zika virus dr. harman
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ZIKAVIRUS
Presented By: Dr. Harman Multani
Moderated By: Dr. Varsha A Singh
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I!R"DU#!I"
Rhesus Monkey- 1948 inUganda , Africa.
Humans - 1968 in Nigeria, Africa
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GLOBAL RISK
2007 - Yap I!and,"icr#neia
Prior 2015 - O$%&rea' in par% #f Africa ,S#$%(ea%Aia and %(e )aci*c I!and
May 2015 +ir% #$%&rea' in Brai!
21 October 2015 1 dea%( in %(e /#r!d.
1. 0i!!i#n cae6 dea%( fr#0 0icr#cep(a!2 in Brai!
Since November - 4,333 cae #f 0icr#cep(a!2in &a&ie infec%ed 0#%(er.
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IRUS 5LASSI+I5AION
Arthroo! borne "irus #rou$Gr#$p I77RNA %ami&y$ +!a:i:iridae #enus$ +!a:i:ir$ Secies$;i'a :ir$
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IRUS SRU5UR< = 5O")OSIION
Mature virions '(0 nm) Nuc&eocasi! '25-*0 nm)
+ii! ,i&ayer ith enve&oe! . an! Mroteins
ssRNA /cosahe!ra& symmetry
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PR$#URS"R M$MBRA$ PR"!$I %&rM'
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large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*
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R.PRO3/". 4+. /N HOS3 .++
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!he re&rodu*ti+e *y*le same as other -non /la+i+iruses.
Virion -en+elo&e &rotein
endocytosis.
fuses with the endosomal membrane
ssRNA genome released- cytoplasm
translated - structural and non-structural proteins.
01 #R - RNA packaging, cyclization, genome stabilization, andrecognition
21 #R )translation ( methylated nucleotide cap or a genome- linkedprotein
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Assembly- endoplasmic reiticulum
new !irions - "olgi apparatus
release
new !irions can infect new host cells.
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PA3HO#.N.S/S O% /6A"/RS
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)ri0ar2 >#%I)?- @a2
IiiIinInfec%i#ni
Spread
RRep!ica%i#n
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SIGNS AN@ SY")O"S
"i!d and !a% f#r - da2. >eadac(e
+e:er
S'in ra(e 7ean%(e0a )in' e2e
5#n$nc%i:i%i
"$c!e and #in% pain
"a!aie
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N
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/A#NOS/S O% /6A "/RS
Sam&e$B!##d, Sa!i:a, Urine.
PR$ Uef$! in *r% C- da2 af%er %(e
#ne%.@irec% de%ec%i#n #f RNA #r peci*c
:ira! an%igen in c!inica! peci0en.
Sero&o8y 3est$ @e%ec% %(e preence #fan%idie $ef$! #n!2 af%er
da2.
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!R$A!M$! "6 ZIKA VIRUS
#here is no specific treatment or !accine currently a!ailable.
America has !7"potential $ika !accines ready for human
trials - but officials admit they won%t be in use for %se!eralyears%
#he Bharat Biote*h International 3imited in &yderabad
say they ha!e de!eloped the world%s first !accine against the$ikaVirus. ('rishna lla, chairman and managing director
http://www.ndtv.com/topic/Zika-Virushttp://www.ndtv.com/topic/Zika-Virushttp://www.ndtv.com/topic/Zika-Virushttp://www.ndtv.com/topic/Zika-Virus -
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PR$V$!I" AD #"!R"3 "6 ZIKA VIRUS
A!oid tra!el to areas with an acti!e infestation.
#ra!elers should take the basic precautions to protect themsel!es
from mos)uito bites.
*uring outbreaks, health authorities may ad!ise that spraying of
insecticides be carried out.
Reducing mos)uito populations and a!oiding bites, which occurmainly during the day.
liminating and controllingAedes aegyptimos)uito breeding sites
reduces the chances that $ika will be transmitted.
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!HAK
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