yeast - why it simply has a lot to say about human disease
TRANSCRIPT
Yeast - why it simply has a lot to say about human disease
Genetic mutations identified in human disorders
A richness of data allows yeast to tell a multi-dimensional story
Zhu, et al. (2012), Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. PLoS Biology
metabolites
genes
genes w/cis-eQTLs
Leu3p binding sites
Human connections into SGD
Homology& Disease
X
FunctionalComplementation
Phenotypes & Orthology
Literature
DrugInteractions
Searchable Connectionsgene name
Searchable Connectionsyeast gene
Searchable Connectionshuman gene
disorder
Searchable Connections
A real and present connection
A real and present connection
NGLY1
SGD’s Advanced Search
A real and present connection
yeastPNG1
phenotypes
function
pathways
literature
protein properties
genetic interactions
NGLY1
SGD’s Advanced Search
Connection start points
Human genes
Yeast homologs
Function known,human homologs
Yeast genes
4500 genes1340 diseases
2750genes
SGD: Powering Connections