xt 2000i cell counter autoanalyser
TRANSCRIPT
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SYSMEX SINGAPORE PTE LTD
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XT-2000iXT-2000i
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Actual Trends in HealthcareActual Trends in Healthcare
. Increase in elderly population
.Total reform of medical/hospital system
.Overall reduction of public spending
.Reduction of public healthcare costs
.Outcome related medicine
. Information instead of data required
.Software solutions demanded
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Hospital structure JapanHospital structure Japan
Long-term careHospital
UniversityHospital
Basic care Hospital
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Common Structure in AsiaCommon Structure in Asia
H e a lthC lin ic
H e a lthC lin ic
H e a lthC lin ic
D is tric tH o sp ita l
H e a lthC lin ic
H e a lthC lin ic
H e a lthC lin ic
D is tric tH o sp ita l
H e a lthC lin ic
H e a lthC lin ic
H e a lthC lin ic
D is tric tH o sp ita l
G e n e ra lH o sp ita l
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Core-Lab
SatelliteLab.
Sender/Ward
Sender/Ward
SatelliteLab.
Sender/Ward
Sender/Ward
SatelliteLab.
Sender/Ward
Hospital/Commercial Lab structure Hospital/Commercial Lab structure
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
XT-2000i Development PhilosophyXT-2000i Development Philosophy
.Reduction of healthcare expenses
. Improve lab productivity and hospital cost efficiency
.Support Disease management (outcome related medicine)
.Adapt to new hospital/commercial lab structures
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XT-2000XT-2000ii
ConceptConcept
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Main CharacteristicsMain Characteristics
. Taking over the technology established by XE-2100.
. unifying the results, reagents, and operation with XE.
. User friendly, easy to use data management
. Additional parameters (clinical information)
. Discrete analysis
. 48 hr sample stability
. Provides additional features:
. Network function
. Windows 2000
. SNCS (on line QC and remote maintenance: under development)
. Full-auto Ret analysis
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Main CharacteristicsMain Characteristics
. Suggests a solution of:
. XE-2100 for core lab
. XT-2000i for satellite lab
. To maintain high reputation and market price for XE and XT-2000i
. Introduction of XT-1800i
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
XE family conceptXE family concept
. Breeding the analyzer.
.XE developments are continued.
.new algorithm
.new functions
. When new feature or technology is adopted to XE-2100, also XT will get this
.vice versa
.except the technical limitation.
.i.e. NRBC for XT.
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Year
Valu
e
Ver. UP
Ver. UP
XE-2100
XE-2100L
XT-2000i
XT-1800i
XE-2100
XE-2100L
XT-2000i
XT-1800i
XE-2100
XE-2100L
XT-2000i
XT-1800i
Progress of XE FamilyProgress of XE Family
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Core and Satellite Lab.Core and Satellite Lab.
Sysmex
XE-2100
Sysmex
XE-2100
Core Lab
SysmexXT-2000i
Satellite Lab B
Same ReagentsSame Results
Same Operation
HSTAlpha
SysmexXT-2000i
Satellite Lab C
SysmexXT-2000i
Satellite Lab A
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Inherit XE technologiesInherit XE technologies
. Analysis principle
. FCM (Semiconductor Laser)
. Reagent System
. Network function
.TCP/IP connection
. Research Parameter
. IG
. Research Screen
. Q-Flag system
. SNCS:
.online QC/remote maintenance
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
PhilosophyPhilosophy
.Provide clinically relevant information of high accuracy to doctors
.Resting cost reduction in compliance with governmental regulations
.Top-level network system: internal and external
.Shorten TAT
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
XT-SeriesXT-Series
Model Parameter
XT-2000i CBC+DIFF+RET
XT-1800i CBC+DIFF
Two types of XT series
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Schedule Schedule
XT-2000i XT-1800i
Release Date
EU and AP: February, 2002
EU and AP: May, 2002
US: June, 2002 *after FDA approval
US: July, 2002 *after FDA approval
Japan: April, 2002
Japan: May, 2002
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Running cost comparison XT vs. SFRunning cost comparison XT vs. SF
. Theoretical Calculation
.XT > SF-3000
. Actual simulation
.XT < SF-3000
.Discrete testing: cost effective
.Less maintenance: cost effective
.Fully automated RET analysis (XT-2000i)
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XT-2000iXT-2000i
SpecificationsSpecifications
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
XT-2000i ParametersXT-2000i Parameters
.33 ParametersWBC, RBC, HGB, Hct, MCV, MCH, MCHC, PLTRDW-CV, RDW-SD, MPV, PDW, P-LCR, PCT,NEUT %, LYMPH %, MONO %, EO %, BASO %, IG %, NEUT #, LYMPH #, MONO #, EO #, BASO #, IG #‚ RET %, RET #, LFR, MFR, HFR, IRF, PLT-fl
.2 HistogramsRBC, PLT
.5 ScattergramsDIFF, WBC/BASO, RET, PLT-O, RET-EXT
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Sample VolumeSample Volume
.Capillary Blood 40 µl
.Open Mode 85 µl
.Manual Closed 150 µl
.Automode 150 µl
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
ThroughputThroughput
.CBC 80 samples/h
.CBC + Diff 80 samples/h
.CBC + Diff + RET 80 samples/h
.CBC + RET 80 samples/h
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
AutomationAutomation
.Samples for 50 samples (5 rack 10 tubes)
.Barcode reader for positive patient identification
.Continuous sample loading
.Comprehensive Information Processing System
.Minimised maintenance
.Selectivity
.Closed mode sampling
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Information Processing System (IPU)Information Processing System (IPU)
.Storage 10.000 patient results inclusive all scattergrams and histograms
.Work list 1000 samples
.Auto validation
. Interpretive messages
.Quality Control
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Reagent SystemReagent System
NameAbbreviation
Cellpack EBKSulfolyser SLSStromatolyser 4DS FFSStromatolyser FB FBAStromatolyser 4DL FFDRet Search 2 Dye REDRet Search 2 Lyse RED
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Order information• CBC• CBC + DIFF• CBC + DIFF + RET• CBC + RET
Selectivity of XT-2000iSelectivity of XT-2000i
Barcode readingof each sample
Selective Analyse after ordering
Central-PCWork listBarcode
Results
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Configurations XT-2000iConfigurations XT-2000i
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
OptionsOptions
. PIM software
. TCM software: two unit connection with 1 x IPU** only for the same model type available.
. Twin of “XT-2000i and XT-1800i” or “XE-2100 and XT-2000” is not possible.
. Sampler (50samples)
. Bar coder reader (sampler)
. Handheld barcode reader local supply
. Printer (GP/LP) local supply
. Ticket printer (DP-510)
•
XT Twin
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
XT-2000i Twin ConfigurationXT-2000i Twin Configuration
Two XT-2000i systems, one Information Processing System (IPU)
160 Samples per hour Every 23 seconds a CBC + differential result
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Configuration ImageConfiguration Image
Main UnitXT IPU
Pneumatic unit
TCP/IP connection
Sampler
accessory
PIM
TCM
BCR
O/M Basic soft
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XT-seriesXT-series
Analysis PrincipleAnalysis Principle
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
AnalysisBlock
Principle
Analysischannel
Information
RBC/PLT WBC
Hydrodynamic Focusing - DC Detection -
Flow cytometry
RBC/PLTchannel
PLThistogram
Parameter PLT HGB
HGBchannel
ColorimetricDetermination
HGB
Whole blood sample
DIFFchannel
RETchannel
DIFF
scattergram
WBC#Baso
RETPLT-OIRF
RETscattergram
LymphMonoNeut+BaEO*IG - research
RET
Flow cytometry
WBC/Bachannel
WBCscattergramRBC
histogram
RBC
XT-2000i Multi Channel AnalyserXT-2000i Multi Channel Analyser
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
XT-2000i Multi Channel AnalyserXT-2000i Multi Channel Analyser
Channel Principle / Dilution Parameters
WBC/BASO WBC, Baso #‚ Baso %
Flow CytometryDiode laser - 1:50
4 Diff Flow cytometryDiode laser - 1:51
Lymph #‚Lymph %, Mono #, Mono %, Eo #, Eo %, Neut #‚ Neut %
RET/PLT-OFlow cytometry
Diode laser - 1:204RET #, RET%, PLT-OHFR , MFR , LFR, IRF
HGB SLS-Method, Photometry1:500
HGB
RBC/PLT-Detector
RBC, HCT, PLT-I, RDW-SD, RDW-CV, PDW, MPV, P-LCR
HDF DC-Detection methodImpulse summary
1:500
MCH, MCHC, MCV
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fluorescence Flow CytometryFluorescence Flow Cytometry
Semiconductor Laser
( = 633nm)
Flow Cell
Photo Diode(Forward Scattered Light)
Photo Multiplier(Side Scattered Light)
Photo Multiplier(Fluorescence Light)
DichroicMirror
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fluorescence Flow CytometryFluorescence Flow Cytometry
Forward Scattered Light:Cell Volume Information
Laser Beam
( = 633nm)
Side Fluorescence Light:RNA/DNA Information
Side Scattered Light:Internal Cell Structure
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
4 Diff-Channel4 Diff-Channel
2. DIFF-Scattergram
1. Principles and technology
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
4 Diff-Channel 4 Diff-Channel
Neutrophil
Eosinophil
Basophil Monocyte
Lymphocyte
Band Myelocyte
Promyelocyte BlastMetamyelocyte
Neutrophil
Eosinophil
Basophil Monocyte
Lymphocyte
Lyse & Staining
Band Myelocyte
BlastMetamyelocyte
Promyelocyte
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
4 Diff-Channel 4 Diff-Channel
DIFF Scattergram Mono
Neut + Baso
Lymph
Eo
Side Scatter
Fluorescence
Ghost
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
4 Diff-Channel 4 Diff-Channel (pathological sample)(pathological sample)
DIFF Scattergram
Side Scatter
Fluorescence
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Diff ScattergramDiff Scattergram
Band
Metamyelo
Myelo
Promyelo
Abn. Lymph/Blasts
Atypical Lymph
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
WBC/Baso ChannelWBC/Baso Channel
2. DIFF-Scattergram
1. Principles and technology
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
WBC/Baso ChannelWBC/Baso Channel
Lyse Lyse
Neutrophil
Eosinophil
Basophil Monocyte
Lymphocyte
Neutrophil
Eosinophil
Basophil Monocyte
Lymphocyte
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
WBC/Baso ChannelWBC/Baso Channel
WBC/BASO Scattergram
Baso
WBC
Side Scatter
Forward Scatter
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
RET ChannelRET Channel
2. DIFF-Scattergram
1. Principles and technology
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Ret ChannelRet Channel
Lyse & Lyse & StainingStaining
Staining: Polymethine: RNAOxazine: DNA
RBC RET PLT NRBC WBC
RBC RET PLT NRBC WBC
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Ret ChannelRet Channel
IRF
Forward Scatter
Fluorescence
PLT-O
RET(LFR, MFR, HFR)
RBC
RET Scattergram
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
HDF TechnologyHDF Technology
2. DIFF-Scattergram
1. Principles and technology
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Hydrodynamic FocussingHydrodynamic Focussing
. DC resistance measurement with hydrodynamic focussing for measurement of erythrocytes, thrombocytes and hematocrit
CELLPACK (Sheath solution)
Aperture
Sample
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
aperture
Pulse A
C BA
cells
Hydrodynamic FocussingHydrodynamic Focussing
Pulse B Pulse C
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
HemoglobinHemoglobin
2. Reaction Mechanism
1. SLS
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
SLS-Hemoglobin SLS-Hemoglobin
.Cyanide free SLS-Method
.Alternative for KCN
.SLS is Sodium lauryl sulphate
.Equal to the KCN method
.Cyanide free, not poisoned, is part of a lot of soaps
.Sysmex Sulfolyser is used for K-, E-, NE, SF, SE and and XE-instruments
.The SLS-Method is Standard for Sysmex instruments
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Reaction Mechanism of HemoglobinReaction Mechanism of Hemoglobin
Hydrophobic group
Hydrophilic group
SLS (Sodium Lauryl Sulfate)
Heme
Globin
Hemoglobin-Molecule
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Reaction Mechanism of HemoglobinReaction Mechanism of Hemoglobin
2. 0xidation of Ferro: Fe2+ --> Fe3+
1. Hydrophobic groups of SLS binds to globulin
3. Hydrophilic groups of SLS binds to Fe3+. and SLS-Hgb is formed
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XT XT
Flagging SystemFlagging System
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
FlagFlag
.NEGATIVE
.No abnormality
.POSITIVE
.One or more of the IP messages is generated
.ERROR
.Classified as Functional abnormality
.Classified as Result, Low reliability
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Result
NEGATIVE
POSITIVE
Report
Review Report
XT flagging system can provide valuable information for review
Error Review Report
XT Flagging SystemXT Flagging System
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
FlaggingFlagging
Low Reliability of Data
POSITIVE
Diff
Morph
Count
ERROR
Func
Result
Delta
Abnormality in Cell Differential
Abnormality in Cell Morphology
Abnormality in Cell Count
Analysis error other than ID Barcode
Abnormalities with Delta Check
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
IP MessageIP Message
Two Types
.Abnormal IP Message:
. Indicates that the sample is definitely abnormal. The IP abnormal message criteria can be set except for some items.
.Suspect IP Message:
. Indicates that there is a possibility that the sample is abnormal.
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
IP messageIP message
. IP messages are detected from:
. Cell information
.Fluorescence
.Forward Scatter Light
.Side Scatter Light
. Scattergrams
. Histograms
Flowcytometry
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
WBC FlaggingWBC Flagging
Abnormal Messages
. WBC abnormal Scattergram
. Neutropenia
. Neutrophilia
. Lymphopenia
. Lymphocytosis
. Monocytosis
. Eosinophilia
. Basophilia
. Leukopenia
. Leukocytosis
Suspect Messages
. Blasts?
. Immature Gran?
. Left Shift?
. Atypical Lympho?
. Abn Lympho/L-Blasts?
. RBC Lyse Resistance?
. NRBC?
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
RBC FlaggingRBC Flagging
Abnormal Messages
. RBC ABN Distribution
. Dimorphic Population
. Ret ABN Scattergram
. Reticulocytosis
. Anisocytosis
. Microcytosis
. Macrocytosis
. Hypochromasia
. Anaemia
. Erythrocytosis
Suspect Messages
. RBC Agglutination?
. Turbidity / HGB inter
. Iron Def?
. HGB Defect?
. Fragments?
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
PLT FlaggingPLT Flagging
Abnormal Messages
. PLT ABN Distribution
. PLT ABN Scattergram
. Thrombocytopenia
. Thrombocytosis
Suspect Messages
. PLT Clumps ?
. PLT C(s) ?
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Product PortfolioProduct Portfolio
Current and FutureCurrent and Future
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fu
ncti
on
/Dia
gn
osti
c V
alu
e
Current MCC PortfolioCurrent MCC Portfolio
Low end Middle High end
Price
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fu
ncti
on
/Dia
gn
osti
c V
alu
e
Current MCC PortfolioCurrent MCC Portfolio
Low end Middle High end
Price
XE-2100L XE-2100
F series
KX-21/KX-21N
K-4500
SF-3000
SE/R
SE
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fu
ncti
on
/Dia
gn
osti
c V
alu
e
Current MCC PortfolioCurrent MCC Portfolio
Low end Middle High end
Price
Pentra-60AcT 5 DiffADVIA 70
MicrosCD-1200Act DiffⅡ
ADVIA-120
CD-4000
Gen*S/LH750
Pentra-120R
HmXCD-3700Pentra-120CD-3200
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fu
ncti
on
/Dia
gn
osti
c V
alu
e
Current MCC PortfolioCurrent MCC Portfolio
Low end Middle High end
Price
Pentra-60AcT 5 DiffADVIA 70
MicrosCD-1200Act DiffⅡ
ADVIA-120
CD-4000
Gen*S/LH750
Pentra-120R
HmXCD-3700Pentra-120CD-3200
XE-2100L XE-2100
F series
KX-21/KX-21N
K-4500
SF-3000
SE/R
SE
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fu
ncti
on
/Dia
gn
osti
c V
alu
e
MCC Portfolio - Future -MCC Portfolio - Future -
Low end Middle High end
Price
Pentra-60AcT 5 DiffADVIA 70
MicrosCD-1200Act DiffⅡ
ADVIA-120
CD-4000
Gen*S/LH750
Pentra-120R
HmXCD-3700Pentra-120CD-3200
XE-2100L XE-2100
F series
KX-21/KX-21N
K-4500
SE/R
SEXT-2000i
XT-1800i
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DifferencesDifferences
XT-2000i & XE-2100XT-2000i & XE-2100
Sysmex
XE-2100
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
XT-2000i XE-2100
Parameters 30 32
Throughput CBC 80 samples/hour
150 samples/hour
+ RET
80 samples/hour
113 samples/hour
Discrete mode 4 7
Sample Volume
Manual
85 uL 130 uL
Closed
150 uL 200 uL
Sample No digit 15 15
Sampler 50 samples 100 samples
SpecificationsSpecifications
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
ParametersParameters
XT-2000i XE-2100
Reportable
CBC Yes Yes
DIFF Yes Yes
RET Yes Yes
PLT-O Yes Yes
NRBC No Yes
Research HPC No Yes
IG Yes Yes
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
ReagentReagent
XT-2000i XE-2100
CELLPACK use use
CELLSHEATH not use use
STROMATOLYSER-FB
use use
STROMATOLYSER-4DL
use use
STROMATOLYSER-4DS
use use
STROMATOLYSER-IM not use use
SULFOLYSER use use
STROMATOLYSER-NR
not use use
RETSEARCH II use use
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
IPUIPU
XT-2000i XT-1800i XE-2100 XE-2100L
OS Windows 2000 Windows NT*
Database SQL-Anywhere 5.5.05
SQL-Anywhere 5.5.04
CPU > Pentium III 733 MHz
> Pentium II 450MHz
Memory > 128MB > 64Mb
HDD > 10 GB > 3 GB
ATA > 100 -
result 10,000 10,000
workload 1,000 1,000
Patient Information
5,000 5,000
QC files 21 files (300 points/file)
21 files (300 points/file)
Sto
rage
* The OS of XE will be changed to Windows 2000 from Ver. 19
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Difference: IPUDifference: IPU
Measure Sample - analysis result - differential - flagging
Measure Sample - raw data
Store the results
Analysis the raw data- differential- flaggingStore the results
Sysmex
XE-2100
XE-Series
SysmexXT-2000i
XT-Series
OS: Windows NT
OS: Windows 2000
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Coffee breakCoffee break
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
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XT-2000XT-2000ii
FeaturesFeatures
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
FeaturesFeatures
1.Flowcytometry2.Multi Channel Analyzer3.Semi Conductor Laser4.Network5.Fully Automated RET analysis (XT-2000i)6.Random access testing7.Common operation & reagent system with XE8.Hydrodynamic Focusing System9.Effective Hematology Information10.SNCS11.X-bar-M Control12.Q-Flag
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FeaturesFeatures
FlowcytometryFlowcytometry
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Principle in HematologyPrinciple in Hematology
.Resistance
.Optical Measurement
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Optical PrincipleOptical Principle
.Scatter light
Information
Forward-scatter
Cell volume
Side-scatter
GranularityInternal Cell Structure
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
DNA/RNA-Content Cell cyclesCell proliferationReticulocytesChromosome..
Optical PrincipleOptical Principle
. Fluorescence
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Optical PrincipleOptical Principle
Light source:
. Tungsten lamp
. He-Ne laser
. Argon laser
. Semiconductor laser
Forward-scatter Fluorescence
Side-scatter
Semi conductorlaser
Tungsten lamp
He-Ne-Laser
Argon laser
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
FlowcytometryFlowcytometry
Definition:
. Is an optical system which detects scatter light and fluorescence of sheath flow focussed single cells
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
FlowcytometryFlowcytometry
Argon laser
. Wavelength = 488 nm
Staining (RET)
. Acridine orange, Ethidium bromide, Thiazole orange, Auramine O
Semiconductor Laser
. Wavelength = 633 nm
Staining
. on basis of Polymethine for fluorescence optical detection
. with long stability and high fluorescence gain
. Fluorescence stimulation with semiconductor laser
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Formula of Polymethine Formula of Polymethine
X=O, S, Se, N-alkyl or C(Ch3)n
R1,2 = alkyl (1-6C) ;
R3,4 = alkyl, metoxy or no
n = 0-1
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
FlowcytometryFlowcytometry
How does SYSMEX use the new technology?
.Diff
.Reticulocytes
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Flowcytometry with XT-SeriesFlowcytometry with XT-Series
What is so special on it ?
.There is Forward and Side Scatter, a lot of information’s about nucleus and granularity! Why Fluorescence?
.Why is that so new ?Other are also offering IG count!
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Flowcytometry with XT-SeriesFlowcytometry with XT-Series
What is so special?
Polymethine stains DNA/RNA, however important is
staining including RNA, and the use of these reagents make supra vital staining possible. Beside the information of - Cell volume - Intracellular components ,nucleus and granularity we get also information about the Cell Activity - Replication activity of the nucleus
(cause high RNA) - Cytoplasm activity
(Protein syntheses causes high RNA)
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
1 2
3
8
4
5 6
10
7
The CellThe Cell
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
The CellThe Cell
. Cell nucleus (1)
(DNA) . Function: Auto replication and syntheses Ribonucleinacid (RNA) in the Nucleolus (2) Cells with no possibility of replication have less RNA.These are mature cells (except lymphocytes) and NRBC (except pro erythroblast)
. Cytoplasm (3)
- Mitochondria (5) energy factory no RNA/DNA- Golgi machine (4) pack up enzymes no RNA/DNA
- Endoplasmatic Reticulum (10) is a membran structure with Ribosome (RNA) for protein synthesis (not in RBC)
- Lysosomen (8) Granula no RNA/DNA, enzymes
1 2
3
8
45 6
10
7
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
4 Diff-Channel 4 Diff-Channel
Neutrophil
Eosinophil
Basophil Monocyte
Lymphocyte
Band Myelocyte
Promyelocyte BlastMetamyelocyte
Neutrophil
Eosinophil
Basophil Monocyte
Lymphocyte
Band Myelocyte
BlastMetamyelocyte
Promyelocyte
Lyse & Staining
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FeaturesFeatures
Semiconductor LaserSemiconductor Laser
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fluorescence Flow CytometryFluorescence Flow Cytometry
Semiconductor Laser
( = 633nm)
Flow Cell
Photo Diode(Forward Scattered Light)
Photo Multiplier(Side Scattered Light)
Photo Multiplier(Fluorescence Light)
DichroicMirror
Optical System
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Semiconductor LaserSemiconductor Laser
Feature
. Long-life Laser
. Saves money
. Quick start-up
. Stat samples
. Compact
. Less space – small analyser
. Low power consumption
. Save money
. High stability
. Less maintenance cost
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FeaturesFeatures
Fully automated RET Fully automated RET analysisanalysis
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fully automated RET analysisFully automated RET analysis
. Just 60 seconds analysis
.No pre-treatment
.Useful information
. IRF, LFR, MFR, HFR
Fast reportLess laborProvides valuable information
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
IRF for monitoring of erythropoesisIRF for monitoring of erythropoesis
.Ratio of immature reticulocyte
.Useful predictive parameter of
.bone marrow suppression
. recovery in terms of erythropoesis
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FeaturesFeatures
Efficient Hematology Efficient Hematology InformationInformationOptical Platelets Optical Platelets
PLT-flPLT-fl
Atypical LymphAtypical Lymph
IG CountIG Count
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FeatureFeature
Optical Platelets PLT-flOptical Platelets PLT-fl
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fluorescence PLT CountFluorescence PLT Count
If there is a problem with the size of RBC and PLT,
than the impedance count often is not enough.
. Pseudo thrombopenia : - Giant PLT - PLT Aggregation
. Pseudo thrombocytose: - Fragments
A chamber count (lysed RBC) or a flow cytometry measurement CD 61 (membran antigen) or a check of the RNA is requested.
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
““Optical” PLT CountOptical” PLT Count
. Impedance platelet analysis has limitations in the identification and discrimination of platelets from interfering particles
. RBC fragments (similar in size to PLT)
.Counted as platelets
. Small RBC (similar in size to PLT)
.Counted as platelets
. Large platelets (similar in size to RBC)
. Excluded from the platelet count
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Fluorescence PLT
X
Fluorescence PLT CountFluorescence PLT Count
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
RBC ratio v XE (PLT-i)
y = 0.9047x + 2.1817r = 0.8852
0
30
60
90
120
150
0 30 60 90 120 150
RBC ratio x 10 ^9/L
XE (P
LT-i)
x 1
0 ^9
/LRBC Ratio v XE (PLT-o)
y = 1.0068x + 1.8778r = 0.9735
0
30
60
90
120
150
0 30 60 90 120 150
RBC ratio x 10 ^9/L
XE
(PLT
-o) x
10
^9/L
Immunocount versus XE impedance count
Immunocount versus XE “optical” count
PLT < 100 X 10PLT < 100 X 1099/L vs. Immunocount/L vs. Immunocount
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Results
XE2100 (PLT i) versus CD61
• All counts R²=0.98• PLT <100 R²=0.78
XE2100 (PLT fl) versus CD61
• All counts R²=0.97• PLT<100 R²=0.95
Fluorescence PLT CountFluorescence PLT Count
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Ret ChannelRet Channel
Reliable PLT Count
With the addition of the optical method for PLT counting, the XT-2000i
Can automatically report reliable PLT counts when interferences with
The impedance method are detected
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
PLT-I and PLT-FL Switching AlgorithmPLT-I and PLT-FL Switching Algorithm
PLT-I, unreliable
PLT-O, unreliable
PLT Vote out
PLT-I Result
PLT-O Result
No
Yes
Yes
No
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Dysplastic Thrombocytes (MDS)Dysplastic Thrombocytes (MDS)
. Dysplastic Erythrocyte (could be with Fragments)
. Dysplastic Thrombocyte (possible with degranulated PLT)
. Problem with Impedance and FSC and SSC (7°).
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Dysplasia (MDS)Dysplasia (MDS)
90% of all measured Fragments are related to MDS
In case of MDS:
dysplastic Erythrocytes (Fragments)
dysplastic Platelets (degranulated)
Problems with Impedance and optical Measurement (FSC and SSC (no granularity)), only fluorescence RNA is possible.
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FeaturesFeatures
IG CountIG Count
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Maturation of neutrophil
promyelo myelo metamyelomyeloblast band segment
IG
IG CountIG Count
.Useful information on WBC extended differential (Not reportable - research parameter)
. IG:
.promyelocyte
.myelocyte
.metamyelocyte
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Diff ScattergramDiff Scattergram
Band
Metamyelo
Myelo
Promyelo
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Immature Granulocytes Immature Granulocytes
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Immature Granulocytes Immature Granulocytes
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
y = 1.2278x - 0.7245
R2 = 0.8751
0
5
10
15
20
25
30
35
0 5 10 15 20 25 30
XE-2100 IG%
MIC
RO
IG
%
No. samples: 134
XE-2100 range: 1.0-24%
MICRO range: 0.0-33.0%
Inaccuracy of IG proportionInaccuracy of IG proportion
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FeaturesFeatures
Atypical LymphAtypical Lymph
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Diff ScattergramDiff Scattergram
Band
Metamyelo
Myelo
Promyelo
Abn. Lymph/Blasts
Atypical Lymph
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Atyp. LymphAtyp. Lymph
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Activated B-Lymphocytes
Atyp. LymphAtyp. Lymph
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Atyp. LymphAtyp. Lymph
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Comparison: XT vs. ADVIAComparison: XT vs. ADVIA
LUC - What is that ?
Blast or Blast-like
. ALL or AML
. NHL (IB or CC-CB)
Large Lymphocytes
. Activated T-Cells
. Activated B-Cells
. O-Lymphocytes
. NHL all kinds.
Monocytes (Low perox.)
. CMML
. Macrophage
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Comparison: XT vs. ADVIAComparison: XT vs. ADVIA
The result was Other: 11.5%, LUC: 10.8% and manual: 9% respectively,
it showed excellent correlation.
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Big differences between Other: 0.1% and LUC: 15.3%, but the result of manual method was Atyp. Lymph 0.5% and Monocytes: 40%. It is considered that LUC includes Monocytes
Comparison: XT vs. ADVIAComparison: XT vs. ADVIA
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
SummarySummary
.XT-2000i gives information about replication activity of the nucleus (higher RNA content)
.XT-2000i gives information about cytoplasm activity (Protein syntheses high RNA)Sub-population for B-lymphocytes.
.Separates Lymphatic diseases from others
.No problem with Giant-PLT or Fragments (PLT-fl)
.XT-2000i provide a total count of IG´s (Sepsis)
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FeaturesFeatures
Network capacity Network capacity
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
NetworkNetwork
.The XT can be integrated into computer network
Room A
Room BRoom C
PC room
Sysmex
XE-2100
Doctor’s room
NETWORK
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Network ConnectionNetwork Connection
Hospital Information System
Clinical Laboratory (1)
Clinical Laboratory (1)
Laboratory Information System
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Features Features
Quality ControlQuality Control
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
.24 files for either x bar or L-J
.1 file for x bar M
.300 points each file
.Delta checking is also available for cumulative review
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Primary Goals in Quality ControlPrimary Goals in Quality Control
.Error Detection
.Error Prevention
.Reliable Test Results
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Errors of Laboratory MeasurementsErrors of Laboratory Measurements
. Random errors are the result of chance or sampling errors.
. Random errors do not affect the entire batch of specimens
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Systematic Error Systematic Error
. Systematic errors affect all specimens in a batch.
. Systematic errors are attributed to causes other than chance: e.g., deteriorating reagents, instrument malfunction.
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FeaturesFeatures
X-bar-M ControlX-bar-M Control
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Patient Moving AveragePatient Moving Average
.Quality control tool developed by Dr. Brian Bull in 1974.
.This algorithm is based on the inherent stability of the red blood cell indices in a general hospital populations.
.Utilizes patient data, recording the MCV, MCH and MCHC of each patient sample.
.Monitors stability over time of:
. Instrumentation
.Reagents
.Technique
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
FeatureFeature
.Use of routine samples
.Fresh blood, cells without fixation, optimal to check lyse processes
.NO additional costs, because the control runs in the back ground with routine samples
.no manual handling
.Optimal controlling of reagents
.especially after reagent change
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
FeatureFeature
. Check of the analyzer every 20, 30, 40 or ... (corresponding batch size)
. Longtime and continuing control
. QC is only one shot
.No optimal check of reagent
.Check of dilutions
.Check of lyse processes limited
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Advantages of x-bar-m controlAdvantages of x-bar-m control
. Inexpensive, simple to use
.Utilizes unfixed patient blood
. Incorporated into current Hematology analyzers
.Real time QC
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FeaturesFeatures
Online QCOnline QC
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
On-line QCOn-line QC
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Online-QC on the XE-2100Online-QC on the XE-2100
. Internal & External QC simultaneously
.Daily Data Comparison against Reference and Peer Group Values
.QC-Error Detection in Real-Time by Means of a QC-Flag System
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Categories of Quality ControlCategories of Quality Control
. IQC
.Available anytime, butif any abnormality found...
. Instrument condition?
.Control Blood Problem?
EQC
.Not Available anytime
. Long period to get statistics Result
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
1111
Action Limit flag
If data exceeds Group Mean +/- Action
Limit triggers QC-error mail
SDI Limit flag
When data exceeds Group Mean +/- 3SD
Reproducibility flag
When data deference against the
previous QC data in SDI is more than “4”, Trend flag
When SDI increased or decreased continuously 6 times
QC flagging InformationQC flagging Information
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FeaturesFeatures
Remote MaintenanceRemote Maintenance
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Remote ServiceRemote Service
Line for Remote Support Sysmex
SupportCenter
Line forRemote Support
ClinicalLabs
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
SNCS ConceptSNCS Concept
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FeaturesFeatures
Random Access TestingRandom Access Testing
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Random Access TestingRandom Access Testing
CBC
CBC + DIFF
CBC + DIFF + RET
CBC + RET
.Real-time random access testing
. Quick report
. Cost saving
Various types of real-time discrete analysis modes save on reagent
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FeatureFeature
XE / XT Family ConceptXE / XT Family Concept
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Operation & reagent system with XEOperation & reagent system with XE
.Solution for
. HST (XE) series: Core lab.
. XT series: for satellite lab.
Core Lab
Same ReagentsSame Results
Same Operation
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FeaturesFeatures
Hydrodynamic FocusingHydrodynamic Focusing
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Hydrodynamic Focusing SystemHydrodynamic Focusing System
. New system
. Compact
. Prevent re-circulating and coincidence
. No Cellsheath required
Less maintenanceMore accurate result in RBC and PLT
CELLPACK (Sheath solution)
Aperture
Sample
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FeaturesFeatures
Q-FlagQ-Flag
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Unique Q-Flag SystemUnique Q-Flag System
. Q-Flag system visualizes level of each sample abnormalities and allow to perform the patient monitoring effectively.
. Quantitative monitoring of suspect flags:
. Blasts?
. Imm Gran?
. Left Shift?
. Atypical Ly?
. Abn Ly/Blasts?
. RBC Lyse Res?
. RBC Agglut?
. Turb/HGB?
. HGB Defect?
. Fragments?
. PLT Clumps?
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Q-Flag SystemQ-Flag System
300
200
100
80
BLASTS ?300
200
100
250
BLASTS ?
IP Message
Numerical value of the bar height
Red, ifabove 100
Green, ifbelow 100
Sysmex Q-Flag system gives the operator the full picture.
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Degree of the abnormality Trigger
level
Blasts? Imm Gran?Left Shift?
Positiveexample
Negativeexample
Q-Flag SystemQ-Flag System
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FeaturesFeatures
ACAS - ACAS - Adaptive Cluster Analysis Adaptive Cluster Analysis SystemSystem
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
ACAS ACAS Adaptive Cluster Analysis SystemAdaptive Cluster Analysis System
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
ACASACASACAS
1. Analysis of the first 500 signals of cells with moving centroids.
2. Determination of clusters of lymphocytes granulocytes, monocytes and ghost when analysing 1000 signals of cells.
3. Repitition of steps 1 and 2 until the values are stabil (max. 5 times), I. e. the centroides are in a fixed position.
4. If the differences are not stable after the 5. repetition, there will be no separation of WBC populations (grey area).
5. Adaptive Cluster Analysis System is done for all counted leucocytes (f.e. 25.670 cells, if the WBC concentration is 25,67 x 10^3/µL).
6. Result: Very exact differentiation, compared to flowcytometrie and the manual mikroscopic differential.
7. Result: Good differentiation even in pathological and older samples (24 h).
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
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Position StatementPosition Statement
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Purpose Positioning StatementPurpose Positioning Statement
It’s up to us to choose :
the image or perception
However we intend to generate in the customer´s mind
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Position Statement ElementsPosition Statement Elements
. Images or Perception
.Customer Target Groups
.Competitor Target
.Core Strategy
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Images or PerceptionImages or Perception
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Image or perception we intend to Image or perception we intend to generate in customer’s mind:generate in customer’s mind:
.State of the art
.we continue to deliver what we promise in time reliable and innovative products
.Appealing Software
.Unique menu of clinically relevant parameters
.PLT-fl
. IG
. Fluorescence : ‘brightest’ hematology system
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Image or perception we intend to Image or perception we intend to generate in customer’s mind:generate in customer’s mind:
. Is it IT or is it Haematology ? It is the best of both !
.The only true WBC count
.21st Century laboratory management concept
.perfect combination between research and routine
.High class full hematology
.a system for eXperTs
.Network connectivity
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Image or perception we intend to Image or perception we intend to generate in customer’s mind:generate in customer’s mind:
.Perfect link between technology and organisation
. the golden combination
. selectivity : cost effective
. compact
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Image or perception we intend to Image or perception we intend to generate in customer’s mind:generate in customer’s mind:
. Fluorescence Activated Differential (F.A.D.) :
.a new standard in WBC-differential:the DIFF is stained, therefore optimum quality
.True Selectivity : random access profiling:CBC, CBC+DIFF, CBC+DIFF+RET, CBC+RET
. reduce running costs and increase efficiency
.New parameters: IG, PLT-fl, RBC-O
.a world of new important information
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Image or perception we intend to Image or perception we intend to generate in customer’s mind:generate in customer’s mind:
.The top of the range analyzer made by Sysmex
.a high quality product of a successful range
.High Tech : Windows 2000, Dual, QC, Maint.
.Up-to-date computer system
. Latest Laser Technology : Diode Laser
. Long life, trouble free high stability
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Customer Target GroupsCustomer Target Groups
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Positioning StatementPositioning Statement
Customer Target Groups:
. the Scientist
. the Altruist
. the Money Maker
. the Lab-manager
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Target Group: the Scientist Target Group: the Scientist
The XT-2000i delivers several important new parameter to be evaluated:
. IG % and IG #
.80 % of all diseases have an increased IG
. further reduction of manual diff!
.Better accuracy for IG detection!
.PLT-fl
.Monitoring of Anemia
.New Parameter: RBC-Y and RET-Y
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Target Group: the AltruistTarget Group: the Altruist
The XT-2000i delivers several important new parameter which improve Patient Care:
. IG count: fast and reliable
.PLT-fl: correct PLT count even at fragmented RBC or PLT-clumps
.RBC-O: correct RBC count also at agglutination
. IG % at low concentrations : the only clinical indicator for some diseases
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Target Group: the MoneymakerTarget Group: the Moneymaker
The XT-2000i delivers several important new innovations which improve efficiency:
. full selectivity reduces costs/test
. IG count reduces manual differentials further
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Target Group: the Lab-ManagerTarget Group: the Lab-Manager
The XT-2000i delivers several important high tech features which improve lab-service:
.Windows 2000 software
.Online QC support
.Online Maintenance
.Online Application Support
.Online Service Support
. Internet Communications
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Competitor TargetCompetitor Target
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Competitor Target BayerCompetitor Target Bayer
Position themselves as THE differential counter
.Where is the IG count ?
.How about peroxidase deficiency ?
.What about maintenance ?
.What's about degranulated cells
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Competitor Target AbbottCompetitor Target Abbott
Worked hard to become the new standard
.Did not make it (only a few CD-4000 installations world wide)
.No real flowcytometry with fluorochrome
.9 part diff ? No scientific evidence
.Reliability problems: pinch valves, no SRV
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Competitor Target CoulterCompetitor Target Coulter
.Used to be Nr. 1
.No random access selectivity
.No IG
.No innovations
. Just a Max-M repacked: old technology
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Competitor Target ABXCompetitor Target ABX
.A newcomer
.No random access selectivity
.No IG
.No Dual System
.Not fast
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Core StrategyCore Strategy
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Core Strategy MMCore Strategy MM
Convince the money-maker that …………...the XT-2000i improves his lab-efficiencydramatically and in a unique way because :
. the IG count reduces his manual differential count further
. full selectivity reduces his costs/test
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Core Strategy ACore Strategy A
Convince the Altruist that ………………….The XT-2000i produces reliable results on new parameters which improve the healthcare of his patients because :
.PLT-fl: correct PLT count even at appearance of Fragments
.RBC-O: correct RBC count also at agglutination
. IG count provided within 30 seconds: inflammation and sepsis (I/T ratio)
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Core Strategy SCore Strategy S
Convince the Scientist that ……..The XT-2000i is the superb analyser which provides a lot of scientific important parameters to be investigated for clinical relevance/importance because:
.How powerful is IG% and IG# in detecting sepsis in an early stage ?
.At what diseases IG appearance at the same time in the same in the peripheral blood ?
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
Core Strategy LMCore Strategy LM
Convince the Lab-manager that ………..the XT-2000i has a powerful impact onto his lab-organisation because:
. the Windows 2000 is so easy to operate by all people
. the Internet-connection allows him to communicate : QC-results, application issue’s, maintenance, service support
.powerful QC-package
.adjust screens to his needs: flexibility
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SYSMEX SINGAPORE PTE LTD XT-2000i Launch
The END!
EndeEnde