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http://www.xigris.com/200-sepsis-management-challenges.jsp http://blogs.cgdev.org/globalhealth/ under_5_deaths.gif Invasive Infection Immune Cells and Cytokines HMGB1 Release Receptor Binding Toll- Like Receptor RAGE Dual Knockout Receptor TNF Release Dual knockout receptor cells will have similar TNF levels as compared to each other and single knockout receptor cells, when exposed to all HMGB1 and LPS concentrations. The dual knockouts will have the lowest TNF levels in both the HMGB1 and TNF Trials. To determine the effectiveness of the dual knockout receptors T2R and TR4, in lowering TNF levels as compared to single knockout receptors. Capture Sample Detection Second Substrate ELISA Pro-Inflammatory Protection- Critical Illness Normal –Lethal Response Appears in 16-24 hrs Plateaus 24-32 hrs Late Action-Therapeutic Target in Inflammation High Mobility Group Box-1 http://www.uic.edu/classes/bios/bios100/lecturesf04am/ inflammation01a.jpg Purpose Hypothesis 1 Hypothesis 2 Cytokines and Proteins linked to Sepsis-HMGB1 Normal/ Septic Conditions. TLR4, TLR2, RAGE. Single Knockout Receptors Yang (2005) Yang, 2005 Introduct ion

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Introduction. http://www.xigris.com/200-sepsis-management-challenges.jsp. Invasive Infection. Immune Cells and Cytokines. http:// blogs.cgdev.org/globalhealth/under_5_deaths.gif. HMGB1 Release. Receptor Binding Toll- Like Receptor RAGE Dual Knockout Receptor. TNF Release. - PowerPoint PPT Presentation

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Page 1: xigris/200-sepsis-management-challenges.jsp

http://www.xigris.com/200-sepsis-management-challenges.jsp

http://blogs.cgdev.org/globalhealth/under_5_deaths.gif

Invasive Infection

Immune Cells and Cytokines

HMGB1 ReleaseReceptor Binding

Toll- Like Receptor

RAGE

Dual Knockout Receptor

TNF Release

Dual knockout receptor cells will have similar TNF levels as compared to each other and single knockout receptor cells, when exposed to all HMGB1 and LPS concentrations.

The dual knockouts will have the lowest TNF levels in both the HMGB1 and TNF Trials.

To determine the effectiveness of the dual knockout receptors T2R and TR4, in lowering TNF levels as compared to single knockout receptors.

Capture Sample Detection Secondary Substrate

ELISA

Pro-InflammatoryProtection- Critical IllnessNormal –Lethal ResponseAppears in 16-24 hrsPlateaus 24-32 hrs Late Action-Therapeutic Target in Inflammation

High Mobility Group Box-1http://www.uic.edu/classes/bios/bios100/lecturesf04am/inflammation01a.jpg

Purpose

Hypothesis 1 Hypothesis 2

Cytokines and Proteins linked to Sepsis-HMGB1

Normal/ Septic Conditions. TLR4, TLR2, RAGE. Single Knockout Receptors

Yang (2005)

Yang, 2005

Introduction

http://upload.wikimedia.org/wikipedia/commons/4/4b/ELISA-sandwich.svg

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