youscript, care, seattle, wa (usa)
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YouScript® Precision PGx Analytics System
Saving Time. Savings Lives. Saving Money.
YouScript® Precision PGx Analytics System
YouScript, a Traffic App for Navigating Medication Management
� Most comprehensive drug-gene and drug-drug interaction software
• 2,700 drugs & metabolites
• 11,500 clinical interaction notes
• 14,000 PubMed references & product inserts
• New data updated daily
� Population Risk Analysis
� Ranked Alternate Selector
� Incorporates herbals, over-the-counter and recreational drugs
� Genotype-based drug and dosage recommendations
� Only solution to factor multi-drug and cumulative effects
© 2016 YouScript Inc. All Rights Reserved.
YouScript® Precision PGx Analytics System
National Priorities: Value-based Care & Precision Medicine
� 10% of healthcare costs spent treating adverse drug events (ADEs)
� 75% of all medicines are processed by genetic-specific enzymes
� More than 90% of the population have genetic variations that can increase their risk for ADEs
� ADEs increased by polypharmacy
� 15% or 50 million U.S. citizens take five or more medications, most are elderly
� 90% of Medicare Value-based by 2018, commercial plans following
© 2016 YouScript Inc. All Rights Reserved.
YouScript® Precision PGx Analytics System
Adverse Drug Event Impact Highest in 65+
� Occur in 5.7% of patients annually
� Occur in 33% of patients within
one year of discharge
� Cause 1 in 8 hospitalizations
� Cause 10.7% of readmissions
© 2016 YouScript Inc. All Rights Reserved.
YouScript® Precision PGx Analytics System
© 2007 - 2015 Genelex Corporation. All Rights Reserved.
Without YouScript most ADE Causing Interactions Missed
44%
19%
23%
14%
44% Identified by DDI systems
Drug–drug19% Identified by most PGx labs
Drug-gene37% Identified by YouScript alone
Drug-drug-geneMulti-drug
Evidence-based, the additional interaction warnings YouScript provides are derived from
>14,000 curated, peer-reviewed publications and established pharmacokinetic principles.
YouScript® Precision PGx Analytics System
© 2007 - 2015 Genelex Corporation. All Rights Reserved.
Without YouScript most ADE Causing Interactions Missed
44%
19%
23%
14%
44% Identified by DDI systems
Drug–drug19% Identified by most PGx labs
Drug-gene37% Identified by YouScript alone
Drug-drug-geneMulti-drug
Evidence-based, the additional interaction warnings YouScript provides are derived from
>14,000 curated, peer-reviewed publications and established pharmacokinetic principles.
Only YouScript Covers Them All
YouScript® Precision PGx Analytics System
Hospitalizations and ER visits increase with YouScript Calculated Risk
� Hospitalizations
� Emergency Department Visits
• Patients 65+ taking 3 or more drugs
including 1 or more impacted by
genetic variability.
• Adjusted for age, gender, race,
Charlson Comorbidity Index, and
known drug-drug interactions,
p<0.00001
0.440.48
0.51 0.5
0.710.77
0.84
0.94
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
Zero(reference)
Low (>0-20%)
Medium (20-40%)
High (>40%)
YouScript Genetic Risk Score
© 2016 YouScript Inc. All Rights Reserved.
YouScript® Precision PGx Analytics System
YouScript Reduces Hospitalizations and ED visits
Testing and YouScript reports resulted in $1132 per patient savings in 4-months
39% reduction 71% reduction
0.00%
2.00%
4.00%
6.00%
8.00%
10.00%
12.00%
14.00%
16.00%
18.00%
Hospitalizations (p=.0273) ED visits (p=.0002)
untested arm
tested arm
© 2016 YouScript Inc. All Rights Reserved.J Med Econ. 2015 Oct 19:1-16
If reproduced across
Medicare, this would prevent
6.7M hospitalizations
YouScript® Precision PGx Analytics System
Phase 2
CLIA/CAPPGx Testing as
needed:Laboratory analysis of
genotype for 75% most
commonly prescribed
drugs
Personalized Prescribing Suggestions
Genotype Results- CAP, CLIA, NYDOH
Cumulative Risk
Analysis –5 patents
Clinical Literature-14,800
references
Phase 3
YouScript© Actionable PGxReporting Tool
Phase 4
YouScript© Consult Tool:
Clinical Pharmacist or
Clinician Review
(80500)
Phase 5
YouScript© Clinical Decision Support Tool:Interactive Personalized
Prescribing Report
Web-based or EHR-
integrated
Phase 1
YouScript© Risk Stratification:Identify high-risk
polypharmacy patients
with physician
confirmation of
medication issues
*Patent pending
© 2016 YouScript Inc. All Rights Reserved.
YouScript® Precision PGx Analytics System
CustomersUnder Contract In Pipeline
© 2016 YouScript Inc. All Rights Reserved.
YouScript® Precision PGx Analytics System
Partners
Under Contract In Pipeline
© 2016 YouScript Inc. All Rights Reserved.
YouScript® Precision PGx Analytics System
YouScript Management
Chief Financial Officer
• 25+ years of Healthcare
Experience as CFO, COO, CEO
• Experienced in multiple system-
wide implementation
• Experienced in profit and non-
profit startups with VC funding
Janet Carbary
Chief Executive Officer
• 15+ years in Precision
Medicine and PGX analytics
• 20+ years Sales and
Business Development
• Experience managing fast
growth
• Babson MBA, Magna Cum
Laude
Dave GaretsKristine Ashcraft Chief Strategy Officer
• Internationally known HIT Expert
• 25 years CEO, CIO, industry
analyst and author
• HIMSS Analytics, Gartner,
Healthlink, Advisory Board
Company, Next Wave Health
Advisors, Mountain Summit
Advisors
© 2016 YouScript Inc. All Rights Reserved.
John Nelson Chief Medical Officer
• MD, MPH, board-certified OB/GYN
• President, American Medical
Association, 2004-2005
• Served on Advisory Committee to the
Director of the NIH
• Charter member Prospective Payment
Assessment Commission (now
MedPAC)
YouScript® Precision PGx Analytics System
“The integration of pharmacogenomic results into the electronic health record is a key
step in the promise of precision medicine to improve patient care. By connecting
electronically, YouScript and Epic are delivering on this promise.”
- Dr. Michael Raff, Director of the Genomics Institute, Multicare Health System
“YouScript’s clinical studies are impressive. Their results point to a tremendous
opportunity for healthcare organizations to enhance their clinical decision support and
improve the effectiveness of their population health programs.”
- Brad Strock, Genomic Workgroup Lead, Epic
© 2016 Genelex Corporation. All Rights Reserved.
YouScript® Precision PGx Analytics System
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