xvii. circulating mast-granulated hemohistioblasts
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354 HAh’DBOOK OF HEMATOLOGY SECTION IV
Furthermore, during the inoculation period the basophile level dropped, while during the disease regression of basophiles persisted or became more marked.
XYII. CIRCULATING MAST-GRANULATED HEMOHISTIOBLASTS
According to the Italian school, under pathologic conditions, especially myelogenous leucemia, blood mast cells may be differentiated from hemo- histioblasts, the myelocytic stages being skipped (Di Guglielmo, 1925; Capocaccia, 1928; Callerio, 1930; Cattaneo, 1933; also Sabrazks, 1926) .
In films stained with Giemsa, hemohistioblasts appear as extremely large cells; the nuclei have a widely meshed network of chromatin (sponge like, Ferrata) in which there are lodged conspicuous blue-stain- ing nucleoli. The cytoplasm is extremely labile, abundantly present and markedly polymorphous (Plate 11, Fig. 43). In short, the cells appear as squashed or damaged promyelocytic cells, an interpretation given of them by Lambin (1927). Ringoen (1927) denied their specificity en- tirely, the cells in his opinion representing artifacts. Outside of Italy to date, Naegeli, Sabrazks (1926), Richter (ig25), Sabin and Doan (1926), Rinehardt (1932) have admitted the morphology and specific significance of these cells, albeit that Sabin and Doan interpret them as circulating clasmatocytes which have phagocytosed eosinophile or neutrophile gran- ules. In a study with Ferrata (1923), I had ample occasion to ascertain the specificity of circulating hemohistioblasts, as they occur in the pre- hepatic blood picture. Their mast granulopoietic potency has been con- sidered on page 302 and is illustrated in Plate 11, Figure 43.
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