-Scattering 935Halo Around GX 5-1 Observed with ROSATP. Predehl, J. H. M. M. Schmitt, S. L. Snowden,J. Trumper
High-Velocity Pulsars in the Galactic Halo 937D. Eichler and J. Silk
Benzene Forms Hydrogen Bonds r 942with WaterS. Suzuki, P. G. Green, R. E. Bumgamer,S. Dasgupta, W. A. Goddard III, G. A. Blake
Synthesis of Fluoropolymers in 945Supercritical Carbon Dioxide
J. M. DeSimone, Z. Guan, C. S. Elsbernd
Internal Stark Effect Measurement of the 947Electric Field at the Amino Terminus of an a HelixD. J. Lockhart and P. S. Kim
The Reversal and Splitting of Waves in an 951Excitable Medium Caused by an Electrical FieldH. Sevclfkova, M. Marek, S. C. Muller
Coeval 40ArM9Ar Ages of 65.0 Million ° 954Years Ago from Chicxulub Crater Melt Rockand Cretaceous-Tertiary Boundary TektitesC. C. Swisher III, J. M. Grajales-Nishimura,A. Montanari, S. V. Margolis, P. Claeys,W. Alvarez,P. Renne, E. Cedillo-Pardo, F. J-M. R. Maurrasse,G. H. Curtis, J. Smit, M. 0. McWilliams
Pseudo-Half-Knot Formation with RNA 95D. J. Ecker, T. A. Vickers, T. W. Bruice,S. M. Freier, R. D. Jenison, M. Manoharan,M. Zounes
Combining Experimental Information from 96Crystal and Solution Studies: Joint X-rayand NMR RefinementB. Shaanan, A. M. Gronenbom, G. H. Cohen,G. L. Gilliland, B. Veerapandian, D. R. Davies,G. M. Clore
A Critical Role for Conserved Residues Fin the Cleft of HLA-A2 in Presentationof a Nonapeptide to T CellsF. Latron, L. Pazmany, J. Morrison, R. Moots,M. A. Saper, A. McMichael, J. L. Strominger
Differential Display of EukaryoticMessenger RNA by Means of thePolymerase Chain ReactionP. Liang and A. B. Pardee
Biosynthesis of Human Papillomavirusfrom a Continuous Cell Line UponEpithelial DifferentiationC. Meyers, M. G. Frattini, J. B. Hudson,L. A. Laimins
Rapamycin-Induced Inhibition of the70-Kilodalton S6 Protein KinaseD. J. Price, J. R. Grove, V. Calvo, J. Avruch,B. E. Bierer
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A Point Mutation of the a2-Adrenoceptor 977That Blocks Coupling to Potassium But NotCalcium CurrentsA. Surprenant, D. A. Horstman, H. Akbarali,L. E. Limbird
PI Indicates accompanying feature
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Bulk rates on request. Authorization to photocopy material for internal or personal use undercircumstances not falling within the fair use provisions of the Copyright Act is granted by AAAS tclibraries and other users registered with the Copyright Clearance Center (CCC) TransactionalReporting Service, provided that the base fee of $1 per copy plus $0.10 per page is paid directlyto CCC, 27 Congress Street, Salem, MA 01970. The identification code for Science is 0036-8075/83$1 + .10. Science is indexed in the Reader's Guide to Periodical Literature and in severalspecialized indexes.* TheAmerican Association fortheAdvancementof Science wasfounded in 1848and incorporatedin 1874. Its objectives are to further the work of scientists, to facilitate cooperation among them, tofoster scientific freedom and responsibility, to improve the effectiveness of science in the promotionof human welfare, to advance education in science, and to increase public understanding and appre-ciation of the importance and promise of the methods of science in human progress.
SCIENCE * VOL. 257 * 14 AUGUST 1992
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