you don't think being overweight impacts …...you don't think...

1
Body Mass Index (BMI) is an approximate measure of whether someone is underweight, healthy weight or overweight. It is calculated by (weight in kg ÷ height in m 2 ) [1]. Although BMI does not perfectly correlate with fat mass, it provides an estimated risk of disease [1]. BMI is divided into four categories: The World Health Organization estimates 39% of adults worldwide are overweight and 13% are obese [2]. Over 340 million children worldwide, aged 5-19 years, are overweight or obese [2]. How does weight gain cause infertility in men? Excess weight disrupts hormone levels resulting in ovulation problems and conception difficulties [9]. Excess weight increases the risk of miscarriage, gestational diabetes and stillbirth [9,10]. Obese women with a history of unexplained recurrent miscarriages have a 73% increased risk of experiencing another miscarriage [10]. Excess weight in women with polycystic ovarian syndrome (the leading cause of infertility among women of reproductive age) impairs ovulation and conception chances [9]. Folate supplementation is less effective in preventing neural tube defects in obese women [16]. Maternal overweight and obesity increases a prospective child’s risk of asthma. Gaining more than 25 kg during pregnancy increases inflammation in the child’s airways, causing asthma by 9 years of age [17, 18]. Excessive weight gain during pregnancy increases a prospective child’s risk of obesity. This predisposes them to chronic diseases later in life [19]. Obese women have a 37% increased risk of miscarriage [14]. Obese women with poor blood sugar control (as seen in diabetes) have a 4-fold increased risk of miscarriage [15]. Maternal obesity increases the risk of a child developing neural tube defects and structural heart defects 3-fold [16]. Obesity increases the risk of stillbirth and miscarriage [10]. There is good news! Losing weight helps to regulate the menstrual cycle, can restore ovulation and improves sperm parameters. This directly increases a couple’s chance of conceiving and taking home a healthy baby [13]. Weight loss of 10% body weight for women over 100 kg can restart ovulation. Even a 5 kg loss increases the chance of giving birth to a baby by 61.9% [13]. The closer to your ideal weight when trying to conceive, the better your chances of taking home a healthy baby when all major factors impacting conception in a couple’s case are taken into consideration. Overweight and obese women require higher doses of hormones, have fewer oocytes retrieved and have increased cycle cancellation rates when undergoing assisted reproductive therapies. This reduces the chance of successful conception even through ICSI or IVF [12]. Obesity increases the risk of gestational diabetes, a condition that affects ~14% of pregnant women worldwide [11]. Gestational diabetes increases the risk of preterm and Caesarean delivery, and giving birth to a large-for-gestational age baby. This increases the child’s risk of obesity, heart disease and blood sugar problems [11]. Increased weight affects hormone levels which decreases the production of testosterone from Leydig cells in the testes. The number of sperm is reduced, their ability to swim is decreased and their size and shape are abnormal. This inhibits sperm’s ability to fertilize an egg [5]. Excess weight upregulates expression of the hormone - Ghrelin, which inhibits testicular function, also causing poor sperm health and infertility [7]. Overweight and obese men have increased heat around the testes. This induces oxidative stress and damages sperm [8]. 41 million children worldwide, under the age of 5, are overweight or obese [2]. KG WEIGHT m 2 HEIGHT BMI - Less than 18.5 kg/is underweight - 18.5-24.9 kg/is healthy weight - More than 25 kg/is overweight - More than 30 kg/is obese U N D E R W E I G H T H E A L T H Y W E I G H T O V E R W E I G H T O B E S E 18.5 kg/m 2 25 kg/m 2 30 kg/m 2 39% Overweight 13% Obese 5-19 YEARS Reduced number of sperm Abnormal size and shape Decreased ability to swim 73% 14% ICSI IVF 100 KG 5kg / 10% 61.9% 37% 4x 3x [1] http://apps.who.int/iris/bitstream/han- dle/10665/44583/9789241501491_eng.pdf?sequence=1 [2] http://www.who.int/mediacentre/factsheets/fs311/en/ [3] https://www.betterhealth.vic.gov.au/health/healthyliving/pregnancy-and-diet [4] https://www.iasj.net/iasj?func=fulltext&aId=64666 [5] https://www.ncbi.nlm.nih.gov/pubmed/22693175/ [6] https://www.ncbi.nlm.nih.gov/pubmed/14511216/ [7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464503/ [8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492061/ [9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456969/ [10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515955/ [11] http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009021.pub2/full [12]https://www.researchgate.net/publication/233740615_Impact_of_overweight_a nd_underweight_on_assisted_reproduction_treatmen [13] https://www.ncbi.nlm.nih.gov/pubmed/28739335?dopt=Abstract [14] https://www.fertstert.org/article/S0015-0282(07)01525-7/fulltext [15] https://academic.oup.com/humrep/article/19/7/1644/2356447 [16] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096465/ [17] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695645/ [18] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735244/ [19] https://www.ncbi.nlm.nih.gov/pubmed/29421859 [20] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691969/ [21] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405647/ [22] https://www.ncbi.nlm.nih.gov/pubmed/29698651 [23] https://www.ncbi.nlm.nih.gov/pubmed/20858697 [24] http://www.who.int/dietphysicalactivity/factsheet_adults/en/ References: THINK AGAIN! A HEALTHY BABY ? BEING OVERWEIGHT IMPACTS YOUR CHANCES OF GETTING PREGNANT AND TAKING HOME YOU DON'T THINK [email protected] AUS: 1300 858 490 INT: +61 2 807 3939 USA: +1 (646) 641-4061 UK: +44 20 3871 8494 PO Box 2342. Bondi Junction NSW 1355. Australia Who do you know who has been trying to conceive or take a healthy pregnancy to term for over 2 years? Apply for a complimentary fertility assessment with our team today. For more information visit: www.naturalfertilitybreakthrough.com Increased weight in males disrupts hormones and increases inflammation in the body, leading to infertility [5]. The Thermal Effect The Real Impact of Excess Weight on Fertility, Miscarriage Risk and Reproductive Outcomes Revealed Waist-to-hip ratio (WHR) can be used in conjunction with BMI to determine abdominal adiposity and the risk of type 2 diabetes, cardiovascular disease and reproductive function issues including ovarian and testicular cancers. WHR is calculated by (waist measurement in cm ÷ hip measurement in cm) [1]. To decrease disease risk and subfertility, the ideal waist circumference and waist-to-hip ratios are: For Men 85cm (waist circumference) 0.9 (WHR) For Women 80cm (waist circumference) 0.7 (WHR) THE IMPACT OF OVERWEIGHT AND OBESITY ON MALE FERTILITY AND REPRODUCTIVE OUTCOMES THE IMPACT OF OVERWEIGHT AND OBESITY ON FEMALE FERTILITY AND REPRODUCTIVE OUTCOMES For women of a healthy weight, gaining 11.5 to 16 kg during pregnancy is recommended [3]. For women overweight, gaining 5 to 11.5 kg during pregnancy is suggested. However, the recommendation is to optimise weight prior to becoming pregnant to reduce complications [3]. Overweight and obesity increase the risk of type 2 diabetes, high blood pressure, cardiovascular disease, metabolic syndrome, pancreatitis and musculoskeletal diseases [4]. 11.5 to 16 kg 5 to 11.5 kg HEALTHY OVERWEIGHT Overweight and obesity are a rising global problem. Overcoming inferfility and recurrent pregnancy loss in most instances is a task you are very unlikely to be able to accomplish on your own. The trouble of staying in this place too long is that it can result in no baby. Self-prescription and treatment when it comes to fertility and recurrent miscarriage is a recipe for continuing to try with very low (to no) chance of success. Finding the right team for you is of paramount importance. VITAL CONSIDERATION WHEN WORKING TO OPTIMISE YOUR CHANCES OF TAKING HOME A HEALTHY BABY You will need a qualified team, with a proven track record to support you along this journey because under each area addressed here, there are dozens (if not many more) clues leading to different paths—and if you don’t know what you are doing and lack a very strong, scientific and objective compass, you will get lost and continue going around in circles until, eventually, you run out of time all together. Unfortunately, the number one issue that keeps couples stuck on their journey to parenthood, without getting there anytime fast is that they “don’t know what they don’t know”. Whenever someone says “I’ve tried everything and nothing has worked” it is a sure fire clue they have exhausted the end of what they knew could help them and they have arrived in the land of “I don’t know what I don’t know”. Fertility is a team sport. Male fertility has a 50% impact on the increased risk of miscarriage and adverse pregnancy outcomes [20]. Hence why it is essential for both prospective parents to optimise their health prior to a conception attempt, and why not doing so could mean the difference between having a baby or not. Here are some suggestions you and your partner can begin implementing now. SCIENTIFICALLY VALIDATED SELF-CARE RECOMMENDATIONS 50% INCREASE PHYSICAL ACTIVITY The WHO recommends a minimum of 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic exercise each week for healthy weight and reduced chronic disease risk. This translates to just 2.5 hours of moderate exercise or 1.25 hours of vigorous exercise per week [24]. For optimum fertility, aim for 300 minutes (or 5 hours) of moderate-intensity exercise per week [24]. Moderate-intensity aerobic exercise Vigorous-intensity aerobic exercise 150-300 Minutes 75 Minutes Regular, moderate exercise is important for optimising fertility [21]. Physically active men can improve all parameters of their sperm health as exercise reduces inflammation and oxidative stress [22]. 40% In females, regular exercise positively influences ovarian reserve markers, balances hormones, reduces the risk of ovulatory infertility, and when combined with dietary modifications, can improve ovulation rates by almost 40% (particularly in overweight and obese women with PCOS) [21,23].

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Body Mass Index (BMI) is an approximate measure of whether someone is underweight, healthy weight or overweight. It is calculated by (weight in kg ÷ height in m2) [1].

Although BMI does not perfectly correlate with fat mass, it provides an estimated risk of disease [1].

BMI is divided into four categories:

The World Health Organization estimates

39% of adults worldwide are

overweight and 13% are obese [2].

Over 340 million children worldwide, aged 5-19 years, are overweight or obese [2].

How does weight gain cause infertility in men?

Excess weight disrupts hormone levels resulting in

ovulation problems and conception

di�culties [9].

Excess weight increases the risk of

miscarriage, gestational diabetes

and stillbirth [9,10].

Obese women with a history of unexplained recurrent miscarriages have a 73%

increased risk of experiencing another miscarriage [10].

Excess weight in women with polycystic ovarian syndrome (the leading cause of infertility among

women of reproductive age) impairs ovulation and conception

chances [9].

Folate supplementation is

less e�ective in preventing neural

tube defects in obese women [16].

Maternal overweight and obesity increases a

prospective child’s risk of asthma. Gaining more

than 25 kg during pregnancy increases

inflammation in the child’s airways, causing asthma by 9 years of age [17, 18].

Excessive weight gain during pregnancy increases a prospective child’s risk of

obesity. This predisposes them to chronic diseases later in life [19].

Obese women have a 37% increased risk of

miscarriage [14].

Obese women with poor blood sugar control (as seen in

diabetes) have a 4-fold increased risk of miscarriage [15].

Maternal obesity increases the risk of a

child developing neural tube defects and structural heart defects 3-fold [16].

Obesity increases the risk of stillbirth and

miscarriage [10].

There is good news!

Losing weight helps to regulate the menstrual cycle, can

restore ovulation and improves sperm parameters. This directly increases a couple’s chance of conceiving and taking home a

healthy baby [13].

Weight loss of 10% body weight for women over 100 kg can restart ovulation. Even a 5 kg loss increases the chance of

giving birth to a baby by 61.9% [13].

The closer to your ideal weight when trying to conceive, the better your chances of taking home a healthy baby when all major factors impacting conception in a couple’s case are

taken into consideration.

Overweight and obese women require higher doses of hormones, have fewer oocytes retrieved and have increased cycle cancellation rates when undergoing assisted reproductive therapies. This

reduces the chance of successful conception even through ICSI or IVF [12].

Obesity increases the risk of gestational diabetes, a condition

that a�ects ~14% of pregnant women worldwide [11].

Gestational diabetes increases the risk of preterm and Caesarean

delivery, and giving birth to a large-for-gestational age baby. This increases the child’s risk of obesity, heart disease and blood

sugar problems [11].

Increased weight a�ects hormone levels which decreases the production of testosterone from Leydig cells in the testes.

The number of sperm is reduced, their ability to swim is decreased and their size and shape are abnormal. This inhibits sperm’s ability

to fertilize an egg [5].

Excess weight upregulates expression of the hormone - Ghrelin, which inhibits testicular function, also causing poor sperm health and infertility [7].

Overweight and obese men have increased heat around the testes. This induces oxidative stress and damages sperm [8].

41 million children worldwide, under the age of 5, are overweight or obese [2].

KGWEIGHT m2

HEIGHT

BMI

- Less than 18.5 kg/㎡ is underweight

- 18.5-24.9 kg/㎡ is healthy weight

- More than 25 kg/㎡ is overweight

- More than 30 kg/㎡ is obese

UN

DER

WEI

GH

T

HEALTHY

WEIGHT

OVERWEIGHT

OB

ESE

18.5 kg/m2

25 kg/m2

30 kg/m2

39%Overweight

13%Obese

5-19YEARS

Reduced numberof sperm

Abnormal sizeand shape

Decreasedability to swim

73%

14%

ICSI

IVF

100KG 5kg / 10%

61.9%

37%

4x

3x

[1] http://apps.who.int/iris/bitstream/han-

dle/10665/44583/9789241501491_eng.pdf?sequence=1

[2] http://www.who.int/mediacentre/factsheets/fs311/en/

[3] https://www.betterhealth.vic.gov.au/health/healthyliving/pregnancy-and-diet

[4] https://www.iasj.net/iasj?func=fulltext&aId=64666

[5] https://www.ncbi.nlm.nih.gov/pubmed/22693175/

[6] https://www.ncbi.nlm.nih.gov/pubmed/14511216/

[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464503/

[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492061/

[9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456969/

[10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515955/

[11] http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009021.pub2/full

[12]https://www.researchgate.net/publication/233740615_Impact_of_overweight_a

nd_underweight_on_assisted_reproduction_treatmen

[13] https://www.ncbi.nlm.nih.gov/pubmed/28739335?dopt=Abstract

[14] https://www.fertstert.org/article/S0015-0282(07)01525-7/fulltext

[15] https://academic.oup.com/humrep/article/19/7/1644/2356447

[16] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096465/

[17] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695645/

[18] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735244/

[19] https://www.ncbi.nlm.nih.gov/pubmed/29421859

[20] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691969/

[21] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405647/

[22] https://www.ncbi.nlm.nih.gov/pubmed/29698651

[23] https://www.ncbi.nlm.nih.gov/pubmed/20858697

[24] http://www.who.int/dietphysicalactivity/factsheet_adults/en/

References:

THINK AGAIN!A H E A LT H Y B A B Y ?

B E I N G O V E R W E I G H TI M PA C T S Y O U RC H A N C E S O F G E T T I N G P R E G N A N T A N D TA K I N G H O M E

YOU DON'T THINK

[email protected]

AUS: 1300 858 490

INT: +61 2 807 3939

USA: +1 (646) 641-4061

UK: +44 20 3871 8494

PO Box 2342. Bondi Junction

NSW 1355. Australia

Who do you know who has been trying to conceive or take a healthy pregnancy to term for over 2 years? Apply for a complimentary fertility assessment with our team today.

For more information visit:

www.naturalfertilitybreakthrough.com

Increased weight in males disrupts hormones and

increases inflammation in the body, leading to

infertility [5].

The Thermal E�ect

The Real Impact of Excess Weight on Fertility, Miscarriage Risk and Reproductive Outcomes Revealed

Waist-to-hip ratio (WHR) can be used in conjunction with BMI to determine abdominal adiposity and the risk of type 2 diabetes, cardiovascular disease and reproductive function issues including ovarian and testicular cancers. WHR is calculated by (waist measurement in cm ÷ hip measurement in cm) [1].

To decrease disease risk and subfertility, the ideal waist circumference and waist-to-hip ratios are:

For Men

85cm (waist circumference) 0.9 (WHR)

For Women

80cm (waist circumference) 0.7 (WHR)

THE IMPACT OF OVERWEIGHT AND OBESITY ON MALE FERTILITY AND REPRODUCTIVE OUTCOMES

THE IMPACT OF OVERWEIGHT AND OBESITY ON FEMALE FERTILITY AND REPRODUCTIVE OUTCOMES

For women of a healthy weight, gaining 11.5 to 16 kg

during pregnancy is recommended [3].

For women overweight, gaining 5 to 11.5 kg during pregnancy is suggested.

However, the recommendation is to optimise weight prior to becoming pregnant to reduce

complications [3].

Overweight and obesity increase the risk of type 2 diabetes, high blood pressure,

cardiovascular disease, metabolic syndrome, pancreatitis and musculoskeletal diseases [4].

11.5 to 16 kg 5 to 11.5 kg

HEALTHY OVERWEIGHT

Overweight and obesity are a rising global problem.

Overcoming inferfility and recurrent

pregnancy loss in most instances is a task you are very unlikely to be able to accomplish on

your own.

The trouble of staying in this

place too long is that it can result

in no baby.

Self-prescription and treatment when it comes to fertility and recurrent miscarriage is a recipe for continuing to try with very low (to no) chance of

success. Finding the right team for you is of paramount importance.

VITAL CONSIDERATION WHEN WORKINGTO OPTIMISE YOUR CHANCES OFTAKING HOME A HEALTHY BABY

You will need a qualified team, with a proven track record to support you along this journey because under each area

addressed here, there are dozens (if not many more) clues leading to di�erent paths—and if you don’t know what you are doing and lack a very strong, scientific and objective compass,

you will get lost and continue going around in circles until, eventually, you run out of time all together.

Unfortunately, the number one issue that keeps couples

stuck on their journey to

parenthood, without getting there anytime

fast is that they “don’t know what they don’t know”.

Whenever someone says “I’ve tried everything and nothing has worked” it is a sure fire

clue they have exhausted the end of what they knew could

help them and they have arrived in the land of “I don’t

know what I don’t know”.

Fertility is a team sport. Male fertility has a 50% impact on the increased risk of miscarriage and adverse

pregnancy outcomes [20].

Hence why it is essential for both prospective parents to optimise their health prior to a conception attempt,

and why not doing so could mean the di�erence between having a baby or not.

Here are some suggestions you and your partner can begin implementing now.

SCIENTIFICALLY VALIDATED SELF-CARE RECOMMENDATIONS

50%

INCREASE PHYSICAL ACTIVITY

The WHO recommends a minimum of 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic exercise each week for healthy weight and reduced chronic disease risk.

This translates to just 2.5 hours of moderate exercise or 1.25 hours of vigorous exercise per week [24].

For optimum fertility, aim for 300 minutes (or 5 hours) of moderate-intensity exercise per week [24].

Moderate-intensity aerobic exercise

Vigorous-intensity aerobic exercise

150-300 Minutes

75 Minutes

Regular, moderate exercise is important for optimising fertility [21].

Physically active men can improve all parameters of

their sperm health as exercise reduces in�ammation and

oxidative stress [22].

40%

In females, regular exercise positively in�uences ovarian reserve markers, balances

hormones, reduces the risk of ovulatory infertility, and when combined with dietary

modi�cations, can improve ovulation rates by almost 40% (particularly in overweight and

obese women with PCOS) [21,23].