zilos-tk- november 2005 1 zilos-tk zona infrared laser optical system version 5.2 hamilton thorne...

ZILOS-tk- November 2005

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ZILOS-tkZona Infrared Laser Optical System

Version 5.2

Hamilton Thorne Biosciences


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Introducing the ZILOS-tk

Integrated into 50x objective – compact and portable

Installs on all current & older models of inverted microscopes

Turret rotates easily to use other objectives

Leaves both the fluorescent and filter cube ports open

Compatible with Spindleview® and all micromanipulators


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Applications of ZILOS-tk

Laser Assisted Hatching*

Embryo Biopsy for PGD

ICSI

Polar Body Biopsy

* Only cleared indication in US


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Precision and Control of the ZILOS-tk

“The zona effect that is reached is precise, consistent, and controllable… inadvertent use is virtually impossible.” Josiane Van der Elst, Ph. D., Infertility Centre, Ghent University Hospital

“The ZILOS-tk system has proven itself to me and my colleagues time and again as the easiest and most effective tool for breaching the zona pellucida. Long-term experience within our labs has shown clearly that it is not only fast and user-friendly, but also "embryo-friendly.” Michael Tucker, Ph.D., Scientific Director, Georgia Reproductive Specialists and IVF Lab Director, Shady Grove Fertility RCS

“The precision of the ZILOS-tk allowed Sydney IVF to move to day 5 trophectoderm biopsy, as the routine biopsy procedure. We are the only laboratory in the world able to make this claim. Kylie de Boer, Ph.D., PGD Director, Deputy Director of Embryology, Sydney IVF


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Take a Closer Look

1480 nm, Class 1 Laser

Specially designed 50x objective – functions in both infrared and visible wavelengths

Completely closed system for user safety

Power @ focus = 300 mW


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Easy Installation

Install turret adapter with hex key

Attach ZILOS-tk to adapter

Tighten lock nut

Connect controller


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No Laser Alignment Needed

Laser aligned at factory and LOCKED in place

Allows easy transfer between microscopes

Simply align target to laser and you are ready to go


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Software Interface


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Overview of ZILOS-tk Software Features

Choice of laser modes

Unlimited image capture with thumbnail preview

Auto-capture on laser fire; Capture overlay

Three target types: Isotherm Rings, Circle, or Arrow

Real-time video capture

Measurement utility

Calibrate and store multiple objectives

Digital zoom / pan

Built-in patient reports


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Simple to Use

User-friendly interface for quick learning

Easy to understand setup screens

All actions accessed from control panel • No need to continuously

open menus

• No need to remember shortcut keys


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Clinical Mode

Three preset power and pulse combinations• Low

• Medium

• High

Automatic laser shutoff timer for safety

Choice of arrow, circle or Isotherm targets


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Validation Mode

Adjustable pulse duration (1 µsec – 3000 µsec)

Adjustable power range (0 – 100%)

Validation Mode not for use with human embryos


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About the Isotherm Rings (Patent Pending)

Indicate the peak temperature down to 50°C (purple)

Show approximate drill hole size (orange)

Interactive – Isotherm Ring sizes change based on pulse duration

Select which rings to view


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Bovine Oocyte: Drill Hole SizesPower: 300 mWDuration: Variable

200 µs

300 µs

400 µs

500 µs 600 µs

700 µs

1200 µs

900 µs

1000 µs

700 µs

1100 µs

100 µm

100 µs


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Thumbnail Images

Capture up to 15 thumbnail images

One-click “Save All” and “Delete All”

Print individual images or entire thumbnail gallery

Objective calibration stored with image, allowing accurate measuring upon recall


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Video Recording

Record up to 1000 seconds continuous video

Set maximum record time to save disk space

One-touch start record / stop record

Automtic or manual file naming options

Recall and play video within ZILOS-tk


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Measurement Utility

Store 5 separate sets of measurements

Automatically calculates mean and standard deviation

Transferred to report at touch of a button

Dimensions shown on image; may be saved with measurements


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Built-in Data Management

Storage of individual images

Integrated report generation

Add pre- and post-treatment images to report

Choose 2 or 4 image format

Export data to ASCII (.txt and .mer)

Compatible with IDS, BabySentry and Recdate


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What You Get

ZILOS-tk laser - 50x objective combination and laser control module

Three turret adapters

CCD camera with c-mount adapter

Full function software

High speed PC system – desktop or laptop


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The Results Speak for Themselves

270% increase in successful FET rates (frozen embryo transfer), from 15% to 41% (under 38 age group)

Harley Street Fertility Centre

Pregnancy rate of 35% achieved in most difficult group (40+ and repeat failures)

Assisted Conception Unit, Glasgow Nuffield Hospital


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Hamilton Thorne Contact Information

Phone: 978-921-2050, 800-323-0503

Fax: 978-921-0250

E-mail: [email protected]

Web: www.hamiltonthorne.com

100 Cummings Center, Suite 465EBeverly, MA 01915 USA

zilos-tk- november 2005 1 zilos-tk zona infrared laser optical system version 5.2 hamilton thorne...

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