2018/10/178thIASPSymposiumonYogaResearch,Kripalu

Yogatherapyformyalgicencephalomyeli2s/chronicfa2guesyndrome(ME/CFS):

Effec2venessanduderlyingmechanisms

TakakazuOka,M.D.,Ph.D.

DepartmentofPsychosoma1cMedicine,GraduateSchoolofMedicalSciences,

Interna1onalUniversityofHealthandWelfare,Japan

Outline

•  Whatismyalgicencephalomyeli2s/

chronicfa2guesyndrome(ME/CFS)?

•  IsometricyogaforME/CFS

•  Resultsofrecentstudies

TakakazuOkaof30yearsago �

Youmustknowhim. �

CarruthersBM,etal:JInternMed2011,270:327-338.

ME/CFS:Interna2onalConsensusCriteria

(A) Post-exer2onalneuroimmuneexhaus2on(malaise):• Marked,rapidphysicaland⁄orcogniOvefaOgueinresponsetoexerOon•  ExacerbaOon/exhausOonofpost-exerOonsymptoms

（B）Neurologicalimpairments• NeurocogniOveimpairments

• DifficultyprocessinginformaOon(slowedthoughts,impaired concentraOon)

•  Short-termmemoryloss(difficultyremembering)•  Pain(headache,widespreadpain)•  Sleepdisturbance(unrefreshingsleep)

(C)Immune,gastro-intes2nalandgenitourinaryimpairments•  Flu-likesymptoms

(D)Energyproduc2on⁄transportimpairments:• OrthostaOcintolerance,thermoregulatoryinstability

Comorbidi2es•  fibromyalgia,irritablebowelsyndrome,reacOvedepression

TGF-β↑,Proinflamm.cytokines(TNF-α)↑NKcellacOvity↓Th2-predominant,

AutoanObody,Treg↑BcelldysfuncOon

ImmuneEndocrine

DLPFCfuncOon↓,reducedvolumeReducedACCand

basalgangliafuncOonMicroglialacOvaOon

CNS

HPAaxisdysfuncOoncorOsol↓

(bluntedawakeningresponse)DHEA-S↓

Intes2nalflora

Psychologicalstress

ParasympatheOcn.↓(RelaOvesympatheOc

predominancy)

ANS

Smallheart,tachycardia,CO↓,SV↓RAA�system↓

ADHsystem↓

PosturalorthostaOctachycardia

GlycolyOcandTCAcycledysfuncOon

Energy/metabolismCardiovascular

Comorbiddiseases

Oxida2vestress

Treatment(basedonCanadianConsensusDocument)

1)  Self-helpstrategies,Pacing•  AssistspaOentsincopingwiththeirchronicillnessbyconservingenergy,minimizingsymptomflare-ups,andmaximizingcopingskillsandfuncOonality

•  Bodymovementandfitness:EncouragepaOentstousegoodbodymechanicsaswellastechniquesandpracOces,suchasyoga,toimprovebalance

2)  Self-poweredexercise•  TradiOonalexerciseprogramscanprovokediseaserelapse•  Exercisemustbeindividualized,undertakenwithcauOon,and diligentlymonitored

3)  Symptommanagementandtreatment•  Physicalremedies•  Pharmacotherapy

AClinicalCaseDefiniOonandGuidelinesforMedicalPracOOoners,2005

Whattypesofyoga?

Yogahasbeenreportedtoimprovefa2gueinmanyclinicalpopula2onssuchascancerpa2ents.However,pa2entswithME/CFScan’tprac2cemanykindsoftradi2onalyogaposes.Iconsultedyogatherapistsanddevelopedaprogramthatconsidersdiseasepathophysiologyandpa2entlimits

ME/CFSpa2entshave:•  Severefa2gueandpost-exer2onalmalaise

•  PracOcingyogashouldnotexacerbatesymptoms,especiallypostexerOonalmalaise

•  Decondi2oning•  Yogashouldactasexercisetherapy

•  Impairedconcentra2onandmemory•  Theprogramshouldbesimpleandeasytoperform

•  Orthosta2cintolerance•  Nostandingposturesshouldbeperformed

•  Soundandlightsensi2vity•  YogainstrucOonshouldnotinvolveamicrophoneormusicandclassesshouldbeheldinadimly-litroom

Whatwasconsidered?

Weacceptedseatedisometricyoga

Benefitsofisometricyoga:1)  ResistancecanbeadjustedrelaOvetothepaOent’scondiOonto

avoidexacerbaOonoffaOgueandpost-exerOonmalaise2)  Norequirementforstrongstretchesandphysicalflexibility-

prevenOonofoverstretchingthatcanincreasepain3)Post-isometricrelaxa2onthatinducesmuscular(andalso

psychological)relaxaOonandincreasesmuscularstrengthSeatedIsometricYogaissimilartotradi2onalyoga:PosesareconductedslowlyinaccordancewithbreathingandwithawarenessofinnersensaOons(propriocepOon)

SeatedisometricyogaforME/CFSpa2ents(20min)

position. Electrodes were placed on both wrists. Beat-to-beat HR was assessed on the ECG, and HRV indices andrespiratory rate were measured using the “Kiritsu Meijin”(Crosswell Co., Inc., Yokohama, Japan) [33], which in-cluded a HR monitor LRR-03 (GMS, Tokyo, Japan). Themajority of previous studies have used spectral techniquesbased on the Fast Fourier Transform (FFT). However, FFTis insufficient to estimate the precise power spectral dens-ity from short time series data. The MemCalc method[34] is a new technique for time series analysis. It is acombination of the maximum entropy method for spectralanalysis and the non-linear least squares method for fit-ting analysis. This enabled us to achieve a reliable analysisof the low- (LF; 0.05–0.15 Hz) and high-frequency com-ponents (HF; 0.15–0.4 Hz) over a minimum interval of30 s. Time domain analysis and spectral analyses of HRvariability using the MemCalc system were performedover a 1-min period. In the time domain analysis, thecoefficient of variation of R-R intervals (CVR-R) =component coefficient of variance (total power) wasshown. HF was used as an index of parasympatheticactivity, while LF was used as a mixed index of sym-pathetic and parasympathetic activity. LF/ HF wasused as an index of sympathetic activity [34–36].

Blood biomarkersSerum markersSerum levels of DHEA-S were measured using achemiluminescent enzyme immunoassay (CLEIA).Cortisol and prolactin (PRL) were measured byelectro-chemiluminescence immunoassay. Total carnitine,

acylcarnitine, and free carnitine were measured bythe enzyme cycling method. IL-6 was measuredusing a human IL-6 CLEIA cartridge (Fujirebio,Tokyo, Japan), with a minimum detectable concen-tration of 0.2 pg/mL. TNF-α was measured byenzyme-linked immunosorbent assay (ELISA) usingQuantikine high-sensitivity ELISA human TNF-α im-munoassay (R&D Systems, Inc., Minneapolis, MN,USA), with a minimum detectable concentration of0.07 pg/mL. IFN-α was measured using the Veri-Kine™ Human Interferon Alpha Multi-Subtype SerumELISA Kit (pbl assay science, Piscataway, NJ, USA),with a minimum detectable concentration of 12.5 pg/mL.IFN-γ was measured by enzyme amplified sensitivityimmunoassay (EASIA) using the MEDGENIX humanIFN-γ EASIA kit (BioSource Europe S.A., Nivelles,Belgium), with a minimum detectable concentrationof 0.1 IU/mL.

Plasma makersPlasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG)and homovanillic acid (HVA) were measured by highperformance liquid chromatography. Brain-derivedneurotrophic factor (BDNF) was measured using theQuantikine ELISA human BDNF kit (R&D Systems,Inc., Minneapolis, MN, USA), with a minimumdetectable concentration of 20 pg/mL. TGF-β1 wasassessed using the Quantikine ELISA human TGF-β1kit (R&D Systems, Inc., Minneapolis, MN, USA), witha minimum detectable concentration of 0.50 pg/mL.

Fig. 2 Sitting isometric yoga program. The 20-min sitting isometric yoga program consisted of three parts. (1) Patients practiced being aware oftheir spontaneous breathing for 1 min to facilitate interoceptive and proprioceptive awareness. (2) Patients slowly practiced six isometric postures,taking 3–10 s each (5 s in average), in association with exhalation with/without sounds, using 50% maximal physical strength. (3) Patients practicedabdominal breathing for 1 min

Oka et al. BioPsychoSocial Medicine (2018) 12:3 Page 4 of 11

Beawareofspontaneousbreathingfor1min.

(2)Sixisometricposes(performed4-6Omeseach)SlowmovementssynchronizedwithbreathingIsometricexerciseat50%ofmaximalphysicalstrengthSlowlyrelaxandreturntothebasalposiOon

Abdominalbreathingfor1min.

Study1Short-andlong-termeffectsofseatedisometricyogaforME/CFSpa2ents:arandomizedcontrolledtrial

Excluded

SaOsfactoryimprovement(n=35)<20years-old(n=12)

Diseasetoosevere(n=2)DeclinedtoparOcipate(n=2)

CompletedtheintervenOon(n=15)

CompletedtheintervenOon(n=15)

RandomizaOon(n=30)

Analysis

Yoga+TAUgroup(n=15)

TAU(control)group(n=15)

AllocaOon

Assessedforeligibility(n=81)

Inclusioncriteria(1)Lackofsufficientimprovementdespiteatleast6monthsofconvenOonaltherapy(2)Between20and70years-old(3)FaOguelevelthatdoesnotrequireassistance(4)AbletocompletequesOonnairewithoutassistance(5)Abletositforatleast30minutes(6)Abletovisithospitalregularly

TAU:treatmentasusual

IntervenOon:TAUwith/without20-minyogafor8weeks

5101520253035

F V

PrePost

**

10

15

20

25

30

35

pre post

Yoga

Control

Totalscore

**

#

***

Long-termeffects(preintervenOon-8weeks)

Chalderfa2guescale

Short-termeffects(pre-andpost-20minyoga

withayogatherapist-valuesforweek8)

MoodstatusprofileF(faOgue)　V(vigor)

***p<0.001.**p<0.01.(pairedt-test) **p<0.01(pairedt-test)#p<0.05(independent-samplet-test)

Totalscore

OkaTetal.,BiopsychosocMed2014,8,27

TAU

Yoga+TAU

Seatedisometricyogaprogramdecreasesfa2gueandimprovesmoodstatusprofile

Short-termeffectsofseatedisometricyogaprogramonautonomicparameters

Resultssuggestac2va2onofparasympathe2cnervousfunc2on

Parameter Pre Post Pvalue

HR(bpm) 84.5±9.3 80.0±6.3 0.047

HF(ms2) 103.7±88.6 168.1±138.8 0.028

LF(ms2) 365.0±676.6 268.3±223.8 n.s.

LF/HF 5.4±8.3 2.2±1.3 n.s.

CVR-R(%) 3.4±1.5 3.4±1.2 n.s.

HF:HighfrequencyLF:LowfrequencyLF/HF:raOolowtohighfrequencyCVR-R:CoefficientofvarianceofR-Rintervalsofheartratevariabilityn.s.:notsignificant

OkaTetal,BiopsychosocMed2018,12,3

Short-termeffectsofseatedisometricyogaprogramonbloodbiomarkers

Parameter Pre Post Pvalue

Cor2sol(µg/dL) 11.0±6.4 7.9±3.5 0.016

DHEA-S(µg/dL) 177.7±63.3 191.1±73.5 0.012

TNF-α(pg/mL) 0.9±0.18 0.8±0.18 0.035

IL-6(pg/mL) 1.2±0.6 1.3±0.5 n.s.

Prolac2n(ng/mL) 11.1±6.3 9.9±5.7 0.08

TotalCarniOne(µmol/L) 52.6±12.4 52.3±12.4 n.s.

TGF-β1(ng/mL) 10.0±8.5 11.2±7.5 n.s.

BDNF(pg/mL) 4237±4522.3 5295±4489.7 n.s.

MHPG(ng/mL) 3.7±1.3 3.8±1.4 n.s.

HVA(ng/mL) 10.9±9.4 10.9±9.3 n.s.

*DopamineactsasprolacOninhibitoryhormone.

-20

-15

-10

-5

0

-20 -10 0 10

r=0.555P=0.049

∆TGF-β1(µmol/L)

∆F(faO

gue)sc

ore

OkaTetal,BiopsychosocMed2018,12,3

-5

0

5

10

15

-5 0 5 10

r=0.573P=0.026

∆V(vigor)score

∆HVA(ng/mL)

←FaO

gueredu

ced

Energyincreased　

→

Correla2onbetweenfa2gueandTGF-β1levelandbetweenvigorandHVAlevelsfollowingseatedisometricyogaprogram

HVA(homovanillicacid):anindicatorofDAfuncOon

SF-8Parameter Pre Post Pvalue

PhysicalfuncOoning(PF) 39.6±9.1 42.5±7.1 n.s.

Physicalrole(PR) 34.4±8.4 38.4±6.4 n.s.

Bodilypain(BP) 41.3±6.7 48.1±7.9 P=0.0001

Generalhealthpercep2on(GH) 39.3±5.3 43.6±6.0 P=0.0021

Vitality(VT) 43.7±4.9 43.5±6.1 n.s.

SocialfuncOoning(SF) 37.6±7.8 37.6±7.8 n.s.

EmoOonalrole(ER) 39.2±12.6 44.4±9.3 n.s.

Mentalhealth(MH) 45.8±9.5 46.8±9.5 n.s.

Physicalcomponentsummary(PCS) 35.8±7.2 40.6±4.7 P=0.024

Mentalcomponentsummary(MCS) 44.1±8.5 44.5±7.9 n.s.

Seatedisometricyogaprogramimprovesqualityoflifebyreducingpainandimprovinggeneralhealthpercep2on

OkaTetal.,BiopsychosocMed2018,12,3

Longtermeffect,prevspost(2months)

YogaDiary

•  AllstudysubjectsreportedthattheirbodiesfeltwarmerandlighteraverpracOcingseatedisometricyoga

•  StudysubjectsreportedreducedfaOgueandpain

•  Studysubjectstatements:•  “Iwokeupmoreeasilythemorning

averpracOcingyoga.”•  “MymindbecamemorecalmandI

feltworry-free.”

Long-termeffectseffectsofseatedisometricyogaprogram

Parameter Pre Post Pvalue

HR(bpm) 88.1±8.5 85±9.5 n.s.

HF(ms2) 74.7±79.4 70.4±62.3 n.s.

LF(ms2) 163.4±197.1 204.9±363.9 n.s.

LF/HF 4.5±5.4 4.8±7.1 n.s.

CVR-R(%) 3.5±1.6 3.5±1.5 n.s.

Parameter Pre Post Pvalue

HADS-Depression 8.3±4.6 5.7±5.4 0.02

HADS-Anxiety 7.7±4.8 6.9±4 n.s.

Autonomicparameters

Psychologicalparameters

Parameter Pre Post Pvalue

CorOsol(µg/dL) 11.5±8.3 10.4±6.3 n.s.

DHEA-S(µg/dL) 178.4±67.7 180.5±66.5 n.s.

TNF-α(pg/mL) 0.9±0.2 0.8±0.2 n.s.

IL-6(pg/mL) 1.1±0.6 1.2±0.6 n.s.

Prolac2n(ng/mL) 11.4±6.3 11.1±6.3 0.08

T-Carn(µmol/L) 53±12.5 52.6±12.4 n.s.

TGF-β1(ng/mL) 13.1±16.2 10±8.5 n.s.

BDNF(ng/mL) 5.8±8.2 4.2±4.5 n.s.

MHPG(ng/mL) 3.6±1.1 3.7±1.3 n.s.

HVA(ng/mL) 9.1±3.7 10.9±9.4 n.s.*DopamineactsasprolacOninhibitoryhormone

Long-termeffectsofseatedisometricyogaprogramonbloodbiomarkerlevels

∆Ch

alde

rFaO

gueScalescore

∆TNF-α(pg/mL)

Long-termeffectsofseatedisometricyogaprogramonChalderFa2gueScoreasafunc2onofTNF-α concentra2on

-25

-20

-15

-10

-5

0

5

-1 -0.5 0 0.5

←FaO

gueredu

ced

Study2Effectsofrecumbentisometricyogaonpa2entswithsevereME/CFS:arandomizedcontrolledtrial

Problemstobesolved1)Todevelopyogaprogramforseverepa2ents 2)Toanalyzefurtheronthemechanismsoflong-termeffectofisometricyoga

(1a)

(3a)

(1b)

(2a) (2b) (2c)

(2d) (2e)

(3c)(3b)

Developmentofa20-minrecumbentisometricyogaprogramforpa2entswithsevereME/CFS

CompletedtheintervenOon(n=24)

CompletedtheintervenOon(n=24)

RandomizaOon(n=50)

Analysis

Yoga+TAUgroup(n=25)

TAU(control)group(n=25)

AllocaOon

Assessedforeligibility(n=358)

Subgroup Yoga+TAU TAU

Severe(PS7-8) 14 13

Mildtomoderate(PS3-6) 10 11

Withfibromyalgia 6 7

PS:performancestatus(indexofseverityandimpairedfuncOon)

IntervenOon:TAUwith/without20-minrecumbentisometricyogafor12weeks

10

15

20

25

30

pre post

Yoga+TAU

TAU

**

#

**p<0.01(pairedt-test)#p<0.05(independent-samplet-test)

**

Chalde

rFaO

guescalescore

Long-termeffectsofrecumbentisometricyoga(preintervenOon-12weeks)

(n=24)

Long-termeffectsofrecumbentisometricyoga(preintervenOon-12weeks)

Classifica2on Pre Post pSevere(n=14) 26.3±4.7 19.2±5.9 P<0.0001Moderate(n=10) 19.3±4.3 16.4±5.7 P=0.1WithFM(n=6) 30.2±2.3 23.8±4.8 P=0.008

Classifica2on Pre Post p

HADSAnxiety 8.2±4.2 5.7±3.6 P=0.007

HADSDepression 10.2±3.9 7.5±3.7 P=0.0003

ChalderFaOgueScalescore

Psychologicalparameters

FM:fibromyalgia

Significanceoftheprefrontalcortex(PFC)inME/CFS

•  Gray-ma{erinthebilateralPFCisreducedinME/CFSpaOents

•  ThevolumereducOoninthertPFCwasassociatedwithfa2gueseverity

OkadaTetal.,BMCNeurology2004,4:14

Within-group analysis of regional changes in grey mattervolume between the pre- and post-CBT scans revealedsignificant regional increases bilaterally in the inferiorfrontal gyrus [left IFG: (–36, 39, 17), t(21) = 5.49,PFWE = 0.010, PFDR = 0.025; right IFG: (39, 35, 23),t(21) = 5.49, PFWE = 0.005, PFDR = 0.011] for the CFS group(Fig. 3), but no changes for the healthy controls. Both these

clusters were located at the most dorsal portion of theinferior frontal gyrus and in the depth of the middle frontalsulcus, within the borders of cyto-architectonicallydefined Brodmann area 46/9 (Rajkowska and Goldman-Rakic, 1995).

In terms of cognitive speed, CFS patients became fasteron the CRT (t21 = 2.30, P= 0.032), while they did not show

Table 2 Baseline and follow-up physical and cognitiveperformance of participants

Baseline Follow-up Difference

CFS patientsFunctional statusCIS fatigue (8^56)a 48.4(1.3) 29.3 (2.9) !19.0 (2.9)"""

SIP total (0^9937)a 1334 (124) 550 (115) !784 (128)"""

Physical activityMean actometer score 63.5 (4.6) 73.2 (3.5) +9.7 (4.8)"

Pervasively passive (%) 32 9 !23Relatively active (%) 68 91 +23

Cognitive speedWAIS-dst 60.2 (2.8) 62.5 (2.9) 2.3 (1.6)NS

CRT (ms) 348 (14.2) 329 (11.5) !19.4 (8.4)""

SRT (ms) 307 (11.6) 297 (12.8) !10.3 (9.6)NS

Cerebral volumeGrey matter (ml) 669.4 (14.4) 674.1 (15.1) +4.7 (2.3)""

White matter (ml) 406.1 (8.9) 404.7 (8.9) !1.4 (1.0)NS

Healthy controlsFunctional statusCIS fatigue (8^56)a 21.2 (2.4) 18.7 (2.1) !2.5 (2.7)NS

SIP total (0^9937)a 131 (63) 169 (69) +38 (36)NS

Cerebral volumeGrey matter (ml) 708.2 (12.0) 708.0 (12.6) !0.2 (1.7)NS

White matter (ml) 423.2 (9.0) 421.4 (8.7) !1.8 (1.7)NS

Values are given as means (SE).aRange of the scale.NS=Not significant. "p50.1. ""p50.05."""p50.001.

Fig. 2 Effect of CBTon grey matter volume. (A) There is a significant increase in GMV between baseline and follow-up in CFS patients, butnot in healthy control subjects. (B) There is a negative correlation between the increase in GMV following CBTand the patient’s age.

Fig. 3 Anatomical localization of grey matter volume increase.Results are superimposed on the average normalized brain of allCFS patients. There is a significant increase in prefrontal greymatter volume (BA 46/9) as a result of CBT in CFS patients.(A) sagittal view. (B) Coronal view. (C) Axial view. Results aredisplayed at P50.001 uncorrected, for display purposes.

2176 Brain (2008), 131, 2172^2180 F. P. de Lange et al.

at (D) K

yushu U R

igakubu on August 31, 2012

http://brain.oxfordjournals.org/D

ownloaded from

CogniOvebehavioraltherapyincreasedgrayma{ervolumeinthelateralPFCinME/CFSpaOents.deLangeFP,etal.Brain2008,131:2172-2180.

High-frequencyrTMSdeliveredtotheltDLPFCreducedfa2gueinME/CFSpaOents.KakudaWetal.,InternMed2016,55:3515-3519.

＜結果＞ ＃症状への影響は、患者各人で異なっていた。しかしながら、総じて、患者 7人中 6人でなんらかの症状の改善、特に生活状況の改善が確認された。

＃例えば、「屋外を長時間歩くことができるようになった」、「人の力をかりずに、入浴や洗髪がで

きるようになった」、「長時間続けて本を読むことができるようになった」、「長時間デスクワーク

にとりくむことができた」、「数年ぶりに集中力が高まる感じを自覚した」などと患者は述べた。 ＃症状をスコア（点数）でも評価したが、TMS治療によってこの点数は、統計学的に有意な改善を示した。たとえば、退院の時点で約 40％の改善が、退院後 2週間の時点で約 30％の改善が、確認された。

＃退院後 2週間の時点までの経過観察では、やや効果の減弱が示唆されたものの、およそは退院後も症状の改善が持続していた。

＃2人の患者では、入院中に一時的に不快感もしくは立ちくらみがみられたが、いずれも特に治療を要することなく回復した。その他、特記すべき有害事象はいずれの患者においてもなかった。

＊対象患者 7人の平均 値をあらわす。

TGF-β↑,Proinflamm.Cytokines(TNF-α)↑NKcellacOvity↓Th2-predominant,

AutoanObody,Treg↑BcelldysfuncOon

ImmuneEndocrine

DLPFCfuncOon↓,reducedvolumeReducedACCand

basalgangliafuncOonMicroglialacOvaOon

CNS

HPAaxisdysfuncOoncorOsol↓

(bluntedawakeningresponse)DHEA-S↓

Intes2nalflora

Psychologicalstress

ParasympatheOcn.↓(RelaOvesympatheOc

predominancy)

ANS

Smallheart,tachycardia,CO↓,SV↓RAA�system↓

ADHsystem↓

PosturalorthostaOctachycardia

GlycolyOcandTCAcycledysfuncOon

Energy/metabolismCardiovascular

Comorbiddiseases

Oxida2vestress

2018/10/02 15(20Isometric yoga program for ME CFS - YouTube

5 / 5 ページhttps://www.youtube.com/watch?v=tuQngCHfrvk&t=256s

Laura Stanley 6 か月前Dr. Takakazu, I am deeply grateful to you for this excellent video and program. I am seriously ill with ME/CFS, and this is the only exercise I can do at this time. As long as I follow your instruction to not use all my strength, it really helps me to feel more balanced and energized. I have begun sharing it with fellow patients in my support groups, and they have been enthusiastic. We hope you will be able to produce additional programs for us someday! Thank you, thank you!

Sophie 7 か月前Thank you so much for making this available. I haven't been doing it for long enough to feel any signiScant changes, but so far I haven't felt any extra fatigue/pain the next day, which is amazing

Adrienne Wooding 11 か月前（編集済み）Helpful to some severe but not too severe MECFS patients but it is a shame that objective physiological markers weren't used to measure the effectiveness of the program. It would have been nice if the DePaul Questionaire (a symptom speciScally scale for people with ME/CFS) used as the disease is far more than fatigue.

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2018/10/02 15(27mecfs yoga - YouTube

2 / 4 ページhttps://www.youtube.com/results?search_query=mecfs+yoga

Oka Takakazu岡 孝和チャンネル登録者数 77 人 • 3 本の動画

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ME/CFS: Katherine's Story of Recoveryfrom Chronic Illness Through YogaME/CFS Community • 1218 回視聴 • 4 年前Katherine's recovery from chronic illness has been a journey ofovercoming pain and suffering. Her's is also a journey of ...

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Yoga for M.E. my personal nighttime yogaroutineYoga, Mybed & M.E • 1708 回視聴 • 1 年前This is my nighttime yoga for M.E. CFS on a good health day.

Dr.Takakazu,Iamdeeplygratefultoyouforthisexcellentvideoandprogram.IamseriouslyillwithME/CFS,andthisistheonlyexerciseIcandoatthisOme.AslongasIfollowyourinstruc2ontonotuseallmystrength,itreallyhelpsmetofeelmorebalancedandenergized.…………….Thankyou,thankyou!�

ViewdemonstraOonsofisometricyogaprogramsonYouTube

Conclusions

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•  Isometricyogaisbeneficialasaself-helpstrategyoradjuncttherapyforME/CFS

•  MulOplefactorsmaycontributetothebeneficialeffectsofisometricyoga:•  AnO-depressiveandanxiolyOceffects•  AnO-stressandanO-inflammatoryeffects

•  TherapeuOcyogaprogramforspecificdiseasesshouldconsider:•  WhethertradiOonalyogaisapplicableandeffecOve•  DiseasepathophysiologyandpaOentlimitaOons

•  CollaboraOonbetweenmedicalspecialistsandyogaspecialistsiscrucialfordevelopingeffecOvetherapeuOcyogaprograms

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2018/06/12 9)04Change the World - Medicine and Public Health | For Researchers | Springer Nature

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dcentral.com/articles/10.1186/s13030-017-0090-z?&utm_medium=other&utm_source=other&utm_content=5022018&utm_campaign=10_dann_ctw2018_5_med_13)Biopsychosocial Medicine

Yoga for bedridden patients

might seem counterintuitive,

but this new style of yoga

can yield impressive benefits

for patients with severe

fatigue.

017-1559-2?&utm_medium=other&utm_source=other&utm_content=5022018&utm_campaign=10_dann_ctw2018_5_med_14)BMC Pregnancy and

Childbirth

As pertussis is now a

growing threat, vaccination

for pregnant women has

become more common.

This study examines the

available evidence on the

efficacy and safety of this

approach and highlights

the need for further

research.

n_ctw2018_5_med_15)Neurotherapeutics

In this study, patients with

amyotrophic lateral sclerosis

(ALS) who received

dextromethorphan plus

quinidine reported improved

speech and swallowing.

Environmental pollutionwith antimicrobialagents from bulk drugmanufacturingindustries in Hyderabad,South India, isassociated withdissemination ofextended-spectrumbeta-lactamase andcarbapenemase-producing pathogens (https://link.springer.com/article/10.1007%2Fs15010-017-1007-2?&utm_medium=other&utm_source=other&utm_content=5022018&utm

Evidence-Based SocialCommunicationInterventions forChildren with AutismSpectrum Disorder (https://link.springer.com/article/10.1007%2Fs12098-015-1938-5?&utm_medium=other&utm_source=other&utm_content=5022018&utm_campaign=10_dann_ctw2018_5_med_17)The Indian Journal of

Pediatrics

Guidance on interventions

for ASD.

Expert consensusdocument:Mitochondrial functionas a therapeutic targetin heart failure (https://www.nature.com/articles/nrcardio.2016.203?&utm_medium=other&utm_source=other&utm_content=5022018&utm_campaign=10_dann_ctw2018_5_med_18)Nature Reviews Cardiology

This Consensus Statement

explores mitochondria as a

therapeutic target for heart

failure, a prevalent condition

2018/06/12 9)04Change the World - Medicine and Public Health | For Researchers | Springer Nature

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Automated analysis offree speech predictspsychosis onset in high-risk youths (https://www.nature.com/articles/npjschz201530?&utm_medium=other&utm_source=other&utm_content=5022018&utm_campaign=10_dann_ctw2018_5_med_10)npj Schizophrenia

People with schizophrenia

experience subtle speech

problems, even before they

first develop psychosis. A

computer program that

analyzes natural speech

could help predict the onset

of psychosis in young

people at risk.

Calretinin as a blood-based biomarker formesothelioma (https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3375-5?&utm_medium=other&utm_source=other&utm_content=5022018&utm_campaign=10_dann_ctw2018_5_med_11)BMC Cancer

This study was featured in

over 50 news outlets. It

describes a new blood test

that could mean earlier

diagnosis for

mesothelioma:

https://survivingmesothelioma.com/a-

new-blood-test-for-

mesothelioma/

Chemical and non-chemical stressorsaffecting childhoodobesity: a systematicscoping review (https://www.nature.com/articles/jes201718?&utm_medium=other&utm_source=other&utm_content=5022018&utm_campaign=10_dann_ctw2018_5_med_12)Journal of Exposure Science

and Environmental

Epidemiology

A critical review of how the

numerous chemical and

non-chemical stressors in a

child’s environment may

combine to affect his or her

health.

Development of arecumbent isometricyoga program forpatients with severechronic fatiguesyndrome/myalgicencephalomyelitis: Apilot study to assessfeasibility and efficacy. (https://bpsmedicine.biomedcentral.com/articles/10.1

Efficacy and safety ofpertussis vaccinationfor pregnant women –a systematic review ofrandomised controlledtrials andobservational studies (https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-017-1559-2?&utm_mediu

Enhanced BulbarFunction in AmyotrophicLateral Sclerosis: TheNuedexta TreatmentTrial (https://link.springer.com/article/10.1007/s13311-016-0508-5?&utm_medium=other&utm_source=other&utm_content=5022018&utm_campaign=10_dann_ctw2018_5_med_15)

2018/06/12 9)18Change the World - One article at a time | For Researchers | Springer Nature

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Acknowledgements

Interna1onalUniversityofHealthandWelfarePsychosoma1cMedicine

YuYamadaBa{uvshin Lkhagvasuren

TheJapanYogaTherapySociety

HisakoWakitaTakakoIshidaKeishinKimura

KyushuUniversityPsychosoma1cMedicine

TokuseiTanahashiKazuhumiYoshiharaShuTakakuraNobuyukiSudo